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PE20140039A1 - Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina - Google Patents

Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina

Info

Publication number
PE20140039A1
PE20140039A1 PE2013001478A PE2013001478A PE20140039A1 PE 20140039 A1 PE20140039 A1 PE 20140039A1 PE 2013001478 A PE2013001478 A PE 2013001478A PE 2013001478 A PE2013001478 A PE 2013001478A PE 20140039 A1 PE20140039 A1 PE 20140039A1
Authority
PE
Peru
Prior art keywords
hepatitis
phenanthridine
serine protease
alkylene
macrocyclics
Prior art date
Application number
PE2013001478A
Other languages
English (en)
Inventor
Keith F Mcdaniel
Hui-Ju Chen
Jason P Shanley
David J Grampovnik
Brian Green
Timothy Middleton
Todd Hopkins
Yat Sun Or
Original Assignee
Enanta Pharm Inc
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46383854&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140039(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Enanta Pharm Inc, Abbvie Inc filed Critical Enanta Pharm Inc
Publication of PE20140039A1 publication Critical patent/PE20140039A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

SE REFIERE A COMPUESTOS MACROCICLICOS DE FENANTRIDINA DE FORMULA (I) DONDE J ES ALQUILENO, -C(O)-, -C(S)-, ENTRE OTROS; A ES ALQUILO, ALCOXI, ARILO, ENTRE OTROS; R1 ES HALOGENO, HIDROXI, AMINO, ENTRE OTROS; G ES -E-R5, EN DONDE E ES ALQUILENO, O, S, ENTRE OTROS; R5 ES H, ARILO, ALQUINILO, ENTRE OTROS; R3 ES ALQUILO, ALQUENILO, ENTRE OTROS; L ESTA AUSENTE O ES ALQUILENO, ALQUENILENO, ENTRE OTROS; n ES DE 1 A 4; m ES DE 0 A 2; k ES DE 0 A 3; j ES DE 0 A 4. SON COMPUESTOS PREFERIDOS: N-((2R,6S,13aS,14aR,16aS,Z)-2-(3-FLUOROFENANTRIDIN-6-ILOXI)-14a-(1-METILCICLOPROPILSULFONILCARBAMOIL)-5,16-DIOXO-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-HEXADECAHIDROCICLOPROPA[e]PIRROLO[1,2-a][1,4]DIAZACICLOPENTADECIN-6-IL)-5-METILISOXAZOL-3-CARBOXAMIDA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON INHIBIDORES DE SERINA PROTEASA DEL VIRUS DE LA HEPATITIS C SIENDO UTILES EN EL TRATAMIENTO DE UNA INFECCION POR HEPATITIS C
PE2013001478A 2010-12-30 2011-12-29 Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina PE20140039A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201061428488P 2010-12-30 2010-12-30
US201161449331P 2011-03-04 2011-03-04

Publications (1)

Publication Number Publication Date
PE20140039A1 true PE20140039A1 (es) 2014-03-01

Family

ID=46383854

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013001478A PE20140039A1 (es) 2010-12-30 2011-12-29 Inhibidores de serina proteasa de hepatitis c a base de macrociclicos de fenantridina

Country Status (18)

Country Link
US (1) US8951964B2 (es)
EP (1) EP2658858A4 (es)
JP (1) JP2014506255A (es)
KR (1) KR20140003521A (es)
CN (1) CN103380132B (es)
AU (1) AU2011352145A1 (es)
BR (1) BR112013016480A2 (es)
CA (1) CA2821340A1 (es)
CO (1) CO6771427A2 (es)
CR (1) CR20130341A (es)
EA (1) EA201390988A1 (es)
EC (1) ECSP13012791A (es)
GT (1) GT201300172A (es)
MX (1) MX2013007698A (es)
PE (1) PE20140039A1 (es)
SG (1) SG191759A1 (es)
WO (1) WO2012092411A2 (es)
ZA (1) ZA201304579B (es)

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US9598433B2 (en) 2012-11-02 2017-03-21 Bristol-Myers Squibb Company Hepatitis C virus inhibitors
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