ME03410B - Heterociklična jedinjenja - Google Patents
Heterociklična jedinjenjaInfo
- Publication number
- ME03410B ME03410B MEP-2019-152A MEP2019152A ME03410B ME 03410 B ME03410 B ME 03410B ME P2019152 A MEP2019152 A ME P2019152A ME 03410 B ME03410 B ME 03410B
- Authority
- ME
- Montenegro
- Prior art keywords
- heterocyclic compound
- heterocyclic
- compound
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/20—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010031899 | 2010-02-17 | ||
| JP2010131950 | 2010-06-09 | ||
| EP11744685.6A EP2540728B1 (en) | 2010-02-17 | 2011-02-16 | Heterocyclic compound |
| PCT/JP2011/053303 WO2011102399A1 (ja) | 2010-02-17 | 2011-02-16 | 複素環化合物 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME03410B true ME03410B (me) | 2020-01-20 |
Family
ID=44482985
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2019-152A ME03410B (me) | 2010-02-17 | 2011-02-16 | Heterociklična jedinjenja |
Country Status (37)
| Country | Link |
|---|---|
| US (6) | US8722660B2 (me) |
| EP (2) | EP3533797B1 (me) |
| JP (1) | JP5689454B2 (me) |
| KR (1) | KR101735868B1 (me) |
| CN (1) | CN102844320B (me) |
| AU (1) | AU2011216404B2 (me) |
| BR (1) | BR112012020311B1 (me) |
| CA (1) | CA2790284C (me) |
| CL (1) | CL2012002250A1 (me) |
| CO (1) | CO6592104A2 (me) |
| CR (1) | CR20120448A (me) |
| CY (1) | CY1121792T1 (me) |
| DK (1) | DK2540728T3 (me) |
| DO (1) | DOP2012000224A (me) |
| EA (1) | EA020724B1 (me) |
| EC (1) | ECSP12012160A (me) |
| ES (1) | ES2733221T3 (me) |
| GE (1) | GEP20146202B (me) |
| HR (1) | HRP20190947T1 (me) |
| HU (1) | HUE043514T2 (me) |
| IL (1) | IL221442A0 (me) |
| LT (1) | LT2540728T (me) |
| MA (1) | MA34064B1 (me) |
| ME (1) | ME03410B (me) |
| MX (1) | MX353500B (me) |
| MY (1) | MY164776A (me) |
| NZ (1) | NZ602089A (me) |
| PE (1) | PE20130184A1 (me) |
| PH (1) | PH12012501650B1 (me) |
| PL (1) | PL2540728T3 (me) |
| PT (1) | PT2540728T (me) |
| RS (1) | RS58796B1 (me) |
| SG (1) | SG183304A1 (me) |
| SI (1) | SI2540728T1 (me) |
| SM (1) | SMT201900385T1 (me) |
| TN (1) | TN2012000401A1 (me) |
| WO (1) | WO2011102399A1 (me) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG187795A1 (en) * | 2010-08-11 | 2013-03-28 | Millennium Pharm Inc | Heteroaryls and uses thereof |
| EP3100742B1 (en) | 2014-01-31 | 2020-05-20 | Carna Biosciences Inc. | Anticancer agent composition comprising a cdc7 inhibitor and a wee1 inhibitor |
| TW201620879A (zh) | 2014-04-28 | 2016-06-16 | 杜邦股份有限公司 | 除草性經取代之3-苯基-4-氟基苯甲醯基吡唑 |
| US10174032B2 (en) * | 2014-05-05 | 2019-01-08 | Signalrx Pharmaceuticals, Inc. | Heterocyclic compound classes for signaling modulation |
| CA3105722C (en) | 2015-12-07 | 2022-10-11 | Zymergen Inc. | Microbial strain improvement by a htp genomic engineering platform |
| CN109311868B (zh) | 2015-12-22 | 2022-04-01 | 尚医治疗有限责任公司 | 用于治疗癌症和炎性疾病的化合物 |
| ES2884398T3 (es) * | 2016-03-28 | 2021-12-10 | Takeda Pharmaceuticals Co | Formas cristalinas de 2-[(2s)-1-azabiciclo[2.2.2]oct-2-il]-6-(3-metil-1H-pirazol-4-il)tieno[3,2-d]pirimidin-4(3H)-ona hemihidrato |
| EA035560B1 (ru) * | 2016-07-28 | 2020-07-07 | Такеда Фармасьютикал Компани Лимитед | Кристаллические формы гемигидрата 2-[(2s)-1-азабицикло[2.2.2]окт-2-ил]-6-(3-метил-1h-пиразол-4-ил)тиено[3,2- d]пиримидин-4(3h)-она |
| EP3538523B1 (en) | 2016-11-08 | 2021-05-19 | Cancer Research Technology Limited | Pyrimidinone derivatives as cdc7 inhibitors |
| US11155879B2 (en) * | 2017-03-01 | 2021-10-26 | Takeda Pharmaceutical Company Limited | Method of predicting effects of CDC7 inhibitor |
| CN112409373A (zh) * | 2017-05-21 | 2021-02-26 | 南京正济医药研究有限公司 | 作为抗癌剂的取代的[5,6]环-4(3h)-嘧啶酮 |
| EA201992780A1 (ru) | 2017-06-21 | 2020-06-02 | ШАЙ ТЕРАПЬЮТИКС ЭлЭлСи | Соединения, которые взаимодействуют с суперсемейством ras, для лечения рака, воспалительных заболеваний, ras-опатий и фиброзного заболевания |
| US11524957B2 (en) * | 2018-04-02 | 2022-12-13 | Takeda Pharmaceutical Company Limited | Process for the synthesis of 2-[(2S)-1-azabicyclo[2.2.2]oct-2-yl]-6-(3-methyl-1H-pyrazol-4-yl)thieno[3,2-d]pyrimidin-4(3H)-one |
| TWI846703B (zh) | 2018-06-19 | 2024-07-01 | 日商武田藥品工業股份有限公司 | 癌症治療方法 |
| IL280130B2 (en) * | 2018-07-19 | 2024-11-01 | Takeda Pharmaceuticals Co | Pharmaceutical compositions with a cdc7 inhibitor |
| EP3898609A1 (en) | 2018-12-19 | 2021-10-27 | Shy Therapeutics LLC | Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease |
| KR20220027883A (ko) * | 2019-05-30 | 2022-03-08 | 치아타이 티안큉 파마수티컬 그룹 주식회사 | Cdc7 억제제로서의 테트라사이클릭 화합물 |
| CN114126621A (zh) * | 2019-07-19 | 2022-03-01 | 武田药品工业株式会社 | 用于癌症治疗的组合疗法 |
| JP2022546294A (ja) * | 2019-08-20 | 2022-11-04 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Cdc7阻害剤として使用される四環式化合物 |
| EP4069369A4 (en) * | 2019-12-06 | 2024-02-14 | Schrödinger, Inc. | CYCLIC COMPOUNDS AND METHODS OF USE THEREOF |
| JP2023541047A (ja) * | 2020-09-10 | 2023-09-27 | シュレーディンガー, インコーポレイテッド | がんの治療のための複素環式ペリ縮環cdc7キナーゼ阻害剤 |
| EP4253388A1 (en) * | 2020-11-30 | 2023-10-04 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Salt form used as cdc7 inhibitor and crystal form thereof |
| CN112661770B (zh) * | 2020-12-24 | 2022-11-08 | 南京正济医药研究有限公司 | 一种化合物及利用其制备取代的[5,6]环-4(3h)-嘧啶酮化合物的方法 |
| WO2022167999A1 (en) | 2021-02-08 | 2022-08-11 | Takeda Pharmaceutical Company Limited | Combination therapy for cancer treatment |
| TW202300150A (zh) * | 2021-03-18 | 2023-01-01 | 美商薛定諤公司 | 環狀化合物及其使用方法 |
| CN117120447A (zh) * | 2021-03-18 | 2023-11-24 | 薛定谔公司 | 环状化合物和其使用方法 |
| EP4416156A1 (en) * | 2021-10-13 | 2024-08-21 | Remix Therapeutics Inc. | Compounds and methods for modulating nucleic acid splicing |
| WO2025160538A1 (en) * | 2024-01-26 | 2025-07-31 | The Board Of Regents Of The University Of Texas System | Compositions and methods for treating hair graying and loss associated with aging |
| WO2025168620A1 (en) | 2024-02-07 | 2025-08-14 | Bayer Aktiengesellschaft | Heteroaryl-substituted 4,5-dihydro-1h-2,4,5-oxadiazines as novel fungicides |
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| FI20055498A0 (fi) | 2005-09-16 | 2005-09-16 | Biotie Therapies Corp | Sulfonamidijohdannaisia |
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| US7618982B2 (en) * | 2005-12-19 | 2009-11-17 | Nerviano Medical Sciences S.R.L. | Heteroarylpyrrolopyridinones active as kinase inhibitors |
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| AR065081A1 (es) | 2007-01-29 | 2009-05-13 | Xenon Pharmaceuticals Inc | Compuestos de quinazolinona y pirimidona fusionados y composicion farmaceutica |
| WO2009001214A2 (en) | 2007-06-28 | 2008-12-31 | Pfizer Products Inc. | Thieno[2,3-d]pyrimidin-4(3h)-one, isoxazolo[5,4-d]pyrimidin-4(5h)-one and isothiazolo[5,4-d]pyrimidin-4(5h)-one derivatives as calcium receptor antagonists |
| US20090118276A1 (en) | 2007-11-02 | 2009-05-07 | Wyeth | Thienopyrimidines, thienopyridines, and pyrrolopyrimidines as b-raf inhibitors |
| US20110098288A1 (en) | 2008-03-11 | 2011-04-28 | Jeremy Major | Sulfonamides as zap-70 inhibitors |
| PE20091928A1 (es) | 2008-05-29 | 2009-12-31 | Bristol Myers Squibb Co | Tienopirimidinas hidroxisustituidas como antagonistas de receptor-1 de hormona concentradora de melanina no basicos |
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| US8691828B2 (en) | 2009-03-05 | 2014-04-08 | Takeda Pharmaceutical Company Limited | Thienopyrimidine as CDC7 kinase inhibitors |
| WO2010126002A1 (ja) | 2009-04-28 | 2010-11-04 | 塩野義製薬株式会社 | ヘテロ環スルホンアミド化合物を含有する医薬 |
| TW201111378A (en) | 2009-09-11 | 2011-04-01 | Bayer Schering Pharma Ag | Substituted (heteroarylmethyl) thiohydantoins |
| CN102481294A (zh) | 2009-09-11 | 2012-05-30 | 拜耳医药股份有限公司 | 作为抗癌药物的取代(杂芳基甲基)乙内酰硫脲 |
| JO2978B1 (en) | 2009-12-21 | 2016-03-15 | ايلي ليلي اند كومباني | MGLU2 aids |
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2011
- 2011-02-16 ES ES11744685T patent/ES2733221T3/es active Active
- 2011-02-16 MA MA35205A patent/MA34064B1/fr unknown
- 2011-02-16 SG SG2012059994A patent/SG183304A1/en unknown
- 2011-02-16 JP JP2012500632A patent/JP5689454B2/ja active Active
- 2011-02-16 LT LTEP11744685.6T patent/LT2540728T/lt unknown
- 2011-02-16 BR BR112012020311-8A patent/BR112012020311B1/pt active IP Right Grant
- 2011-02-16 US US13/578,959 patent/US8722660B2/en active Active
- 2011-02-16 PH PH1/2012/501650A patent/PH12012501650B1/en unknown
- 2011-02-16 HR HRP20190947TT patent/HRP20190947T1/hr unknown
- 2011-02-16 CN CN201180019478.3A patent/CN102844320B/zh active Active
- 2011-02-16 WO PCT/JP2011/053303 patent/WO2011102399A1/ja not_active Ceased
- 2011-02-16 RS RS20190639A patent/RS58796B1/sr unknown
- 2011-02-16 DK DK11744685.6T patent/DK2540728T3/da active
- 2011-02-16 GE GEAP201112855A patent/GEP20146202B/en unknown
- 2011-02-16 AU AU2011216404A patent/AU2011216404B2/en active Active
- 2011-02-16 SI SI201131722T patent/SI2540728T1/sl unknown
- 2011-02-16 NZ NZ602089A patent/NZ602089A/en unknown
- 2011-02-16 SM SM20190385T patent/SMT201900385T1/it unknown
- 2011-02-16 PE PE2012001253A patent/PE20130184A1/es active IP Right Grant
- 2011-02-16 EA EA201290800A patent/EA020724B1/ru unknown
- 2011-02-16 EP EP19168244.2A patent/EP3533797B1/en active Active
- 2011-02-16 CA CA2790284A patent/CA2790284C/en active Active
- 2011-02-16 MY MYPI2012003715A patent/MY164776A/en unknown
- 2011-02-16 KR KR1020127024086A patent/KR101735868B1/ko active Active
- 2011-02-16 PT PT11744685T patent/PT2540728T/pt unknown
- 2011-02-16 ME MEP-2019-152A patent/ME03410B/me unknown
- 2011-02-16 HU HUE11744685A patent/HUE043514T2/hu unknown
- 2011-02-16 PL PL11744685T patent/PL2540728T3/pl unknown
- 2011-02-16 MX MX2012009602A patent/MX353500B/es active IP Right Grant
- 2011-02-16 EP EP11744685.6A patent/EP2540728B1/en active Active
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2012
- 2012-08-09 TN TNP2012000401A patent/TN2012000401A1/en unknown
- 2012-08-14 CL CL2012002250A patent/CL2012002250A1/es unknown
- 2012-08-14 IL IL221442A patent/IL221442A0/en active IP Right Grant
- 2012-08-15 DO DO2012000224A patent/DOP2012000224A/es unknown
- 2012-08-29 CR CR20120448A patent/CR20120448A/es unknown
- 2012-09-13 CO CO12158066A patent/CO6592104A2/es active IP Right Grant
- 2012-09-17 EC ECSP12012160 patent/ECSP12012160A/es unknown
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2014
- 2014-03-24 US US14/223,259 patent/US8921354B2/en active Active
- 2014-03-24 US US14/223,329 patent/US8933069B2/en active Active
- 2014-12-10 US US14/566,157 patent/US9388195B2/en active Active
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2016
- 2016-06-08 US US15/176,893 patent/US9655900B2/en active Active
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2017
- 2017-04-11 US US15/484,755 patent/US20170209452A1/en not_active Abandoned
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2019
- 2019-07-09 CY CY20191100721T patent/CY1121792T1/el unknown
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