[go: up one dir, main page]

MC2151A1 - Derives d'acides amines - Google Patents

Derives d'acides amines

Info

Publication number
MC2151A1
MC2151A1 MC902146A MC2146A MC2151A1 MC 2151 A1 MC2151 A1 MC 2151A1 MC 902146 A MC902146 A MC 902146A MC 2146 A MC2146 A MC 2146A MC 2151 A1 MC2151 A1 MC 2151A1
Authority
MC
Monaco
Prior art keywords
methyl
imidazol
tert
cyclohexylmethyl
cyclopropyl
Prior art date
Application number
MC902146A
Other languages
English (en)
French (fr)
Inventor
Branca Quirico
Neidhart Werner
Ramuz Henri
Stadler Heinz
Wostl Wolfgang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MC2151A1 publication Critical patent/MC2151A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
    • C07C311/23—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms
    • C07C311/25—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atoms of the sulfonamide groups bound to acyclic carbon atoms of a saturated carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
MC902146A 1989-09-04 1990-08-30 Derives d'acides amines MC2151A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH319289 1989-09-04
CH233690 1990-07-12

Publications (1)

Publication Number Publication Date
MC2151A1 true MC2151A1 (fr) 1992-03-10

Family

ID=25690187

Family Applications (1)

Application Number Title Priority Date Filing Date
MC902146A MC2151A1 (fr) 1989-09-04 1990-08-30 Derives d'acides amines

Country Status (14)

Country Link
US (1) US5688946A (no)
EP (1) EP0416373A3 (no)
JP (1) JPH0399047A (no)
KR (1) KR910006224A (no)
AU (1) AU646640B2 (no)
CA (1) CA2023099A1 (no)
FI (1) FI904360A7 (no)
HU (1) HUT58060A (no)
IE (1) IE903197A1 (no)
IL (1) IL95503A0 (no)
MC (1) MC2151A1 (no)
NO (1) NO903832L (no)
NZ (1) NZ235057A (no)
PT (1) PT95192A (no)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68045B1 (en) * 1990-05-11 1996-05-15 Abbott Lab Renin inhibitors
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
US5278161A (en) * 1990-06-28 1994-01-11 Hoffmann-La Roche Inc. Amino acid derivatives useful as renin inhibitors
DE4040056A1 (de) * 1990-12-14 1992-06-17 Merck Patent Gmbh Saeureamide
TW198712B (no) * 1991-04-17 1993-01-21 Hoffmann La Roche
US5268361A (en) * 1991-06-07 1993-12-07 Sri International Hydroxyazido derivatives and related compounds as renin inhibitors
CA2095671A1 (en) * 1992-06-04 1993-12-05 Quirico Branca Amino acid derivatives
US5559256A (en) * 1992-07-20 1996-09-24 E. R. Squibb & Sons, Inc. Aminediol protease inhibitors
US5317039A (en) * 1992-07-20 1994-05-31 G. D. Searle & Co. Cyclopropyl-alanine aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension
US5268391A (en) * 1992-07-20 1993-12-07 C. D. Searle & Co. Propargyl-terminated cycloalkylalkyl-P2-site substituted aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension
US5246969A (en) * 1992-07-20 1993-09-21 G. D. Searle & Co. Di-propargyl-containing aryl/alkylsulfonyl-terminated alanine amino-diol compounds for treatment of hypertension
US5314920A (en) * 1992-07-20 1994-05-24 G. D. Searle & Co. Ethynyl-alanine aryl/alkylsulfonyl-terminated amino-diol compounds for treatment of hypertension
US5212185A (en) * 1992-08-14 1993-05-18 G. D. Searle & Co. Piperidinyl-terminated alkylamino ethynyl alanine amino diol compounds for treatment of hypertension
US5312838A (en) * 1992-09-21 1994-05-17 G. D. Searle & Co. β-alanineamide aryl/alkylsulfide/sulfonyl-terminated amino-diol compounds for treatment of hypertension
ES2100109B1 (es) * 1993-07-14 1998-02-16 Squibb & Sons Inc Inhibidores de proteasas de aminodiol.
US5414018A (en) * 1993-09-24 1995-05-09 G. D. Searle & Co. Alkylaminoalkyl-terminated sulfide/sulfonyl-containing propargyl amino-diol compounds for treatment of hypertension
US5416119A (en) * 1993-10-25 1995-05-16 G. D. Searle & Co. Alkylaminoalkyl-terminated sulfide/sulfonyl-containing cycloalkyl-alanine amino-diol compounds for treatment of hypertension
US5432201A (en) * 1993-11-22 1995-07-11 G. D. Searle & Co. Alkylaminoalkyl-sulfonyl-terminated β-alanineamide amino-diol compounds for treatment of hypertension
IL140499A0 (en) 1998-07-06 2002-02-10 Guilford Pharm Inc Nalladase inhibitors useful as pharmaceutical compounds and compositions
JP2002538151A (ja) * 1999-03-02 2002-11-12 ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド カテプシンの可逆的インヒビターとして有用な化合物
JP2002201168A (ja) * 2000-12-28 2002-07-16 Kaken Pharmaceut Co Ltd シクロヘキサン誘導体
WO2002062850A2 (en) * 2001-02-02 2002-08-15 Millennium Pharmaceuticals, Inc. Hybrid antibodies and uses thereof
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US7232924B2 (en) 2001-06-11 2007-06-19 Xenoport, Inc. Methods for synthesis of acyloxyalkyl derivatives of GABA analogs
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
UA108742C2 (uk) 2009-09-23 2015-06-10 Фармацевтична композиція для лікування запальних захворювань, опосередкованих mcp-1
WO2015049239A1 (en) * 2013-10-04 2015-04-09 Solvay Specialty Polymers Italy S.P.A. Process for the synthesis of fluoralkyl sulfonate salts
KR20190068537A (ko) * 2016-09-18 2019-06-18 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 Yap1과 oct4의 상호작용을 표적으로 하는 yap1 저해제
GB202217507D0 (en) * 2022-11-23 2023-01-04 Imperial College Innovations Ltd Natural killer cells

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4652551A (en) * 1984-06-22 1987-03-24 Abbott Laboratories Renin inhibiting compounds
US4845079A (en) * 1985-01-23 1989-07-04 Luly Jay R Peptidylaminodiols
WO1987004349A1 (en) * 1986-01-16 1987-07-30 Joseph Dellaria Peptide analogs
NZ218937A (en) * 1986-01-16 1990-03-27 Abbott Lab Functionalised peptidyl aminodiols and -triols as renin inhibitors and pharmaceutical compositions
US4726941A (en) * 1986-01-23 1988-02-23 Regents Of The University Of Minnesota Acylated cyanamide composition for treating ethanol ingestion
US5032577A (en) * 1986-12-31 1991-07-16 Abbott Laboratories Peptidylaminodiols
DE3856166T2 (de) * 1987-09-29 1998-08-06 Banyu Pharma Co Ltd N-Acylaminosäurederivate und deren Verwendung
EP0313847A3 (en) * 1987-10-01 1989-11-29 G.D. Searle & Co. Non-peptidyl alpha-succinamidoacyl aminodiols as anti-hypertensive agents
CA1328333C (en) * 1988-03-04 1994-04-05 Quirico Branca Amino acid derivatives
TW225540B (no) * 1990-06-28 1994-06-21 Shionogi & Co
ZA917693B (en) * 1990-09-27 1992-05-27 Merck & Co Inc Fibrinogen receptor antagonists

Also Published As

Publication number Publication date
US5688946A (en) 1997-11-18
JPH0399047A (ja) 1991-04-24
AU646640B2 (en) 1994-03-03
FI904360A0 (fi) 1990-09-04
IE903197A1 (en) 1991-03-13
HU905676D0 (en) 1991-03-28
AU6136090A (en) 1991-03-07
NZ235057A (en) 1994-12-22
KR910006224A (ko) 1991-04-27
CA2023099A1 (en) 1991-03-05
IL95503A0 (en) 1991-06-30
EP0416373A2 (de) 1991-03-13
PT95192A (pt) 1991-05-22
NO903832D0 (no) 1990-09-03
NO903832L (no) 1991-03-05
FI904360A7 (fi) 1991-03-05
EP0416373A3 (en) 1992-05-27
HUT58060A (en) 1992-01-28

Similar Documents

Publication Publication Date Title
MC2151A1 (fr) Derives d'acides amines
MC2106A1 (fr) Derives d'aminoacides
MC2022A1 (fr) Derives d'acides amines
FR2778406A1 (fr) Derives d'alpha-cetoamides, procede pour leur preparation, preparations pharmaceutiques les contenant, et leur utilisation en tant que medicaments anti-viraux
FR2577557A1 (fr) Peptides et derives peptidiques, leur preparation, leur utilisation en therapeutique et compositions pharmaceutiques les contenant
AU627156B2 (en) Amino acid derivatives
HU207508B (en) Process for producing renin-inhibiting glycolic acid derivatives and pharmaceutical compositions containing them
US5250517A (en) Renin inhibiting compounds
KR100432618B1 (ko) 시클릭아미노산유도체
JP2628820B2 (ja) アミノ酸誘導体及びその医薬品としての利用
EP0211744B1 (fr) Dérivés aminoalcools peptidiques contenant un atome de carbone tetrasubstitué inhibiteurs de la rénine et des protéases acides - Procédé d'obtention et compositions pharmaceutiques
MC2107A1 (fr) Derives d'acides amines
HU208427B (en) Process for producing renine-inhibiting amino-acid derivatives and pharmaceutical compositions containing them
BE1001618A4 (fr) Peptides et derives peptidiques, leur preparation et leur utilisation comme medicaments.
MC2109A1 (fr) Dérivés d'acides aminés
WO2001040198A2 (fr) Derives macrocycliques de l'acide hydroxamique et leur utilisation en tant qu'antimicrobiens
FR2577931A1 (fr) Derives aminodiols peptidiques inhibiteurs de la renine et des proteases acides, leur procede de preparation et leur application en therapeutique
JPH03505584A (ja) 抗高血圧剤としてのエーテル状ｎ―末端アミノジオールアミノ酸誘導体
WO2006009325A1 (ja) メタロプロテアーゼ阻害剤

Legal Events

Date Code Title Description
YP Annual fee paid