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MA43619B1 - Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci - Google Patents

Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci

Info

Publication number
MA43619B1
MA43619B1 MA43619A MA43619A MA43619B1 MA 43619 B1 MA43619 B1 MA 43619B1 MA 43619 A MA43619 A MA 43619A MA 43619 A MA43619 A MA 43619A MA 43619 B1 MA43619 B1 MA 43619B1
Authority
MA
Morocco
Prior art keywords
isoquinolin
carboxamides
preparation
isoquinoline
disorders
Prior art date
Application number
MA43619A
Other languages
English (en)
Other versions
MA43619A1 (fr
Inventor
Sunil Kumar Kc
Gopi Kumar Mittapalli
Chi Ching Mak
Venkataiah Bollu
Chandramouli Chiruta
Jianguo Cao
Brian Eastman
Original Assignee
Samumed Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samumed Llc filed Critical Samumed Llc
Publication of MA43619A1 publication Critical patent/MA43619A1/fr
Publication of MA43619B1 publication Critical patent/MA43619B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

L'invention concerne des composés isoquinoline destinés à traiter diverses maladies et pathologies. Plus particulièrement, la présente invention concerne l'utilisation d'un composé isoquinoline, ou d'analogues de celui-ci, dans le traitement de troubles caractérisés par l'activation de la signalisation de la voie wnt (par exemple un cancer, une prolifération cellulaire anormale, une angiogenèse, des troubles fibrotiques, des maladies osseuses ou cartilagineuses, et une ostéoarthrite), la modulation d'évén
MA43619A 2016-04-27 2017-04-27 Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci MA43619B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662328255P 2016-04-27 2016-04-27
PCT/US2017/029805 WO2017189829A1 (fr) 2016-04-27 2017-04-27 Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci

Publications (2)

Publication Number Publication Date
MA43619A1 MA43619A1 (fr) 2019-10-31
MA43619B1 true MA43619B1 (fr) 2020-10-28

Family

ID=60157337

Family Applications (1)

Application Number Title Priority Date Filing Date
MA43619A MA43619B1 (fr) 2016-04-27 2017-04-27 Isoquinolin-3-yl carboxamides et préparation et utilisation de ceux-ci

Country Status (30)

Country Link
US (8) US10106527B2 (fr)
EP (3) EP4559905A3 (fr)
JP (1) JP6993985B2 (fr)
KR (1) KR102374844B1 (fr)
CN (1) CN109310690B (fr)
AR (1) AR108325A1 (fr)
AU (1) AU2017258193B2 (fr)
CA (1) CA3022002A1 (fr)
CL (2) CL2018003065A1 (fr)
CO (1) CO2018012299A2 (fr)
CY (1) CY1124302T1 (fr)
DK (1) DK3448386T3 (fr)
ES (1) ES2865374T3 (fr)
HR (1) HRP20210607T1 (fr)
HU (1) HUE054103T2 (fr)
IL (1) IL262470B (fr)
LT (1) LT3448386T (fr)
MA (1) MA43619B1 (fr)
MD (1) MD3448386T2 (fr)
MX (1) MX385859B (fr)
MY (1) MY198966A (fr)
PE (1) PE20190326A1 (fr)
PH (1) PH12018502258A1 (fr)
PL (1) PL3448386T3 (fr)
PT (1) PT3448386T (fr)
RS (1) RS61879B1 (fr)
SG (2) SG11201809301YA (fr)
SI (1) SI3448386T1 (fr)
SM (1) SMT202100224T1 (fr)
WO (1) WO2017189829A1 (fr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12017500997A1 (en) 2012-04-04 2018-02-19 Samumed Llc Indazole inhibitors of the wnt signal pathway and therapeutic uses thereof
WO2017079765A1 (fr) 2015-11-06 2017-05-11 Samumed, Llc Traitement de l'ostéoarthrite
HUE055031T2 (hu) 2015-12-10 2021-10-28 Ptc Therapeutics Inc Módszerek Huntington-kór kezelésére
TW201803869A (zh) 2016-04-27 2018-02-01 健生藥品公司 作為ＲＯＲγＴ調節劑之６－胺基吡啶－３－基噻唑
AR108326A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108325A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
EP4067347B1 (fr) * 2016-05-24 2024-06-19 Genentech, Inc. Inhibiteurs hétérocycliques de cbp/ep300 pour le traitement du cancer
MD3464285T2 (ro) 2016-06-01 2023-01-31 Biosplice Therapeutics Inc Procedeu pentru prepararea N-(5-(3-(7-(3-fluorfenil)-3H-imidazo[4,5-c]piridin-2-il)-1H-indazol-5-il)piridin-3-il)-3-metilbutanamidei
WO2018183964A1 (fr) 2017-03-30 2018-10-04 Genentech, Inc. Isoquinoléines utilisées en tant qu'inhibiteurs de hpk1
JP7376471B2 (ja) 2017-06-05 2023-11-08 ピーティーシー セラピューティクス， インコーポレイテッド ハンチントン病を処置するための化合物
CN111182898B (zh) 2017-06-28 2024-04-16 Ptc医疗公司 用于治疗亨廷顿氏病的方法
WO2019005993A1 (fr) 2017-06-28 2019-01-03 Ptc Therapeutics, Inc. Méthodes de traitement de la maladie de huntington
WO2019079626A1 (fr) * 2017-10-19 2019-04-25 Samumed, Llc 6-(hétéroaryle à 5 chaînons)isoquinolin-3-yl carboxamides, leur préparation et leur utilisation
US10413537B2 (en) 2017-10-27 2019-09-17 Samumed, Llc 6-(5-membered heteroaryl)isoquinolin-3-yl-(5-membered heteroaryl) carboxamides and preparation and use thereof
WO2019084497A1 (fr) 2017-10-27 2019-05-02 Samumed, Llc 6-(hétéroaryle et aryle à 6 chaînons)isoquinolin-3-yl carboxamides, leur préparation et leur utilisation
WO2019089835A1 (fr) * 2017-10-31 2019-05-09 Samumed, Llc Diazanaphthalèn-3-yl carboxamides, préparation et utilisation de ceux-ci
CN112135815A (zh) 2018-03-27 2020-12-25 Ptc医疗公司 用于治疗亨廷顿氏病的化合物
US10975057B2 (en) 2018-06-18 2021-04-13 Janssen Pharmaceutica Nv 6-aminopyridin-3-yl pyrazoles as modulators of RORgT
US11345666B2 (en) 2018-06-18 2022-05-31 Janssen Pharmaceutica Nv Phenyl and pyridinyl substituted imidazoles as modulators of RORγT
CN112292373A (zh) 2018-06-18 2021-01-29 詹森药业有限公司 作为RORγt的调节剂的吡啶基吡唑类
EP3790865A1 (fr) 2018-06-18 2021-03-17 Janssen Pharmaceutica NV Pyrazoles substitués par phényle utilisés en tant que modulateurs de roryt
US11685746B2 (en) 2018-06-27 2023-06-27 Ptc Therapeutics, Inc. Heteroaryl compounds for treating Huntington's disease
ES2983003T3 (es) 2018-06-27 2024-10-21 Ptc Therapeutics Inc Compuestos heterocíclicos y heteroarílicos para el tratamiento de la enfermedad de Huntington
MX2020014315A (es) 2018-06-27 2021-05-27 Ptc Therapeutics Inc Compuestos de heteroarilo para tratar la enfermedad de huntington.
CN112601584A (zh) 2018-07-24 2021-04-02 豪夫迈·罗氏有限公司 异喹啉化合物及其用途
TW202024053A (zh) 2018-10-02 2020-07-01 美商建南德克公司 異喹啉化合物及其用途
US11612606B2 (en) 2018-10-03 2023-03-28 Genentech, Inc. 8-aminoisoquinoline compounds and uses thereof
US20230000842A1 (en) 2019-01-17 2023-01-05 Samumed, Llc Methods of treating cartilage disorders through inhibition of clk and dyrk
WO2021004547A1 (fr) * 2019-07-11 2021-01-14 Guangdong Newopp Biopharmaceuticals Co., Ltd. Composés hétérocycliques utilisés en tant qu'inhibiteurs de hpk1
WO2021007378A1 (fr) * 2019-07-11 2021-01-14 Ptc Therapeutics, Inc. Composés destinés à être utilisés dans le traitement de la maladie de huntington
WO2021089395A1 (fr) * 2019-11-08 2021-05-14 Nerviano Medical Sciences S.R.L. Composés hétérocycliques à double substitution gem et leur utilisation en tant qu'inhibiteurs d'idh
WO2021235293A1 (fr) * 2020-05-20 2021-11-25 国立大学法人大阪大学 Agent liant de séquence de répétition cug
CN116348469B (zh) * 2020-10-28 2025-07-08 杭州阿诺生物医药科技有限公司 一种高活性Wnt通路抑制剂化合物
WO2022093881A1 (fr) 2020-10-29 2022-05-05 Merck Sharp & Dohme Corp. Amides isoquinoline liés à n en tant qu'inhibiteurs de lrrk2, compositions pharmaceutiques et utilisations associées
KR20230106648A (ko) * 2020-11-10 2023-07-13 포그혼 쎄라퓨틱스 인크. 화합물 및 그의 용도
TW202321244A (zh) * 2021-07-26 2023-06-01 大陸商杭州阿諾生物醫藥科技有限公司 一種Ｗｎｔ通路抑制劑化合物
TW202334157A (zh) * 2022-01-29 2023-09-01 大陸商杭州阿諾生物醫藥科技有限公司 一種Ｗｎｔ通路抑制劑化合物
CN117396482A (zh) * 2022-07-28 2024-01-12 杭州阿诺生物医药科技有限公司 一种Wnt通路抑制剂化合物
WO2024022365A1 (fr) * 2022-07-28 2024-02-01 杭州阿诺生物医药科技有限公司 Composé inhibiteur de la voie wnt
WO2024238620A1 (fr) * 2023-05-17 2024-11-21 Woolsey Pharmaceuticals, Inc. Méthodes de traitement du syndrome d'encéphalopathie traumatique

Family Cites Families (109)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4164559A (en) 1977-09-21 1979-08-14 Cornell Research Foundation, Inc. Collagen drug delivery device
US4474752A (en) 1983-05-16 1984-10-02 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4783443A (en) 1986-03-03 1988-11-08 The University Of Chicago Amino acyl cephalosporin derivatives
GB9414139D0 (en) 1994-07-13 1994-08-31 Smithkline Beecham Plc Novel compounds
ES2131463B1 (es) 1997-04-08 2000-03-01 Lilly Sa Derivados de ciclopropilglicina con propiedades farmaceuticas.
DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US6440102B1 (en) 1998-07-23 2002-08-27 Durect Corporation Fluid transfer and diagnostic system for treating the inner ear
DE19853299C2 (de) 1998-11-19 2003-04-03 Thomas Lenarz Katheter zur Applikation von Medikamenten in Flüssigkeitsräumen des menschlichen Innenohrs
US6120484A (en) 1999-02-17 2000-09-19 Silverstein; Herbert Otological implant for delivery of medicament and method of using same
AU770377B2 (en) 1999-05-21 2004-02-19 Bristol-Myers Squibb Company Pyrrolotriazine inhibitors of kinases
PE20010306A1 (es) 1999-07-02 2001-03-29 Agouron Pharma Compuestos de indazol y composiciones farmaceuticas que los contienen utiles para la inhibicion de proteina kinasa
US6967023B1 (en) 2000-01-10 2005-11-22 Foamix, Ltd. Pharmaceutical and cosmetic carrier or composition for topical application
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
JP3729343B2 (ja) 2000-04-27 2005-12-21 アステラス製薬株式会社 縮合ヘテロアリール誘導体
EP1401831A1 (fr) 2001-07-03 2004-03-31 Chiron Corporation Composes d'indazole benzimidazole utilises comme inhibiteurs de tyrosine et de serine/threonine kinase
US6648873B2 (en) 2001-09-21 2003-11-18 Durect Corp. Aural catheter system including anchor balloon and balloon inflation device
EP1448557A4 (fr) 2001-10-26 2005-02-02 Univ Connecticut Heteroindanes: nouvelle classe de ligands cannabimimetiques efficaces
BR0213562A (pt) 2001-10-26 2004-08-31 Aventis Pharma Inc Benzimidazóis e análogos e seu uso como inibidores de cinases de proteìna
FR2831536A1 (fr) 2001-10-26 2003-05-02 Aventis Pharma Sa Nouveaux derives de benzimidazoles, leur procede de preparation, leur application a titre de medicament, compositions pharmaceutiques et nouvelle utilisation notamment comme inhibiteurs de kdr
US20030187026A1 (en) 2001-12-13 2003-10-02 Qun Li Kinase inhibitors
MXPA04008130A (es) 2002-02-19 2004-11-26 Pharmacia Corp Derivados triciclicos de pirazol para el tratamiento de la inflamacion.
WO2003070236A2 (fr) 2002-02-19 2003-08-28 Pharmacia Italia S.P.A. Derives de pyrazole tricyclique, procedes de leur preparation et leur utilisation en tant qu'agents anti-tumoraux
JP4751063B2 (ja) 2002-05-17 2011-08-17 ファイザー イタリア ソシエタ ア レスポンサビリタ リミタータ キナーゼ阻害剤として活性のアミノインダゾール誘導体、それらの調製方法、及びそれらを含む薬学的組成物
KR20050004214A (ko) 2002-05-31 2005-01-12 에자이 가부시키가이샤 피라졸 화합물 및 이것을 포함하여 이루어지는 의약 조성물
EP1511751B1 (fr) 2002-06-04 2008-03-19 Neogenesis Pharmaceuticals, Inc. Composes de pyrazolo[1,5a]pyrimidine servant d'agents antiviraux
GB0218625D0 (en) 2002-08-10 2002-09-18 Astex Technology Ltd Pharmaceutical compounds
FR2845382A1 (fr) 2002-10-02 2004-04-09 Sanofi Synthelabo Derives d'indazolecarboxamides, leur preparation et leur utilisation en therapeutique
WO2004076450A1 (fr) 2003-02-27 2004-09-10 J. Uriach Y Compañia S.A. Derives de pyrazolopyridine
GB0310867D0 (en) * 2003-05-12 2003-06-18 Novartis Ag Organic compounds
WO2005012256A1 (fr) 2003-07-22 2005-02-10 Astex Therapeutics Limited Composes 1h-pyrazole 3,4-disubstitues et leur utilisation en tant que kinases dependant des cyclines (cdk) et modulateurs de la glycogene synthase kinase-3 (gsk-3)
US7008953B2 (en) 2003-07-30 2006-03-07 Agouron Pharmaceuticals, Inc. 3, 5 Disubstituted indazole compounds, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation
CN1829713A (zh) 2003-07-30 2006-09-06 辉瑞大药厂 3,5二取代的吲唑化合物、药物组合物和介导或抑制细胞增殖的方法
WO2005014554A1 (fr) 2003-08-08 2005-02-17 Astex Therapeutics Limited Composes 1h-indazole-3-carboxamide utilises comme modulateurs de la mapkap kinase
EP1692113B1 (fr) 2003-11-14 2017-09-27 Lorus Therapeutics Inc. Imidazoles d'aryle et leur utilisation comme agents anticancereux
EP1532980A1 (fr) 2003-11-24 2005-05-25 Novo Nordisk A/S Carboxamides d'indole n-heteroarylé et leurs analogues, utiles comme des activateurs de glucokinase pour le traitement de diabetes
FR2867778B1 (fr) 2004-03-16 2006-06-09 Sanofi Synthelabo Utilisation de derives d'indazolecarboxamides pour la preparation d'un medicament destine au traitement et a la prevention du paludisme
BRPI0508771A (pt) 2004-03-25 2007-08-14 Memory Pharm Corp indazóis, benzotiazóis, benzoisotiazóis, benzisoxazóis, e a preparação e usos dos mesmos
CA2567977A1 (fr) 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, leur preparation et leurs utilisations
EP1753428A4 (fr) 2004-05-14 2010-09-15 Abbott Lab Inhibiteurs de kinases en tant qu'agents therapeutiques
CA2573573A1 (fr) 2004-07-27 2006-02-09 Sgx Pharmaceuticals, Inc. Modulateurs heterocycliques a cycles fusionnes pour les kinases
WO2006024945A1 (fr) 2004-09-03 2006-03-09 Pfizer Inc. Compositions pharmaceutiques contenant un inhibiteur des cdk
US20060116519A1 (en) 2004-11-17 2006-06-01 Agouron Pharmaceuticals, Inc. Synthesis of 5-bromo-4-methyl-pyridin-3-ylmethyl)-ethyl-carbamic acid tert-butyl ester
WO2006054143A1 (fr) 2004-11-17 2006-05-26 Pfizer Inc. Formes polymorphes de {5-[3-(4,6-difluoro-1h-benzimidazol-2-yl)-1h-indazol-5-yl]-4-methyl-pyridin-3-ylmethyl}-ethyl-amine
US20060127388A1 (en) 2004-12-10 2006-06-15 Wyeth Variants of glycogen synthase kinase 3 and uses thereof
US20060142247A1 (en) 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
EP1861161A4 (fr) 2005-01-24 2012-05-16 Neurosystec Corp Appareil et methode permettant de distribuer des agents therapeutiques et/ou autres a l'oreille interne et a d'autres tissus
WO2006130673A1 (fr) 2005-05-31 2006-12-07 Janssen Pharmaceutica, N.V. 3-benzoimidazolyl-pyrazolopyridines utilisees pour traiter des troubles dont la mediation est assuree par des kinases
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
TW200804338A (en) 2005-11-24 2008-01-16 Astrazeneca Ab New compounds
EP1957109A2 (fr) 2005-12-02 2008-08-20 Sirtris Pharmaceuticals, Inc. Modulateurs de kinases de type cdc2 (clks) et leurs procédés d'utilisation
WO2007107346A1 (fr) 2006-03-23 2007-09-27 F. Hoffmann-La Roche Ag Dérivés d'indazole substitués, leur fabrication et leur utilisation comme agents pharmaceutiques
MX2008012482A (es) 2006-03-31 2008-10-10 Abbott Lab Compuestos de indazol.
WO2007125405A2 (fr) * 2006-05-01 2007-11-08 Pfizer Products Inc. Composés hétérocycliques 2-amino-substitués à cycles fusionnés
WO2008061109A2 (fr) 2006-11-15 2008-05-22 Forest Laboratories Holdings Limited Dérivés d'indazole utiles en tant que ligands des récepteurs de l'hormone concentrant la mélanine
DE602006021591D1 (de) 2006-12-11 2011-06-09 Genetics Co Inc Aromatische 1,4-DI-Carboxylamide und deren Verwendung
EP1932830A1 (fr) 2006-12-11 2008-06-18 The Genetics Company, Inc. Sulfamides et leur utilisation en tant que médicament
BRPI0719991A2 (pt) 2006-12-14 2014-03-18 Bayer Schering Pharma Ag Derivados de di-hidropiridina úteis como inibidores de proteína cinase
JP2010524858A (ja) 2007-04-10 2010-07-22 エスジーエックス ファーマシューティカルズ、インコーポレイテッド 縮合環複素環キナーゼ調節因子
EP2148865B1 (fr) 2007-04-30 2017-05-17 Genentech, Inc. Inhibiteurs pyrazolés de la signalisation des wnt
NZ597731A (en) 2007-05-10 2013-08-30 Avalon Pharmaceuticals Derivatives of fluorene, anthracene, xanthene, dibenzosuberone and acridine and uses thereof
US8304408B2 (en) 2007-05-24 2012-11-06 The Regents Of The University Of California Wnt signaling inhibitors, and methods for making and using them
CL2008001540A1 (es) 2007-05-29 2009-05-22 Sgx Pharmaceuticals Inc Compuestos derivados de pirrolopiridinas y pirazolopiridinas; composicion farmaceutica; y uso en el tratamiento del cancer.
WO2008154241A1 (fr) 2007-06-08 2008-12-18 Abbott Laboratories Indazoles à substitution 5-hétéroaryle servant d'inhibiteurs de kinases
WO2008156757A1 (fr) 2007-06-19 2008-12-24 Takeda Pharmaceutical Company Limited Composés d'indazole permettant d'activer la glucokinase
US20090069288A1 (en) 2007-07-16 2009-03-12 Breinlinger Eric C Novel therapeutic compounds
EP2182984A2 (fr) 2007-08-02 2010-05-12 Nerviano Medical Sciences S.r.l. Dérivé de la morpholinyle anthracycline combiné à des inhibiteurs de protéine kinases
CN101821279A (zh) 2007-08-15 2010-09-01 赛特凯恩蒂克公司 某些化学个体、组合物和方法
WO2009061345A2 (fr) 2007-11-07 2009-05-14 Cornell Research Foundation, Inc. Ciblage de cdk4 et cdk6 dans une thérapie contre le cancer
WO2009085226A2 (fr) 2007-12-21 2009-07-09 Sirtris Pharmaceuticals, Inc. Inhibiteurs des kinases de type cdc2 (clk) et leurs procédés d'utilisation
KR101061599B1 (ko) 2008-12-05 2011-09-02 한국과학기술연구원 비정상 세포 성장 질환의 치료를 위한 단백질 키나아제 저해제인 신규 인다졸 유도체, 이의 약학적으로 허용가능한염 및 이를 유효성분으로 함유하는 약학적 조성물
CN101440092B (zh) 2008-12-25 2010-11-17 浙江大学 2-吲唑-4-氮杂吲哚-5-氨基衍生物及制备和应用
UA103918C2 (en) 2009-03-02 2013-12-10 Айерем Элелси N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators
AR076126A1 (es) 2009-03-18 2011-05-18 Schering Corp Compuestos biciclicos como inhibidores de diacilglicerol aciltransferasa
JP2012521429A (ja) 2009-03-23 2012-09-13 メルク・シャープ・エンド・ドーム・コーポレイション 疼痛治療用のｐ２ｘ３受容体アンタゴニスト
BR112012001532A2 (pt) 2009-07-23 2019-09-24 Univ Vanderbilt "substituída azolesulfonamides benzoimid e indolesulfonamides substituído como potenciadores mglur4"
CA2770320A1 (fr) 2009-08-10 2011-02-17 Epitherix, Llc Indazoles utiles comme inhibiteurs de la voie de signalisation de wnt/beta-catenine et utilisations therapeutiques de ceux-ci
EP2464232B1 (fr) 2009-08-10 2015-10-07 Samumed, LLC Composés d indazole inhibant la voie de signalisation des wnt et utilisations thérapeutiques de ceux-cithereof
WO2011050245A1 (fr) 2009-10-23 2011-04-28 Yangbo Feng Hétéroaryles bicycliques formant inhibiteurs de la kinase
US7998878B2 (en) 2009-11-20 2011-08-16 Eastman Kodak Company Method for selective deposition and devices
EP2515655B1 (fr) 2009-12-21 2015-08-05 Samumed, LLC 1h-pyrazolo[3,4-beta]pyridines et leurs utilisations thérapeutiques
MX2012007329A (es) 2009-12-21 2012-10-15 Array Biopharma Inc Compuestos de n-(1h-indazol-4-il) imidazo [1, 2-a] piridin-3-carboxamida substituida como inhibidores de cfms.
MX2012010666A (es) 2010-03-31 2012-10-05 Actelion Pharmaceuticals Ltd Derivados de isoquinolin-3-ilurea antibacterianos.
USRE46943E1 (en) 2010-04-06 2018-07-10 Peter Maccallum Cancer Institute Radioprotector compounds and methods
WO2012068589A2 (fr) 2010-11-19 2012-05-24 Constellation Pharmaceuticals Modulateurs d'enzymes de modification par méthylation, compositions et utilisations associées
KR20130129244A (ko) * 2010-12-17 2013-11-27 에프. 호프만-라 로슈 아게 치환된 6,6-융합된 질소 헤테로환형 화합물 및 이의 용도
CN102558173B (zh) * 2010-12-31 2015-05-20 广州源生医药科技有限公司 抑制wnt信号传导的化合物、组合物及其应用
US8889684B2 (en) 2011-02-02 2014-11-18 Boehringer Ingelheim International Gmbh Azaindolylphenyl sulfonamides as serine/threonine kinase inhibitors
US9464065B2 (en) 2011-03-24 2016-10-11 The Scripps Research Institute Compounds and methods for inducing chondrogenesis
RU2014105624A (ru) 2011-08-12 2015-09-20 Ф. Хоффманн-Ля Рош Аг Соединения индазола, способ их применения и фармацевтическая композиция
IN2014CN02646A (fr) 2011-09-14 2015-08-07 Samumed Llc
WO2013169793A2 (fr) * 2012-05-09 2013-11-14 Ipierian, Inc. Procédés et compositions pour des protéinopathies tdp-43
US9557993B2 (en) 2012-10-23 2017-01-31 Analog Devices Global Processor architecture and method for simplifying programming single instruction, multiple data within a register
US9908867B2 (en) 2013-01-08 2018-03-06 Samumed, Llc 3-(benzoimidazol-2-yl)-indazole inhibitors of the Wnt signaling pathway and therapeutic uses thereof
EA201591327A1 (ru) 2013-01-16 2015-12-30 СИГНАЛ ФАРМАСЬЮТИКАЛЗ, ЭлЭлСи Замещенные пирролопиримидиновые соединения, их композиции и способы лечения с использованием таких соединений
SG10201914111XA (en) 2014-03-20 2020-03-30 Samumed Llc 5-substituted indazole-3-carboxamides and preparation and use thereof
WO2016040180A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-1h-benzo[d]imidazol-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040181A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040193A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-(1h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques
WO2016040182A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 2-(1h-indazol-3-yl)-1h-imidazo[4,5-c]pyridine et ses utilisations thérapeutiques
WO2016040188A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-3h-imidazo[4,5-c]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
WO2016040190A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-(3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-b]pyridine et ses utilisations thérapeutiques
WO2016040185A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 2-1h-indazol-3-yl)-3h-imidazo[4,5-b]pyridine et ses utilisations thérapeutiques
WO2016040184A1 (fr) 2014-09-08 2016-03-17 Samumed, Llc 3-3h-imidazo[4,5-b]pyridin-2-yl)-1h-pyrazolo[3,4-c]pyridine et ses utilisations thérapeutiques
GB201416754D0 (en) 2014-09-23 2014-11-05 Mission Therapeutics Ltd Novel compounds
AR108326A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
AR108325A1 (es) 2016-04-27 2018-08-08 Samumed Llc Isoquinolin-3-il carboxamidas y preparación y uso de las mismas
CN109937039A (zh) 2016-09-30 2019-06-25 斯坦福国际研究院 用于癌症治疗的双重clk/cdk1抑制剂
US20220062240A1 (en) 2018-06-26 2022-03-03 Biosplice Therapeutics, Inc. Methods of treating cancer using a clk inhibitor
WO2020150545A1 (fr) 2019-01-17 2020-07-23 Samumed, Llc DÉRIVÉS DE PYRAZOLE UTILISÉS COMME MODULATEURS DE LA VOIE DE SIGNALISATION WNT/β-CATÉNINE

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