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MA37765A1 - Composés de pyrazole substitués utilisés comme antagonistes de lpar - Google Patents

Composés de pyrazole substitués utilisés comme antagonistes de lpar

Info

Publication number
MA37765A1
MA37765A1 MA37765A MA37765A MA37765A1 MA 37765 A1 MA37765 A1 MA 37765A1 MA 37765 A MA37765 A MA 37765A MA 37765 A MA37765 A MA 37765A MA 37765 A1 MA37765 A1 MA 37765A1
Authority
MA
Morocco
Prior art keywords
compounds used
pyrazole compounds
substituted pyrazole
lpar antagonists
lpar
Prior art date
Application number
MA37765A
Other languages
English (en)
Inventor
Stephen Deems Gabriel
Matthew Michael Hamilton
Yimin Qian
Achyutharao Sidduri
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48656033&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA37765(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA37765A1 publication Critical patent/MA37765A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/38—Nitrogen atoms
    • C07D231/40—Acylated on said nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés de formule (i) ainsi que des sels pharmaceutiquement acceptables de ceux-ci, les substituants étant ceux qui sont indiqués dans la description. Ces composés, et les compositions pharmaceutiques les contenant, sont utiles pour le traitement de maladies et de troubles inflammatoires tels que le fibrose pulmonaire par exemple.
MA37765A 2012-06-20 2013-06-17 Composés de pyrazole substitués utilisés comme antagonistes de lpar MA37765A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661958P 2012-06-20 2012-06-20
PCT/EP2013/062458 WO2013189862A1 (fr) 2012-06-20 2013-06-17 Composés de pyrazole substitués utilisés comme antagonistes de lpar

Publications (1)

Publication Number Publication Date
MA37765A1 true MA37765A1 (fr) 2017-04-28

Family

ID=48656033

Family Applications (1)

Application Number Title Priority Date Filing Date
MA37765A MA37765A1 (fr) 2012-06-20 2013-06-17 Composés de pyrazole substitués utilisés comme antagonistes de lpar

Country Status (22)

Country Link
US (1) US20150259295A1 (fr)
EP (1) EP2864294A1 (fr)
JP (1) JP2015520201A (fr)
KR (1) KR20150011003A (fr)
CN (1) CN104411690A (fr)
AU (1) AU2013279510A1 (fr)
BR (1) BR112014031108A2 (fr)
CA (1) CA2869602A1 (fr)
CL (1) CL2014003242A1 (fr)
CO (1) CO7160077A2 (fr)
CR (1) CR20140516A (fr)
EA (1) EA201492283A1 (fr)
HK (1) HK1206341A1 (fr)
IL (1) IL236091A0 (fr)
IN (1) IN2014DN09347A (fr)
MA (1) MA37765A1 (fr)
MX (1) MX2014014105A (fr)
PE (1) PE20142445A1 (fr)
PH (1) PH12014502364A1 (fr)
SG (1) SG11201407229UA (fr)
UA (1) UA109867C2 (fr)
WO (1) WO2013189862A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8975235B2 (en) 2011-03-20 2015-03-10 Intermune, Inc. Lysophosphatidic acid receptor antagonists
BR112015023267B1 (pt) 2013-03-15 2023-01-31 Epigen Biosciences, Inc Composto, e medicamento para tratar um indivíduo com doença ou condição lisofosfatídica dependente de ácido
EP3162801B1 (fr) 2014-06-27 2020-07-22 UBE Industries, Ltd. Sel d'un composé hétérocyclique substitué par un groupe halogène
EP3728216B1 (fr) * 2017-12-19 2023-09-06 Bristol-Myers Squibb Company Acides carbamoyle cyclohexyliques à liaison n pyrazole utilisés en tant qu'antagonistes de lpa
CN111434655A (zh) * 2019-01-15 2020-07-21 武汉朗来科技发展有限公司 溶血磷脂酸受体拮抗剂及其制备方法
WO2021097039A1 (fr) 2019-11-15 2021-05-20 Gilead Sciences, Inc. Pyridylsulfonamides de carbamate de triazole utilisées en tant qu'antagonistes du récepteur de lpa et leurs utilisations
WO2021247215A1 (fr) 2020-06-03 2021-12-09 Gilead Sciences, Inc. Antagonistes du récepteur lpa et leurs utilisations
TWI838626B (zh) 2020-06-03 2024-04-11 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
TWI818538B (zh) * 2021-05-11 2023-10-11 美商基利科學股份有限公司 Ｌｐａ受體拮抗劑及其用途
JP7691522B2 (ja) 2021-05-13 2025-06-11 ギリアード サイエンシーズ， インコーポレイテッド Ｌｐａ受容体アンタゴニスト及びそれらの使用
KR20240115978A (ko) 2021-12-08 2024-07-26 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제 및 이의 용도

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2005063241A1 (ja) * 2003-12-26 2007-07-19 小野薬品工業株式会社 ミトコンドリアベンゾジアゼピン受容体介在性疾患の予防および／または治療剤
TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
US20090036425A1 (en) 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
WO2011017350A2 (fr) * 2009-08-04 2011-02-10 Amira Pharmaceuticals, Inc. Composés en tant qu'antagonistes du récepteur de l'acide lysophosphatidique
MX2013006040A (es) * 2010-12-07 2013-08-26 Amira Pharmaceuticals Inc Antagonistas del receptor de acido lisofosfatidico y su uso en el tratamiento de fibrosis.
US8975235B2 (en) * 2011-03-20 2015-03-10 Intermune, Inc. Lysophosphatidic acid receptor antagonists
WO2012138648A1 (fr) * 2011-04-06 2012-10-11 Irm Llc Compositions et procédés pour la modulation de récepteurs au lpa

Also Published As

Publication number Publication date
CO7160077A2 (es) 2015-01-15
HK1206341A1 (en) 2016-01-08
SG11201407229UA (en) 2014-12-30
EA201492283A1 (ru) 2015-04-30
PH12014502364A1 (en) 2015-01-12
WO2013189862A1 (fr) 2013-12-27
CL2014003242A1 (es) 2015-03-20
AU2013279510A1 (en) 2014-10-16
UA109867C2 (ru) 2015-10-12
CN104411690A (zh) 2015-03-11
PE20142445A1 (es) 2015-01-28
JP2015520201A (ja) 2015-07-16
IN2014DN09347A (fr) 2015-07-17
MX2014014105A (es) 2015-03-05
KR20150011003A (ko) 2015-01-29
BR112014031108A2 (pt) 2017-06-27
CR20140516A (es) 2014-12-01
CA2869602A1 (fr) 2013-12-27
US20150259295A1 (en) 2015-09-17
IL236091A0 (en) 2015-02-01
EP2864294A1 (fr) 2015-04-29

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