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MA31432B1 - Metabolites de derives de (thio) carbamoyl-cyclohexane - Google Patents

Metabolites de derives de (thio) carbamoyl-cyclohexane

Info

Publication number
MA31432B1
MA31432B1 MA32403A MA32403A MA31432B1 MA 31432 B1 MA31432 B1 MA 31432B1 MA 32403 A MA32403 A MA 32403A MA 32403 A MA32403 A MA 32403A MA 31432 B1 MA31432 B1 MA 31432B1
Authority
MA
Morocco
Prior art keywords
metabolites
derivatives
theo
carbamoyl
cyclohexane
Prior art date
Application number
MA32403A
Other languages
Arabic (ar)
English (en)
Inventor
Csongor Éva Ágainé
Norbert Antal Kirschner
Éva Schmidt
István Gyertyán
Béla Kiss
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of MA31432B1 publication Critical patent/MA31432B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/22—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with hetero atoms directly attached to ring nitrogen atoms
    • C07D295/24—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des métabolites de dérivés de (thio)-carbamoyl-cyclohexane, en particulier des métabolites de la trans-4-{2-[4-(2,3-dichlorophényl)-piperazin-1-yl]-éthyl}-n,n-diméthylcarbamoyl-cyclohexylamine) et leurs sels acceptables sur le plan pharmaceutique, des compositions pharmaceutiques en contenant et leur utilisation en vue du traitement et/ou de la prévention d'une affection exigeant une modulation des récepteurs de la dopamine.
MA32403A 2007-05-18 2009-12-07 Metabolites de derives de (thio) carbamoyl-cyclohexane MA31432B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU0700353A HUP0700353A2 (en) 2007-05-18 2007-05-18 Metabolites of (thio)carbamoyl-cyclohexane derivatives
PCT/HU2008/000046 WO2008142461A1 (fr) 2007-05-18 2008-05-15 Métabolites de dérivés de (thio)carbamoyl-cyclohexane

Publications (1)

Publication Number Publication Date
MA31432B1 true MA31432B1 (fr) 2010-06-01

Family

ID=89987527

Family Applications (1)

Application Number Title Priority Date Filing Date
MA32403A MA31432B1 (fr) 2007-05-18 2009-12-07 Metabolites de derives de (thio) carbamoyl-cyclohexane

Country Status (24)

Country Link
US (1) US8765765B2 (fr)
EP (1) EP2155707B1 (fr)
JP (1) JP5406827B2 (fr)
CN (1) CN101679330A (fr)
AP (1) AP2009005011A0 (fr)
AU (1) AU2008252619A1 (fr)
BR (1) BRPI0811744A2 (fr)
CA (1) CA2684149C (fr)
CO (1) CO6251252A2 (fr)
CU (1) CU23852B1 (fr)
EA (1) EA200971069A1 (fr)
EC (1) ECSP099819A (fr)
GE (1) GEP20125523B (fr)
HU (1) HUP0700353A2 (fr)
IL (1) IL201534A0 (fr)
MA (1) MA31432B1 (fr)
MX (1) MX2009012371A (fr)
MY (1) MY150784A (fr)
NI (1) NI200900202A (fr)
NZ (1) NZ580646A (fr)
TN (1) TN2009000459A1 (fr)
TW (1) TW201002324A (fr)
WO (1) WO2008142461A1 (fr)
ZA (1) ZA200907425B (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
US7875610B2 (en) 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CN102014909B (zh) * 2008-02-21 2013-03-13 田边三菱制药株式会社 口服用固体制剂
RS53866B1 (sr) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
HU230067B1 (hu) * 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) * 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) * 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts
CN102762201B (zh) * 2009-11-06 2013-12-18 爱思开生物制药株式会社 注意力缺陷/多动症的治疗方法
US20110117214A1 (en) * 2009-11-16 2011-05-19 Auspex Pharmaceuticals, Inc. Cyclohexyl urea modulators of d2 receptors and/or d3 receptors
HUP0900790A2 (en) * 2009-12-17 2011-09-28 Richter Gedeon Nyrt A new process for the preparation of piperazine and their hydrochloric salts
US8912197B2 (en) 2012-08-20 2014-12-16 Forest Laboratories Holdings Ltd. Crystalline form of carbamoyl-cyclohexane derivatives
US11274087B2 (en) 2016-07-08 2022-03-15 Richter Gedeon Nyrt. Industrial process for the preparation of cariprazine
US12319659B2 (en) 2017-02-24 2025-06-03 Shenzhen Linglan Bio-Pharmaceutical Technology Co., Ltd Selective ligand for dopamine D3 receptor, preparation method therefor, and pharmaceutical application thereof
CN108586389B (zh) * 2018-06-29 2020-06-12 成都福柯斯医药技术有限公司 一种合成卡利拉嗪的方法
US11547707B2 (en) 2019-04-10 2023-01-10 Richter Gedeon Nyrt. Carbamoyl cyclohexane derivatives for treating autism spectrum disorder
HU231500B1 (hu) 2019-04-10 2024-04-28 Richter Gedeon Nyrt Karbamoil-ciklohexán származékok autizmus spektrum betegség kezelésére
CN112239433B (zh) * 2019-07-17 2024-05-14 北京盈科瑞创新药物研究有限公司 一种环己烷衍生物、制备方法及其应用
WO2021088920A1 (fr) * 2019-11-05 2021-05-14 上海翰森生物医药科技有限公司 Régulateur de dérivé de benzothiophène, son procédé de préparation et son utilisation
WO2024072930A1 (fr) * 2022-09-30 2024-04-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Agonistes partiels du récepteur d3/d2 de la dopamine destinés au traitement de troubles neuropsychiatriques

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HU227543B1 (en) 2001-09-28 2011-08-29 Richter Gedeon Nyrt N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them
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HU227534B1 (en) * 2003-08-04 2011-08-29 Richter Gedeon Nyrt (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them
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HU230748B1 (hu) * 2007-05-11 2018-02-28 Richter Gedeon Nyrt Új piperazin só és előállítási eljárása
KR20100027137A (ko) * 2007-05-11 2010-03-10 리히터 게데온 닐트. 카르바모일-사이클로헥산 유도체의 신규한 용매화물 및 결정 형태
HUP0700353A2 (en) 2007-05-18 2008-12-29 Richter Gedeon Nyrt Metabolites of (thio)carbamoyl-cyclohexane derivatives
HUP0700369A2 (en) * 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment in the manufacture of a medicament for the treatment of schizophrenia
HUP0700370A2 (en) * 2007-05-24 2009-04-28 Richter Gedeon Nyrt Use of (thio)-carbamoyl-cyclohexane derivatives in the manufacture of a medicament for the treatment of acute mania
MX2010001171A (es) * 2007-08-01 2010-03-01 Lundbeck & Co As H Uso de abridores de canales de potasio kcnq para reducir los sintomas o tratar desordenes o afecciones en las cuales se encuentra anulado el sistema dopaminergico.
US7875610B2 (en) * 2007-12-03 2011-01-25 Richter Gedeon Nyrt. Pyrimidinyl-piperazines useful as D3/D2 receptor ligands
CN102014909B (zh) * 2008-02-21 2013-03-13 田边三菱制药株式会社 口服用固体制剂
RS53866B1 (sr) 2008-07-16 2015-08-31 Richter Gedeon Nyrt. Farmaceutske formulacije koje sadrže ligande dopaminskih receptora
HU230067B1 (hu) * 2008-12-17 2015-06-29 Richter Gedeon Nyrt Új piperazin só és eljárás előállítására
HUP0800766A2 (en) * 2008-12-18 2010-11-29 Richter Gedeon Vegyeszet Process for the preparation of piperazine derivatives
HUP0800765A2 (en) * 2008-12-18 2010-11-29 Richter Gedeon Nyrt A new process for the preparation of piperazine derivatives and their hydrochloric salts

Also Published As

Publication number Publication date
HU0700353D0 (en) 2007-07-30
NZ580646A (en) 2012-03-30
ECSP099819A (es) 2010-03-31
CN101679330A (zh) 2010-03-24
CO6251252A2 (es) 2011-02-21
AU2008252619A1 (en) 2008-11-27
MY150784A (en) 2014-02-28
MX2009012371A (es) 2009-12-03
US8765765B2 (en) 2014-07-01
ZA200907425B (en) 2010-07-28
AP2009005011A0 (en) 2009-10-31
EP2155707B1 (fr) 2013-03-13
GEP20125523B (en) 2012-05-25
EA200971069A1 (ru) 2010-04-30
JP2010527983A (ja) 2010-08-19
TN2009000459A1 (en) 2011-03-31
CA2684149A1 (fr) 2008-11-27
US20100137335A1 (en) 2010-06-03
IL201534A0 (en) 2010-05-31
EP2155707A1 (fr) 2010-02-24
HUP0700353A2 (en) 2008-12-29
BRPI0811744A2 (pt) 2014-11-11
CU23852B1 (es) 2012-10-15
NI200900202A (es) 2010-03-11
TW201002324A (en) 2010-01-16
WO2008142461A1 (fr) 2008-11-27
JP5406827B2 (ja) 2014-02-05
CA2684149C (fr) 2012-12-04
CU20090196A7 (es) 2011-07-11

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