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MA26692A1 - Compositions pharmaceutiques contenant un complexe stable insoluble, procede de preparation et complexe stable insoluble obtenu - Google Patents

Compositions pharmaceutiques contenant un complexe stable insoluble, procede de preparation et complexe stable insoluble obtenu

Info

Publication number
MA26692A1
MA26692A1 MA25778A MA25778A MA26692A1 MA 26692 A1 MA26692 A1 MA 26692A1 MA 25778 A MA25778 A MA 25778A MA 25778 A MA25778 A MA 25778A MA 26692 A1 MA26692 A1 MA 26692A1
Authority
MA
Morocco
Prior art keywords
stable complex
insoluble
insoluble stable
preparation
pharmaceutical compositions
Prior art date
Application number
MA25778A
Other languages
English (en)
Inventor
Phuapradit Wantanee
K Sandhu Harpreet
A Albano Antonio
Hargovindas Shah Navnit
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26798138&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA26692(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MA26692A1 publication Critical patent/MA26692A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Des complexes stables et insolubles dans l'eau de composés faiblement solubles et dispersés moléculairement dans des polymères ioniques insolubles dans l'eau sont décrits. Les polymères ioniques insolubles utiles possèdent une masse moléculaire supérieure à environ 80 000 D et une température de transition vitreuse égale ou supérieure à environ 50o.C. Les composés sont microprécipités dans les polymères ioniques sous forme amorphe. Les complexes selon la présente invention augmentent de manière significative la biodisponibilité des composés thérapeutiquement actifs faiblement solubies.
MA25778A 1998-09-22 1999-09-21 Compositions pharmaceutiques contenant un complexe stable insoluble, procede de preparation et complexe stable insoluble obtenu MA26692A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10133698P 1998-09-22 1998-09-22
US13653199P 1999-05-28 1999-05-28

Publications (1)

Publication Number Publication Date
MA26692A1 true MA26692A1 (fr) 2004-12-20

Family

ID=26798138

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25778A MA26692A1 (fr) 1998-09-22 1999-09-21 Compositions pharmaceutiques contenant un complexe stable insoluble, procede de preparation et complexe stable insoluble obtenu

Country Status (32)

Country Link
US (1) US6350786B1 (fr)
EP (1) EP0988863B2 (fr)
JP (5) JP2000095708A (fr)
KR (1) KR100362019B1 (fr)
CN (1) CN1201821C (fr)
AR (2) AR022096A1 (fr)
AT (1) ATE265232T1 (fr)
AU (1) AU770745B2 (fr)
BR (1) BR9904283A (fr)
CA (1) CA2282906C (fr)
CO (1) CO5140077A1 (fr)
CZ (1) CZ300215B6 (fr)
DE (1) DE69916733T3 (fr)
DK (1) DK0988863T4 (fr)
ES (1) ES2218918T5 (fr)
HR (1) HRP990287B1 (fr)
HU (1) HU228341B1 (fr)
ID (1) ID24034A (fr)
IL (1) IL131957A (fr)
MA (1) MA26692A1 (fr)
MY (1) MY124377A (fr)
NO (1) NO326928B1 (fr)
NZ (1) NZ337884A (fr)
PE (1) PE20001049A1 (fr)
PL (1) PL202757B1 (fr)
PT (1) PT988863E (fr)
RS (1) RS50193B (fr)
RU (1) RU2240827C2 (fr)
SG (1) SG97131A1 (fr)
SI (1) SI0988863T2 (fr)
TR (1) TR199902324A2 (fr)
TW (1) TWI234465B (fr)

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RU2240827C2 (ru) 2004-11-27
JP2016196515A (ja) 2016-11-24
PT988863E (pt) 2004-07-30
JP2015187170A (ja) 2015-10-29
HRP990287B1 (en) 2004-12-31
ID24034A (id) 2000-07-06
CZ330499A3 (cs) 2000-04-12
SI0988863T2 (sl) 2009-08-31
BR9904283A (pt) 2000-09-26
EP0988863B2 (fr) 2009-03-18
NZ337884A (en) 2001-02-23
JP2013035875A (ja) 2013-02-21
CA2282906C (fr) 2010-07-20
SI0988863T1 (en) 2004-08-31
CO5140077A1 (es) 2002-03-22
RS50193B (sr) 2009-05-06
DE69916733D1 (de) 2004-06-03
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IL131957A (en) 2005-06-19
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DK0988863T4 (da) 2009-06-08
EP0988863A3 (fr) 2000-08-09
HUP9903189A3 (en) 2009-07-28
CN1251312A (zh) 2000-04-26
HRP990287A2 (en) 2000-06-30
HUP9903189A2 (hu) 2000-06-28
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CA2282906A1 (fr) 2000-03-22
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