PE20091214A1 - Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion - Google Patents
Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucionInfo
- Publication number
- PE20091214A1 PE20091214A1 PE2008002033A PE2008002033A PE20091214A1 PE 20091214 A1 PE20091214 A1 PE 20091214A1 PE 2008002033 A PE2008002033 A PE 2008002033A PE 2008002033 A PE2008002033 A PE 2008002033A PE 20091214 A1 PE20091214 A1 PE 20091214A1
- Authority
- PE
- Peru
- Prior art keywords
- seq
- peptide fragment
- solution
- amino acid
- acid sequence
- Prior art date
Links
- 230000002473 insulinotropic effect Effects 0.000 title abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 239000007790 solid phase Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 9
- 102000007079 Peptide Fragments Human genes 0.000 abstract 9
- 150000001413 amino acids Chemical group 0.000 abstract 8
- 239000012634 fragment Substances 0.000 abstract 3
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- 101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 1
- DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
- 102400000322 Glucagon-like peptide 1 Human genes 0.000 abstract 1
- ULEBESPCVWBNIF-BYPYZUCNSA-N L-arginine amide Chemical compound NC(=O)[C@@H](N)CCCNC(N)=N ULEBESPCVWBNIF-BYPYZUCNSA-N 0.000 abstract 1
- 230000001012 protector Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE REFIERE A UN METODO PARA OBTENER UN PEPTIDO INSULINOTROPICO TALES COMO GLP-1 Y SUS HOMOLOGOS NATURALES Y NO NATURALES, QUE COMPRENDE: A) PROPORCIONAR UN PRIMER FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 5); B) ACOPLAR EL PRIMER FRAGMENTO PEPTIDICO EN SOLUCION CON ARGININA AMIDA PARA PROPORCIONAR UN SEGUNDO FRAGMENTO PEPTIDICO CUYA SECUENCIA DE AMINOACIDOS ES ID. SEC. Nº 6; C) ELIMINAR EL GRUPO PROTECTOR EN N-TERMINAL PARA CONSEGUIR UN TERCER FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 6); D) PROPORCIONAR UN CUARTO FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 7); E) ACOPLAR EL CUARTO FRAGMENTO PEPTIDICO AL TERCER FRAGMENTO PEPTIDICO EN SOLUCION PARA PROPORCIONAR UN QUINTO FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 8); F) ELIMINAR EL GRUPO PROTECTOR EN N-TERMINAL PARA CONSEGUIR UN SEXTO FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 14); G) PROPORCIONAR UN SEPTIMO FRAGMENTO PEPTIDICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 9); H) ACOPLAR EL SEPTIMO FRAGMENTO PEPTIDICO AL SEXTO FRAGMENTO PEPTIDICO EN SOLUCION PARA PROPORCIONAR UN PEPTIDO INSULINOTROPICO QUE INCLUYE LA SECUENCIA DE AMINOACIDOS (ID. DE SEC. Nº 10)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US723807P | 2007-12-11 | 2007-12-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20091214A1 true PE20091214A1 (es) | 2009-08-14 |
Family
ID=40755926
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2008002033A PE20091214A1 (es) | 2007-12-11 | 2008-12-09 | Sintesis de peptidos insulinotropicos utilizando una combinacion de tecnicas en fase solida y en solucion |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8227571B2 (es) |
| EP (1) | EP2222695A2 (es) |
| JP (1) | JP2011506376A (es) |
| KR (1) | KR20100102652A (es) |
| CN (1) | CN101903400B (es) |
| AR (1) | AR069608A1 (es) |
| AU (1) | AU2008334783A1 (es) |
| BR (1) | BRPI0820765A2 (es) |
| CA (1) | CA2707132A1 (es) |
| CL (1) | CL2008003660A1 (es) |
| IL (1) | IL205932A0 (es) |
| MX (1) | MX2010006044A (es) |
| PE (1) | PE20091214A1 (es) |
| RU (1) | RU2010128247A (es) |
| TW (1) | TWI374890B (es) |
| WO (1) | WO2009074483A2 (es) |
| ZA (1) | ZA201003849B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010054326A2 (en) * | 2008-11-07 | 2010-05-14 | The General Hospital Corporation | C-terminal fragments of glucagon-like peptide-1 (glp-1) |
| CN102414220A (zh) * | 2009-05-01 | 2012-04-11 | 霍夫曼-拉罗奇有限公司 | 使用固相和液相组合技术的促胰岛素肽合成 |
| US20110313131A1 (en) | 2010-06-21 | 2011-12-22 | Christelle Carl | Reversed phase hplc purification of a glp-1 analogue |
| US20120157382A1 (en) | 2010-12-21 | 2012-06-21 | Siegfried Krimmer | Pharmaceutical glp-1 compositions having an improved release profile |
| ES2777502T3 (es) | 2011-04-05 | 2020-08-05 | Fraunhofer-Gesellschaft zur Förderung der Angewandten Forschung Ev | Novedosos péptidos y su uso en diagnóstico y tratamiento |
| WO2013006692A2 (en) | 2011-07-06 | 2013-01-10 | The General Hospital Corporation | Methods of treatment using a pentapeptide derived from the c-terminus of glucagon-like peptide 1 (glp-1) |
| WO2014077801A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification process for preparing highly pure taspoglutide |
| WO2014077802A1 (en) | 2012-11-13 | 2014-05-22 | Ipsen Pharma S.A.S. | Purification method of a glp-1 analogue |
| JP2016505640A (ja) | 2013-01-28 | 2016-02-25 | ソレイ リミテッド ライアビリティ カンパニー | 満腹ホルモン放出活性を有する新規なポリペプチド |
| EP2976325B1 (en) | 2013-03-21 | 2017-03-01 | Sanofi-Aventis Deutschland GmbH | Synthesis of cyclic imide containing peptide products |
| HK1219477A1 (zh) | 2013-03-21 | 2017-04-07 | Sanofi-Aventis Deutschland Gmbh | 合成含有乙内酰脲的肽产物 |
| GR20140100479A (el) * | 2014-09-23 | 2016-05-05 | Novetide, Ltd., | Συνθεση λιραγλουτιδης |
| WO2019069274A1 (en) * | 2017-10-04 | 2019-04-11 | Chemical & Biopharmaceutical Laboratories Of Patras S.A. | PROCESS FOR THE PREPARATION OF A GLUCAGON-LIKE PEPTIDE |
| KR20200001546A (ko) * | 2018-06-27 | 2020-01-06 | 주식회사 시선바이오머티리얼스 | Pna 올리고머의 제조방법 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR9909018A (pt) * | 1998-03-23 | 2001-10-16 | Trimeris Inc | Processo para a sìntese de um peptìdeo, conjunto de fragmentos de peptìdeo, e, peptìdeo |
| KR20050037004A (ko) * | 1998-12-07 | 2005-04-20 | 소시에떼 더 콘세이유 더 레세르세 에 다플리까띠옹 시엔띠피끄, 에스.아.에스. | Ｇｌｐ-1의 유사체 |
| US6469136B1 (en) * | 1999-07-07 | 2002-10-22 | Trimeris, Inc. | Methods and composition for peptide synthesis |
| CN1918177A (zh) * | 2003-12-18 | 2007-02-21 | 诺和诺德公司 | 新型glp－1化合物 |
| EP1709071A4 (en) * | 2004-01-08 | 2007-05-30 | Theratechnologies Inc | GLUCAGON LIKE PEPTIDE-1 ANALOGS WITH LONG PERFORMANCE |
| CN101133078B (zh) * | 2004-12-30 | 2011-07-27 | 弗·哈夫曼-拉罗切有限公司 | 使用肽中间片段合成肽t-20 |
| ATE439371T1 (de) * | 2004-12-30 | 2009-08-15 | Hoffmann La Roche | Synthese von peptid t-1249 mit peptidzwischenproduktfragmenten |
| ES2332418T3 (es) * | 2004-12-30 | 2010-02-04 | F. Hoffmann-La Roche Ag | Sintesis del peptido t-20 empleando fragmentos intermedios del peptido. |
| EP1891106A2 (en) * | 2005-05-05 | 2008-02-27 | Cadila Healthcare Ltd. | Novel compounds as glp-i agonists |
| DE602007014184D1 (de) * | 2006-02-08 | 2011-06-09 | Lonza Ag | Synthese von glucagon-ähnlichen peptiden |
| AU2007263043B2 (en) * | 2006-06-23 | 2012-11-29 | F. Hoffmann-La Roche Ag | Insulinotropic peptide synthesis |
| JP5473925B2 (ja) * | 2007-10-27 | 2014-04-16 | コーデン ファーマ コロラド インコーポレイテッド | 固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成 |
-
2008
- 2008-12-02 JP JP2010537379A patent/JP2011506376A/ja active Pending
- 2008-12-02 KR KR1020107015264A patent/KR20100102652A/ko not_active Abandoned
- 2008-12-02 MX MX2010006044A patent/MX2010006044A/es active IP Right Grant
- 2008-12-02 WO PCT/EP2008/066585 patent/WO2009074483A2/en not_active Ceased
- 2008-12-02 EP EP08860359A patent/EP2222695A2/en not_active Withdrawn
- 2008-12-02 RU RU2010128247/10A patent/RU2010128247A/ru not_active Application Discontinuation
- 2008-12-02 AU AU2008334783A patent/AU2008334783A1/en not_active Abandoned
- 2008-12-02 CA CA2707132A patent/CA2707132A1/en not_active Abandoned
- 2008-12-02 CN CN2008801198008A patent/CN101903400B/zh not_active Expired - Fee Related
- 2008-12-02 BR BRPI0820765-8A patent/BRPI0820765A2/pt not_active IP Right Cessation
- 2008-12-08 TW TW097147695A patent/TWI374890B/zh not_active IP Right Cessation
- 2008-12-09 PE PE2008002033A patent/PE20091214A1/es not_active Application Discontinuation
- 2008-12-09 AR ARP080105329A patent/AR069608A1/es not_active Application Discontinuation
- 2008-12-10 CL CL2008003660A patent/CL2008003660A1/es unknown
- 2008-12-11 US US12/316,309 patent/US8227571B2/en not_active Expired - Fee Related
-
2010
- 2010-05-24 IL IL205932A patent/IL205932A0/en unknown
- 2010-05-28 ZA ZA2010/03849A patent/ZA201003849B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL205932A0 (en) | 2010-11-30 |
| WO2009074483A3 (en) | 2010-05-14 |
| KR20100102652A (ko) | 2010-09-24 |
| EP2222695A2 (en) | 2010-09-01 |
| AU2008334783A1 (en) | 2009-06-18 |
| AR069608A1 (es) | 2010-02-03 |
| WO2009074483A2 (en) | 2009-06-18 |
| US20090292108A1 (en) | 2009-11-26 |
| RU2010128247A (ru) | 2012-01-20 |
| CN101903400B (zh) | 2013-12-18 |
| TW200927756A (en) | 2009-07-01 |
| CA2707132A1 (en) | 2009-06-18 |
| JP2011506376A (ja) | 2011-03-03 |
| BRPI0820765A2 (pt) | 2015-06-16 |
| MX2010006044A (es) | 2010-06-23 |
| ZA201003849B (en) | 2011-04-28 |
| CL2008003660A1 (es) | 2010-01-04 |
| US8227571B2 (en) | 2012-07-24 |
| TWI374890B (en) | 2012-10-21 |
| CN101903400A (zh) | 2010-12-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |