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MX2010008523A - Inhibidores macrociclicos de serina proteasa. - Google Patents

Inhibidores macrociclicos de serina proteasa.

Info

Publication number
MX2010008523A
MX2010008523A MX2010008523A MX2010008523A MX2010008523A MX 2010008523 A MX2010008523 A MX 2010008523A MX 2010008523 A MX2010008523 A MX 2010008523A MX 2010008523 A MX2010008523 A MX 2010008523A MX 2010008523 A MX2010008523 A MX 2010008523A
Authority
MX
Mexico
Prior art keywords
serine protease
protease inhibitors
macrocyclic serine
macrocyclic
compounds
Prior art date
Application number
MX2010008523A
Other languages
English (en)
Inventor
Frederic Leroy
Christophe Claude Parsy
Dominique Surleraux
Francois-Rene Alexandre
Michel Derock
Original Assignee
Idenix Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Idenix Pharmaceuticals Inc filed Critical Idenix Pharmaceuticals Inc
Publication of MX2010008523A publication Critical patent/MX2010008523A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Aquí se proporcionan compuestos macrocíclicos inhibidores de serina proteasa, por ejemplo, de la Fórmula (I), composiciones farmacéuticas que comprenden los compuestos, y procesos para la preparación de los mismos. También se proporcionan los métodos para su uso, para el tratamiento de una infección por HCV en un hospedero en necesidad del mismo. (ver fórmula (I)).
MX2010008523A 2008-02-04 2009-02-03 Inhibidores macrociclicos de serina proteasa. MX2010008523A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2608608P 2008-02-04 2008-02-04
US8386708P 2008-07-25 2008-07-25
PCT/US2009/000688 WO2009099596A2 (en) 2008-02-04 2009-02-03 Macrocyclic serine protease inhibitors

Publications (1)

Publication Number Publication Date
MX2010008523A true MX2010008523A (es) 2010-08-31

Family

ID=40568607

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008523A MX2010008523A (es) 2008-02-04 2009-02-03 Inhibidores macrociclicos de serina proteasa.

Country Status (21)

Country Link
US (2) US8003659B2 (es)
EP (1) EP2250174B1 (es)
JP (1) JP5574982B2 (es)
KR (1) KR20100118991A (es)
CN (1) CN101977915B (es)
AR (1) AR070413A1 (es)
AU (1) AU2009210789B2 (es)
BR (1) BRPI0908021A2 (es)
CA (1) CA2712971A1 (es)
CO (1) CO6501153A2 (es)
CR (1) CR11618A (es)
EC (1) ECSP10010413A (es)
ES (1) ES2437147T3 (es)
IL (1) IL207333A0 (es)
MX (1) MX2010008523A (es)
NI (1) NI201000136A (es)
NZ (1) NZ587133A (es)
RU (1) RU2490272C2 (es)
TW (1) TW200936131A (es)
WO (1) WO2009099596A2 (es)
ZA (1) ZA201005318B (es)

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