[go: up one dir, main page]

ZA200903334B - Substituted diazepan compounds as orexin receptor antagonists - Google Patents

Substituted diazepan compounds as orexin receptor antagonists

Info

Publication number
ZA200903334B
ZA200903334B ZA200903334A ZA200903334A ZA200903334B ZA 200903334 B ZA200903334 B ZA 200903334B ZA 200903334 A ZA200903334 A ZA 200903334A ZA 200903334 A ZA200903334 A ZA 200903334A ZA 200903334 B ZA200903334 B ZA 200903334B
Authority
ZA
South Africa
Prior art keywords
receptor antagonists
orexin receptor
diazepan compounds
substituted diazepan
substituted
Prior art date
Application number
ZA200903334A
Inventor
Jeffrey M Bergman
Michael J Breslin
Paul J Coleman
Christopher D Cox
Swati P Mercer
Anthony J Roecker
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of ZA200903334B publication Critical patent/ZA200903334B/en

Links

ZA200903334A 2006-12-01 2009-05-14 Substituted diazepan compounds as orexin receptor antagonists ZA200903334B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87239306P 2006-12-01 2006-12-01

Publications (1)

Publication Number Publication Date
ZA200903334B true ZA200903334B (en) 2010-04-28

Family

ID=41522310

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200903334A ZA200903334B (en) 2006-12-01 2009-05-14 Substituted diazepan compounds as orexin receptor antagonists

Country Status (4)

Country Link
CN (1) CN101627028B (en)
HN (1) HN2009001067A (en)
UA (2) UA106873C2 (en)
ZA (1) ZA200903334B (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2015005891A (en) * 2012-11-12 2015-12-09 Reddys Lab Ltd Dr Polymorphic forms of suvoroxant.
CN103012293A (en) * 2012-12-13 2013-04-03 同济大学 Synthetic method for anti-sleeplessness medicine MK-4305 intermediate
CN103923068B (en) * 2014-02-13 2016-09-07 武汉珈瑜科技有限公司 For compound preparing suvorexant and preparation method thereof
WO2015180060A1 (en) * 2014-05-28 2015-12-03 杭州普晒医药科技有限公司 Salt of diazacycloheptane compound and crystal form and amorphous substance thereof
US10030010B2 (en) * 2014-08-04 2018-07-24 Sandoz Ag Route of synthesis for the preparation of suvorexant
CN105461699B (en) * 2014-09-25 2019-07-09 广东东阳光药业有限公司 Substituted heterocyclic compound and its application method and purposes
CN104327061A (en) * 2014-10-19 2015-02-04 湖南华腾制药有限公司 Preparation method of bromobenzo[d]oxazole derivative
CN104649983B (en) * 2014-12-23 2018-01-23 广东东阳光药业有限公司 A kind of sour preparation method
CN106349228B (en) * 2015-07-17 2019-07-09 广东东阳光药业有限公司 Substituted quinazolinone compounds and preparation method and use thereof
CN106749269B (en) * 2015-11-23 2019-01-04 广东东阳光药业有限公司 Octahydro pyrrolo- [3,4-c] azole derivatives and application thereof
CN106916149A (en) * 2015-12-25 2017-07-04 上海奥博生物医药技术有限公司 A kind of method for preparing Su Woleisheng
CN107021964A (en) * 2016-02-01 2017-08-08 广东东阳光药业有限公司 7-naphthyridine derivatives and application thereof
CN105949203B (en) * 2016-05-24 2018-07-13 广东东阳光药业有限公司 Octahydro pyrrolo- [3,4-c] azole derivatives and its application method and purposes
CN106866632A (en) * 2017-01-19 2017-06-20 成都美域高制药有限公司 A kind of method for preparing Suvorexant intermediates and the like
CN109942563A (en) * 2017-12-21 2019-06-28 上海医药工业研究院 A kind of preparation method of Su Woleisheng midbody compound
WO2020247445A1 (en) * 2019-06-04 2020-12-10 Hager Biosciences, Llc Imidazolo derivatives, compositions and methods as orexin antagonists
CN111943945B (en) * 2020-09-03 2022-07-12 上海应用技术大学 Suvorexant intermediate and preparation method thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4966691A (en) * 1972-10-30 1974-06-27
EP0794178A4 (en) * 1994-11-25 1998-02-25 Nippon Chemiphar Co Quinazoline derivative
CA2538135C (en) * 2003-09-09 2015-01-27 F. Hoffmann-La Roche Ag 1-benzoyl-piperazine derivatives as glycine uptake inhibitors for the treatment of psychoses

Also Published As

Publication number Publication date
CN101627028B (en) 2013-03-27
HN2009001067A (en) 2011-05-11
CN101627028A (en) 2010-01-13
UA106873C2 (en) 2014-10-27
UA100974C2 (en) 2013-02-25

Similar Documents

Publication Publication Date Title
IL198825A0 (en) Substituted diazepan compounds as orexin receptor antagonists
ZA200903334B (en) Substituted diazepan compounds as orexin receptor antagonists
EP2099454A4 (en) Aminopyrrolidines as chemokine receptor antagonists
IL205665A0 (en) Heteroaryl derivatives as orexin receptor antagonists
SI2094690T1 (en) 2-AZA-BICYCLO?á3.1.0?åHEXANE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
IL202665A0 (en) Piperidine derivatives useful as orexin receptor antagonists
IL196587A0 (en) 2-phenyl-indoles as prostaglandin d2 receptor antagonists
IL184816A0 (en) 2-phenyl-indoles as prostaglandin d2 receptor antagonists
IL196056A0 (en) Il-8 receptor antagonists
ZA201001597B (en) Octahydropentalene compounds as chemokine receptor antagonists
PT1981902E (en) Nogo receptor antagonists
IL201112A0 (en) Thiazolidine derivatives as orexin receptor antagonists
BRPI0910592A2 (en) somatostatin receptor 2 antagonists
IL202657A0 (en) Imidazole derivatives as ccr2 receptor antagonists
ZA200808358B (en) IL-8 receptor antagonists
IL198241A0 (en) Pyrazoline compounds as mineralocorticoid receptor antagonists
ZA201001125B (en) Pyrrolidine Aryl-Ether as NK3 receptor antagonists
ZA201000676B (en) Pyrrolidine aryl-ether as NK3 receptor antagonists
IL194700A0 (en) Il-8 receptor antagonists
EP2099300A4 (en) Il-8 receptor antagonists
IL195807A0 (en) Cgrp receptor antagonists
IL209264A0 (en) Heteroaromatic monoamides as orexinin receptor antagonists
IL198542A0 (en) 2-aminoquinolines as 5-ht(5a)receptor antagonists
EP1993554A4 (en) Urotensin ii receptor antagonists
IL200781A0 (en) Heterocycles as orexin antagonists