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MA33772B1 - Dérivés d'acide carboxylique cyclique substitué par acylamino et leur utilisation en tant qu'agents pharmaceutiques - Google Patents

Dérivés d'acide carboxylique cyclique substitué par acylamino et leur utilisation en tant qu'agents pharmaceutiques

Info

Publication number
MA33772B1
MA33772B1 MA34905A MA34905A MA33772B1 MA 33772 B1 MA33772 B1 MA 33772B1 MA 34905 A MA34905 A MA 34905A MA 34905 A MA34905 A MA 34905A MA 33772 B1 MA33772 B1 MA 33772B1
Authority
MA
Morocco
Prior art keywords
acilamino
cyclo
pharmaceuticals
alternative
carboxylic acid
Prior art date
Application number
MA34905A
Other languages
Arabic (ar)
English (en)
Inventor
Josef Pernerstorfer
Heinz-Werner Kleemann
Matthias Schaefer
Alena Safarova
Marcel Patek
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42040612&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA33772(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of MA33772B1 publication Critical patent/MA33772B1/fr

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    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/54—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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Abstract

A PRÉSENTE INVENTION CONCERNE DES COMPOSÉS PHARMACEUTIQUEMENT ACTIFS INTÉRESSANTS DE FORMULE (I), OÙ A, Y, Z, R20 À R22 ET R50 SONT TELS QUE DÉFINIS DANS LES REVENDICATIONS. L'INVENTION CONCERNE, PLUS PRÉCISÉMENT, DES INHIBITEURS DU RÉCEPTEUR 2 DU GÈNE DE LA DIFFÉRENTIATION ENDOTHÉLIALE (EDG-2, EDG2), QUI EST ACTIVÉ PAR L'ACIDE LYSOPHOSPHATIDIQUE (LPA) ET QUI EST ÉGALEMENT CONNU SOUS LE NOM DE RÉCEPTEUR LPA1. LESDITS COMPOSÉS PEUVENT ÊTRE UTILISÉS DANS LE CADRE DU TRAITEMENT DE MALADIES TELLES QUE L'ATHÉROSCLÉROSE, L'INFARCTUS DU MYOCARDE ET L'INSUFFISANCE CARDIAQUE PAR EXEMPLE. L'INVENTION CONCERNE, EN OUTRE, DES PROCÉDÉS DE PRÉPARATION DES COMPOSÉS DE FORMULE (I), LEUR UTILISATION ET DES COMPOSITIONS PHARMACEUTIQUES EN CONTENANT.
MA34905A 2009-11-02 2012-05-30 Dérivés d'acide carboxylique cyclique substitué par acylamino et leur utilisation en tant qu'agents pharmaceutiques MA33772B1 (fr)

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EP09290831 2009-11-02
US31961910P 2010-03-31 2010-03-31
PCT/US2010/055035 WO2011053948A1 (fr) 2009-11-02 2010-11-02 Dérivés cycliques acylamino-substitués de l'acide carboxylique et leur utilisation en tant que produits pharmaceutiques

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