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YU72201A - Derivati di-aril kiseline kao ppar receptorski ligandi - Google Patents

Derivati di-aril kiseline kao ppar receptorski ligandi

Info

Publication number
YU72201A
YU72201A YU72201A YUP72201A YU72201A YU 72201 A YU72201 A YU 72201A YU 72201 A YU72201 A YU 72201A YU P72201 A YUP72201 A YU P72201A YU 72201 A YU72201 A YU 72201A
Authority
YU
Yugoslavia
Prior art keywords
fused
acid derivatives
ppar
receptor ligands
ppar receptor
Prior art date
Application number
YU72201A
Other languages
English (en)
Inventor
Zaid Jayyosi
Gerard M. Mcgeehan
Michael F. Kelley
Richard F. Labaudiniere
Litao Zhang
Robert D. Groneberg
Daniel G. Mcgarry
Thomas J. Caulfild
Anne Minnich
Mark Bobko
Original Assignee
Aventis Pharma Deutschland Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland Gmbh. filed Critical Aventis Pharma Deutschland Gmbh.
Publication of YU72201A publication Critical patent/YU72201A/sh

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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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Abstract

Ovaj pronalazak je usmeren na di-aril kiseline derivate formule (I) i na njihove farmaceutske preparate kao PPAR ligandna receptorska veziva. PPAR ligandna receptorska veziva ovog pronalaska su pimenljiva kao agonisti ili antagonisti PPAR receptora gde: (a) i (b) su nezavisno aril, fuzirana arilcikloaikenil, fuzirana arilcikloalkil, fuzirana arilheterociklenil, fuzirana arilheterociklil, heteroaril, fuzirana heteroarilcikloalkenil, fuzirana heteroarilcikloalkil, fuzirana heteroarilheterociklenil ili fuzirana heteroarilheterociklil grupa; A je -O-, -S-, -SO-, -SO2-, -NR13-, -C(O)-, -N(R14)C(O)-, -C(O)N(R15)-, N(R14)C(O)N(R15-, -C(R14)=N-, (c), (d), (e), hemijska veza, (f) ili (g), B je -O-, -S-, -NR19- hemijska veza, -C(O)-, -N(R20)C(O)- ili -C(O)N(R20)-, Z je R21O2C-, R21OC-, ciklo-imid, -CN, R21O2SHNCO-, R21O2SHN-, (R21)2NCO-, R21O- 2,4-tiazolidindionil ili tetrazolil grupa.
YU72201A 1999-04-28 2000-04-28 Derivati di-aril kiseline kao ppar receptorski ligandi YU72201A (sh)

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