[go: up one dir, main page]

MA47503A - Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales - Google Patents

Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales

Info

Publication number
MA47503A
MA47503A MA047503A MA47503A MA47503A MA 47503 A MA47503 A MA 47503A MA 047503 A MA047503 A MA 047503A MA 47503 A MA47503 A MA 47503A MA 47503 A MA47503 A MA 47503A
Authority
MA
Morocco
Prior art keywords
intestine
compounds
treatment
methods
inflammatory diseases
Prior art date
Application number
MA047503A
Other languages
English (en)
Inventor
Cheryl Geraldine Lassen
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61622673&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA47503(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of MA47503A publication Critical patent/MA47503A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
MA047503A 2017-02-16 2018-02-16 Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales MA47503A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762459881P 2017-02-16 2017-02-16
US201762459870P 2017-02-16 2017-02-16

Publications (1)

Publication Number Publication Date
MA47503A true MA47503A (fr) 2021-04-21

Family

ID=61622673

Family Applications (1)

Application Number Title Priority Date Filing Date
MA047503A MA47503A (fr) 2017-02-16 2018-02-16 Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales

Country Status (11)

Country Link
US (2) US11478448B2 (fr)
EP (1) EP3582814B1 (fr)
JP (1) JP2020507610A (fr)
KR (1) KR20190113955A (fr)
CN (1) CN110545848A (fr)
AU (1) AU2018222747A1 (fr)
CA (1) CA3053416A1 (fr)
ES (1) ES2981521T3 (fr)
MA (1) MA47503A (fr)
MX (2) MX2019009843A (fr)
WO (1) WO2018151834A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2786994C (fr) 2010-01-27 2018-01-16 Arena Pharmaceuticals, Inc. Procedes de preparation d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta]indol-3-yl) acetique et de ses sels
MX386419B (es) 2015-01-06 2025-03-18 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
MA42807A (fr) 2015-06-22 2018-07-25 Arena Pharm Inc Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
MX2019009843A (es) 2017-02-16 2020-01-30 Arena Pharm Inc Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales.
KR102859841B1 (ko) 2018-06-06 2025-09-12 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 병태의 치료 방법
CN112955431A (zh) * 2018-09-06 2021-06-11 艾尼纳制药公司 可用于治疗自身免疫性病症和炎性病症的化合物
ES2951870T3 (es) * 2018-10-03 2023-10-25 Arena Pharm Inc Etrasimod para su uso en procedimientos para el tratamiento de la esclerodermia
TW202114656A (zh) * 2019-10-01 2021-04-16 美商艾尼納製藥公司 治療與s1p1 受體相關之病況的方法
WO2023135506A1 (fr) * 2022-01-13 2023-07-20 Arena Pharmaceuticals, Inc. Etrasimod destiné à être utilisé dans le traitement de troubles liés au récepteur s1p1 en association avec un traitement hormonal
KR20250102260A (ko) 2023-12-27 2025-07-07 가톨릭대학교 산학협력단 에타너셉트를 발현하는 줄기세포의 배양물을 유효성분으로 포함하는 염증성 장질환의 예방 또는 치료용 약학적 조성물

Family Cites Families (173)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL293572A (fr) 1962-06-07
DE2226703A1 (de) 1972-05-25 1973-12-13 Schering Ag Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung
US4057559A (en) 1973-10-01 1977-11-08 American Home Products Corporation Carbazole acetic acid derivatives
US4476248A (en) 1983-02-28 1984-10-09 The Upjohn Company Crystallization of ibuprofen
US4810699A (en) 1987-02-20 1989-03-07 American Home Products Corporation Substituted 1,3,4,9-tetrahydropyrano[3,4,-b]indole-1-acetic acids, pharmaceutical compositions containing them, and methods for treating inflammatory conditions and for analgesic purposes using them
US4782076A (en) 1988-03-01 1988-11-01 American Home Products Corporation Substituted 2,3,4,9-tetrahydro-1H-carbazole-1-acetic acid derivatives, composition and use
PT95692A (pt) 1989-10-27 1991-09-13 American Home Prod Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase
US5221678A (en) 1990-07-26 1993-06-22 Merck Frosst Canada, Inc. (quinolin-2-ylmethoxy)tetrahydrocarbazoles as inhibitors of the biosynthesis of leukotrienes
US5998499A (en) 1994-03-25 1999-12-07 Dentsply G.M.B.H. Liquid crystalline (meth)acrylate compounds, composition and method
US5776967A (en) 1996-07-26 1998-07-07 American Home Products Corporation Pyranoindole inhibitors of COX--2
US5830911A (en) 1996-08-14 1998-11-03 American Home Products Corporation Pyranoindole and tetrahydrocarbazole inhibitors of COX-2
US6861448B2 (en) 1998-01-14 2005-03-01 Virtual Drug Development, Inc. NAD synthetase inhibitors and uses thereof
YU72201A (sh) 1999-04-28 2005-07-19 Aventis Pharma Deutschland Gmbh. Derivati di-aril kiseline kao ppar receptorski ligandi
WO2001003739A1 (fr) 1999-07-12 2001-01-18 Ono Pharmaceutical Co., Ltd. Inhibiteurs de fibrose contenant comme ingredient actif l'agoniste du recepteur de sphingosine-1-phosphate ou la sphingosine-1-phosphate
US6410583B1 (en) 2000-07-25 2002-06-25 Merck Frosst Canada & Co. Cyclopentanoindoles, compositions containing such compounds and methods of treatment
WO2002039987A2 (fr) 2000-11-14 2002-05-23 Neurosearch A/S Mise en oeuvre de bloquants des canaux anioniques des parasites de la malaria pour traiter cette maladie
EP1383778B1 (fr) 2001-01-30 2009-10-21 University Of Virginia Patent Foundation Agonistes et antagonistes de recepteurs de sphingosine-1-phosphate
WO2002079131A1 (fr) 2001-03-29 2002-10-10 Kansai Research Institute, Inc. Compose optiquement actif et composition de resine photosensible
ES2316613T3 (es) 2001-05-10 2009-04-16 Ono Pharmaceutical Co., Ltd. Derivados de acido crboxilico y composiciones farmaceuticas que contienen los mismos como ingrediente activo.
DE60223699T2 (de) 2001-09-27 2008-10-30 Kyorin Pharmaceutical Co., Ltd. Diarylsulfidderivat, dessen additionssalz und immunsuppressivum
JP4430941B2 (ja) 2002-01-18 2010-03-10 メルク エンド カムパニー インコーポレーテッド Ｅｄｇ受容体作動薬
WO2003061567A2 (fr) 2002-01-18 2003-07-31 Merck & Co., Inc. Antagonistes sélectifs du récepteur s1p1/edg1
WO2003059346A1 (fr) 2002-01-18 2003-07-24 The Genetics Company Inc. Inhibiteurs de beta-secretase
EP1482896A4 (fr) 2002-03-01 2005-11-23 Merck & Co Inc Aminoalkylphosphonates et composes associes utilises en tant qu'agonistes du recepteur edg
CA2477423A1 (fr) 2002-03-01 2003-09-12 Merck & Co., Inc. Aminoalkylphosphonates et composes associes utilises en tant qu'agonistes du recepteur edg
EP1549640A4 (fr) 2002-06-17 2008-08-06 Merck & Co Inc 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates et 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates utilises en tant qu'agonistes du recepteur edg
JPWO2004007472A1 (ja) 2002-07-10 2005-11-17 小野薬品工業株式会社 Ｃｃｒ４アンタゴニストおよびその医薬用途
US7241790B2 (en) 2002-07-30 2007-07-10 University Of Virginia Patent Foundation Compounds active in spinigosine 1-phosphate signaling
CA2505322A1 (fr) 2002-11-08 2004-05-21 Takeda Pharmaceutical Company Limited Agent de controle de la fonction recepteur
WO2004058149A2 (fr) 2002-12-20 2004-07-15 Merck & Co., Inc. 1-(amino)indanes et (1,2-dihydro-3-amino)-benzofuranes, benzothiophenes et indoles utilises en tant qu'agonistes du recepteur edg
GB0301259D0 (en) 2003-01-20 2003-02-19 Novartis Ag Organic compounds
AU2004210697B2 (en) 2003-02-11 2007-10-18 Irm Llc Novel bicyclic compounds and compositions
CA2515574C (fr) 2003-02-18 2012-03-13 Kyorin Pharmaceutical Co., Ltd. Derives d'acide aminophosphonique, leurs sels d'addition et des modulateurs de recepteurs s1p
EP1628970A2 (fr) 2003-04-30 2006-03-01 The Institutes of Pharmaceutical Discovery, LLC Acides carboxyliques substitues par des heterocycles comme inhibiteurs de proteine tyrosine phosphatase-1b
WO2004096752A1 (fr) 2003-04-30 2004-11-11 Novartis Ag Derives d'amino-propanol comme modulateurs de recepteur de sphingosine-1-phosphate
CN1809531B (zh) 2003-04-30 2010-05-26 诺瓦提斯公司 作为鞘氨醇-1-磷酸受体调节剂的氨基丙醇衍生物
CA2524867A1 (fr) 2003-05-15 2004-12-02 Merck & Co., Inc. 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles servant d'agonistes du recepteur s1p
WO2004104205A2 (fr) 2003-05-16 2004-12-02 Merck & Co., Inc. Preparation enzymatique d'esters d'indole chiraux
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
MXPA05012459A (es) 2003-05-19 2006-02-22 Irm Llc Compuestos y composiciones inmunosupresoras.
BRPI0410439A (pt) 2003-05-19 2006-06-06 Irm Llc compostos e composições imunossupressoras
MXPA05012460A (es) 2003-05-19 2006-05-25 Irm Llc Compuestos y composiciones inmunosupresoras.
GB0313612D0 (en) 2003-06-12 2003-07-16 Novartis Ag Organic compounds
EP1661879A4 (fr) 2003-08-04 2006-11-29 Ono Pharmaceutical Co Compose d'ether de diphenyle, sa methode de preparation et d'utilisation
MXPA06002349A (es) 2003-08-28 2006-05-22 Novartis Ag Derivados de aminopropanol.
CN101407471A (zh) 2003-08-29 2009-04-15 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
US7732442B2 (en) 2003-09-05 2010-06-08 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonist and medical use thereof
JP2007528872A (ja) 2003-10-01 2007-10-18 メルク　エンド　カムパニー　インコーポレーテッド Ｓ１ｐ受容体アゴニストとしての３，５−アリール置換、ヘテロアリール置換またはシクロアルキル置換された１，２，４−オキサジアゾール化合物
US7638637B2 (en) 2003-11-03 2009-12-29 University Of Virginia Patent Foundation Orally available sphingosine 1-phosphate receptor agonists and antagonists
WO2005044780A1 (fr) 2003-11-10 2005-05-19 Kyorin Pharmaceutical Co., Ltd. Derive d'acide aminocarboxylique, son sel d'addition et agent de regulation du recepteur s1p
CA2547198A1 (fr) 2003-12-17 2005-06-30 Merck & Co., Inc. Carboxylates propanoiques 3,4-disusbstitues utilises en tant qu'agonistes du recepteur s1p (edg)
GB0329498D0 (en) 2003-12-19 2004-01-28 Novartis Ag Organic compounds
EP1695955B1 (fr) 2003-12-19 2011-10-12 Ono Pharmaceutical Co., Ltd. Antagonistes de l'acide lysophosphatidique et leurs utilisations
GB0401332D0 (en) 2004-01-21 2004-02-25 Novartis Ag Organic compounds
AU2005215320B2 (en) 2004-02-24 2008-04-17 Sankyo Company, Limited Amino alcohol compound
TW200538433A (en) 2004-02-24 2005-12-01 Irm Llc Immunosuppressant compounds and compositiions
CN1922135B (zh) 2004-02-24 2011-07-06 Irm责任有限公司 免疫抑制剂化合物和组合物
US7902369B2 (en) 2004-03-05 2011-03-08 Banyu Pharmaceutical Co., Ltd. Diaryl-substituted five-membered heterocycle derivative
GB0405289D0 (en) 2004-03-09 2004-04-21 Novartis Ag Organic compounds
TWI344954B (en) 2004-04-02 2011-07-11 Merck Sharp & Dohme Asymmetric hydrogenation process
WO2005123677A1 (fr) 2004-06-16 2005-12-29 Actelion Pharmaceuticals Ltd Utilisation de derives de 1,1,2-trimethyl-1a,4,5,5a-tetrahydro-1h-4-aza-cyclopropa[a]pentalene a substitution 4-carbonyle comme agonistes du recepteur couple aux proteines g s1p1/edg1 et agents immunosuppresseurs
EP1760071A4 (fr) 2004-06-23 2008-03-05 Ono Pharmaceutical Co Composé ayant une activité de liaison aux récepteurs s1p et utilisation de celui-ci
PL1772145T3 (pl) 2004-07-16 2011-08-31 Kyorin Seiyaku Kk Sposób skutecznego stosowania leku i sposób dotyczący zapobiegania efektom ubocznym
JP2007284350A (ja) 2004-07-27 2007-11-01 Takeda Chem Ind Ltd 糖尿病治療剤
TW200611687A (en) 2004-07-29 2006-04-16 Sankyo Co Pharmaceutical compositions used for immunosuppressant
WO2006010379A1 (fr) 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Nouveaux derives du thiophene utilises comme agents immunosupresseurs
US8022225B2 (en) 2004-08-04 2011-09-20 Taisho Pharmaceutical Co., Ltd Triazole derivative
MX2007001661A (es) 2004-08-13 2007-04-23 Praecis Pharm Inc Metodos y composiciones para modular la actividad del receptor de esfingosina -1 fosfato (sip).
US20060223866A1 (en) 2004-08-13 2006-10-05 Praecis Pharmaceuticals, Inc. Methods and compositions for modulating sphingosine-1-phosphate (S1P) receptor activity
MX2007003371A (es) 2004-09-23 2007-05-07 Wyeth Corp Derivados de carbazol y ciclopentaindol para tratar infeccion con virus de hepatitis c.
EP1799217A4 (fr) 2004-10-12 2008-01-23 Forbes Medi Tech Res Inc Composes et methodes de traitement de la resistance insulinique et de la myocardiopathie
US7659294B2 (en) 2004-10-22 2010-02-09 Merck & Co., Inc. 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists
SI1650186T1 (sl) 2004-10-22 2008-12-31 Bioprojet Soc Civ Novi derivati dikarboksilne kisline
US20060122222A1 (en) 2004-11-18 2006-06-08 The Institutes For Pharmaceutical Discovery, Llc Heterocycle substituted carboxylic acids
WO2006057448A1 (fr) 2004-11-26 2006-06-01 Takeda Pharmaceutical Company Limited Dérivé d’acide arylalcanoïque
EP1827606A2 (fr) 2004-12-06 2007-09-05 University Of Virginia Patent Foundation Analogues d'aryl amide sphingosine 1-phosphate
MX2007006916A (es) 2004-12-13 2007-08-06 Ono Pharmaceutical Co Derivado de acido aminocarboxilico y uso medicinal del mismo.
WO2006079406A1 (fr) 2005-01-25 2006-08-03 Merck Patent Gmbh Composes mesogenes, milieu de cristal liquide et affichage a cristaux liquides
EP1685841A1 (fr) 2005-01-31 2006-08-02 Bayer Health Care Aktiengesellschaft Prevention et traitement de troubles thromboemboliques
WO2006088944A1 (fr) 2005-02-14 2006-08-24 University Of Virginia Patent Foundation Agonistes de sphingosine-1-phosphate comportant des cycloalcanes et heterocycles substitues par des groupes amino et phenyle
US7723378B2 (en) 2005-03-23 2010-05-25 Actelion Pharmaceuticals Ltd. Hydrogenated benzo (C) thiophene derivatives as immunomodulators
CN101180050B (zh) 2005-03-23 2011-07-27 埃科特莱茵药品有限公司 作为鞘氨醇-1-磷酸盐-1受体激动剂的新颖噻吩衍生物
US7605269B2 (en) 2005-03-23 2009-10-20 Actelion Pharmaceuticals Ltd. Thiophene derivatives as Sphingosine-1-phosphate-1 receptor agonists
KR20080014009A (ko) 2005-06-08 2008-02-13 노파르티스 아게 폴리시클릭 옥사디아졸 또는 이속사졸, 및 이들의 ｓ１ｐ수용체 리간드로서의 용도
JP2008546758A (ja) 2005-06-24 2008-12-25 アクテリオン ファーマシューティカルズ リミテッド 新規チオフェン誘導体
TWI418350B (zh) 2005-06-24 2013-12-11 Sankyo Co 含有ｐｐａｒ調節劑之醫藥組成物的用途
US20070060573A1 (en) 2005-08-10 2007-03-15 Lars Wortmann Acyltryptophanols
CA2619101A1 (fr) 2005-08-23 2007-03-01 Irm Llc Composes immunosuppresseurs et compositions associees
WO2007037196A1 (fr) 2005-09-29 2007-04-05 Yamamoto Chemicals, Inc. Composé indoline et procédé pour le produire
RU2421214C2 (ru) 2005-10-07 2011-06-20 Киорин Фармасьютикал Ко., Лтд. Терапевтическое средство для лечения гепатита и способ лечения гепатита
AR057894A1 (es) 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
JP2009520688A (ja) 2005-11-23 2009-05-28 エピックス デラウェア， インコーポレイテッド Ｓ１ｐ受容体調節化合物およびそれらの使用
TWI404706B (zh) 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
TW200736234A (en) 2006-01-17 2007-10-01 Astrazeneca Ab Chemical compounds
AU2007209051A1 (en) 2006-01-24 2007-08-02 Actelion Pharmaceuticals Ltd Novel pyridine derivatives
GB0601744D0 (en) 2006-01-27 2006-03-08 Novartis Ag Organic compounds
TWI389683B (zh) 2006-02-06 2013-03-21 Kyorin Seiyaku Kk A therapeutic agent for an inflammatory bowel disease or an inflammatory bowel disease treatment using a 2-amino-1,3-propanediol derivative as an active ingredient
TW200806611A (en) 2006-02-09 2008-02-01 Daiichi Seiyaku Co Novel amidopropionic acid derivatives and medicine containing the same
EP1987013A1 (fr) 2006-02-09 2008-11-05 University Of Virginia Patent Foundation Analogues de sphingosine 1-phosphate bicyclique
US20070191371A1 (en) 2006-02-14 2007-08-16 Kalypsys, Inc. Heterocyclic modulators of ppar
JP2009526863A (ja) 2006-02-15 2009-07-23 アラーガン、インコーポレイテッド スフィンゴシン−１−リン酸（ｓ１ｐ）受容体アンタゴニスト生物学的活性を有するアリールまたはヘテロアリール基を持つインドール−３−カルボン酸アミド、エステル、チオアミドおよびチオールエステル化合物
CN101460458A (zh) 2006-02-15 2009-06-17 阿勒根公司 具有1－磷酸－鞘氨醇(s1p)受体拮抗剂生物活性的带芳基或者杂芳基基团的吲哚－3－羧酸的酰胺、酯、硫代酰胺和硫羟酸酯化合物
EP1991535A1 (fr) 2006-02-21 2008-11-19 University Of Virginia Patent Foundation Composés de phényl-cycloalkyl contenant des structures à anneau hétérocyclique
US7649098B2 (en) 2006-02-24 2010-01-19 Lexicon Pharmaceuticals, Inc. Imidazole-based compounds, compositions comprising them and methods of their use
EP2001844A2 (fr) 2006-03-14 2008-12-17 Amgen, Inc Derives bicycliques de l'acide carboxylique utiles dans le traitement de troubles metaboliques
EP2010524A2 (fr) 2006-03-21 2009-01-07 Epix Delaware, Inc. Composés modulant le récepteur de la sip
JP2007262009A (ja) 2006-03-29 2007-10-11 Dai Ichi Seiyaku Co Ltd ヘテロアリール低級カルボン酸誘導体
EP2003132B1 (fr) 2006-04-03 2014-03-05 Astellas Pharma Inc. Dérivés d'oxadiazole en tant qu'agonistes du S1P1
GB0607389D0 (en) 2006-04-12 2006-05-24 Novartis Ag Organic compounds
EP2017263A4 (fr) 2006-05-09 2011-11-30 Daiichi Sankyo Co Ltd Derive acide carboxylique inferieur d'heteroarylamide
WO2007129473A1 (fr) 2006-05-09 2007-11-15 Daiichi Sankyo Company, Limited Dérivé arylique bicyclique
RS20080525A (sr) 2006-05-09 2009-09-08 Pfizer Products Inc., Derivati cikloalkilamino kiseline i njihove farmaceutske kompozicije
JP2009545597A (ja) 2006-08-01 2009-12-24 プリーシス・ファーマシューティカルズ・インコーポレイテッド スフィンゴシン−１−ホスフェート受容体（ｓｌｐ）のアゴニスト
AR062156A1 (es) 2006-08-01 2008-10-22 Praecis Pharm Inc Compuestos agonistas y selectivos del receptor s1p-1
EP2099768A2 (fr) 2006-08-04 2009-09-16 Praecis Pharmaceuticals Incorporated Agonistes du recepteur de sphingosine-1-phosphate
DK2058317T3 (da) 2006-08-08 2014-01-06 Kyorin Seiyaku Kk Aminophosphorsyreesterderivat og S1P receptormodulator indeholdende samme som aktiv ingrediens
EP2054377A1 (fr) 2006-08-24 2009-05-06 Praecis Pharmaceuticals Incorporated Composés chimiques
JP2009269819A (ja) 2006-08-25 2009-11-19 Asahi Kasei Pharma Kk アミン化合物
WO2008030843A1 (fr) 2006-09-07 2008-03-13 Allergan, Inc. Composés hétéroaromatiques présentant une activité biologique agoniste et/ou antagoniste sur le récepteur sphingosine-1-phosphate (s1p)
DK2069336T3 (da) 2006-09-07 2013-02-25 Actelion Pharmaceuticals Ltd Pyridin-4-yl-derivater som immunomodulerende midler
AR061841A1 (es) 2006-09-07 2008-09-24 Actelion Pharmaceuticals Ltd Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.
PE20080769A1 (es) 2006-09-08 2008-08-14 Novartis Ag Derivados de biaril-sulfonamida
MX2009002915A (es) 2006-09-21 2009-03-31 Actelion Pharmaceuticals Ltd Derivados de fenilo y su uso como inmunomoduladores.
NZ577111A (en) 2006-12-15 2012-05-25 Abbott Lab Novel oxadiazole compounds
JO2701B1 (en) 2006-12-21 2013-03-03 جلاكسو جروب ليميتد Vehicles
GB0625648D0 (en) 2006-12-21 2007-01-31 Glaxo Group Ltd Compounds
AU2007338700A1 (en) 2006-12-21 2008-07-03 Abbott Laboratories Sphingosine-1 -phosphate receptor agonist and antagonist compounds
KR20090101307A (ko) 2007-01-11 2009-09-24 알러간, 인코포레이티드 스핑고신-1-포스페이트(ｓ1ｐ) 수용체 길항제 생물학적 활성을 갖는 6-치환된 인돌-3-카르복실산 아미드 화합물
WO2008091967A1 (fr) 2007-01-26 2008-07-31 Smithkline Beecham Corporation Composés chimiques
WO2008097819A2 (fr) 2007-02-05 2008-08-14 Smithkline Beecham Corporation Composés chimiques
MX2009009597A (es) 2007-03-16 2009-09-16 Actelion Pharmaceuticals Ltd Derivados de amino-piridina como agonistas del receptor s1p1/edg1.
EP2121648A2 (fr) 2007-03-21 2009-11-25 EPIX Pharmaceuticals, Inc. Composés modulant les récepteurs de la s1p et leur utilisation
NZ579595A (en) 2007-04-19 2012-06-29 Glaxo Group Ltd Oxadiazole substituted indazole derivatives for use as sphingosine 1-phosphate (S1P) agonists
EP2014653A1 (fr) 2007-06-15 2009-01-14 Bioprojet Nouveaux dérivés d'acide dicarboxylique comme agonistes du recepteur S1P1
WO2009011850A2 (fr) 2007-07-16 2009-01-22 Abbott Laboratories Nouveaux composés thérapeutiques
WO2009019506A1 (fr) 2007-08-03 2009-02-12 Astrazeneca Ab Sulfonamides hétérocycliques ayant une activité antagoniste de edg-1
EA201070238A1 (ru) 2007-08-08 2010-08-30 Мерк Сероно С.А. Соединения пиримидина
TW200930368A (en) 2007-11-15 2009-07-16 Astrazeneca Ab Bis-(sulfonylamino) derivatives in therapy
US8637704B2 (en) 2007-11-28 2014-01-28 Synta Pharmaceuticals Corp. Polymorphs of N-malonyl-bis(N′-methyl-N′-thiobenzoylhydrazide)
EP2222668B1 (fr) 2007-12-18 2011-11-02 Arena Pharmaceuticals, Inc. Dérivés d'acide tétrahydrocyclopenta[b]indol-3-ylcarboxylique utiles dans le traitement de troubles auto-immuns et inflammatoires
EP2252615A1 (fr) 2008-01-25 2010-11-24 Arena Pharmaceuticals, Inc. Dérivés carboxyliques dihydro-1h-pyrrolo[1,2-a]indol-1-yle agissant comme des agonistes de s1p1
AR070398A1 (es) 2008-02-22 2010-03-31 Gruenenthal Chemie Derivados sustituidos de indol
WO2009108924A2 (fr) 2008-02-28 2009-09-03 Solar Roofing Systems, Inc. Tuile photovoltaïque avec matériau anti-incendie
KR101718639B1 (ko) 2008-03-17 2017-03-21 액테리온 파마슈티칼 리미티드 선별적 ｓ1ｐ₁ 수용체 작동약에 대한 투약 섭생
PL2291080T3 (pl) 2008-05-14 2015-12-31 Scripps Research Inst Nowe modulatory receptorów sfingozyno-1-fosforanu
WO2009151626A1 (fr) 2008-06-13 2009-12-17 Arena Pharmaceuticals, Inc. Dérivés de l’acide (1, 2, 4-oxadiazol-3-yl)indolin-1-yl carboxylique substitué pouvant être utilisés comme agonistes de s1p1
WO2009151621A1 (fr) 2008-06-13 2009-12-17 Arena Pharmaceuticals, Inc. Dérivés de l’acide (1, 2, 4-oxadiazol-3-yl)indolin-1-yl carboxylique substitué utiles comme agonistes de s1p1
KR20220084423A (ko) 2008-07-23 2022-06-21 아레나 파마슈티칼스, 인크. 자가면역성 및 염증성의 장애의 치료에 유용한 치환된 1,2,3,4-테트라히드로시클로펜타[ｂ]인돌-3-일)아세트산 유도체
CA2733671C (fr) 2008-08-27 2018-01-02 Arena Pharmaceuticals, Inc. Derives d'acides tricycliques substitues, utiles dans le traitement des troubles auto-immuns et inflammatoires
RS59857B1 (sr) 2008-12-22 2020-02-28 Novartis Ag Režim doziranja agonista s1p receptora
JP5657565B2 (ja) 2008-12-22 2015-01-21 ノバルティス アーゲー Ｓ１ｐ受容体アゴニストの投与レジメン
AU2010213794A1 (en) 2009-02-10 2011-09-01 Abbott Laboratories Agonists and antagonists of the S1P5 receptor, and methods of uses thereof
WO2011005290A1 (fr) 2009-06-23 2011-01-13 Arena Pharmaceuticals, Inc. Dérivés d'oxadiazole disubstitués utiles dans le traitement de troubles auto-immuns et inflammatoires
WO2011005295A1 (fr) 2009-06-24 2011-01-13 Arena Pharmaceuticals, Inc. Modulateurs du récepteur sphingosine-1-phosphate (s1p) utiles pour le traitement de troubles associés à ceux-ci
MX336881B (es) 2009-10-29 2016-02-04 Bristol Myers Squibb Co Compuestos heterociclicos triciclicos.
US8299059B2 (en) 2009-10-30 2012-10-30 Eli Lilly And Company Crystalline compound and a process for its preparation
EP2470529B1 (fr) 2009-12-30 2014-11-19 Medichem, S.A. Dérivé de 1-(1h-1,2,4-triazol-1-yl)butan-2-ol à usage pharmaceutique et utilisation d'un dérivé de 1-(1h-1,2,4-triazol-1-yl)butan-2-ol présentant une forme cristalline en grande partie non définie pour la préparation dudit dérivé de 1-(1h-1,2,4-triazol-1-yl)butan-2-ol
CA2786994C (fr) 2010-01-27 2018-01-16 Arena Pharmaceuticals, Inc. Procedes de preparation d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta]indol-3-yl) acetique et de ses sels
CN102884064B (zh) 2010-03-03 2016-01-13 艾尼纳制药公司 制备s1p1受体调节剂及其晶体形式的方法
EP2598126A2 (fr) 2010-07-30 2013-06-05 Saint Louis University Méthodes de traitement de la douleur
ES2929077T3 (es) 2011-02-07 2022-11-24 Biogen Ma Inc Agentes moduladores de S1P
CN106063787A (zh) 2012-02-03 2016-11-02 泰华制药工业有限公司 拉喹莫德用于治疗一线抗TNFα疗法失败的克罗恩氏病患者的用途
US20160038506A1 (en) 2012-02-14 2016-02-11 Repros Therapeutics Inc. Selective Estrogen Receptor Modulators With Short Half-Lives and Uses Thereof
US8962888B2 (en) 2012-12-03 2015-02-24 Physical Sciences, Inc. Forming spherical crystal habit
JP5589110B1 (ja) 2013-03-08 2014-09-10 株式会社ポーラファルマ 晶癖を有する結晶及び該結晶を有効成分として含有する医薬組成物
MX386419B (es) * 2015-01-06 2025-03-18 Arena Pharm Inc Metodos de condiciones de tratamiento relacionadas con el receptor s1p1.
MA42807A (fr) 2015-06-22 2018-07-25 Arena Pharm Inc Sel l-arginine cristallin d'acide (r)-2-(7-(4-cyclopentyl-3-(trifluorométhyl)benzyloxy)-1,2,3,4-tétrahydrocyclo-penta[b]indol-3-yl)acétique (composé 1) pour une utilisation dans des troubles associés au récepteur de s1p1
MX2019009843A (es) 2017-02-16 2020-01-30 Arena Pharm Inc Compuestos y metodos para el tratamiento de la enfermedad inflamatoria intestinal con manifestaciones extraintestinales.
KR20190116416A (ko) 2017-02-16 2019-10-14 아레나 파마슈티칼스, 인크. 원발 담즙성 담관염을 치료하기 위한 화합물 및 방법
KR102859841B1 (ko) 2018-06-06 2025-09-12 아레나 파마슈티칼스, 인크. S1p1 수용체와 관련된 병태의 치료 방법
ES2951870T3 (es) 2018-10-03 2023-10-25 Arena Pharm Inc Etrasimod para su uso en procedimientos para el tratamiento de la esclerodermia
EP3886841A1 (fr) 2018-11-30 2021-10-06 Arena Pharmaceuticals, Inc. Méthodes de traitement d'états liés au récepteur s1p1
CN118976023A (zh) 2019-01-08 2024-11-19 艾尼纳制药公司 治疗与s1p1受体有关的病况的方法

Also Published As

Publication number Publication date
CN110545848A (zh) 2019-12-06
ES2981521T3 (es) 2024-10-09
US20200016121A1 (en) 2020-01-16
EP3582814B1 (fr) 2024-05-01
MX2022011834A (es) 2022-10-18
US11478448B2 (en) 2022-10-25
US12097182B2 (en) 2024-09-24
AU2018222747A1 (en) 2019-09-05
MX2019009843A (es) 2020-01-30
US20230092353A1 (en) 2023-03-23
WO2018151834A1 (fr) 2018-08-23
JP2020507610A (ja) 2020-03-12
EP3582814A1 (fr) 2019-12-25
KR20190113955A (ko) 2019-10-08
CA3053416A1 (fr) 2018-08-23

Similar Documents

Publication Publication Date Title
MA47503A (fr) Composés et méthodes pour le traitement de maladies inflammatoires chroniques de l'intestin avec manifestations extra-intestinales
MA51200A (fr) Nouveaux composés et compositions pharmaceutiques associées pour le traitement de maladies
EP3390634A4 (fr) Compositions et méthodes pour le traitement de maladies oculaires
EP3452166A4 (fr) Stimulation intranasale pour le traitement de la maladie de la glande de meibomius et de la blépharite
EP3621973A4 (fr) Composés pour la prévention et le traitement de maladies et leur utilisation
EP3340982A4 (fr) Composés pour le traitement de troubles immunitaires et inflammatoires
MA51203A (fr) Combinaison d'un dérivé de 4-pyrimidinesulfamide avec un inhibiteur de sglt-2 pour le traitement de maladies liées à l'endothéline
IL262608A (en) Combination treatment of ocular inflammatory disorders and diseases
EP3448875A4 (fr) Compositions pour le traitement de maladies
EP3448987A4 (fr) Compositions pour le traitement de maladies
MA45481A (fr) Utilisation d'exosomes pour le traitement de maladies
EP3718561A4 (fr) Agent thérapeutique pour une maladie inflammatoire de l'intestin
MA52873A (fr) Nouveaux composés et compositions pharmaceutiques associées pour le traitement de maladies
EP3704108A4 (fr) Composés et compositions pour le traitement de troubles hématologiques
EP3661553A4 (fr) Méthodes et compositions pour le traitement des maladies à dépôts amyloïdes
EP2967062A4 (fr) Déséthylhydroxychloroquine pour le traitement de maladies associées avec l'inflammation
EP3639833A4 (fr) Agent pour la prévention ou le traitement de maladies liées à la graisse et/ou de l'inflammation
EP3655403A4 (fr) Composés affectant la production de pigments et leur utilisation pour le traitement de maladies bactériennes
MA44126A (fr) Méthodes de traitement de maladies et troubles pulmonaires
EP3443962A4 (fr) Dérivé de quinoline pour le traitement du cancer de l'estomac
MA39950A (fr) Dérivé de 2-acylaminothiazole pour le traitement des maladies des voies urinaires et de la vessie
EP3805216A4 (fr) Composés pour le traitement ou la prévention de maladies hépatiques
MA53614A (fr) Protéine pour le traitement de maladies inflammatoires
EP3861131A4 (fr) Thérapie génique pour le traitement de l'acidémie propionique
EP3737363A4 (fr) Méthodes de traitement de maladies inflammatoires chroniques