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MA29870B1 - Nouveaux dérivés de 1-azabicycloalkyles dans le traitement de troubles psychotiques et neurodégénératifs - Google Patents

Nouveaux dérivés de 1-azabicycloalkyles dans le traitement de troubles psychotiques et neurodégénératifs

Info

Publication number
MA29870B1
MA29870B1 MA30848A MA30848A MA29870B1 MA 29870 B1 MA29870 B1 MA 29870B1 MA 30848 A MA30848 A MA 30848A MA 30848 A MA30848 A MA 30848A MA 29870 B1 MA29870 B1 MA 29870B1
Authority
MA
Morocco
Prior art keywords
psychotic
novel
treatment
neurodegenerative disorders
azabicycloalkyl
Prior art date
Application number
MA30848A
Other languages
English (en)
Inventor
Dominik Feuerbach
Mathias Frederiksen
Martin Marzi
Bernard Lucien Roy
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of MA29870B1 publication Critical patent/MA29870B1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Reproductive Health (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)

Abstract

La présente invention prévoit un composé de formule (I) dans laquelle, X, R, Y, D, A et B sont tels que définis dans la présente.
MA30848A 2005-10-21 2008-04-15 Nouveaux dérivés de 1-azabicycloalkyles dans le traitement de troubles psychotiques et neurodégénératifs MA29870B1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0521508.2A GB0521508D0 (en) 2005-10-21 2005-10-21 Organic compounds

Publications (1)

Publication Number Publication Date
MA29870B1 true MA29870B1 (fr) 2008-10-03

Family

ID=35458483

Family Applications (1)

Application Number Title Priority Date Filing Date
MA30848A MA29870B1 (fr) 2005-10-21 2008-04-15 Nouveaux dérivés de 1-azabicycloalkyles dans le traitement de troubles psychotiques et neurodégénératifs

Country Status (23)

Country Link
US (1) US8173667B2 (fr)
EP (1) EP1940832B1 (fr)
JP (1) JP4838313B2 (fr)
KR (1) KR101026330B1 (fr)
CN (1) CN101268071A (fr)
AT (1) ATE536354T1 (fr)
AU (1) AU2006303453B2 (fr)
BR (1) BRPI0617508A2 (fr)
CA (1) CA2622356A1 (fr)
CR (1) CR9866A (fr)
EC (1) ECSP088369A (fr)
ES (1) ES2376890T3 (fr)
GB (1) GB0521508D0 (fr)
IL (1) IL190394A0 (fr)
MA (1) MA29870B1 (fr)
MY (1) MY143250A (fr)
NO (1) NO20082266L (fr)
NZ (1) NZ567081A (fr)
RU (1) RU2008119692A (fr)
TN (1) TNSN08174A1 (fr)
UA (1) UA95257C2 (fr)
WO (1) WO2007045478A1 (fr)
ZA (1) ZA200802725B (fr)

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GB0220581D0 (en) 2002-09-04 2002-10-09 Novartis Ag Organic Compound
AR049401A1 (es) * 2004-06-18 2006-07-26 Novartis Ag Aza-biciclononanos
GB0415746D0 (en) * 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0525672D0 (en) * 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
CN102573842A (zh) * 2009-07-23 2012-07-11 诺瓦提斯公司 氮杂双环烷基衍生物或吡咯烷-2-酮衍生物的用途
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
WO2012101060A1 (fr) 2011-01-27 2012-08-02 Novartis Ag Utilisation d'activateurs du récepteur nicotinique de l'acétylcholine alpha 7
WO2012127393A1 (fr) 2011-03-18 2012-09-27 Novartis Ag Combinaisons d'activateurs des récepteurs nicotiniques à l'acétylcholine alpha 7 et d'antagonistes des mglur5 destinées à être utilisées dans la dyskinésie induite par la dopamine dans la maladie de parkinson
JP6162705B2 (ja) 2011-10-20 2017-07-12 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体活性化剤による処置に対する応答性を予測するバイオマーカー
CA2894384C (fr) 2012-12-11 2018-03-06 Novartis Ag Biomarqueur de prediction de la sensibilite a un traitement par un activateur du recepteur alpha 7 nicotinique de l'acetylcholine
CA2898043C (fr) * 2013-01-15 2019-08-06 Novartis Ag Utilisation d'agonistes du recepteur nicotinique alpha 7 pour le traitement de la narcolepsie
JP2016508159A (ja) * 2013-01-15 2016-03-17 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アゴニストの使用
WO2014111838A1 (fr) 2013-01-15 2014-07-24 Novartis Ag Utilisation d'agonistes du récepteur nicotinique alpha 7 de l'acétylcholine
US20150313884A1 (en) 2013-01-15 2015-11-05 Novartis Ag Use of alpha 7 nicotinic acetylcholine receptor agonists
ES2764660T3 (es) 2014-12-16 2020-06-04 Axovant Sciences Gmbh Compuestos de amida de quinuclidina sustituida geminal como agonistas de receptores alfa-7 nicotínicos de acetilcolina
MX2017016231A (es) 2015-06-10 2018-11-29 Axovant Sciences Gmbh Compuestos de aminobencisoxazol como agonistas de receptores a7-nicotínicos de acetilcolina.
HK1253295A1 (zh) 2015-08-12 2019-06-14 Axovant Sciences Gmbh 作为7-烟碱乙酰胆碱受体的激动剂的偕取代的氨基苯并异恶唑化合物
KR20250037575A (ko) 2017-10-20 2025-03-17 반더빌트유니버시티 무스카린성 아세틸콜린 수용체 m4의 길항제
CA3081324A1 (fr) 2017-10-31 2019-05-09 Vanderbilt University Antagonistes du recepteur muscarinique m4 a l'acetylcholine
IL276411B2 (en) * 2018-02-02 2024-04-01 Univ Vanderbilt M4 muscarinic acetylcholine receptor antagonists
UY38687A (es) 2019-05-17 2023-05-15 Novartis Ag Inhibidores del inflamasoma nlrp3, composiciones, combinaciones de los mismos y métodos para su uso
UY40374A (es) 2022-08-03 2024-02-15 Novartis Ag Inhibidores de inflamasoma nlrp3

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JP2009515820A (ja) 2009-04-16
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TNSN08174A1 (en) 2009-10-30
ATE536354T1 (de) 2011-12-15
BRPI0617508A2 (pt) 2011-07-26
KR101026330B1 (ko) 2011-03-31
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CR9866A (es) 2008-06-09
US20080255135A1 (en) 2008-10-16
CA2622356A1 (fr) 2007-04-26
IL190394A0 (en) 2008-11-03
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US8173667B2 (en) 2012-05-08
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MY143250A (en) 2011-04-15
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