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MX2009003892A - Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico. - Google Patents

Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico.

Info

Publication number
MX2009003892A
MX2009003892A MX2009003892A MX2009003892A MX2009003892A MX 2009003892 A MX2009003892 A MX 2009003892A MX 2009003892 A MX2009003892 A MX 2009003892A MX 2009003892 A MX2009003892 A MX 2009003892A MX 2009003892 A MX2009003892 A MX 2009003892A
Authority
MX
Mexico
Prior art keywords
diseases
disorders
nicotinic acetylcholine
oxadiazole
receptor modulators
Prior art date
Application number
MX2009003892A
Other languages
English (en)
Inventor
Dan Peters
Gunnar M Olsen
Bjarne H Dahl
Daniel B Timmermann
Susanne Joergensen
Original Assignee
Neurosearch As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch As filed Critical Neurosearch As
Publication of MX2009003892A publication Critical patent/MX2009003892A/es

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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A61P25/36—Opioid-abuse
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
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    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Reproductive Health (AREA)
  • Psychology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)

Abstract

La presente invención se refiere a derivados de oxadiazolilo y tiadiazolilo, los cuales se encuentran por ser moduladores de los receptores de acetilcolina nicotínicos. Debido a su perfil farmacológico, los compuestos de la invención pueden ser útiles para el tratamiento de diversas enfermedades o trastornos como aquellos relacionados al sistema colinérgico del sistema nervioso central (SNC), el sistema nervioso periférico (SNP), enfermedades y trastornos relacionados a contracción del músculo liso, enfermedades o trastornos endocrinos, enfermedades o trastornos relacionados a neurodegeneración, enfermedades o trastornos relacionados a inflamación, dolor y síntomas de abstinencia causados por el término de abuso de sustancias químicas.
MX2009003892A 2006-10-25 2007-10-24 Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico. MX2009003892A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US85407806P 2006-10-25 2006-10-25
DKPA200601380 2006-10-25
PCT/EP2007/061433 WO2008049864A1 (en) 2006-10-25 2007-10-24 Oxadiazole and thiadiazole compounds and their use as nicotinic acetylcholine receptor modulators

Publications (1)

Publication Number Publication Date
MX2009003892A true MX2009003892A (es) 2009-04-23

Family

ID=38962931

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009003892A MX2009003892A (es) 2006-10-25 2007-10-24 Compuestos de oxadiazol y tiadiazol y su uso como moduladores del receptor de acetilcolina nicotinico.

Country Status (9)

Country Link
US (1) US20100029685A1 (es)
EP (1) EP2079734A1 (es)
JP (1) JP2010507619A (es)
AU (1) AU2007310897A1 (es)
CA (1) CA2667545A1 (es)
IL (1) IL197397A0 (es)
MX (1) MX2009003892A (es)
NO (1) NO20091977L (es)
WO (1) WO2008049864A1 (es)

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US20100029685A1 (en) 2010-02-04

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