ZA200406937B - Derivatives of 4-(imidazol-5-YL)-2-(4-sulfoanilino) pyrimidine with CDK inhibitory activity. - Google Patents
Derivatives of 4-(imidazol-5-YL)-2-(4-sulfoanilino) pyrimidine with CDK inhibitory activity. Download PDFInfo
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- ZA200406937B ZA200406937B ZA200406937A ZA200406937A ZA200406937B ZA 200406937 B ZA200406937 B ZA 200406937B ZA 200406937 A ZA200406937 A ZA 200406937A ZA 200406937 A ZA200406937 A ZA 200406937A ZA 200406937 B ZA200406937 B ZA 200406937B
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- South Africa
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- compound
- formula
- acceptable salt
- pharmaceutically acceptable
- vivo hydrolysable
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- 108009000000 signalling pathways Proteins 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000001117 sulphuric acid Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000001984 thiazolidinyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000005505 thiomorpholino group Chemical group 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1
- 229920002554 vinyl polymer Polymers 0.000 description 1
Classifications
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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Landscapes
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- Gastroenterology & Hepatology (AREA)
- Endocrinology (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| GBGB0205693.5A GB0205693D0 (en) | 2002-03-09 | 2002-03-09 | Chemical compounds |
Publications (1)
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| ZA200406937B true ZA200406937B (en) | 2006-02-22 |
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| GB0004887D0 (en) | 2000-03-01 | 2000-04-19 | Astrazeneca Uk Ltd | Chemical compounds |
| GB0113041D0 (en) | 2001-05-30 | 2001-07-18 | Astrazeneca Ab | Chemical compounds |
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| WO2003076434A1 (en) | 2002-03-09 | 2003-09-18 | Astrazeneca Ab | 4- imidazolyl substuited pyrimidine derivatives with cdk inhibitiory activity |
| GB0311274D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
| GB0311276D0 (en) | 2003-05-16 | 2003-06-18 | Astrazeneca Ab | Chemical compounds |
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| GB0504753D0 (en) * | 2005-03-08 | 2005-04-13 | Astrazeneca Ab | Chemical compounds |
| US20080280906A1 (en) | 2005-07-30 | 2008-11-13 | David Andrews | Imidazolyl-Pyrimidine Compounds for Use in the Treatment of Proliferative Disorders |
| US7858807B2 (en) * | 2005-08-23 | 2010-12-28 | Ube Industries, Ltd. | Method for producing 1-substituted-5-acylimidazole compound |
| US8378096B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| US8378117B2 (en) * | 2005-09-23 | 2013-02-19 | Janssen Pharmaceutica N.V. | Hexahydro-cycloheptapyrazole cannabinoid modulators |
| AR058073A1 (es) * | 2005-10-03 | 2008-01-23 | Astrazeneca Ab | Derivados de imidazol 5-il-pirimidina, procesos de obtencion, composiciones farmaceuticas y usos |
| JP2009510160A (ja) * | 2005-10-03 | 2009-03-12 | アストラゼネカ・アクチエボラーグ | アルツハイマー病を予防および／または治療するための医薬の製造におけるピリミジン誘導体の使用 |
| TW200811169A (en) * | 2006-05-26 | 2008-03-01 | Astrazeneca Ab | Chemical compounds |
| ATE482948T1 (de) | 2006-06-21 | 2010-10-15 | Astrazeneca Ab | Chemische verbindungen |
| KR20090033904A (ko) * | 2006-07-21 | 2009-04-06 | 노파르티스 아게 | 벤즈이미다졸릴 피리딜 에테르의 제제 |
| ES2539518T3 (es) * | 2007-04-24 | 2015-07-01 | Astrazeneca Ab | Inhibidores de proteínas quinasas |
| US8507511B2 (en) | 2007-04-24 | 2013-08-13 | Ingenium Pharmaceuticals Gmbh | Inhibitors of protein kinases |
| JP5379787B2 (ja) * | 2007-04-24 | 2013-12-25 | インゲニウム ファーマシューティカルズ ジーエムビーエイチ | プロテインキナーゼの阻害剤 |
| US8507498B2 (en) | 2007-04-24 | 2013-08-13 | Ingenium Pharmaceuticals Gmbh | 4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases |
| MX2010011258A (es) * | 2008-04-14 | 2011-06-20 | Univ Texas | Inhibidores de molecula pequeña del dominio de homologia de pleckstrin y metodos para usar los mismos. |
| UA103319C2 (en) | 2008-05-06 | 2013-10-10 | Глаксосмитклайн Ллк | Thiazole- and oxazole-benzene sulfonamide compounds |
| CN102459252A (zh) * | 2009-04-15 | 2012-05-16 | 阿斯利康(瑞典)有限公司 | 用于治疗糖原合酶激酶3相关疾病诸如阿尔茨海默病的咪唑取代的嘧啶 |
| EP2909176B1 (en) * | 2012-10-18 | 2016-07-20 | Bayer Pharma Aktiengesellschaft | 5-fluoro-n-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group |
| US9340532B2 (en) | 2012-12-14 | 2016-05-17 | Phusis Therapeutics, Inc. | Methods and compositions for inhibiting CNKSR1 |
| US10227356B2 (en) | 2015-04-20 | 2019-03-12 | Phusis Therapeutics, Inc. | Compounds, compositions and methods for inhibiting CNKSR1 |
| JP6902025B2 (ja) * | 2015-06-18 | 2021-07-14 | ティン セラピューティックス エルエルシー | 聴覚損失の予防および治療のための方法および組成物 |
| KR102765922B1 (ko) | 2018-02-06 | 2025-02-11 | 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 | 선택적인 에스트로겐 수용체 분해제로서의 치환된 벤조티오펜 유사체 |
| CN110314161B (zh) * | 2018-03-30 | 2025-10-31 | 山东第二医科大学 | 化合物在制备治疗肿瘤的药物中的用途 |
| CN114981298B (zh) | 2019-12-12 | 2024-08-20 | 听治疗有限责任公司 | 用于预防和治疗听力损失的组合物和方法 |
| US11857551B1 (en) | 2020-07-10 | 2024-01-02 | Ting Therapeutics Llc | Methods for the prevention and treatment of hearing loss |
| IL303237A (en) * | 2020-11-27 | 2023-07-01 | Anrui Biomedical Tech Guangzhou Co Ltd | Aminoheteroaryl kinase inhibitors |
| CN116102506B (zh) * | 2022-06-23 | 2025-03-25 | 广州大学 | 一种基于氨基嘧啶骨架的多靶点激酶抑制剂及其制备方法和用途 |
| CN115919864B (zh) * | 2022-12-02 | 2024-09-03 | 中南大学湘雅三医院 | 唑嘧啶胺类化合物在用于制备治疗ibd药物中的应用 |
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| CA2148931A1 (en) | 1993-10-01 | 1995-04-13 | Jurg Zimmermann | Pyrimidineamine derivatives and processes for the preparation thereof |
| DE69434721T2 (de) | 1993-10-01 | 2006-11-09 | Novartis Ag | Pharmacologisch wirksame pyrimidinderivate und verfahren zu deren herstellung |
| ES2167377T3 (es) | 1993-10-01 | 2002-05-16 | Novartis Ag | Derivados de piridina farmacologicamente activos y procedimientos para la preparacion de los mismos. |
| US5543520A (en) | 1993-10-01 | 1996-08-06 | Ciba-Geigy Corporation | Pyrimidine derivatives |
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-
2002
- 2002-03-09 GB GBGB0205693.5A patent/GB0205693D0/en not_active Ceased
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2003
- 2003-03-06 US US10/507,081 patent/US7465728B2/en not_active Expired - Fee Related
- 2003-03-06 IL IL16391003A patent/IL163910A0/xx unknown
- 2003-03-06 CN CNA038100053A patent/CN1649863A/zh active Pending
- 2003-03-06 BR BR0308212-1A patent/BR0308212A/pt not_active IP Right Cessation
- 2003-03-06 JP JP2003574653A patent/JP3569524B1/ja not_active Expired - Fee Related
- 2003-03-06 PL PL03372703A patent/PL372703A1/xx not_active Application Discontinuation
- 2003-03-06 RU RU2004130440/04A patent/RU2004130440A/ru not_active Application Discontinuation
- 2003-03-06 EP EP03709965A patent/EP1487823A1/en not_active Ceased
- 2003-03-06 KR KR10-2004-7014055A patent/KR20040091114A/ko not_active Withdrawn
- 2003-03-06 AU AU2003214394A patent/AU2003214394A1/en not_active Abandoned
- 2003-03-06 WO PCT/GB2003/000983 patent/WO2003076436A1/en not_active Ceased
- 2003-03-06 CA CA002478701A patent/CA2478701A1/en not_active Abandoned
- 2003-03-06 MX MXPA04008807A patent/MXPA04008807A/es not_active Application Discontinuation
- 2003-03-07 TW TW092104931A patent/TW200306838A/zh unknown
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- 2003-06-03 UA UA20041008095A patent/UA78292C2/uk unknown
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- 2004-08-31 ZA ZA200406937A patent/ZA200406937B/en unknown
- 2004-09-07 IS IS7439A patent/IS7439A/is unknown
- 2004-09-14 NO NO20043851A patent/NO20043851L/no not_active Application Discontinuation
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| Publication number | Publication date |
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| AR039563A1 (es) | 2005-02-23 |
| MXPA04008807A (es) | 2004-11-26 |
| GB0205693D0 (en) | 2002-04-24 |
| KR20040091114A (ko) | 2004-10-27 |
| EP1487823A1 (en) | 2004-12-22 |
| NO20043851L (no) | 2004-09-14 |
| BR0308212A (pt) | 2004-12-21 |
| IS7439A (is) | 2004-09-07 |
| JP2004256550A (ja) | 2004-09-16 |
| PL372703A1 (en) | 2005-07-25 |
| TW200306838A (en) | 2003-12-01 |
| UY27705A1 (es) | 2003-10-31 |
| UA78292C2 (en) | 2007-03-15 |
| JP3569524B1 (ja) | 2004-09-22 |
| US7465728B2 (en) | 2008-12-16 |
| IL163910A0 (en) | 2005-12-18 |
| AU2003214394A1 (en) | 2003-09-22 |
| RU2004130440A (ru) | 2005-05-10 |
| JP2005519135A (ja) | 2005-06-30 |
| US20050131000A1 (en) | 2005-06-16 |
| WO2003076436A1 (en) | 2003-09-18 |
| CN1649863A (zh) | 2005-08-03 |
| CA2478701A1 (en) | 2003-09-18 |
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