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ZA200810671B - Purine derivatives as A2A agonists - Google Patents

Purine derivatives as A2A agonists

Info

Publication number
ZA200810671B
ZA200810671B ZA200810671A ZA200810671A ZA200810671B ZA 200810671 B ZA200810671 B ZA 200810671B ZA 200810671 A ZA200810671 A ZA 200810671A ZA 200810671 A ZA200810671 A ZA 200810671A ZA 200810671 B ZA200810671 B ZA 200810671B
Authority
ZA
South Africa
Prior art keywords
agonists
purine derivatives
purine
derivatives
Prior art date
Application number
ZA200810671A
Other languages
English (en)
Inventor
Robin Alec Fairhurst
Roger John Taylor
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA200810671B publication Critical patent/ZA200810671B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/14—Antitussive agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA200810671A 2006-07-13 2008-12-18 Purine derivatives as A2A agonists ZA200810671B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06117168A EP1889846A1 (en) 2006-07-13 2006-07-13 Purine derivatives as A2a agonists

Publications (1)

Publication Number Publication Date
ZA200810671B true ZA200810671B (en) 2009-11-25

Family

ID=37496423

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200810671A ZA200810671B (en) 2006-07-13 2008-12-18 Purine derivatives as A2A agonists

Country Status (20)

Country Link
US (1) US8071565B2 (xx)
EP (2) EP1889846A1 (xx)
JP (1) JP2009542753A (xx)
KR (1) KR20090016017A (xx)
CN (1) CN101479267B (xx)
AU (1) AU2007271944A1 (xx)
BR (1) BRPI0714216A2 (xx)
CA (1) CA2656012A1 (xx)
CR (1) CR10520A (xx)
EC (1) ECSP099063A (xx)
ES (1) ES2393931T3 (xx)
GT (1) GT200900007A (xx)
IL (1) IL196330A0 (xx)
MA (1) MA30693B1 (xx)
MX (1) MX2009000375A (xx)
NO (1) NO20090664L (xx)
RU (1) RU2009104764A (xx)
TN (1) TNSN08544A1 (xx)
WO (1) WO2008006563A1 (xx)
ZA (1) ZA200810671B (xx)

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RU2457209C2 (ru) 2006-04-21 2012-07-27 Новартис Аг Производные пурина, предназначенные для применения в качестве агонистов аденозинового рецептора а2а
EP1889846A1 (en) 2006-07-13 2008-02-20 Novartis AG Purine derivatives as A2a agonists
EP1903044A1 (en) 2006-09-14 2008-03-26 Novartis AG Adenosine Derivatives as A2A Receptor Agonists
RU2009121819A (ru) * 2006-11-10 2010-12-20 Новартис АГ (CH) Производные моноацетата циклопентендиола
KR20100068286A (ko) * 2007-10-17 2010-06-22 노파르티스 아게 아데노신 ａ1 수용체 리간드로서의 퓨린 유도체
CN102203058B (zh) * 2008-09-05 2014-11-12 奥克塞拉有限公司 用于治疗眼科疾病和紊乱的连接有硫的化合物
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IL279829B2 (en) 2018-07-05 2025-05-01 Incyte Holdings Corp Fused pyrazine derivatives as A2A/A2B inhibitors
TWI829857B (zh) 2019-01-29 2024-01-21 美商英塞特公司 作為a2a / a2b抑制劑之吡唑并吡啶及三唑并吡啶
CN117069627B (zh) * 2022-10-13 2025-08-26 上海康斯维克生物医药有限公司 4-(3-(3-氨磺酰基苯基)脲基)丁酸化合物、其荧光标记物、制备方法及用途

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Also Published As

Publication number Publication date
GT200900007A (es) 2009-11-30
JP2009542753A (ja) 2009-12-03
US8071565B2 (en) 2011-12-06
TNSN08544A1 (en) 2010-04-14
KR20090016017A (ko) 2009-02-12
ES2393931T3 (es) 2013-01-02
US20100240680A1 (en) 2010-09-23
NO20090664L (no) 2009-02-11
CA2656012A1 (en) 2008-01-17
EP2044070B1 (en) 2012-08-22
ECSP099063A (es) 2009-02-27
CN101479267B (zh) 2012-05-02
EP2044070A1 (en) 2009-04-08
MX2009000375A (es) 2009-01-27
WO2008006563A1 (en) 2008-01-17
MA30693B1 (fr) 2009-09-01
CN101479267A (zh) 2009-07-08
AU2007271944A1 (en) 2008-01-17
EP1889846A1 (en) 2008-02-20
CR10520A (es) 2009-03-19
IL196330A0 (en) 2009-09-22
RU2009104764A (ru) 2010-08-20
BRPI0714216A2 (pt) 2013-01-29

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