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MX2010001995A - Identificacion de receptores t2r humanos que responden a compuestos amargos que provocan el sabor amargo en composiciones, y uso de los mismos en ensayos para identificar compuestos que inhiben (bloquean) sabor amargo en composiciones y uso de los mi - Google Patents

Identificacion de receptores t2r humanos que responden a compuestos amargos que provocan el sabor amargo en composiciones, y uso de los mismos en ensayos para identificar compuestos que inhiben (bloquean) sabor amargo en composiciones y uso de los mi

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Publication number
MX2010001995A
MX2010001995A MX2010001995A MX2010001995A MX2010001995A MX 2010001995 A MX2010001995 A MX 2010001995A MX 2010001995 A MX2010001995 A MX 2010001995A MX 2010001995 A MX2010001995 A MX 2010001995A MX 2010001995 A MX2010001995 A MX 2010001995A
Authority
MX
Mexico
Prior art keywords
discovery
coffee
relates
present
taste
Prior art date
Application number
MX2010001995A
Other languages
English (en)
Inventor
Donald S Karanewsky
Andrew Patron
Catherine Tachdjian
Xiaodong Li
Hong Xu
Alexey Pronin
Guy Servant
Paul Brust
Vincent Darmohusodo
Qing Li
Lan Zhang
Thomas Brady
Melissa Arellano
Victor Selchau
Brett Weylan Ching
Jing Ling
Wen Zhao
Chad Priest
Original Assignee
Senomyx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senomyx Inc filed Critical Senomyx Inc
Publication of MX2010001995A publication Critical patent/MX2010001995A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
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    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
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    • A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
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Abstract

La presente invención se refiere al descubrimiento de que receptores de sabor humanos específicos en la familia de receptores de sabor TR2 responden a compuestos amargos particulares presentes en, por ejemplo, café. También, la invención se refiere al descubrimiento de compuestos y composiciones específicos que contienen esa función como bloqueadores de sabor amargo y al uso de los mismos como bloqueadores de sabor amargo o moduladores de sabor en, por ejemplo, café y alimentos, bebidas y medicamentos con sabor a café. Asimismo, la presente invención se refiere al descubrimiento de un compuesto que antagoniza numerosos T2R5 humanos diferentes y al uso de los mismos en ensayos y como un bloqueador de sabor amargo en composiciones para su ingestión por humanos y animales.
MX2010001995A 2007-08-21 2008-08-19 Identificacion de receptores t2r humanos que responden a compuestos amargos que provocan el sabor amargo en composiciones, y uso de los mismos en ensayos para identificar compuestos que inhiben (bloquean) sabor amargo en composiciones y uso de los mi MX2010001995A (es)

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US4718708P 2008-04-23 2008-04-23
PCT/US2008/009864 WO2009025793A2 (en) 2007-08-21 2008-08-19 Human t2r bitterness receptors and uses thereof

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CZ2010180A3 (cs) 2010-10-13
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CA2696995C (en) 2017-11-21
ES2545121T3 (es) 2015-09-08
NZ583350A (en) 2012-03-30
CA2696995A1 (en) 2009-02-26
HUE025137T2 (en) 2016-01-28
EP2195656A4 (en) 2011-10-19
HK1174334A1 (en) 2013-06-07
KR20100076949A (ko) 2010-07-06
EP2195656A2 (en) 2010-06-16
EP2487169A1 (en) 2012-08-15
US20110207937A1 (en) 2011-08-25
KR101599715B1 (ko) 2016-03-08
WO2009025793A8 (en) 2009-07-30
US20090274632A1 (en) 2009-11-05
BRPI0815634B1 (pt) 2024-01-09
RU2010110557A (ru) 2011-09-27
CN101828111B (zh) 2014-07-23
KR101558193B1 (ko) 2015-10-12
US20130183252A1 (en) 2013-07-18
BRPI0815634A2 (pt) 2015-02-18
KR20150034819A (ko) 2015-04-03
CA2982520A1 (en) 2009-02-26
CL2008002473A1 (es) 2009-03-27
AU2008289485B2 (en) 2014-08-14
US8148544B2 (en) 2012-04-03
WO2009025793A2 (en) 2009-02-26
TW200912306A (en) 2009-03-16
CN104130247A (zh) 2014-11-05
US7939671B2 (en) 2011-05-10
WO2009025793A3 (en) 2009-05-14
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EP2487169B1 (en) 2015-05-20
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