LT3138397T - Humanizuoti il-15 gyvūnai - Google Patents

Humanizuoti il-15 gyvūnai

Info

Publication number: LT3138397T
Authority: LT; Lithuania
Prior art keywords: humanized; animals
Prior art date: 2013-10-15

Application number

LTEP16192440.2T

Other languages

English (en)

Inventor

Jose F. Rojas

Ka-Man Venus Lai

Andrew J Murphy

Original Assignee

Regeneron Pharmaceuticals, Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2013-10-15

Filing date

2014-10-15

Publication date

2019-04-10

2014-10-15 Application filed by Regeneron Pharmaceuticals, Inc. filed Critical Regeneron Pharmaceuticals, Inc.

2019-04-10 Publication of LT3138397T publication Critical patent/LT3138397T/lt

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5443—IL-15
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0387—Animal model for diseases of the immune system
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8527—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic for producing animal models, e.g. for tests or diseases

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Zoology (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Environmental Sciences (AREA)
Veterinary Medicine (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biodiversity & Conservation Biology (AREA)
Animal Husbandry (AREA)
Animal Behavior & Ethology (AREA)
Toxicology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Medicinal Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

LTEP16192440.2T 2013-10-15 2014-10-15 Humanizuoti il-15 gyvūnai LT3138397T (lt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US201361891013P	2013-10-15	2013-10-15

Publications (1)

Publication Number	Publication Date
LT3138397T true LT3138397T (lt)	2019-04-10

Family

ID=51830649

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
LTEP16192440.2T LT3138397T (lt)	2013-10-15	2014-10-15	Humanizuoti il-15 gyvūnai
LTEP14790452.8T LT2908626T (lt)	2013-10-15	2014-10-15	Gyvunai su humanizuotu il15

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
LTEP14790452.8T LT2908626T (lt)	2013-10-15	2014-10-15	Gyvunai su humanizuotu il15

Country Status (27)

Country	Link
US (5)	US9155290B2 (lt)
EP (3)	EP3461331A1 (lt)
JP (3)	JP6492095B2 (lt)
KR (1)	KR102376041B1 (lt)
CN (2)	CN105744829B (lt)
AU (2)	AU2014337526B2 (lt)
BR (1)	BR112016008175A2 (lt)
CA (1)	CA2926090C (lt)
CY (2)	CY1118675T1 (lt)
DK (2)	DK3138397T3 (lt)
ES (2)	ES2613379T3 (lt)
HR (2)	HRP20170380T1 (lt)
HU (2)	HUE033272T2 (lt)
IL (2)	IL244525B (lt)
LT (2)	LT3138397T (lt)
MX (1)	MX2016004781A (lt)
NZ (1)	NZ718655A (lt)
PL (2)	PL2908626T3 (lt)
PT (2)	PT3138397T (lt)
RS (2)	RS55472B1 (lt)
RU (1)	RU2674910C2 (lt)
SG (2)	SG11201601828XA (lt)
SI (2)	SI2908626T1 (lt)
SM (3)	SMT201900177T1 (lt)
TR (1)	TR201904342T4 (lt)
WO (1)	WO2015057758A1 (lt)
ZA (1)	ZA201601676B (lt)

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ES2908587T3 (es)	2009-10-06	2022-05-03	Regeneron Pharma	Ratones modificados genéticamente e injerto
EP3375284B1 (en)	2011-02-15	2023-03-29	Regeneron Pharmaceuticals, Inc.	Humanized m-csf mice and uses thereof
CA2881468C (en)	2012-09-07	2023-03-21	Yale University	Genetically modified mice which express human cytokines and methods of use thereof, including engraftment
NZ724353A (en)	2012-11-05	2022-05-27	Regeneron Pharma	Genetically modified non-human animals and methods of use thereof
SI2908626T1 (sl)	2013-10-15	2017-02-28	Regeneron Pharmaceuticals, Inc.	Humanizirane živali IL-15
AU2014353347B2 (en)	2013-11-19	2020-07-02	Regeneron Pharmaceuticals, Inc.	Non-human animals having a humanized a proliferation-inducing ligand gene
SG11201608696RA (en)	2014-05-05	2016-11-29	Regeneron Pharma	Humanized c5 and c3 animals
NO2785538T3 (lt)	2014-05-07	2018-08-04
KR20250096864A (ko)	2014-05-19	2025-06-27	리제너론 파마슈티칼스 인코포레이티드	인간 epo를 발현하는 유전자 변형된 비-인간 동물
WO2016089692A1 (en)	2014-12-05	2016-06-09	Regeneron Pharmaceuticals, Inc.	Non-human animals having a humanized cluster of differentiation 47 gene
CN115943929B (zh)	2015-04-13	2025-01-10	再生元制药公司	人源化SIRPα-IL15敲入小鼠及其使用方法
MX2018009513A (es)	2016-02-04	2019-01-31	Regeneron Pharma	Animales no humanos que tienen un gen angptl8 modificado genéticamente.
EP3422845B1 (en)	2016-02-29	2021-06-02	Regeneron Pharmaceuticals, Inc.	Rodents having a humanized tmprss gene
US10912287B2 (en)	2016-06-28	2021-02-09	Biocytogen Pharmaceuticals (Beijing) Co., Ltd	Genetically modified mice expressing humanized PD-1
WO2018041118A1 (en)	2016-08-31	2018-03-08	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric pd-l1
US11279948B2 (en)	2016-08-31	2022-03-22	Biocytogen Pharmaceuticals (Beijing) Co., Ltd.	Genetically modified non-human animal with human or chimeric OX40
WO2018041121A1 (en)	2016-08-31	2018-03-08	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric ctla-4
WO2018041120A1 (en)	2016-08-31	2018-03-08	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric tigit
CN107815468B (zh)	2016-08-31	2021-03-16	百奥赛图(北京)医药科技股份有限公司	人源化基因改造动物模型的制备方法及应用
CN107815467B (zh)	2016-08-31	2021-03-16	百奥赛图(北京)医药科技股份有限公司	人源化基因改造动物模型的制备方法及应用
WO2018086594A1 (en)	2016-11-11	2018-05-17	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric tim-3
CN108070613B (zh)	2016-11-11	2020-03-13	百奥赛图江苏基因生物技术有限公司	人源化基因改造动物模型的制备方法及应用
WO2018102546A1 (en)	2016-11-30	2018-06-07	The Jackson Laboratory	Humanized mouse model with improved human innate immune cell development
CN108239659B (zh)	2016-12-23	2020-03-03	百奥赛图江苏基因生物技术有限公司	人源化基因改造动物模型的制备方法及应用
CN108424928B (zh)	2016-12-30	2021-03-16	百奥赛图(北京)医药科技股份有限公司	人源化基因改造动物模型的制备方法及应用
US11629340B2 (en)	2017-03-03	2023-04-18	Obsidian Therapeutics, Inc.	DHFR tunable protein regulation
CN108467873B (zh)	2017-03-17	2020-03-13	百奥赛图江苏基因生物技术有限公司	一种cd132基因缺失的免疫缺陷动物模型的制备方法及应用
CN108588126B (zh)	2017-03-31	2020-04-10	北京百奥赛图基因生物技术有限公司	Cd47基因人源化改造动物模型的制备方法及应用
WO2018177441A1 (en)	2017-03-31	2018-10-04	Beijing Biocytogen Co., Ltd	GENETICALLY MODIFIED NON-HUMAN ANIMAL WITH HUMAN OR CHIMERIC SIRPα
CN109136261B (zh)	2017-06-19	2021-03-16	百奥赛图(北京)医药科技股份有限公司	人源化cd28基因改造动物模型的制备方法及应用
CN109136275B (zh)	2017-06-19	2021-03-16	百奥赛图(北京)医药科技股份有限公司	人源化gitr基因改造动物模型的制备方法及应用
CN109136274B (zh)	2017-06-19	2021-04-23	百奥赛图江苏基因生物技术有限公司	人源化cd40基因改造动物模型的制备方法及应用
WO2019032836A1 (en) *	2017-08-09	2019-02-14	The Jackson Laboratory	IMMUNODEFICIENT MOUSE EXPRESSING THE HUMAN INTERLEUKINE 15
ES2962277T3 (es)	2017-09-29	2024-03-18	Regeneron Pharma	Roedores que comprenden un locus Ttr humanizado y métodos de uso
WO2019072241A1 (en)	2017-10-13	2019-04-18	Beijing Biocytogen Co., Ltd	NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH PD-1 HUMAN OR CHIMERIC
CN109913493B (zh)	2017-12-12	2021-03-16	百奥赛图江苏基因生物技术有限公司	人源化cd3基因改造动物模型的制备方法及应用
AU2019308205B2 (en)	2018-07-16	2025-11-06	Regeneron Pharmaceuticals, Inc.	Non-human animal models of DITRA disease and uses thereof
WO2020074005A1 (en)	2018-10-12	2020-04-16	Beijing Biocytogen Co., Ltd	Genetically modified non-human animal with human or chimeric genes
WO2020125763A1 (en)	2018-12-20	2020-06-25	Biocytogen Jiangsu Co., Ltd.	Genetically modified non-human animal with human or chimeric lag3
CN111304248B (zh) *	2018-12-25	2021-08-24	百奥赛图江苏基因生物技术有限公司	人源化细胞因子il15基因改造非人动物的构建方法及应用
CN114164177A (zh) *	2019-01-17	2022-03-11	百奥赛图(北京)医药科技股份有限公司	人源化转基因动物
CN117178959A (zh)	2019-04-04	2023-12-08	瑞泽恩制药公司	包括人源化凝血因子12基因座的非人动物
EP3801011A1 (en)	2019-06-04	2021-04-14	Regeneron Pharmaceuticals, Inc.	Non-human animals comprising a humanized ttr locus with a beta-slip mutation and methods of use
US11622547B2 (en)	2019-06-07	2023-04-11	Regeneran Pharmaceuticals, Inc.	Genetically modified mouse that expresses human albumin
CN114786479B (zh) *	2019-12-25	2023-12-15	江苏集萃药康生物科技股份有限公司	一种il-15人源化小鼠模型及其用途
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CN111485001A (zh) *	2020-04-14	2020-08-04	澎立生物医药技术（上海）有限公司	具有nk细胞及adcc能力的人源化免疫系统小鼠的构建方法
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2014
- 2014-10-15 SI SI201430109T patent/SI2908626T1/sl unknown
- 2014-10-15 RU RU2016116847A patent/RU2674910C2/ru active
- 2014-10-15 SM SM20190177T patent/SMT201900177T1/it unknown
- 2014-10-15 ES ES14790452.8T patent/ES2613379T3/es active Active
- 2014-10-15 SG SG11201601828XA patent/SG11201601828XA/en unknown
- 2014-10-15 PT PT16192440T patent/PT3138397T/pt unknown
- 2014-10-15 CN CN201480056455.3A patent/CN105744829B/zh active Active
- 2014-10-15 HU HUE14790452A patent/HUE033272T2/en unknown
- 2014-10-15 PT PT147904528T patent/PT2908626T/pt unknown
- 2014-10-15 PL PL14790452T patent/PL2908626T3/pl unknown
- 2014-10-15 AU AU2014337526A patent/AU2014337526B2/en active Active
- 2014-10-15 RS RS20161140A patent/RS55472B1/sr unknown
- 2014-10-15 US US14/514,454 patent/US9155290B2/en active Active
- 2014-10-15 DK DK16192440.2T patent/DK3138397T3/en active
- 2014-10-15 SM SM20170024T patent/SMT201700024T1/it unknown
- 2014-10-15 DK DK14790452.8T patent/DK2908626T3/en active
- 2014-10-15 HR HRP20170380TT patent/HRP20170380T1/hr unknown
- 2014-10-15 LT LTEP16192440.2T patent/LT3138397T/lt unknown
- 2014-10-15 CN CN201810808707.3A patent/CN109090037B/zh active Active
- 2014-10-15 NZ NZ718655A patent/NZ718655A/en unknown
- 2014-10-15 MX MX2016004781A patent/MX2016004781A/es unknown
- 2014-10-15 EP EP18206034.3A patent/EP3461331A1/en not_active Withdrawn
- 2014-10-15 ES ES16192440T patent/ES2715949T3/es active Active
- 2014-10-15 SI SI201431130T patent/SI3138397T1/sl unknown
- 2014-10-15 BR BR112016008175A patent/BR112016008175A2/pt not_active Application Discontinuation
- 2014-10-15 RS RS20190349A patent/RS58465B1/sr unknown
- 2014-10-15 HU HUE16192440A patent/HUE043969T2/hu unknown
- 2014-10-15 SG SG10201607768YA patent/SG10201607768YA/en unknown
- 2014-10-15 EP EP16192440.2A patent/EP3138397B1/en active Active
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2015
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2016
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2017
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2018
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2019
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EP3461331A1 (en)	2019-04-03
EP3138397B1 (en)	2018-12-26
ZA201601676B (en)	2019-12-18
JP6600061B2 (ja)	2019-10-30
SMT201700024B (it)	2017-03-08
KR20160068774A (ko)	2016-06-15
AU2020286186A1 (en)	2021-01-07
RS55472B1 (sr)	2017-04-28
CN109090037B (zh)	2021-05-28
PT2908626T (pt)	2017-01-09
JP2019216750A (ja)	2019-12-26
SMT201700024T1 (it)	2017-03-08
RS58465B1 (sr)	2019-04-30
CN109090037A (zh)	2018-12-28
NZ718655A (en)	2022-08-26
AU2014337526B2 (en)	2020-09-10
CN105744829B (zh)	2018-08-07
US20150106961A1 (en)	2015-04-16
EP2908626B1 (en)	2016-12-07
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EP3138397A1 (en)	2017-03-08
PT3138397T (pt)	2019-03-26
BR112016008175A2 (pt)	2017-10-03
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LT2908626T (lt)	2017-01-25
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SG10201607768YA (en)	2016-11-29
US20230189772A1 (en)	2023-06-22
WO2015057758A1 (en)	2015-04-23
US12369570B2 (en)	2025-07-29
TR201904342T4 (tr)	2019-05-21
CY1118675T1 (el)	2018-03-07
DK2908626T3 (en)	2017-03-20
IL244525A0 (en)	2016-04-21
SI2908626T1 (sl)	2017-02-28
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AU2014337526A1 (en)	2016-04-28
CA2926090C (en)	2022-07-05

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IL269907B (en)	2020-09-30	Humanized animals for – il–15
SG11201510653YA (en)	2016-01-28	Anti-fcrh5 antibodies
GB201322583D0 (en)	2014-02-05	Antibodies
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