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MX2014004083A - Metodo para aislar ingenol. - Google Patents

Metodo para aislar ingenol.

Info

Publication number
MX2014004083A
MX2014004083A MX2014004083A MX2014004083A MX2014004083A MX 2014004083 A MX2014004083 A MX 2014004083A MX 2014004083 A MX2014004083 A MX 2014004083A MX 2014004083 A MX2014004083 A MX 2014004083A MX 2014004083 A MX2014004083 A MX 2014004083A
Authority
MX
Mexico
Prior art keywords
ingenol
isolating
esters
isolating ingenol
c20h28o5
Prior art date
Application number
MX2014004083A
Other languages
English (en)
Inventor
Giovanni Appendino
Cabello De Alba Maria Luz Bellido
Alberto Pagani
Blanco Eduardo Muñoz
Original Assignee
Indena Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indena Spa filed Critical Indena Spa
Publication of MX2014004083A publication Critical patent/MX2014004083A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/80—Separation; Purification; Stabilisation; Use of additives by liquid-liquid treatment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/78—Separation; Purification; Stabilisation; Use of additives
    • C07C45/85—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/723—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic
    • C07C49/727—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups polycyclic a keto group being part of a condensed ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
    • C07D319/08—1,3-Dioxanes; Hydrogenated 1,3-dioxanes condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/86—Ring systems containing bridged rings containing four rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a un nuevo método para aislar ingenol (C20H28O5) a partir de mezclas de ésteres de diterpenoide y ésteres de ingenol en un solo paso; el ingenol aislado por este método se puede usar como un precursor para la síntesis de derivados de ingenol biológicamente activos, como ingenol-3-angelato e ingenol-3-tigliato.
MX2014004083A 2011-10-04 2012-10-02 Metodo para aislar ingenol. MX2014004083A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES201131601A ES2408507B1 (es) 2011-10-04 2011-10-04 Método de aislamiento de ingenol.
PCT/EP2012/069452 WO2013050365A1 (en) 2011-10-04 2012-10-02 Method of isolating ingenol

Publications (1)

Publication Number Publication Date
MX2014004083A true MX2014004083A (es) 2014-05-30

Family

ID=47080451

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014004083A MX2014004083A (es) 2011-10-04 2012-10-02 Metodo para aislar ingenol.

Country Status (20)

Country Link
US (2) US20140243551A1 (es)
EP (1) EP2763948B1 (es)
JP (1) JP2014534183A (es)
KR (1) KR20140084015A (es)
AU (1) AU2012320602A1 (es)
CA (1) CA2848339A1 (es)
DK (1) DK2763948T3 (es)
ES (2) ES2408507B1 (es)
HK (1) HK1200806A1 (es)
HU (1) HUE038126T2 (es)
IL (1) IL231893A (es)
MX (1) MX2014004083A (es)
NO (1) NO2763948T3 (es)
PL (1) PL2763948T3 (es)
PT (1) PT2763948T (es)
RU (1) RU2014112957A (es)
SG (1) SG11201401224RA (es)
SI (1) SI2763948T1 (es)
TR (1) TR201809269T4 (es)
WO (1) WO2013050365A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014273108A1 (en) * 2013-05-31 2015-12-03 Leo Laboratories Limited Methods of synthesis of ingenol and intermediates thereof
CN103483193A (zh) * 2013-09-10 2014-01-01 南京奇鹤医药科技有限公司 一种巨大戟醇甲基丁烯酸酯的制备方法
CN103694096B (zh) * 2013-12-23 2015-04-08 成都普思生物科技有限公司 一种巨大戟醇单体的分离纯化方法
CN104447339A (zh) * 2014-11-28 2015-03-25 天津耀宇生物技术有限公司 一种二萜醇酯类化合物大戟因子l2的制备方法
US10172306B2 (en) 2015-03-20 2019-01-08 Phyton Holdings, Llc Production of ingenol, ingenol esters and/or tiglian-3-one derivatives by euphorbiaceae plant cell suspension cultures
CN106083555A (zh) * 2016-06-14 2016-11-09 宁波绿之健药业有限公司 巨大戟醇的提取方法
CN115160336B (zh) * 2022-07-21 2023-10-03 复旦大学 续随子烷型二萜的含氧五元环衍生物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2007016115A (es) * 2005-06-28 2008-03-11 Amazonia Fitomedicamentos Ltda Fraccion activa de un extracto de latex de las plantas de la familia de las euphorbiaceae en solvente polar.
RU2438689C9 (ru) * 2005-06-28 2012-03-10 Амазония Фитомедикаментус ЛТДА Активная фракция экстракта млечного сока растения семейства euphorbiaceae, способ ее получения, композиция на ее основе (варианты) и способ лечения заболеваний, связанных с пролиферацией клеток (варианты)

Also Published As

Publication number Publication date
SI2763948T1 (en) 2018-07-31
NO2763948T3 (es) 2018-09-01
KR20140084015A (ko) 2014-07-04
JP2014534183A (ja) 2014-12-18
HUE038126T2 (hu) 2018-09-28
PL2763948T3 (pl) 2018-10-31
HK1200806A1 (en) 2015-08-14
EP2763948A1 (en) 2014-08-13
TR201809269T4 (tr) 2018-07-23
US20160039733A1 (en) 2016-02-11
CA2848339A1 (en) 2013-04-11
IL231893A (en) 2016-10-31
US20140243551A1 (en) 2014-08-28
AU2012320602A1 (en) 2014-04-24
ES2408507A1 (es) 2013-06-20
US9416083B2 (en) 2016-08-16
RU2014112957A (ru) 2015-11-10
SG11201401224RA (en) 2014-08-28
EP2763948B1 (en) 2018-04-04
CN103974926A (zh) 2014-08-06
ES2674150T3 (es) 2018-06-27
PT2763948T (pt) 2018-06-22
WO2013050365A1 (en) 2013-04-11
IL231893A0 (en) 2014-05-28
ES2408507B1 (es) 2014-04-21
DK2763948T3 (en) 2018-06-25

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