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MX2011012353A - Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus. - Google Patents

Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.

Info

Publication number
MX2011012353A
MX2011012353A MX2011012353A MX2011012353A MX2011012353A MX 2011012353 A MX2011012353 A MX 2011012353A MX 2011012353 A MX2011012353 A MX 2011012353A MX 2011012353 A MX2011012353 A MX 2011012353A MX 2011012353 A MX2011012353 A MX 2011012353A
Authority
MX
Mexico
Prior art keywords
pyrimidines
pyrrolo
hetero
aryl
pyrrol
Prior art date
Application number
MX2011012353A
Other languages
English (en)
Inventor
James D Rodgers
Haisheng Wang
Argyrios G Arvanitis
Stacey Shepard
Louis Storace
Wenyu Zhu
Beverly Folmer
Lixin Shao
Joseph P Glenn
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42543342&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2011012353(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Incyte Corp filed Critical Incyte Corp
Publication of MX2011012353A publication Critical patent/MX2011012353A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
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    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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Abstract

La presente invención se relaciona con derivados de N-(hetero)aril-pirrolidina de Fórmula I: (ver fórmula (I)) que son inhibidores de JAK, tal como inhibidores selectivos de JAK1 ¡ útiles en el tratamiento de enfermedades asociadas con JAK, entre las que se incluyen, por ejemplo, los trastornos inflamatorios y autoinmunes y también el cáncer.
MX2011012353A 2009-05-22 2010-05-21 Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus. MX2011012353A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18062209P 2009-05-22 2009-05-22
US22509209P 2009-07-13 2009-07-13
PCT/US2010/035783 WO2010135650A1 (en) 2009-05-22 2010-05-21 N-(HETERO)ARYL-PYRROLIDINE DERIVATIVES OF PYRAZOL-4-YL-PYRROLO[2,3-d]PYRIMIDINES AND PYRROL-3-YL-PYRROLO[2,3-d]PYRIMIDINES AS JANUS KINASE INHIBITORS

Publications (1)

Publication Number Publication Date
MX2011012353A true MX2011012353A (es) 2011-12-14

Family

ID=42543342

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011012353A MX2011012353A (es) 2009-05-22 2010-05-21 Derivados de n-(hetero)aril-pirrolidina de pirazol-4-il-pirrolo[2, 3-d]pirimidinas y pirrol-3-il-pirrolo[2,3-d]pirimidinas como inhibidores de la cinasa janus.

Country Status (22)

Country Link
US (2) US8716303B2 (es)
EP (1) EP2432555B1 (es)
JP (1) JP5775070B2 (es)
KR (1) KR101771401B1 (es)
CN (1) CN102458581B (es)
AR (1) AR076794A1 (es)
AU (1) AU2010249380B2 (es)
BR (1) BRPI1012159B1 (es)
CA (1) CA2762174C (es)
CL (1) CL2011002956A1 (es)
CO (1) CO6440524A2 (es)
CR (1) CR20110620A (es)
EA (1) EA025520B1 (es)
ES (1) ES2487542T3 (es)
IL (1) IL216463A (es)
MX (1) MX2011012353A (es)
MY (1) MY156727A (es)
NZ (1) NZ596479A (es)
SG (1) SG176130A1 (es)
TW (1) TW201100429A (es)
WO (1) WO2010135650A1 (es)
ZA (1) ZA201108544B (es)

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