ZA200803488B - GLP-1 (Glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance - Google Patents

GLP-1 (Glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance

Info

Publication number: ZA200803488B
Authority: ZA; South Africa
Prior art keywords: glp; peptide; component; sequence; glucagon
Prior art date: 2005-09-22

Application number

ZA200803488A

Other languages

English (en)

Inventor

Geigle Peter

Wallrapp Christine

Thoenes Eric

Original Assignee

Uk Biocompatibles Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2005-09-22

Filing date

2006-09-22

Publication date

2009-10-28

2006-09-22 Application filed by Uk Biocompatibles Ltd filed Critical Uk Biocompatibles Ltd

2009-10-28 Publication of ZA200803488B publication Critical patent/ZA200803488B/xx

Links

102400000322 Glucagon-like peptide 1 Human genes 0.000 title abstract 6
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 title abstract 6
108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
230000004927 fusion Effects 0.000 title abstract 4
102000004196 processed proteins & peptides Human genes 0.000 title abstract 2
101800000224 Glucagon-like peptide 1 Proteins 0.000 title 2
102000035195 Peptidases Human genes 0.000 title 1
108091005804 Peptidases Proteins 0.000 title 1
229920001184 polypeptide Polymers 0.000 title 1
235000019833 protease Nutrition 0.000 title 1
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 4
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 1
101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 1
102400000326 Glucagon-like peptide 2 Human genes 0.000 abstract 1
101800000221 Glucagon-like peptide 2 Proteins 0.000 abstract 1
206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
150000001413 amino acids Chemical class 0.000 abstract 1
208000034615 apoptosis-related disease Diseases 0.000 abstract 1
201000010099 disease Diseases 0.000 abstract 1
208000035475 disorder Diseases 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
239000012634 fragment Substances 0.000 abstract 1
TWSALRJGPBVBQU-PKQQPRCHSA-N glucagon-like peptide 2 Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(O)=O)[C@@H](C)CC)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)CC)C1=CC=CC=C1 TWSALRJGPBVBQU-PKQQPRCHSA-N 0.000 abstract 1
238000001727 in vivo Methods 0.000 abstract 1
208000015122 neurodegenerative disease Diseases 0.000 abstract 1
208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- G—PHYSICS
- G07—CHECKING-DEVICES
- G07F—COIN-FREED OR LIKE APPARATUS
- G07F11/00—Coin-freed apparatus for dispensing, or the like, discrete articles
- G07F11/02—Coin-freed apparatus for dispensing, or the like, discrete articles from non-movable magazines
- G07F11/04—Coin-freed apparatus for dispensing, or the like, discrete articles from non-movable magazines in which magazines the articles are stored one vertically above the other
- G07F11/16—Delivery means
- G07F11/165—Delivery means using xyz-picker or multi-dimensional article picking arrangements

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Biochemistry (AREA)
Endocrinology (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Obesity (AREA)
Hematology (AREA)
Psychiatry (AREA)
Child & Adolescent Psychology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Physics & Mathematics (AREA)
General Physics & Mathematics (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

ZA200803488A 2005-09-22 2006-09-22 GLP-1 (Glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance ZA200803488B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP05020718A EP1767545B1 (en)	2005-09-22	2005-09-22	GLP-1 (Glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance

Publications (1)

Publication Number	Publication Date
ZA200803488B true ZA200803488B (en)	2009-10-28

Family

ID=35700191

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200803488A ZA200803488B (en)	2005-09-22	2006-09-22	GLP-1 (Glucagon-like peptide-1) fusion polypeptides with increased peptidase resistance

Country Status (23)

Country	Link
US (2)	US8431533B2 (xx)
EP (5)	EP2045265B1 (xx)
JP (2)	JP5222729B2 (xx)
KR (1)	KR20080064840A (xx)
CN (1)	CN101273058A (xx)
AT (1)	ATE448247T1 (xx)
AU (1)	AU2006299134B2 (xx)
BR (1)	BRPI0616107A2 (xx)
CA (1)	CA2619053A1 (xx)
CY (1)	CY1109778T1 (xx)
DE (1)	DE602005017628D1 (xx)
DK (1)	DK1767545T3 (xx)
EA (1)	EA013796B1 (xx)
ES (3)	ES2336575T3 (xx)
HR (1)	HRP20100062T1 (xx)
IL (1)	IL188904A0 (xx)
PL (1)	PL1767545T3 (xx)
PT (1)	PT1767545E (xx)
RS (1)	RS51319B (xx)
SG (1)	SG165414A1 (xx)
SI (1)	SI1767545T1 (xx)
WO (1)	WO2007039140A1 (xx)
ZA (1)	ZA200803488B (xx)

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KR102508651B1 (ko)	2015-12-23	2023-03-13	더 존스 홉킨스 유니버시티	신경계 및 신경변성 상태의 요법으로서 장기간 작용하는 glf-1r 작용제
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KR101827245B1 (ko) *	2017-12-26	2018-02-08	(주)제이유타이드	알라린을 주성분으로 하는 요독증 치료제
CA3086918A1 (en)	2018-01-03	2019-07-11	Mederis Diabetes, Llc	Improved peptide pharmaceuticals for treatment of nash and other disorders
KR101903564B1 (ko) *	2018-01-31	2018-11-13	한국지질자원연구원	제지공정에서 발생되는 부산물의 재활용 방법
PL4122954T3 (pl)	2018-04-05	2024-08-12	Sun Pharmaceutical Industries Limited	Nowe analogi GLP-1
WO2020125744A1 (zh)	2018-12-21	2020-06-25	江苏恒瑞医药股份有限公司	双特异性蛋白
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2005
- 2005-09-22 PT PT05020718T patent/PT1767545E/pt unknown
- 2005-09-22 AT AT05020718T patent/ATE448247T1/de active
- 2005-09-22 DK DK05020718.2T patent/DK1767545T3/da active
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Also Published As

Publication number	Publication date
EP1767545A1 (en)	2007-03-28
RS51319B (sr)	2010-12-31
DE602005017628D1 (de)	2009-12-24
CA2619053A1 (en)	2007-04-12
SG165414A1 (en)	2010-10-28
CY1109778T1 (el)	2014-09-10
EP2174952A3 (en)	2010-11-17
ES2394218T3 (es)	2013-01-23
US8853159B2 (en)	2014-10-07
CN101273058A (zh)	2008-09-24
US8431533B2 (en)	2013-04-30
AU2006299134A1 (en)	2007-04-12
EP1767545B1 (en)	2009-11-11
JP5222729B2 (ja)	2013-06-26
JP2009508505A (ja)	2009-03-05
EA200800699A1 (ru)	2008-10-30
JP2013099352A (ja)	2013-05-23
EP2174952A2 (en)	2010-04-14
US20110130329A1 (en)	2011-06-02
DK1767545T3 (da)	2010-03-15
EP2045265B1 (en)	2012-11-21
ATE448247T1 (de)	2009-11-15
US20120238497A1 (en)	2012-09-20
EP2045265A1 (en)	2009-04-08
PT1767545E (pt)	2010-02-05
ES2397289T3 (es)	2013-03-06
IL188904A0 (en)	2008-04-13
ES2336575T3 (es)	2010-04-14
PL1767545T3 (pl)	2010-04-30
KR20080064840A (ko)	2008-07-09
WO2007039140A1 (en)	2007-04-12
AU2006299134B2 (en)	2012-02-23
HK1129121A1 (en)	2009-11-20
EP1926748B1 (en)	2012-08-29
SI1767545T1 (sl)	2010-03-31
EA013796B1 (ru)	2010-06-30
EP2261245A1 (en)	2010-12-15
HRP20100062T1 (hr)	2010-03-31
BRPI0616107A2 (pt)	2011-06-07
EP1926748A1 (en)	2008-06-04

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