[go: up one dir, main page]

MX2007010143A - Formas cristalinas de intermedio de linezolid. - Google Patents

Formas cristalinas de intermedio de linezolid.

Info

Publication number
MX2007010143A
MX2007010143A MX2007010143A MX2007010143A MX2007010143A MX 2007010143 A MX2007010143 A MX 2007010143A MX 2007010143 A MX2007010143 A MX 2007010143A MX 2007010143 A MX2007010143 A MX 2007010143A MX 2007010143 A MX2007010143 A MX 2007010143A
Authority
MX
Mexico
Prior art keywords
crystalline forms
linezolid intermediate
linezolid
oxazolidinyl
methylamine
Prior art date
Application number
MX2007010143A
Other languages
English (en)
Inventor
Viviana Braude
Serguei Fine
Tamar Nidam
Tomas Koltai
Original Assignee
Teva Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Pharma filed Critical Teva Pharma
Publication of MX2007010143A publication Critical patent/MX2007010143A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La presente invencion se relaciona con formas cristalinas novedosas del intermedio de linezolid S-N-(4-morfolinil-3- fluorofenil)-2-oxo-5-oxazolidinil-metil amina denominadas aqui Forma A, Forma B y Forma C.
MX2007010143A 2005-02-24 2006-02-24 Formas cristalinas de intermedio de linezolid. MX2007010143A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US65664605P 2005-02-24 2005-02-24
US65677805P 2005-02-24 2005-02-24
US69082205P 2005-06-14 2005-06-14
PCT/US2006/006529 WO2006091777A1 (en) 2005-02-24 2006-02-24 Crystalline forms of linezolid intermediate

Publications (1)

Publication Number Publication Date
MX2007010143A true MX2007010143A (es) 2007-09-27

Family

ID=36498839

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2007010141A MX2007010141A (es) 2005-02-24 2006-02-23 Procesos para la preparacion de intermedios de linezolid.
MX2007010143A MX2007010143A (es) 2005-02-24 2006-02-24 Formas cristalinas de intermedio de linezolid.
MX2007010136A MX2007010136A (es) 2005-02-24 2006-02-24 Bis-linezolid aislado, preparacion de el, y su uso como estandar de referencia.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2007010141A MX2007010141A (es) 2005-02-24 2006-02-23 Procesos para la preparacion de intermedios de linezolid.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2007010136A MX2007010136A (es) 2005-02-24 2006-02-24 Bis-linezolid aislado, preparacion de el, y su uso como estandar de referencia.

Country Status (8)

Country Link
US (4) US7291614B2 (es)
EP (3) EP1866295A2 (es)
JP (2) JP2008530028A (es)
CA (2) CA2602073A1 (es)
IL (3) IL183379A0 (es)
MX (3) MX2007010141A (es)
TW (1) TW200640886A (es)
WO (3) WO2006091731A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011114210A2 (en) 2010-03-15 2011-09-22 Jubilant Life Sciences Limited Processes for the preparation of linezolid
KR20130108975A (ko) 2010-04-30 2013-10-07 인디애나 유니버시티 리서치 앤드 테크놀로지 코포레이션 리네졸리드의 제조 방법
CN103140487A (zh) 2010-08-11 2013-06-05 斯索恩有限公司 制备利奈唑胺的方法
EP2690100A1 (en) 2010-08-11 2014-01-29 Synhton B.V. Process for making linezolid
WO2012094622A2 (en) * 2011-01-07 2012-07-12 The Regents Of The University Of California Amination of aryl alcohol derivatives
US20150025236A1 (en) 2012-01-24 2015-01-22 Jubilant Life Sciences Limited Process for the preparation of stable crystalline form-i of linezolid, substantially free of residual solvent
WO2014071990A1 (en) 2012-11-09 2014-05-15 Synthon Bv Process for making linezolid
WO2014174522A1 (en) * 2013-04-25 2014-10-30 Symed Labs Limited Improved processes for the preparation of linezolid using novel intermediates
RU2021125455A (ru) 2013-11-15 2021-10-05 Экебиа Терапьютикс, Инк. Твердые формы { [5-(3-хлорфенил)-3-гидроксипиридин-2-карбонил]амино} уксусной кислоты, их композиции и применения
CN109265407B (zh) * 2018-10-23 2020-05-29 扬子江药业集团北京海燕药业有限公司 一种双利奈唑胺的合成方法
CN109444294B (zh) * 2018-12-27 2021-06-22 苏州莱奥生物技术有限公司 一种分离利奈唑胺和其手性异构体的高效液相色谱方法
GB202013383D0 (en) * 2020-08-26 2020-10-07 Givaudan Sa Process

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4705799A (en) 1983-06-07 1987-11-10 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl benzenes useful as antibacterial agents
US4801600A (en) 1987-10-09 1989-01-31 E. I. Du Pont De Nemours And Company Aminomethyl oxooxazolidinyl cycloalkylbenzene derivatives useful as antibacterial agents
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
KR100257418B1 (ko) 1991-11-01 2000-05-15 로렌스 티. 마이젠헬더 치환된 아릴-및 헤테로아릴-페닐옥사졸리디논
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
MY115155A (en) * 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
DE69524737T2 (de) * 1994-03-02 2002-06-13 Daicel Chemical Industries, Ltd. 2-isoxazolin-derivate, verfahren zu deren herstellung sowie verfahren zur herstellung von verwandten verbindungen
JP3831954B2 (ja) * 1995-05-19 2006-10-11 ダイソー株式会社 ４−ヒドロキシ−２−ピロリドンの製法
GB9812413D0 (en) 1998-06-10 1998-08-05 Glaxo Group Ltd Compound and its use
DE19827282A1 (de) * 1998-06-19 1999-12-23 Bayer Ag Verfahren zur Herstellung von cycloaliphatischen Aminen
US6444813B2 (en) 2000-02-02 2002-09-03 Pharmacia & Upjohn Company Linezolid-crystal form II
AR027261A1 (es) * 2000-02-02 2003-03-19 Upjohn Co Linezolid forma cristalina ii
US6514529B2 (en) * 2000-03-22 2003-02-04 Pharmacia & Upjohn Company Oxazolidinone tablet formulation
YU52403A (sh) * 2000-12-26 2006-03-03 Dr.Reddy's Research Foundation Heterociklična jedinjenja koja imaju antibakterijsko dejstvo, postupak za njihovo dobijanje i farmaceutske smeše koje ih sadrže
CA2440842A1 (en) * 2001-04-16 2002-10-24 Eisai Co., Ltd. Novel 1h-indazole compounds
AU2001100437A4 (en) 2001-10-03 2001-11-01 Pfizer Limited Reference standards for determining the purity or stability of amlodipine maleate and processes therefor
WO2003093247A2 (en) * 2002-04-30 2003-11-13 Orchid Chemicals & Pharmaceuticals Ltd Antibacterial agents
WO2004026848A1 (en) 2002-09-20 2004-04-01 Lupin Limited Oxazolidinone derivatives, process for their preperation and their use as antimycobacterial agents
ES2803516T3 (es) * 2003-10-16 2021-01-27 Symed Labs Ltd Una forma cristalina de linezolid
MX2007000084A (es) * 2004-06-29 2007-06-14 Teva Pharma Formas solidas de linezolid y procesos para la preparacion delas mismas.

Also Published As

Publication number Publication date
EP1853571A1 (en) 2007-11-14
IL183379A0 (en) 2007-09-20
MX2007010141A (es) 2007-09-27
US20080045707A1 (en) 2008-02-21
US20060258655A1 (en) 2006-11-16
CA2588876A1 (en) 2006-08-31
WO2006091777A1 (en) 2006-08-31
TW200640886A (en) 2006-12-01
JP2008530028A (ja) 2008-08-07
WO2006091848A3 (en) 2006-12-28
WO2006091848A9 (en) 2006-11-09
JP2008530144A (ja) 2008-08-07
EP1861383A2 (en) 2007-12-05
US20060252932A1 (en) 2006-11-09
IL184038A0 (en) 2007-10-31
MX2007010136A (es) 2007-09-27
WO2006091731A3 (en) 2006-10-19
US7291614B2 (en) 2007-11-06
EP1866295A2 (en) 2007-12-19
IL183380A0 (en) 2007-09-20
WO2006091731A2 (en) 2006-08-31
CA2602073A1 (en) 2006-08-31
US20070021417A1 (en) 2007-01-25
WO2006091848A2 (en) 2006-08-31

Similar Documents

Publication Publication Date Title
MX2010002836A (es) Bortezomib y proceso para la produccion del mismo.
TW200730490A (en) Photoactive compounds
WO2007093627A3 (de) Biozide zusammensetzung
TW200626171A (en) Fixed dosing of HER antibodies
MX2010005889A (es) Derivados de tiofeno como agonistas de s1p1/edg1.
EA200801959A1 (ru) Высокоразветвленный полипропилен
TW200734311A (en) New compounds
WO2006136357A3 (de) Kristalline modifikationen des pyraclostrobins
TW200716558A (en) Heteroaroyl-substituted serineamides
TW200942524A (en) Novel aminomethyl benzene derivatives
MX2012008141A (es) Compuestos y metodos.
GB2461659A (en) Structured compositions comprising a clay
ZA200802848B (en) Potassium channel inhibitors
PL1891004T3 (pl) Pentafluorosulfanylo-podstawiony związek i jego zastosowanie do wytwarzania środków leczniczych
TW200942530A (en) Pyridine compounds
TW200613256A (en) Photoactive compounds
MX2007010143A (es) Formas cristalinas de intermedio de linezolid.
MY149433A (en) Nutritional compositions containing punicalagins
MX2007000224A (es) Uso de 2-tio-3,5-diciano-4-fenil-6-aminopiridinas sustituidas en el tratamiento de nauseas y vomitos.
TW200732410A (en) Sprayable acoustic compositions
MX2010008668A (es) Composiciones fungicidas que comprenden 3'-bromo-2,3,4,6'-tetramet oxy-2'-6-dimetilbenzofenona.
MX2009005117A (es) Uso de bacteria clostridium perfringens de tipo c para la elaboracion de una vacuna.
TW200728310A (en) Process for the preparation of ferri-succinylcasein
MX2007006042A (es) Bengamidas que poseen un ciclo caprolactama sustituido, procedimiento de preparacion, composiciones que las contienen y utilizacion.
UA96476C2 (ru) Фармацевтические композиции, которые содержат ирбесартан

Legal Events

Date Code Title Description
FA Abandonment or withdrawal