MX2010006044A - Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion. - Google Patents
Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion.Info
- Publication number
- MX2010006044A MX2010006044A MX2010006044A MX2010006044A MX2010006044A MX 2010006044 A MX2010006044 A MX 2010006044A MX 2010006044 A MX2010006044 A MX 2010006044A MX 2010006044 A MX2010006044 A MX 2010006044A MX 2010006044 A MX2010006044 A MX 2010006044A
- Authority
- MX
- Mexico
- Prior art keywords
- fragment
- solution phase
- solid
- different
- coupled
- Prior art date
Links
- 230000002473 insulinotropic effect Effects 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 238000010647 peptide synthesis reaction Methods 0.000 title 1
- 239000012634 fragment Substances 0.000 abstract 13
- 239000012071 phase Substances 0.000 abstract 5
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 2
- 239000007790 solid phase Substances 0.000 abstract 2
- 101800004295 Glucagon-like peptide 1(7-36) Proteins 0.000 abstract 1
- 230000008878 coupling Effects 0.000 abstract 1
- 238000010168 coupling process Methods 0.000 abstract 1
- 238000005859 coupling reaction Methods 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000010532 solid phase synthesis reaction Methods 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención refiere a la preparación de péptidos insulinotrópicos que se sintetizan utilizando una técnica en fase sólida y en solución ("híbrida") Generalmente la técnica incluye la síntesis de tres fragmentos intermediarios de péptido diferentes utilizando la química en fase sólida. Luego se utiliza la química en fase de solución para añadir material aminoácido adicional al tercer fragmento que entonces se acopla al segundo fragmento y luego al primer fragmento en solución. Alternativamente, un segundo fragmento diferente se acopla al primer fragmento en la fase sólida. Luego, se utiliza la química en fase de solución para añadir material aminoácido adicional a un tercer fragmento diferente. A continuación, este tercer fragmento diferente se acopla al primero acoplado y al segundo fragmento diferente en la fase de solución. La utilización de una pseudoprolina en uno de los fragmentos facilita la síntesis en fase sólida de ese fragmento y también facilita el subsiguiente acoplamiento en fase de solución de este fragmento a otros fragmentos. La presente invención es muy útil en la obtención de péptidos insulinotrópicos tal como el GLP-1 (7-36) y sus homólogos naturales y no naturales.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US723807P | 2007-12-11 | 2007-12-11 | |
| PCT/EP2008/066585 WO2009074483A2 (en) | 2007-12-11 | 2008-12-02 | Insulinotropic peptide synthesis using solid and solution phase combination techniques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010006044A true MX2010006044A (es) | 2010-06-23 |
Family
ID=40755926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010006044A MX2010006044A (es) | 2007-12-11 | 2008-12-02 | Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion. |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8227571B2 (es) |
| EP (1) | EP2222695A2 (es) |
| JP (1) | JP2011506376A (es) |
| KR (1) | KR20100102652A (es) |
| CN (1) | CN101903400B (es) |
| AR (1) | AR069608A1 (es) |
| AU (1) | AU2008334783A1 (es) |
| BR (1) | BRPI0820765A2 (es) |
| CA (1) | CA2707132A1 (es) |
| CL (1) | CL2008003660A1 (es) |
| IL (1) | IL205932A0 (es) |
| MX (1) | MX2010006044A (es) |
| PE (1) | PE20091214A1 (es) |
| RU (1) | RU2010128247A (es) |
| TW (1) | TWI374890B (es) |
| WO (1) | WO2009074483A2 (es) |
| ZA (1) | ZA201003849B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010054326A2 (en) * | 2008-11-07 | 2010-05-14 | The General Hospital Corporation | C-terminal fragments of glucagon-like peptide-1 (glp-1) |
| CN102414220A (zh) * | 2009-05-01 | 2012-04-11 | 霍夫曼-拉罗奇有限公司 | 使用固相和液相组合技术的促胰岛素肽合成 |
| US20110313131A1 (en) | 2010-06-21 | 2011-12-22 | Christelle Carl | Reversed phase hplc purification of a glp-1 analogue |
| US20120157382A1 (en) | 2010-12-21 | 2012-06-21 | Siegfried Krimmer | Pharmaceutical glp-1 compositions having an improved release profile |
| ES2777502T3 (es) | 2011-04-05 | 2020-08-05 | Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung Ev | Novedosos péptidos y su uso en diagnóstico y tratamiento |
| WO2013006692A2 (en) | 2011-07-06 | 2013-01-10 | The General Hospital Corporation | Methods of treatment using a pentapeptide derived from the c-terminus of glucagon-like peptide 1 (glp-1) |
| WO2014077801A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification process for preparing highly pure taspoglutide |
| WO2014077802A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification method of a glp-1 analogue |
| JP2016505640A (ja) | 2013-01-28 | 2016-02-25 | ソレイ リミテッド ライアビリティ カンパニー | 満腹ホルモン放出活性を有する新規なポリペプチド |
| EP2976325B1 (en) | 2013-03-21 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Synthesis of cyclic imide containing peptide products |
| HK1219477A1 (zh) | 2013-03-21 | 2017-04-07 | Sanofi-Aventis Deutschland Gmbh | 合成含有乙内酰脲的肽产物 |
| GR20140100479A (el) * | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
| WO2019069274A1 (en) * | 2017-10-04 | 2019-04-11 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | PROCESS FOR THE PREPARATION OF A GLUCAGON-LIKE PEPTIDE |
| KR20200001546A (ko) * | 2018-06-27 | 2020-01-06 | 주식회사 시선바이오머티리얼스 | Pna 올리고머의 제조방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9909018A (pt) * | 1998-03-23 | 2001-10-16 | Trimeris Inc | Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo |
| KR20050037004A (ko) * | 1998-12-07 | 2005-04-20 | 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. | Ｇｌｐ-1의 유사체 |
| US6469136B1 (en) * | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| CN1918177A (zh) * | 2003-12-18 | 2007-02-21 | 诺和诺德公司 | 新型glp－1化合物 |
| EP1709071A4 (en) * | 2004-01-08 | 2007-05-30 | Theratechnologies Inc | GLUCAGON LIKE PEPTIDE-1 ANALOGS WITH LONG PERFORMANCE |
| CN101133078B (zh) * | 2004-12-30 | 2011-07-27 | 弗·哈夫曼-拉罗切有限公司 | 使用肽中间片段合成肽t-20 |
| ATE439371T1 (de) * | 2004-12-30 | 2009-08-15 | Hoffmann La Roche | Synthese von peptid t-1249 mit peptidzwischenproduktfragmenten |
| ES2332418T3 (es) * | 2004-12-30 | 2010-02-04 | F. Hoffmann-La Roche Ag | Sintesis del peptido t-20 empleando fragmentos intermedios del peptido. |
| EP1891106A2 (en) * | 2005-05-05 | 2008-02-27 | Cadila Healthcare Ltd. | Novel compounds as glp-i agonists |
| DE602007014184D1 (de) * | 2006-02-08 | 2011-06-09 | Lonza Ag | Synthese von glucagon-ähnlichen peptiden |
| AU2007263043B2 (en) * | 2006-06-23 | 2012-11-29 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis |
| JP5473925B2 (ja) * | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
-
2008
- 2008-12-02 JP JP2010537379A patent/JP2011506376A/ja active Pending
- 2008-12-02 KR KR1020107015264A patent/KR20100102652A/ko not_active Abandoned
- 2008-12-02 MX MX2010006044A patent/MX2010006044A/es active IP Right Grant
- 2008-12-02 WO PCT/EP2008/066585 patent/WO2009074483A2/en not_active Ceased
- 2008-12-02 EP EP08860359A patent/EP2222695A2/en not_active Withdrawn
- 2008-12-02 RU RU2010128247/10A patent/RU2010128247A/ru not_active Application Discontinuation
- 2008-12-02 AU AU2008334783A patent/AU2008334783A1/en not_active Abandoned
- 2008-12-02 CA CA2707132A patent/CA2707132A1/en not_active Abandoned
- 2008-12-02 CN CN2008801198008A patent/CN101903400B/zh not_active Expired - Fee Related
- 2008-12-02 BR BRPI0820765-8A patent/BRPI0820765A2/pt not_active IP Right Cessation
- 2008-12-08 TW TW097147695A patent/TWI374890B/zh not_active IP Right Cessation
- 2008-12-09 PE PE2008002033A patent/PE20091214A1/es not_active Application Discontinuation
- 2008-12-09 AR ARP080105329A patent/AR069608A1/es not_active Application Discontinuation
- 2008-12-10 CL CL2008003660A patent/CL2008003660A1/es unknown
- 2008-12-11 US US12/316,309 patent/US8227571B2/en not_active Expired - Fee Related
-
2010
- 2010-05-24 IL IL205932A patent/IL205932A0/en unknown
- 2010-05-28 ZA ZA2010/03849A patent/ZA201003849B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL205932A0 (en) | 2010-11-30 |
| WO2009074483A3 (en) | 2010-05-14 |
| KR20100102652A (ko) | 2010-09-24 |
| EP2222695A2 (en) | 2010-09-01 |
| AU2008334783A1 (en) | 2009-06-18 |
| AR069608A1 (es) | 2010-02-03 |
| WO2009074483A2 (en) | 2009-06-18 |
| US20090292108A1 (en) | 2009-11-26 |
| RU2010128247A (ru) | 2012-01-20 |
| CN101903400B (zh) | 2013-12-18 |
| TW200927756A (en) | 2009-07-01 |
| CA2707132A1 (en) | 2009-06-18 |
| JP2011506376A (ja) | 2011-03-03 |
| BRPI0820765A2 (pt) | 2015-06-16 |
| ZA201003849B (en) | 2011-04-28 |
| PE20091214A1 (es) | 2009-08-14 |
| CL2008003660A1 (es) | 2010-01-04 |
| US8227571B2 (en) | 2012-07-24 |
| TWI374890B (en) | 2012-10-21 |
| CN101903400A (zh) | 2010-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |