Konoha's a pretty unfeeling/apathetic and OP main character. She talks in monotone, doesn't really care about anything or anybody 99% of the time, and her gimmick is that she has a "gap moe" when she eats food and becomes super happy and animated. There's basically no manzai at all between Satoko and Konoha. I actually find there to be basically no comedy at all and no actual synergy between the two main characters. Of course Satoko's more of the boke and character that gets thrown into random situations because of her stupidity or curiosity, but Konoha having to bail her out is almost too simple--because she's just that overpowered as a character. Again, when Satoko isn't randomly interacting with other characters and Konoha is just stuck with Satoko, their conversations are incredibly bland. It's just a repeat joke setup of Satoko caring for Konoha and Konoha ignoring or neglecting her over and over and over and over and over again.
See, Saiki K, a similar apathetic protagonist, is entertaining to watch because his monologues are incredibly detailed and fun to watch despite his -- yes kind of boring personality. Konoha's just kind of a shell character. She's very predictable as a character as there's not much going on around her. She reacts to stimuli the same way and doesn't change.
I don't have anything to complain about other than Konoha either. I love Shaft, and the editing and comedic pacing of this show is great. Even if the jokes aren't funny, the eye candy is just great to look at to be honest. I found Marin to be a fun character to watch, and so is Kuro and her girlfriend. Every character seems to fit in a comedic anime other than Konoha.
Again, even in OPM, Saitama's funny because the enemy characters get so much screen time, have personality, and other heroes struggling with them before Saitama ever shows up so there's comedic value. Again, the enemies are just kind of just a backdrop to the actual anime, and don't serve any purpose at all other than flavor text and wasting screen time as the enemy of the week usually. Overall, Konoha being incredibly boring to watch in a comedic show really kills it.
This definitely is illustrated in episode 5, where Satoko is replaced by a robot and the entire episode centers around Konoha and Roboko. Since Roboko just serves as assistant or helper to Konoha and Satoko isn't really featured too much in the episode, you're shown in full glory as to why Konoha is such a bland protagonist as you follow her mechanically do missions, eat food and gets happy, and that's practically it. There's no content without Satoko as the show shrivels up and dies without the premiere fun character watch.