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MA30916B1 - Nouveaux derives de benzamide en tant qu'antagonistes de bradykinine - Google Patents

Nouveaux derives de benzamide en tant qu'antagonistes de bradykinine

Info

Publication number
MA30916B1
MA30916B1 MA31911A MA31911A MA30916B1 MA 30916 B1 MA30916 B1 MA 30916B1 MA 31911 A MA31911 A MA 31911A MA 31911 A MA31911 A MA 31911A MA 30916 B1 MA30916 B1 MA 30916B1
Authority
MA
Morocco
Prior art keywords
benzamide derivatives
compounds
novel benzamide
antagonists
bradykinine
Prior art date
Application number
MA31911A
Other languages
English (en)
Inventor
Istvan Vago
Gyula Beke
Eva Bozo
Sandor Farkas
Katalin Hornok
Gyoergy Keserue
Eva Schmidt
Eva Szentirmay
Monika Vastag
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of MA30916B1 publication Critical patent/MA30916B1/fr

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract

LA PRÉSENTE INVENTION CONCERNE DE NOUVEAUX DÉRIVÉS DE BENZAMIDE PHÉNYLSULFAMOYLE REPRÉSENTÉS PAR LA FORMULE GÉNÉRALE (I) DANS LAQUELLE R1-R5 ET Z DÉSIGNENT DES ÉLÉMENTS DÉCRITS DANS LES REVENDICATIONS, AINSI QUE DES ANTIPODES OPTIQUES OU DES RACÉMATES ET/OU DES SELS ET/OU DES HYDRATES ET/OU DES SOLVATES DE CEUX-CI. CES DÉRIVÉS SONT DES ANTAGONISTES SÉLECTIFS DE LA BRADYKININE B1. L'INVENTION CONCERNE ÉGALEMENT DES PROCÉDÉS DESTINÉS À LA PRODUCTION DE CES COMPOSÉS, DES COMPOSITIONS PHARMACEUTIQUES CONTENANT CES COMPOSÉS ET LEUR UTILISATION DANS LE TRAITEMENT OU LA PRÉVENTION D'ÉTATS DOULOUREUX ET INFLAMMATOIRES.
MA31911A 2006-10-27 2009-05-21 Nouveaux derives de benzamide en tant qu'antagonistes de bradykinine MA30916B1 (fr)

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HUP0600810A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New sulfonamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
JP2011500782A (ja) * 2007-10-27 2011-01-06 リヒター ゲデオン ニルバーノシャン ミーケデーレスベニュタールシャシャーグ ブラジキニンｂ１拮抗剤としての新規非ペプチド誘導体
JP2012500801A (ja) * 2008-08-21 2012-01-12 リヒター ゲデオン ニルバーノシャン ミーケデーレスベニュタールシャシャーグ Ｃｎｓ疾患の治療法
US20110190347A1 (en) * 2008-08-21 2011-08-04 Richter Gedeon Nyrt. Methods for treating neuropathic pain
ME01526B (me) * 2009-02-26 2014-04-20 Boehringer Ingelheim Int Jedinjenja kao b1 antagonisti bradikinina
ES2350077B1 (es) 2009-06-04 2011-11-04 Laboratorios Salvat, S.A. Compuestos inhibidores de 11beta-hidroxiesteroide deshidrogenasa de tipo 1.
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JP6592008B2 (ja) * 2014-04-23 2019-10-16 エックス−アールエックス， インコーポレイテッド オートタキシンの置換ｎ−（２−アミノ）−２−オキソエチルベンズアミド阻害剤およびそれらの調製、ならびにｌｐａ依存性またはｌｐａ媒介性疾患の処置における使用
KR101676850B1 (ko) 2015-04-23 2016-11-18 한일화섬 주식회사 내구성이 우수한 스피커용 댐퍼 및 그 제조 방법
TWI901650B (zh) 2020-03-26 2025-10-21 匈牙利商羅特格登公司 啶及吡啶并〔３，４－ｃ〕嗒衍生物
HU231691B1 (hu) 2021-09-29 2025-10-28 Richter Gedeon Nyrt GABAA ALFA5 receptor modulátor hatású biciklusos aminszármazékok

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EA200900604A1 (ru) 2009-08-28
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AU2007330575B2 (en) 2012-09-20
CA2667387C (fr) 2012-04-17
CU23857B1 (es) 2013-02-26
GEP20125382B (en) 2012-01-25
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MX2009004526A (es) 2009-07-02
BRPI0718436B1 (pt) 2020-11-17
CN101528685B (zh) 2012-09-05
NO20092048L (no) 2009-07-17
KR101321257B1 (ko) 2013-10-25
NZ575764A (en) 2011-12-22
CA2667387A1 (fr) 2008-06-12
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EP2076491A1 (fr) 2009-07-08
HUP0600808A2 (en) 2008-08-28
ES2431143T3 (es) 2013-11-25
WO2008068540A8 (fr) 2009-05-14
HU0600808D0 (en) 2006-12-28
EA014498B1 (ru) 2010-12-30
CY1114354T1 (el) 2016-08-31
CU20090064A7 (es) 2011-07-11
PT2076491E (pt) 2013-09-06
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HUP0600808A3 (en) 2008-09-29
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