MA39165A1 - Dérivés de benzimidazole-proline pour leurs utilisations dans le traitement du syndrome des etats crepusculaires - Google Patents
Dérivés de benzimidazole-proline pour leurs utilisations dans le traitement du syndrome des etats crepusculairesInfo
- Publication number
- MA39165A1 MA39165A1 MA39165A MA39165A MA39165A1 MA 39165 A1 MA39165 A1 MA 39165A1 MA 39165 A MA39165 A MA 39165A MA 39165 A MA39165 A MA 39165A MA 39165 A1 MA39165 A1 MA 39165A1
- Authority
- MA
- Morocco
- Prior art keywords
- crepuscular
- treatment
- benzimidazole
- proline derivatives
- state syndrome
- Prior art date
Links
- 208000011580 syndromic disease Diseases 0.000 title abstract 2
- UBSOHWJGTKOSAS-VWMHFEHESA-N 1H-benzimidazole (2S)-pyrrolidine-2-carboxylic acid Chemical class OC(=O)[C@@H]1CCCN1.c1nc2ccccc2[nH]1 UBSOHWJGTKOSAS-VWMHFEHESA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La présente invention concerne des composés de la formule (i) dans laquelle ar et ar 2 ont la signification indiquée dans la description et leur utilisation en tant que produits pharmaceutiques pour le traitement du syndrome des états crépusculaires. L'invention concerne également la préparation desdits composés et de sels pharmaceutiquement acceptables de ceux-ci.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2013060630 | 2013-12-04 | ||
| PCT/IB2014/066548 WO2015083094A1 (fr) | 2013-12-04 | 2014-12-03 | Utilisation de dérivés de benzimidazole-proline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA39165A1 true MA39165A1 (fr) | 2017-10-31 |
Family
ID=52347368
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA39165A MA39165A1 (fr) | 2013-12-04 | 2014-12-03 | Dérivés de benzimidazole-proline pour leurs utilisations dans le traitement du syndrome des etats crepusculaires |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US9914721B2 (fr) |
| EP (1) | EP3077391B1 (fr) |
| JP (1) | JP6421185B2 (fr) |
| KR (1) | KR102330133B1 (fr) |
| CN (1) | CN105873921B (fr) |
| AU (1) | AU2014358766B2 (fr) |
| CA (1) | CA2930053A1 (fr) |
| CL (1) | CL2016001349A1 (fr) |
| CY (1) | CY1121089T1 (fr) |
| DK (1) | DK3077391T3 (fr) |
| EA (1) | EA029725B1 (fr) |
| ES (1) | ES2696708T3 (fr) |
| HK (1) | HK1225734B (fr) |
| HR (1) | HRP20181710T1 (fr) |
| HU (1) | HUE040555T2 (fr) |
| IL (1) | IL245914B (fr) |
| LT (1) | LT3077391T (fr) |
| MA (1) | MA39165A1 (fr) |
| MX (1) | MX366642B (fr) |
| MY (1) | MY179605A (fr) |
| PH (1) | PH12016500985B1 (fr) |
| PL (1) | PL3077391T3 (fr) |
| PT (1) | PT3077391T (fr) |
| SA (1) | SA516371253B1 (fr) |
| SI (1) | SI3077391T1 (fr) |
| TR (1) | TR201815342T4 (fr) |
| UA (1) | UA116053C2 (fr) |
| WO (1) | WO2015083094A1 (fr) |
| ZA (1) | ZA201604502B (fr) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI570120B (zh) * | 2012-06-04 | 2017-02-11 | 艾克泰聯製藥有限公司 | 苯并咪唑脯胺酸衍生物 |
| UA119549C2 (uk) | 2013-12-03 | 2019-07-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ТА ЇЇ ЗАСТОСУВАННЯ ЯК АНТАГОНІСТА ОРЕКСИНОВОГО РЕЦЕПТОРА |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
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| JP6936224B2 (ja) | 2015-11-23 | 2021-09-15 | サンシャイン・レイク・ファーマ・カンパニー・リミテッドSunshine Lake Pharma Co.,Ltd. | オクタヒドロピロロ[3,4−c]ピロール誘導体およびその使用 |
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| EP4138822A1 (fr) | 2020-04-19 | 2023-03-01 | Idorsia Pharmaceuticals Ltd | Utilisation médicale de daridorexant |
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| WO2014057435A1 (fr) | 2012-10-10 | 2014-04-17 | Actelion Pharmaceuticals Ltd | Antagonistes des récepteurs de l'orexine, qui sont des dérivés [ortho bi (hetero )aryl]-[2-(meta bi (hetero )aryl)-pyrrolidin-1-yl]-methanone |
| WO2014141065A1 (fr) | 2013-03-12 | 2014-09-18 | Actelion Pharmaceuticals Ltd | Dérivés d'amide d'azétidine en tant qu'antagonistes des récepteurs d'oréxine |
| UA119151C2 (uk) | 2013-12-03 | 2019-05-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА |
| UA119549C2 (uk) | 2013-12-03 | 2019-07-10 | Ідорсія Фармасьютікалз Лтд | КРИСТАЛІЧНА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ТА ЇЇ ЗАСТОСУВАННЯ ЯК АНТАГОНІСТА ОРЕКСИНОВОГО РЕЦЕПТОРА |
| HUE040555T2 (hu) | 2013-12-04 | 2019-03-28 | Idorsia Pharmaceuticals Ltd | Benzimidazol prolin származékok alkalmazása |
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