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MX2016015614A - Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso. - Google Patents

Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso.

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Publication number
MX2016015614A
MX2016015614A MX2016015614A MX2016015614A MX2016015614A MX 2016015614 A MX2016015614 A MX 2016015614A MX 2016015614 A MX2016015614 A MX 2016015614A MX 2016015614 A MX2016015614 A MX 2016015614A MX 2016015614 A MX2016015614 A MX 2016015614A
Authority
MX
Mexico
Prior art keywords
gitr
antibodies
glucocorticóides
receiver
methods
Prior art date
Application number
MX2016015614A
Other languages
English (en)
Other versions
MX377844B (es
Inventor
Leger Olivier
J Underwood Dennis
SIEBERT Volker
Van Dijk Marc
Schaer David
Tsuji Takemasa
Ritter Gerd
M Gonzalez Ana
S Wilson Nicolas
ZAPPASODI Roberta
Merghoub Taha
David WOLCHOK Jedd
Seibert Volker
Original Assignee
Agenus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agenus Inc filed Critical Agenus Inc
Publication of MX2016015614A publication Critical patent/MX2016015614A/es
Publication of MX377844B publication Critical patent/MX377844B/es

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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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Abstract

La presente descripción proporciona anticuerpos que se unen específicamente al receptor relacionado con la familia de TNFR inducido por glucocorticoides (GITR) y composiciones que comprenden los anticuerpos. En un aspecto especifico, los anticuerpos se unen específicamente al GITR humano y modulan la actividad del GITR, por ejemplo, aumentan, activan o inducen actividad GITR, mediante el uso de los anticuerpos. La presente descripción también proporciona métodos para tratar trastornos, tales como cáncer y enfermedades infecciosas, mediante la administración de un anticuerpo que se une específicamente al GITR humano y modula la actividad GITR, por ejemplo, mejora, activa o induce actividad GITR.
MX2016015614A 2014-05-28 2015-05-28 Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso. MX377844B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462004071P 2014-05-28 2014-05-28
US201562161250P 2015-05-13 2015-05-13
PCT/US2015/032895 WO2015184099A1 (en) 2014-05-28 2015-05-28 Anti-gitr antibodies and methods of use thereof

Publications (2)

Publication Number Publication Date
MX2016015614A true MX2016015614A (es) 2017-08-21
MX377844B MX377844B (es) 2025-03-11

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Application Number Title Priority Date Filing Date
MX2016015614A MX377844B (es) 2014-05-28 2015-05-28 Anticuerpos anti proteína relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticóides (gitr) y sus métodos de uso.
MX2020013062A MX2020013062A (es) 2014-05-28 2016-11-28 Anticuerpos anti proteina relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticoides (gitr) y sus metodos de uso.

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MX2020013062A MX2020013062A (es) 2014-05-28 2016-11-28 Anticuerpos anti proteina relacionada con el receptor del factor de necrosis tumoral inducida por glucocorticoides (gitr) y sus metodos de uso.

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US (9) US10155818B2 (es)
EP (2) EP3148579B1 (es)
JP (3) JP6847666B2 (es)
KR (2) KR102433464B1 (es)
CN (2) CN115925946A (es)
AU (3) AU2015266958A1 (es)
CA (1) CA2949998A1 (es)
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EA (1) EA201692458A1 (es)
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MX (2) MX377844B (es)
NZ (2) NZ764826A (es)
PH (2) PH12016502345B1 (es)
PL (1) PL3148579T3 (es)
PT (1) PT3148579T (es)
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SG (2) SG11201609721WA (es)
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KR101566539B1 (ko) 2012-06-08 2015-11-05 국립암센터 신규한 Ｔｈ2 세포 전환용 에피토프 및 이의 용도
CA2949998A1 (en) 2014-05-28 2015-12-03 Agenus Inc. Anti-gitr antibodies and methods of use thereof
RS59643B1 (sr) 2014-06-06 2020-01-31 Bristol Myers Squibb Co Antitela na glukokortikoidom indukovani receptor faktora nekroze tumora (gitr) i njihova primena
US11242319B2 (en) 2014-11-05 2022-02-08 Flexus Biosciences, Inc. Immunoregulatory agents
UY36390A (es) * 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
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