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MX2013002150A - Proceso para la preparacion de intermediarios para la elaboracion de inhibidores de nep. - Google Patents

Proceso para la preparacion de intermediarios para la elaboracion de inhibidores de nep.

Info

Publication number
MX2013002150A
MX2013002150A MX2013002150A MX2013002150A MX2013002150A MX 2013002150 A MX2013002150 A MX 2013002150A MX 2013002150 A MX2013002150 A MX 2013002150A MX 2013002150 A MX2013002150 A MX 2013002150A MX 2013002150 A MX2013002150 A MX 2013002150A
Authority
MX
Mexico
Prior art keywords
nep inhibitors
manufacture
intermediates
preparation
amino
Prior art date
Application number
MX2013002150A
Other languages
English (en)
Inventor
David Hook
Jianguang Zhou
Yunzhong Li
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MX2013002150A publication Critical patent/MX2013002150A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C269/06—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups by reactions not involving the formation of carbamate groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/12—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides containing organo-metallic compounds or metal hydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La invención se refiere a un nuevo proceso para producir intermediarios útiles para la elaboración de inhibidores de NEP o pro-fármacos de los mismos, en particular inhibidores de NEP que comprenden una estructura base de ácido o éster de ácido ?-amino-d-bifenil-a-metil-alcanoico, tal como el etil-éster del ácido N-(3-carboxil-1-oxo-propil)-(4S)-(p-fenil-fenil-metil)-4-ami no-(2R)-metil-butanoico o una sal del mismo.
MX2013002150A 2010-08-23 2011-08-22 Proceso para la preparacion de intermediarios para la elaboracion de inhibidores de nep. MX2013002150A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2010076245 2010-08-23
PCT/EP2011/064410 WO2012025501A1 (en) 2010-08-23 2011-08-22 Process for the preparation of intermediates for the manufacture of nep inhibitors

Publications (1)

Publication Number Publication Date
MX2013002150A true MX2013002150A (es) 2013-04-03

Family

ID=44658722

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013002150A MX2013002150A (es) 2010-08-23 2011-08-22 Proceso para la preparacion de intermediarios para la elaboracion de inhibidores de nep.

Country Status (14)

Country Link
US (1) US8835668B2 (es)
EP (1) EP2609075B1 (es)
JP (1) JP5705984B2 (es)
KR (1) KR101476937B1 (es)
AU (1) AU2011295170B2 (es)
BR (1) BR112013004164A2 (es)
CA (1) CA2806780A1 (es)
ES (1) ES2576179T3 (es)
MX (1) MX2013002150A (es)
PL (1) PL2609075T3 (es)
PT (1) PT2609075E (es)
RU (1) RU2588572C2 (es)
SI (1) SI2609075T1 (es)
WO (1) WO2012025501A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20091364A1 (es) 2008-01-17 2009-10-13 Novartis Ag Proceso para la preparacion de inhibidores de nep
PT3218351T (pt) 2014-11-14 2019-09-26 Zentiva Ks Um método para a preparação, isolamento e purificação de formas farmaceuticamente aplicáveis de ahu-377
TW201632493A (zh) 2015-02-13 2016-09-16 諾華公司 新穎方法
WO2016135751A1 (en) 2015-02-25 2016-09-01 Mylan Laboratories Limited Novel process for the preparation of sacubitril and its intermediates
WO2017051326A1 (en) 2015-09-23 2017-03-30 Novartis Ag New processes and intermediates useful in synthesis of nep inhibitors
CA3006254A1 (en) 2015-12-10 2017-06-15 Novartis Ag New process and intermediates
WO2017097275A1 (en) 2015-12-11 2017-06-15 Zentiva, K.S. Solid forms of (2r,4s)-5-(biphenyl-4-yl)-4-[(3-carboxypropionyl)amino]-2- -methylpentanoic acid ethyl ester, its salts and a preparation method
CN109415308B (zh) 2016-07-05 2022-09-06 诺华股份有限公司 用于早期沙卡布曲中间体的新方法
US10851059B2 (en) 2016-08-17 2020-12-01 Novartis Ag Processes and intermediates for NEP inhibitor synthesis
WO2018116203A1 (en) 2016-12-23 2018-06-28 Novartis Ag New process for early sacubitril intermediates
CN106946742A (zh) * 2017-03-28 2017-07-14 常州沃腾化工科技有限公司 一种三苯基氧磷含量低的沙库必曲中间体的制备方法
CN109503404A (zh) * 2018-12-28 2019-03-22 凯瑞斯德生化(苏州)有限公司 一种lcz-696关键中间体的制备方法

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FR2597100A1 (fr) 1986-01-21 1987-10-16 Nippon Shinyaku Co Ltd Derives du pyroglutamide
DE3713127A1 (de) * 1987-04-16 1988-11-03 Consortium Elektrochem Ind Verfahren zur herstellung von tiglinaldehyd
JPH07103101B2 (ja) 1989-07-24 1995-11-08 キッセイ薬品工業株式会社 ピログルタミン酸誘導体
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EP0550313A1 (fr) 1991-12-30 1993-07-07 Synthelabo Nouveaux dérivés de 2-(tétrazol-5-yl)-(1,1'-biphényle), leur préparation et leur utilisation comme intermédiaires de synthèse
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CN103080072B (zh) 2010-08-23 2016-03-16 诺华有限公司 制备可用于生产nep抑制剂的中间体的新方法

Also Published As

Publication number Publication date
SI2609075T1 (sl) 2016-06-30
KR101476937B1 (ko) 2014-12-24
BR112013004164A2 (pt) 2016-05-10
US20130158285A1 (en) 2013-06-20
WO2012025501A1 (en) 2012-03-01
EP2609075B1 (en) 2016-03-16
EP2609075A1 (en) 2013-07-03
ES2576179T3 (es) 2016-07-06
JP5705984B2 (ja) 2015-04-22
KR20130061735A (ko) 2013-06-11
CA2806780A1 (en) 2012-03-01
AU2011295170A1 (en) 2013-03-21
PL2609075T3 (pl) 2016-09-30
AU2011295170B2 (en) 2014-12-18
RU2588572C2 (ru) 2016-07-10
RU2013112946A (ru) 2014-09-27
JP2013539462A (ja) 2013-10-24
PT2609075E (pt) 2016-06-03
US8835668B2 (en) 2014-09-16

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