ZA921405B - Neuroleptic perhydro-1H-pyrido(1,2-a)pyrazines. - Google Patents

Neuroleptic perhydro-1H-pyrido(1,2-a)pyrazines.

Info

Publication number: ZA921405B
Authority: ZA; South Africa
Prior art keywords: alkyl; pyrazines; pyrido; perhydro; neuroleptic
Prior art date: 1991-02-27

Application number

ZA921405A

Other languages

English (en)

Inventor

Gene Michael Bright

Kishor Amratlal Desai

Thomas Francis Seeger

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-27

Filing date

1992-02-26

Publication date

1993-08-26

1992-02-26 Application filed by Pfizer filed Critical Pfizer

1993-08-26 Publication of ZA921405B publication Critical patent/ZA921405B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Psychiatry (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

ZA921405A 1991-02-27 1992-02-26 Neuroleptic perhydro-1H-pyrido(1,2-a)pyrazines. ZA921405B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/661,791 US5157034A (en)	1991-02-27	1991-02-27	Neuroleptic perhydro-1H-pyrido[1,2-a]pyrazines

Publications (1)

Publication Number	Publication Date
ZA921405B true ZA921405B (en)	1993-08-26

Family

ID=24655130

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA921405A ZA921405B (en)	1991-02-27	1992-02-26	Neuroleptic perhydro-1H-pyrido(1,2-a)pyrazines.

Country Status (24)

Country	Link
US (1)	US5157034A (fr)
EP (1)	EP0573467B1 (fr)
JP (1)	JP2546770B2 (fr)
KR (1)	KR0163413B1 (fr)
AT (1)	ATE123284T1 (fr)
AU (1)	AU652422B2 (fr)
CA (2)	CA2163274C (fr)
DE (2)	DE69110135T2 (fr)
DK (1)	DK0573467T3 (fr)
ES (1)	ES2073914T3 (fr)
FI (3)	FI105030B (fr)
HU (1)	HU216637B (fr)
IE (1)	IE67190B1 (fr)
IL (2)	IL112325A (fr)
MX (1)	MX9200803A (fr)
MY (1)	MY108185A (fr)
NO (1)	NO300847B1 (fr)
NZ (1)	NZ241739A (fr)
PT (1)	PT100160B (fr)
RU (1)	RU2090565C1 (fr)
TW (1)	TW207540B (fr)
WO (1)	WO1992015580A1 (fr)
YU (1)	YU48311B (fr)
ZA (1)	ZA921405B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0725736B2 (ja) *	1991-02-27	1995-03-22	ファイザー・インコーポレーテッド	トランス−ピペリジン−２，５−ジカルボキシレートの製法
ATE185565T1 (de) *	1992-06-16	1999-10-15	Pfizer	Verfahren und zwischenprodukte zur herstellung von bis-aza-bicyclischen anxiolytica
US5731307A (en) *	1994-09-30	1998-03-24	Pfizer, Inc.	Neuroleptic 2,7-disubtituted perhydro-1h-pyrido 1, 2-A!pyrazines
NZ290936A (en) *	1994-09-30	1998-01-26	Pfizer	2,7-substituted octahydro-1h-pyrido[1,2-a]pyrazine derivatives
US6231833B1 (en)	1999-08-05	2001-05-15	Pfizer Inc	2,7-substituted octahydro-1H-pyrido[1,2-A]pyrazine derivatives as ligands for serotonin receptors
PA8469101A1 (es) *	1998-04-09	2000-09-29	Pfizer Prod Inc	Ligandos azabiciclicos de receptores 5ht1
UA62015C2 (en) *	1998-12-28	2003-12-15	Pfizer Prod Inc	Benzoizoxazol derivatives, a pharmaceutical composition (variants) based thereon (variants) and a method for treatment (variants)
DE19960204A1 (de) *	1999-12-14	2001-06-28	Aventis Pharma Gmbh	Substituierte Norlbornylamino-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
EP1608648B1 (fr) *	2003-03-12	2012-07-18	Pfizer Products Inc.	Derives azabicycliques de pyridyloxymethyl et de benzisoxazole
HRP20160180T1 (hr)	2003-04-24	2016-03-25	Incyte Holdings Corp	Derivati aza spiro alkana kao inhibitori metaloproteaza
WO2007143600A2 (fr) *	2006-06-05	2007-12-13	Incyte Corporation	Inhibiteurs de la sheddase combinés avec des substances immunothérapeutiques se liant à cd30 destinés au traitement de maladies associées à cd30
US20140206667A1 (en)	2012-11-14	2014-07-24	Michela Gallagher	Methods and compositions for treating schizophrenia

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4681938A (en) *	1984-08-27	1987-07-21	Ciba-Geigy Corporation	Novel polycyclic hydrazones of rifamycins, their manufacture, and their pharmaceutical compositions for treating tuberculosis
US4831031A (en) *	1988-01-22	1989-05-16	Pfizer Inc.	Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
US4957916A (en) *	1988-08-05	1990-09-18	Janssen Pharmaceutica N.V.	Antipsychotic 3-piperazinylbenzazole derivatives
WO1990008148A1 (fr) *	1989-01-23	1990-07-26	Pfizer Inc.	Agents anxiolytiques bis-aza-bicycliques

1991
- 1991-02-27 US US07/661,791 patent/US5157034A/en not_active Expired - Lifetime
- 1991-11-18 CA CA002163274A patent/CA2163274C/fr not_active Expired - Fee Related
- 1991-11-18 RU RU9193045711A patent/RU2090565C1/ru not_active IP Right Cessation
- 1991-11-18 DE DE69110135T patent/DE69110135T2/de not_active Expired - Fee Related
- 1991-11-18 AT AT92904861T patent/ATE123284T1/de not_active IP Right Cessation
- 1991-11-18 CA CA002101518A patent/CA2101518C/fr not_active Expired - Fee Related
- 1991-11-18 EP EP92904861A patent/EP0573467B1/fr not_active Expired - Lifetime
- 1991-11-18 WO PCT/US1991/008378 patent/WO1992015580A1/fr not_active Ceased
- 1991-11-18 JP JP4505183A patent/JP2546770B2/ja not_active Expired - Fee Related
- 1991-11-18 HU HU9302427A patent/HU216637B/hu unknown
- 1991-11-18 DE DE9190206U patent/DE9190206U1/de not_active Expired - Lifetime
- 1991-11-18 AU AU12599/92A patent/AU652422B2/en not_active Ceased
- 1991-11-18 ES ES92904861T patent/ES2073914T3/es not_active Expired - Lifetime
- 1991-11-18 DK DK92904861.9T patent/DK0573467T3/da active
- 1991-11-18 KR KR1019930702554A patent/KR0163413B1/ko not_active Expired - Fee Related
1992
- 1992-01-21 TW TW081100420A patent/TW207540B/zh active
- 1992-02-20 IL IL11232595A patent/IL112325A/xx not_active IP Right Cessation
- 1992-02-20 IL IL10102192A patent/IL101021A/en not_active IP Right Cessation
- 1992-02-25 PT PT100160A patent/PT100160B/pt not_active IP Right Cessation
- 1992-02-25 MX MX9200803A patent/MX9200803A/es not_active IP Right Cessation
- 1992-02-26 IE IE920601A patent/IE67190B1/en not_active IP Right Cessation
- 1992-02-26 ZA ZA921405A patent/ZA921405B/xx unknown
- 1992-02-26 NZ NZ24173992A patent/NZ241739A/en not_active IP Right Cessation
- 1992-02-26 YU YU19892A patent/YU48311B/sh unknown
- 1992-02-26 MY MYPI92000318A patent/MY108185A/en unknown
1993
- 1993-08-26 NO NO933049A patent/NO300847B1/no unknown
- 1993-08-26 FI FI933753A patent/FI105030B/fi not_active IP Right Cessation
2000
- 2000-02-17 FI FI20000354A patent/FI112865B/fi not_active IP Right Cessation
2003
- 2003-03-11 FI FI20030361A patent/FI114214B/fi not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU652422B2 (en)	1994-08-25
IE67190B1 (en)	1996-03-06
IE920601A1 (en)	1992-09-09
DE69110135T2 (de)	1995-10-19
CA2101518C (fr)	1997-11-25
CA2163274C (fr)	1999-02-09
NO933049L (no)	1993-08-26
NO933049D0 (no)	1993-08-26
FI20030361L (fi)	2003-03-11
FI933753A0 (fi)	1993-08-26
CA2101518A1 (fr)	1992-08-28
CA2163274A1 (fr)	1992-08-28
EP0573467B1 (fr)	1995-05-31
YU19892A (sh)	1994-11-15
ATE123284T1 (de)	1995-06-15
US5157034A (en)	1992-10-20
PT100160B (pt)	1999-09-30
FI105030B (fi)	2000-05-31
PT100160A (pt)	1993-05-31
HUT66965A (en)	1995-01-30
TW207540B (fr)	1993-06-11
EP0573467A1 (fr)	1993-12-15
IL112325A (en)	1997-08-14
FI112865B (fi)	2004-01-30
NO300847B1 (no)	1997-08-04
FI114214B (fi)	2004-09-15
HU216637B (hu)	1999-07-28
MY108185A (en)	1996-08-30
HU9302427D0 (en)	1993-11-29
JP2546770B2 (ja)	1996-10-23
DK0573467T3 (da)	1995-10-09
IL101021A (en)	1996-03-31
YU48311B (sh)	1998-05-15
KR930703315A (ko)	1993-11-29
FI933753L (fi)	1993-08-26
IL112325A0 (en)	1995-03-30
AU1259992A (en)	1992-10-06
DE9190206U1 (de)	1993-10-14
JPH06500120A (ja)	1994-01-06
RU2090565C1 (ru)	1997-09-20
MX9200803A (es)	1992-08-31
WO1992015580A1 (fr)	1992-09-17
ES2073914T3 (es)	1995-08-16
KR0163413B1 (ko)	1998-12-01
FI20000354L (fi)	2000-02-17
NZ241739A (en)	1994-07-26
DE69110135D1 (de)	1995-07-06

Publication	Publication Date	Title
ZA921405B (en)	1993-08-26	Neuroleptic perhydro-1H-pyrido(1,2-a)pyrazines.
DK0478954T3 (da)	2001-01-08	Serotonin 5HT1A- og 5HT1D-antagonister
DK0546583T3 (da)	1996-07-01	Piperidinyl- og piperazinylcyclohexanoler
ATE130850T1 (de)	1995-12-15	Fulgimidderivate.
GR3026231T3 (en)	1998-05-29	3-aminopiperidine derivatives and related nitrogen containing heterocycles.
DK0526068T3 (da)	1999-08-30	Phthalocyaninpigmentsammensætninger
HU9201145D0 (en)	1992-06-29	New benzimidazole derivatives
FI922561A0 (fi)	1992-06-03	Derivat av 1-metylkarbapenem, deras framstaellning och anvaendning som antibiotika.
DE69025230D1 (de)	1996-03-21	2,5-Diaryl-tetrahydrofurane und deren Analoge als PAF-Antagonisten
MX9203360A (es)	1992-07-01	Derivados de hexahidroazepinas y composiciones farmaceuticas que los contienen.
ES2083501T3 (es)	1996-04-16	Sintesis de 2-aril-5-(fluormetil)pirroles utiles como agentes pesticidas y como compuestos intermedios para la preparacion de dichos agentes.
RU93045711A (ru)	1996-06-20	Нейролептические пергидро-1h-пиридо(1,2-a)пиразины, способ их получения, фармацевтическая композиция, способ лечения
NZ241659A (en)	1993-03-26	4-pyrimidinone derivatives and pharmaceutical compositions
ATE103316T1 (de)	1994-04-15	Tintenzusammensetzungen auf waesseriger basis.
DK0623620T3 (da)	1999-06-07	5-HT3-pyrrolopyrazinderivater
DK0445013T3 (da)	1994-07-11	N-Cycloalkylalkylaminer, fremgangsmåde til fremstilling deraf, deres anvendelse som lægemiddel og deres syntese-mellemprodukter
FI810618L (fi)	1981-08-30	Nya kefalosporiner foerfarande foer deras framstaellning och dessa foereningar innehaollande laekemedel
DE3684133D1 (de)	1992-04-09	Oximester von stubstituierten chinolin-8-carbonsaeuren und deren verwendung als herbizide.
FI77022B (fi)	1988-09-30	Foerfarande foer framstaellning av nya terapeutiskt anvaendbara pyrrolaettiksyraderivat.
IL66692A0 (en)	1982-12-31	6alpha-methoxy-penicillins and salts thereof,their preparation and pharmaceutical compositions containing them
CA2177392A1 (fr)	1995-07-27	Composes tricycliques pouvant inhiber les tyrosines kinases de la famille des recepteurs du facteur de croissance epidermique
ES2115178T3 (es)	1998-06-16	Derivados de indanotrionas y de hidrazidas y su aplicacion terapeutica.
ES8900014A1 (es)	1988-11-01	Un procedimiento para la preparacion de derivados del acido 1-(fenil-sustituido)-4-carboxi-naftalen-2-carboxilico.