MA30394B1 - Synthese d'acylaminoalcenylene-amides pouvant etre employes en tant qu'antagonistes de la substance p - Google Patents
Synthese d'acylaminoalcenylene-amides pouvant etre employes en tant qu'antagonistes de la substance pInfo
- Publication number
- MA30394B1 MA30394B1 MA31347A MA31347A MA30394B1 MA 30394 B1 MA30394 B1 MA 30394B1 MA 31347 A MA31347 A MA 31347A MA 31347 A MA31347 A MA 31347A MA 30394 B1 MA30394 B1 MA 30394B1
- Authority
- MA
- Morocco
- Prior art keywords
- synthesis
- substance
- acylaminoalcenylene
- agonists
- amides
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 239000000126 substance Substances 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000000556 agonist Substances 0.000 title 1
- 150000001408 amides Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/12—Nitrogen atoms not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
LA PRÉSENTE INVENTION CONCERNE UN PROCÉDÉ DE SYNTHÈSE DE COMPOSÉS DE FORMULE (I) OU DE SOLVATES OU HYDRATES DESDITS COMPOSÉS, R, R1, R2, R3 ET R5 AYANT LES VALEURS DÉFINIES DANS LA DESCRIPTION DE L'INVENTION. DE TELS COMPOSÉS PEUVENT ÊTRE EMPLOYÉS DANS LE TRAITEMENT DE PLUSIEURS ÉTATS PATHOLOGIQUES ASSOCIÉS À LA SUBSTANCE P ET À LA NEUROKININE.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0607532A GB0607532D0 (en) | 2006-04-13 | 2006-04-13 | Organic compounds |
| GB0610244A GB0610244D0 (en) | 2006-05-23 | 2006-05-23 | Organic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA30394B1 true MA30394B1 (fr) | 2009-05-04 |
Family
ID=38324102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA31347A MA30394B1 (fr) | 2006-04-13 | 2008-11-03 | Synthese d'acylaminoalcenylene-amides pouvant etre employes en tant qu'antagonistes de la substance p |
Country Status (28)
| Country | Link |
|---|---|
| US (2) | US8008479B2 (fr) |
| EP (1) | EP2010498B1 (fr) |
| JP (1) | JP5208917B2 (fr) |
| KR (1) | KR20080108291A (fr) |
| AR (1) | AR060506A1 (fr) |
| AT (1) | ATE486853T1 (fr) |
| AU (1) | AU2007237482B2 (fr) |
| CA (1) | CA2645362C (fr) |
| CL (1) | CL2007001040A1 (fr) |
| CY (1) | CY1111294T1 (fr) |
| DE (1) | DE602007010269D1 (fr) |
| DK (1) | DK2010498T3 (fr) |
| EC (1) | ECSP088820A (fr) |
| GT (1) | GT200800209A (fr) |
| HR (1) | HRP20110045T1 (fr) |
| JO (1) | JO2630B1 (fr) |
| MA (1) | MA30394B1 (fr) |
| MX (1) | MX2008013117A (fr) |
| MY (1) | MY145069A (fr) |
| NO (1) | NO20084783L (fr) |
| NZ (1) | NZ571142A (fr) |
| PE (1) | PE20071223A1 (fr) |
| PL (1) | PL2010498T3 (fr) |
| PT (1) | PT2010498E (fr) |
| RU (1) | RU2433122C2 (fr) |
| SI (1) | SI2010498T1 (fr) |
| TW (1) | TW200815358A (fr) |
| WO (1) | WO2007118651A1 (fr) |
Families Citing this family (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006044342A2 (fr) | 2004-10-12 | 2006-04-27 | Fmc Biopolymer As | Systemes d'alginate auto-gelifiants et utilisations associees |
| JP5301991B2 (ja) | 2005-07-29 | 2013-09-25 | コンサート ファーマシューティカルズ インコーポレイテッド | 新規なベンゾ［ｄ］［１，３］−ジオキソール誘導体 |
| US8796267B2 (en) | 2006-10-23 | 2014-08-05 | Concert Pharmaceuticals, Inc. | Oxazolidinone derivatives and methods of use |
| US8071596B2 (en) | 2007-01-12 | 2011-12-06 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
| US8080549B2 (en) | 2007-01-12 | 2011-12-20 | Concert Pharmaceuticals, Inc. | Endothelin receptor antagonists |
| WO2008106125A2 (fr) | 2007-02-26 | 2008-09-04 | Concert Pharmaceuticals, Inc. | Antagonistes du récepteur alpha 1a-adrénergique |
| ES2395241T3 (es) | 2007-03-07 | 2013-02-11 | Concert Pharmaceuticals Inc. | Derivados deuterados de piperazina como compuestos antianginosos |
| EP2136637B1 (fr) | 2007-03-16 | 2015-11-11 | Concert Pharmaceuticals, Inc. | Inhibiteurs de proteine de transfert d'ester de cholesterol |
| WO2008128166A1 (fr) | 2007-04-13 | 2008-10-23 | Concert Pharmaceuticals Inc. | Dérivés deutériés de composés 4-(6-fluoro-1,2-benzisoxazol-3-yl) pipéridine |
| ES2401914T3 (es) | 2007-04-25 | 2013-04-25 | Concert Pharmaceuticals Inc. | Análogos de Cilostazol |
| US8349817B2 (en) | 2007-04-25 | 2013-01-08 | Concert Pharmaceuticals, Inc. | Analogues of cilostazol |
| PT2345653E (pt) | 2007-05-01 | 2013-04-01 | Concert Pharmaceuticals Inc | Compostos de morfinano |
| CA3056205C (fr) | 2007-05-01 | 2023-09-26 | Concert Pharmaceuticals Inc. | Composes de morphinane |
| WO2008141021A1 (fr) | 2007-05-08 | 2008-11-20 | Concert Pharmaceuticals, Inc. | Dérivés deutérés de composés de tétrahydrotriazolopyrazine et leur utilisation en tant qu'inhibiteurs de la dpp-iv |
| RS51226B (sr) | 2007-06-12 | 2010-12-31 | Concert Pharmaceuticals Inc. | Derivati azapeptida kao inhibitori hiv proteaze |
| CA2702317A1 (fr) | 2007-07-09 | 2009-01-15 | Concert Pharmaceuticals, Inc. | Nouveaux derives de pyrimidinecarboxamide |
| EP2190841B1 (fr) | 2007-08-14 | 2013-05-15 | Concert Pharmaceuticals Inc. | Dérivés d'oxazolidinones substituées |
| WO2009032158A2 (fr) | 2007-08-28 | 2009-03-12 | Fmc Corporation, Inc. | Systèmes d'alginate à auto-gélification retardée et leurs utilisations |
| WO2009035662A1 (fr) | 2007-09-12 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Dérivés deutérés de 4-oxoquinoléine pour le traitement de l'infection par le vih |
| JP5647519B2 (ja) | 2007-09-13 | 2014-12-24 | コンサート ファーマシューティカルズ インコーポレイテッド | 重水素化カテコールおよびベンゾ［ｄ］［１，３］ジオキソールおよびその誘導体の合成 |
| WO2009051782A1 (fr) | 2007-10-18 | 2009-04-23 | Concert Pharmaceuticals Inc. | Étravirine deutérée |
| US8592487B2 (en) | 2007-10-26 | 2013-11-26 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
| WO2009079637A1 (fr) | 2007-12-18 | 2009-06-25 | Concert Pharmaceuticals, Inc. | Dérivés de tétrahydroisoquinoline |
| EP2242493B1 (fr) | 2008-01-22 | 2013-06-05 | Concert Pharmaceuticals Inc. | Dérivés de géfitinib |
| WO2009094210A1 (fr) | 2008-01-22 | 2009-07-30 | Concert Pharmaceuticals Inc. | Dérivés de vandetanib |
| WO2009108383A2 (fr) | 2008-02-29 | 2009-09-03 | Concert Pharmaceuticals, Inc. | Dérivés de xanthine substitués |
| US8367674B2 (en) | 2008-04-17 | 2013-02-05 | Concert Pharmaceuticals, Inc. | Piperazine derivatives |
| WO2009154754A2 (fr) | 2008-06-17 | 2009-12-23 | Concert Pharmaceuticals, Inc. | Synthèse de dérivés de morpholine deutérés |
| PL2328414T3 (pl) | 2008-08-29 | 2014-05-30 | Concert Pharmaceuticals Inc | Podstawione pochodne triazolo-pirydazyny |
| WO2010033511A1 (fr) | 2008-09-16 | 2010-03-25 | Concert Pharmaceuticals, Inc. | Dérivés d’acide 2-amino-3-hydroxypropanoïque deutérés |
| SI2334678T1 (sl) | 2008-09-19 | 2013-05-31 | Concert Pharmaceuticals Inc. | Spojine morfinana |
| US9045453B2 (en) | 2008-11-14 | 2015-06-02 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| CA2753330A1 (fr) * | 2009-02-24 | 2010-09-02 | Anton Stuetz | Utilisations d'antagonistes des recepteurs nk |
| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
| DE102009001446A1 (de) | 2009-03-10 | 2010-09-23 | Evonik Rohmax Additives Gmbh | Verwendung von Kammpolymeren als Antifatigue-Additive |
| US8563554B2 (en) | 2009-03-17 | 2013-10-22 | Concert Pharmaceuticals, Inc. | Deuterated pyrazinoisoquinoline compounds |
| WO2010108103A1 (fr) * | 2009-03-19 | 2010-09-23 | Concert Pharmaceuticals, Inc. | Dérivés d'azépan-2-one |
| EP2421808B1 (fr) | 2009-04-23 | 2013-07-31 | Concert Pharmaceuticals Inc. | Analogues de l'acide 4-hydroxybutyrique |
| US8410082B2 (en) | 2009-05-22 | 2013-04-02 | Concert Pharmaceuticals, Inc. | Fluorinated diaryl urea derivatives |
| SI2443089T1 (sl) | 2009-06-18 | 2014-07-31 | Concert Pharmaceuticals, Inc. | Devterirani derivati izoindolin-1,3-diona kot inhibitorji pde4 in tnf-alfa |
| EP2454259A1 (fr) | 2009-06-23 | 2012-05-23 | Concert Pharmaceuticals Inc. | Dérivés de triazolo-pyridazine modifiés par deutérium comme modulateurs du récepteur gaba-a |
| US8557815B2 (en) | 2009-08-14 | 2013-10-15 | Concert Pharmaceuticals, Inc. | Substituted triazolophthalazine derivatives |
| CA2771331A1 (fr) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Derives de xanthine substitues |
| WO2011028820A1 (fr) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Dérivés substitués de composés [4.3.0] hétéroaryle bicycliques |
| US8278460B2 (en) | 2009-10-15 | 2012-10-02 | Concert Pharmaceuticals, Inc. | Substituted benzimidazoles |
| WO2011063001A1 (fr) | 2009-11-18 | 2011-05-26 | Concert Pharmaceuticals, Inc. | Promédicaments de niacine et versions deutérisées de ceux-ci |
| DE102010001040A1 (de) | 2010-01-20 | 2011-07-21 | Evonik RohMax Additives GmbH, 64293 | (Meth)acrylat-Polymere zur Verbesserung des Viskositätsindexes |
| US8513434B2 (en) | 2010-03-02 | 2013-08-20 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| US8575361B2 (en) | 2010-03-02 | 2013-11-05 | Concert Pharmaceuticals Inc. | Tetrahydronaphthalene derivatives |
| US9226801B2 (en) * | 2010-03-08 | 2016-01-05 | Ibur, Llc | Custom linkable imaging and multifunctional tray |
| US8575221B2 (en) | 2010-03-17 | 2013-11-05 | Concert Pharmaceuticals, Inc. | Derivatives of dimethylcurcumin |
| US9107922B2 (en) | 2010-07-16 | 2015-08-18 | Concert Pharmaceuticals, Inc. | Pyrimidinecarboxamide derivatives |
| US9074233B2 (en) | 2010-09-01 | 2015-07-07 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
| US9085788B2 (en) | 2010-09-01 | 2015-07-21 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
| US8759394B2 (en) | 2011-02-14 | 2014-06-24 | Concert Pharmaceuticals, Inc. | 4-hydroxybutyric acid analogs |
| US9145390B2 (en) | 2011-03-03 | 2015-09-29 | Concert Pharmaceuticals, Inc. | Derivatives of pyrazole-substituted amino-heteroaryl compounds |
| WO2012122028A2 (fr) | 2011-03-04 | 2012-09-13 | Concert Pharmaceuticals Inc. | Composés de pyrazino-isoquinoline |
| HUE047354T2 (hu) | 2011-05-18 | 2020-04-28 | Vertex Pharmaceuticals Europe Ltd | Ivacaftor deuterizált származékai |
| EP2836492B1 (fr) | 2012-04-13 | 2018-03-14 | Concert Pharmaceuticals Inc. | Dérivés de xanthine substituée |
| US9249093B2 (en) | 2012-04-20 | 2016-02-02 | Concert Pharmaceuticals, Inc. | Deuterated rigosertib |
| BR122023027277A2 (pt) | 2012-06-15 | 2024-01-23 | Concert Pharmaceuticals, Inc. | Derivados deuterados de ruxolitinib e composição farmacêutica |
| US9181190B2 (en) | 2012-07-04 | 2015-11-10 | Concert Pharmaceuticals, Inc. | Deuterated vercirnon |
| ES2694202T3 (es) | 2012-07-12 | 2018-12-19 | Concert Pharmaceuticals, Inc. | Idebenona deuterada |
| IN2015DN00598A (fr) | 2012-07-30 | 2015-06-26 | Concert Pharmaceuticals Inc | |
| ES2717279T3 (es) | 2012-08-17 | 2019-06-20 | Concert Pharmaceuticals Inc | Baricitinib deuterada |
| JP2015534989A (ja) | 2012-10-22 | 2015-12-07 | コンサート ファーマシューティカルズ インコーポレイテッド | ｛ｓ−３−（４−アミノ−１−オキソ−イソインドリン−２−イル）（ピペリジン−３，４，４，５，５−ｄ５）−２，６−ジオン｝の固体形態 |
| MX2015008829A (es) | 2013-01-09 | 2016-04-25 | Concert Pharmaceuticals Inc | Momelotinib deuterado. |
| EP2968268B1 (fr) | 2013-03-15 | 2020-07-29 | Concert Pharmaceuticals Inc. | Inhibiteurs de l'enzyme udp-glucose : n-acyl-sphingosine glucosyltransférase |
| US8906951B1 (en) | 2013-06-24 | 2014-12-09 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| US9198898B2 (en) | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| WO2015031741A1 (fr) | 2013-08-30 | 2015-03-05 | Concert Pharmaceuticals, Inc. | Thiénotriazolodiazépines substituées |
| EP3105232B1 (fr) | 2014-02-10 | 2019-08-28 | Concert Pharmaceuticals Inc. | Triazolobenzodiazépines substituées |
| WO2016069630A1 (fr) | 2014-10-27 | 2016-05-06 | Concert Pharmaceuticals, Inc. | Esters d'acide phosphonique de pyrimidine portant au moins un atome de deutérium |
| HK1249893A1 (zh) | 2015-03-31 | 2018-11-16 | Vertex Pharmaceuticals (Europe) Limited | 氘代vx-661 |
| US10683305B2 (en) | 2015-04-27 | 2020-06-16 | Concert Pharmaceuticals, Inc. | Deuterated OTX-015 |
| AU2016327603B2 (en) | 2015-09-25 | 2021-04-22 | Vertex Pharmaceuticals (Europe) Limited | Deuterated CFTR potentiators |
| US11267777B2 (en) | 2015-11-19 | 2022-03-08 | Concert Pharmaceuticals, Inc. | Deuterated EPI-743 |
| EP3416629A4 (fr) | 2016-02-16 | 2019-08-07 | CoNCERT Pharmaceuticals, Inc. | Gft-505 deutéré |
| MX2020005336A (es) | 2017-11-22 | 2020-08-13 | Concert Pharmaceuticals Inc | Analogos de d-serina deuterados y usos de los mismos. |
| BR112020010335A2 (pt) | 2017-12-01 | 2020-11-10 | Vertex Pharmaceuticals Incorporated | processos para produzir moduladores de regulador de condutância de transmembrana de fibrose cística |
| US12065395B2 (en) | 2019-04-03 | 2024-08-20 | Sun Pharmaceutical Industries, Inc. | Processes for the preparation of deuterated D-serine |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU226562B1 (en) * | 1995-02-22 | 2009-04-28 | Novartis Ag | 1-aryl-2-acylamino-ethane compounds as neurokinin, especially neurokinin-1 antagonists, and medicaments containing the said compounds. |
| MY132550A (en) * | 1996-08-22 | 2007-10-31 | Novartis Ag | Acylaminoalkenylene-amide derivatives as nk1 and nk2 antogonists |
| GB0010958D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
-
2007
- 2007-04-10 JO JO2007129A patent/JO2630B1/en active
- 2007-04-11 RU RU2008145102/04A patent/RU2433122C2/ru not_active IP Right Cessation
- 2007-04-11 US US12/296,969 patent/US8008479B2/en not_active Expired - Fee Related
- 2007-04-11 AR ARP070101533A patent/AR060506A1/es not_active Application Discontinuation
- 2007-04-11 EP EP07724154A patent/EP2010498B1/fr not_active Not-in-force
- 2007-04-11 AU AU2007237482A patent/AU2007237482B2/en not_active Ceased
- 2007-04-11 KR KR1020087024839A patent/KR20080108291A/ko not_active Ceased
- 2007-04-11 JP JP2009504637A patent/JP5208917B2/ja not_active Expired - Fee Related
- 2007-04-11 PE PE2007000444A patent/PE20071223A1/es not_active Application Discontinuation
- 2007-04-11 SI SI200730483T patent/SI2010498T1/sl unknown
- 2007-04-11 PT PT07724154T patent/PT2010498E/pt unknown
- 2007-04-11 DE DE602007010269T patent/DE602007010269D1/de active Active
- 2007-04-11 PL PL07724154T patent/PL2010498T3/pl unknown
- 2007-04-11 WO PCT/EP2007/003213 patent/WO2007118651A1/fr not_active Ceased
- 2007-04-11 MX MX2008013117A patent/MX2008013117A/es active IP Right Grant
- 2007-04-11 CA CA2645362A patent/CA2645362C/fr not_active Expired - Fee Related
- 2007-04-11 NZ NZ571142A patent/NZ571142A/en not_active IP Right Cessation
- 2007-04-11 DK DK07724154.5T patent/DK2010498T3/da active
- 2007-04-11 HR HR20110045T patent/HRP20110045T1/hr unknown
- 2007-04-11 AT AT07724154T patent/ATE486853T1/de active
- 2007-04-12 TW TW096112886A patent/TW200815358A/zh unknown
- 2007-04-12 CL CL200701040A patent/CL2007001040A1/es unknown
-
2008
- 2008-10-08 MY MYPI20083997A patent/MY145069A/en unknown
- 2008-10-10 GT GT200800209A patent/GT200800209A/es unknown
- 2008-10-13 EC EC2008008820A patent/ECSP088820A/es unknown
- 2008-11-03 MA MA31347A patent/MA30394B1/fr unknown
- 2008-11-12 NO NO20084783A patent/NO20084783L/no not_active Application Discontinuation
-
2011
- 2011-01-26 CY CY20111100082T patent/CY1111294T1/el unknown
- 2011-07-22 US US13/188,795 patent/US20110282053A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MA30394B1 (fr) | Synthese d'acylaminoalcenylene-amides pouvant etre employes en tant qu'antagonistes de la substance p | |
| MA32727B1 (fr) | Pyrazolylaminopyridines au titre d'inhibiteurs de fak | |
| MA31373B1 (fr) | Composes amino-heterocycliques | |
| MA30911B1 (fr) | Nouveaux derives de sulfonamide en tant qu'antagonistes de bradykinine | |
| MA32882B1 (fr) | Nouveaux pyrazole-4-n-alkoxycarboxamides en tant que microbiocides | |
| MA28077A1 (fr) | Derives d'isoquinilone 1,4-disubstitues en tant qu'inhibiteurs de raf-kinase utiles pour le traitement de maladies proliferantes | |
| MA30916B1 (fr) | Nouveaux derives de benzamide en tant qu'antagonistes de bradykinine | |
| MA31597B1 (fr) | Nouveaux herbicides | |
| MA29311B1 (fr) | Derives d'isoxazolines et son nouveau procede de production | |
| MA32407B1 (fr) | Sels et polymorphes d'un composé tétracycline | |
| MA29870B1 (fr) | Nouveaux dérivés de 1-azabicycloalkyles dans le traitement de troubles psychotiques et neurodégénératifs | |
| SE0301368D0 (sv) | Chemical compounds | |
| EP2091328A4 (fr) | Composés de spiropipéridine inhibiteurs de la bêta-sécrétase pour le traitement de la maladie d'alzheimer | |
| ATE457310T1 (de) | Amid substituierte 8-n-benzimidazole, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel | |
| MA31742B1 (fr) | Derives de l'indol-2-one disubstitues en 3, leur preparation et leur application en therapeutique | |
| CA2495960A1 (fr) | Nouveau procede de synthese du (7-methoxy-1-naphtyl)acetonitrile et application a la synthese de l'agomelatine | |
| BRPI0409069A (pt) | compostos quìmicos | |
| MA69005B1 (fr) | Compositions et procédés pour la stabilisation de micro-arn | |
| EP2077719A4 (fr) | Inhibiteurs pipéridines et pyrrolidines de la bêta-secrétase utilisés dans le traitement de la maladie d'alzheimer | |
| MA29248B1 (fr) | Pyrroles substitues, compositions les contenant, procede de fabrication et utilisation | |
| BRPI0519267A2 (pt) | derivado de quinolina, seu uso, produÇço e medicamento contendo o mesmo | |
| ATE460425T1 (de) | Histondeacetylaseinhibitor und verfahren zu dessen herstellung | |
| EA200600560A1 (ru) | Ингибиторы проникновения вируса вич | |
| EA200701584A1 (ru) | Органические соединения, применяемые для лечения болезни альцгеймера, их применение и способ получения | |
| MA43667B1 (fr) | Nouveaux dérivés de pyrrolidine |