ZA201000676B - Pyrrolidine aryl-ether as NK3 receptor antagonists - Google Patents
Pyrrolidine aryl-ether as NK3 receptor antagonistsInfo
- Publication number
- ZA201000676B ZA201000676B ZA201000676A ZA201000676A ZA201000676B ZA 201000676 B ZA201000676 B ZA 201000676B ZA 201000676 A ZA201000676 A ZA 201000676A ZA 201000676 A ZA201000676 A ZA 201000676A ZA 201000676 B ZA201000676 B ZA 201000676B
- Authority
- ZA
- South Africa
- Prior art keywords
- ether
- receptor antagonists
- pyrrolidine
- aryl
- pyrrolidine aryl
- Prior art date
Links
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Natural products C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 title 2
- 101001125071 Homo sapiens Neuromedin-K receptor Proteins 0.000 title 1
- 102100029409 Neuromedin-K receptor Human genes 0.000 title 1
- -1 Pyrrolidine aryl-ether Chemical class 0.000 title 1
- 239000002464 receptor antagonist Substances 0.000 title 1
- 229940044551 receptor antagonist Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07113942 | 2007-08-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201000676B true ZA201000676B (en) | 2010-10-27 |
Family
ID=39865446
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA201000676A ZA201000676B (en) | 2007-08-07 | 2010-01-28 | Pyrrolidine aryl-ether as NK3 receptor antagonists |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8012998B2 (zh) |
| EP (1) | EP2185540B1 (zh) |
| JP (1) | JP2010535733A (zh) |
| KR (1) | KR101167774B1 (zh) |
| CN (1) | CN101778837A (zh) |
| AR (1) | AR067808A1 (zh) |
| AT (1) | ATE517100T1 (zh) |
| AU (1) | AU2008285718A1 (zh) |
| BR (1) | BRPI0815658A2 (zh) |
| CA (1) | CA2695211A1 (zh) |
| CL (1) | CL2008002293A1 (zh) |
| ES (1) | ES2367464T3 (zh) |
| IL (1) | IL203363A (zh) |
| MX (1) | MX2010001080A (zh) |
| PE (1) | PE20090898A1 (zh) |
| RU (1) | RU2010106974A (zh) |
| TW (1) | TW200916456A (zh) |
| WO (1) | WO2009019163A1 (zh) |
| ZA (1) | ZA201000676B (zh) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE519738T1 (de) * | 2007-08-22 | 2011-08-15 | Hoffmann La Roche | Pyrrolidinarylether als nk3-rezeptorantagonisten |
| JP5399518B2 (ja) | 2009-01-30 | 2014-01-29 | エフ．ホフマン−ラ ロシュ アーゲー | Ｎｋ３レセプターアンタゴニストとしてのピペリジン誘導体 |
| US8318759B2 (en) * | 2009-02-18 | 2012-11-27 | Hoffmann-La Roche Inc. | Pyrrolidine derivatives as NK3 receptor antagonists |
| US8394834B2 (en) * | 2009-08-25 | 2013-03-12 | Hoffman-La Roche Inc. | Pyrrolidines as NK3 receptor antagonists |
| WO2011048525A1 (en) * | 2009-10-20 | 2011-04-28 | Pfizer Inc. | Novel heteroaryl imidazoles and heteroaryl triazoles as gamma-secretase modulators |
| US8507535B2 (en) | 2010-07-07 | 2013-08-13 | Hoffmann-La Roche Inc. | Methyl-pyrrolidine ether derivatives |
| ES2838573T3 (es) | 2014-08-21 | 2021-07-02 | Bristol Myers Squibb Co | Derivados de benzamida ligados como inhibidores potentes de ROCK |
| US10246436B2 (en) | 2015-09-02 | 2019-04-02 | Trevena, Inc. | 6-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| WO2017072629A1 (en) | 2015-10-29 | 2017-05-04 | Cadila Healthcare Limited | Pharmaceutical combination of nk3 receptor antagonist and biguanides |
| CN105399661A (zh) * | 2015-12-14 | 2016-03-16 | 华东师范大学 | 2,6-二溴甲基吡啶的制备方法 |
| US11178872B2 (en) | 2016-05-09 | 2021-11-23 | Nippon Soda Co., Ltd. | Cyclic amine compound and pest control agent |
| CA3052479A1 (en) | 2017-02-17 | 2018-08-23 | Trevena, Inc. | 7-membered aza-heterocyclic containing delta-opioid receptor modulating compounds, methods of using and making the same |
| JP7316216B2 (ja) * | 2017-02-17 | 2023-07-27 | トレベナ・インコーポレイテッド | ５員アザ複素環を含有するデルタ－オピオイド受容体調節化合物、その使用方法及び製造方法 |
| WO2021030335A1 (en) * | 2019-08-12 | 2021-02-18 | Millendo Therapeutics, Inc. | A stereoisomerically pure nk-3 receptor antagonist and crystalline forms thereof |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU506399B2 (en) | 1975-12-30 | 1980-01-03 | Showa Denko Kabushiki Kaisha | 3-(2-aryl-2-propyl) ureas |
| IN148482B (zh) | 1977-06-03 | 1981-03-07 | Pfizer | |
| GB9321557D0 (en) * | 1992-11-03 | 1993-12-08 | Zeneca Ltd | Carboxamide derivatives |
| IL111960A (en) | 1993-12-17 | 1999-12-22 | Merck & Co Inc | Morpholines and thiomorpholines their preparation and pharmaceutical compositions containing them |
| ATE364606T1 (de) | 1993-12-29 | 2007-07-15 | Merck Sharp & Dohme | Substituierte morpholinderivate und ihre verwendung als arzneimittel |
| IL112778A0 (en) | 1994-03-04 | 1995-05-26 | Merck & Co Inc | Substituted heterocycles, their preparation and pharmaceutical compositions containing them |
| GB9714129D0 (en) * | 1997-07-04 | 1997-09-10 | Pfizer Ltd | Azetidines |
| US5972938A (en) * | 1997-12-01 | 1999-10-26 | Merck & Co., Inc. | Method for treating or preventing psychoimmunological disorders |
| EP1192952A3 (en) | 2000-09-28 | 2003-03-26 | Pfizer Products Inc. | Combination, for treating depression and anxiety, containing an NK-3 receptor antagonist and a CNS penetrant NK-1 receptor antagonist |
| US6531597B2 (en) | 2001-02-13 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for preparation of 2-phenyl acetic acid derivatives |
| MXPA04011730A (es) * | 2002-05-31 | 2005-07-14 | Takeda Pharmaceutical | Derivados de piperidina, proceso para producir el mismo, y uso. |
| HRP20070471T3 (hr) | 2003-07-03 | 2007-11-30 | F. Hoffmann - La Roche Ag | Dvojni nk1/nk3 antagonisti za liječenje shizofrenije |
| WO2005032464A2 (en) * | 2003-09-30 | 2005-04-14 | Merck & Co., Inc. | Phenyl pyrrolidine ether tachykinin receptor antagonists |
| EP1705176A4 (en) * | 2004-01-14 | 2009-06-03 | Takeda Pharmaceutical | CARBOXYLAMIDE DERIVATIVE AND ITS USE |
| US7138423B2 (en) * | 2004-07-20 | 2006-11-21 | Bristol-Myers Squibb Company | Arylpyrrolidine derivatives as NK-1 /SSRI antagonists |
| KR100939347B1 (ko) | 2005-07-20 | 2010-01-29 | (주)카이로드 | 광학적으로 순수한 (ｓ)-3-히드록시 피롤리딘의 제조방법 |
-
2008
- 2008-07-29 ES ES08786547T patent/ES2367464T3/es active Active
- 2008-07-29 MX MX2010001080A patent/MX2010001080A/es active IP Right Grant
- 2008-07-29 KR KR1020107004881A patent/KR101167774B1/ko not_active Expired - Fee Related
- 2008-07-29 CN CN200880102376A patent/CN101778837A/zh active Pending
- 2008-07-29 EP EP08786547A patent/EP2185540B1/en not_active Not-in-force
- 2008-07-29 JP JP2010519428A patent/JP2010535733A/ja active Pending
- 2008-07-29 AU AU2008285718A patent/AU2008285718A1/en not_active Abandoned
- 2008-07-29 RU RU2010106974/04A patent/RU2010106974A/ru unknown
- 2008-07-29 WO PCT/EP2008/059908 patent/WO2009019163A1/en not_active Ceased
- 2008-07-29 AT AT08786547T patent/ATE517100T1/de active
- 2008-07-29 CA CA2695211A patent/CA2695211A1/en not_active Abandoned
- 2008-07-29 BR BRPI0815658-1A2A patent/BRPI0815658A2/pt not_active IP Right Cessation
- 2008-08-04 US US12/185,157 patent/US8012998B2/en not_active Expired - Fee Related
- 2008-08-04 CL CL2008002293A patent/CL2008002293A1/es unknown
- 2008-08-05 PE PE2008001308A patent/PE20090898A1/es not_active Application Discontinuation
- 2008-08-05 AR ARP080103406A patent/AR067808A1/es unknown
- 2008-08-06 TW TW097129930A patent/TW200916456A/zh unknown
-
2010
- 2010-01-18 IL IL203363A patent/IL203363A/en not_active IP Right Cessation
- 2010-01-28 ZA ZA201000676A patent/ZA201000676B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010001080A (es) | 2010-03-01 |
| CL2008002293A1 (es) | 2009-05-29 |
| EP2185540A1 (en) | 2010-05-19 |
| IL203363A (en) | 2013-03-24 |
| PE20090898A1 (es) | 2009-07-13 |
| US8012998B2 (en) | 2011-09-06 |
| CN101778837A (zh) | 2010-07-14 |
| ES2367464T3 (es) | 2011-11-03 |
| RU2010106974A (ru) | 2011-09-20 |
| AR067808A1 (es) | 2009-10-21 |
| KR101167774B1 (ko) | 2012-07-24 |
| TW200916456A (en) | 2009-04-16 |
| WO2009019163A1 (en) | 2009-02-12 |
| EP2185540B1 (en) | 2011-07-20 |
| KR20100045502A (ko) | 2010-05-03 |
| CA2695211A1 (en) | 2009-02-12 |
| US20090042896A1 (en) | 2009-02-12 |
| BRPI0815658A2 (pt) | 2015-02-18 |
| AU2008285718A1 (en) | 2009-02-12 |
| JP2010535733A (ja) | 2010-11-25 |
| ATE517100T1 (de) | 2011-08-15 |
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