ZA200206806B - Method to potentiate the therapeutic efficacy of taxane and derivatives thereof. - Google Patents

Method to potentiate the therapeutic efficacy of taxane and derivatives thereof. Download PDF

Info

Publication number: ZA200206806B
Authority: ZA; South Africa
Prior art keywords: taxane; metabolite; estramustine phosphate; cancer; estramustine
Prior art date: 2000-02-11

Application number

ZA200206806A

Other languages

English (en)

Inventor

Marius Monshouwer

Robert M J Ings

Maurizio Rocchetti

Original Assignee

Pharmacia Italia Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-11

Filing date

2002-08-26

Publication date

2004-02-26

2002-08-26 Application filed by Pharmacia Italia Spa filed Critical Pharmacia Italia Spa

2004-02-26 Publication of ZA200206806B publication Critical patent/ZA200206806B/en

Links

229940123237 Taxane Drugs 0.000 title claims description 52
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title claims description 26
230000001225 therapeutic effect Effects 0.000 title claims description 25
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238000000034 method Methods 0.000 title description 5
ADFOJJHRTBFFOF-RBRWEJTLSA-N estramustine phosphate Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)OP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 ADFOJJHRTBFFOF-RBRWEJTLSA-N 0.000 claims description 55
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FRPJXPJMRWBBIH-RBRWEJTLSA-N estramustine Chemical group ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 FRPJXPJMRWBBIH-RBRWEJTLSA-N 0.000 claims description 30
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RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims description 28
AXWYROHIFVWHMR-UGTOYMOASA-N [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] n,n-bis(2-chloroethyl)carbamate Chemical compound ClCCN(CCCl)C(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 AXWYROHIFVWHMR-UGTOYMOASA-N 0.000 claims description 27
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NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
229960000311 ritonavir Drugs 0.000 description 1
238000011808 rodent model Methods 0.000 description 1
RZJQGNCSTQAWON-UHFFFAOYSA-N rofecoxib Chemical compound C1=CC(S(=O)(=O)C)=CC=C1C1=C(C=2C=CC=CC=2)C(=O)OC1 RZJQGNCSTQAWON-UHFFFAOYSA-N 0.000 description 1
229960000371 rofecoxib Drugs 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011734 sodium Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000007306 turnover Effects 0.000 description 1
210000003932 urinary bladder Anatomy 0.000 description 1
LNPDTQAFDNKSHK-UHFFFAOYSA-N valdecoxib Chemical compound CC=1ON=C(C=2C=CC=CC=2)C=1C1=CC=C(S(N)(=O)=O)C=C1 LNPDTQAFDNKSHK-UHFFFAOYSA-N 0.000 description 1
229960002004 valdecoxib Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

ZA200206806A 2000-02-11 2002-08-26 Method to potentiate the therapeutic efficacy of taxane and derivatives thereof. ZA200206806B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GBGB0003201.1A GB0003201D0 (en)	2000-02-11	2000-02-11	Method to potentiate the therapeutic efficacy of taxane and derivatives thereof

Publications (1)

Publication Number	Publication Date
ZA200206806B true ZA200206806B (en)	2004-02-26

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ID=9885436

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200206806A ZA200206806B (en)	2000-02-11	2002-08-26	Method to potentiate the therapeutic efficacy of taxane and derivatives thereof.

Country Status (16)

Country	Link
US (1)	US20030153539A1 (xx)
EP (1)	EP1267889A1 (xx)
JP (1)	JP2003524645A (xx)
KR (1)	KR20020089345A (xx)
CN (1)	CN1398185A (xx)
AU (1)	AU3022901A (xx)
BR (1)	BR0108283A (xx)
CA (1)	CA2398840A1 (xx)
EA (1)	EA200200848A1 (xx)
EE (1)	EE200200440A (xx)
GB (1)	GB0003201D0 (xx)
HK (1)	HK1049967A1 (xx)
MX (1)	MXPA02007677A (xx)
NZ (1)	NZ521061A (xx)
WO (1)	WO2001058455A1 (xx)
ZA (1)	ZA200206806B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2316326C2 (ru) *	2001-12-03	2008-02-10	Байер Фамэсьютиклс Копэрейшн	Способ и композиция для лечения ракового заболевания, тозилат и фармацевтически приемлемые соли n-(4-хлор-3-(трифторметил)фенил)-n'-(4-(2-(n-метилкарбамоил)-4-пиридилокси)фенил)мочевины
DE60328486D1 (de)	2002-05-24	2009-09-03	Angiotech Int Ag	Zusammensetzungen und verfahren zur beschichtung medizinischer implantate
SE0203137D0 (sv) *	2002-10-24	2002-10-24	Karolinska Innovations Ab	Drug target in cancer therapy
CN100340296C (zh) *	2005-02-03	2007-10-03	山东蓝金生物工程有限公司	一种抗癌体内植入剂
US7776832B2 (en) *	2006-04-21	2010-08-17	Gem Pharmaceuticals, Llc	Anticancer treatment with a combination of taxanes and 13-deoxyanthracyclines
WO2007140299A2 (en) *	2006-05-25	2007-12-06	Bristol-Myers Squibb Company	Use of ixabepilone in combination with cyp3a4 inhibitors for pharmaceuticals
WO2024223797A1 (en)	2023-04-28	2024-10-31	Institut National de la Santé et de la Recherche Médicale	Use of cyp3a4 inhibitors for the treatment of hepatitis d virus (hdv) infections

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0914116B1 (en) *	1996-05-22	2000-10-11	Protarga Inc.	Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere
CN1636598A (zh) *	1998-03-27	2005-07-13	法麦希亚－厄普约翰公司	加强静脉内雌莫司汀磷酸盐作用的方法
US6436913B1 (en) *	2000-07-25	2002-08-20	Pharmacia & Upjohn Company	Use of estramustine phosphate in the treatment of bone metastasis
US6541509B2 (en) *	2000-09-15	2003-04-01	Albert Einstein College Of Medicine Of Yeshiva University	Method for treating neoplasia using combination chemotherapy

2000
- 2000-02-11 GB GBGB0003201.1A patent/GB0003201D0/en not_active Ceased
2001
- 2001-02-01 HK HK03102235.8A patent/HK1049967A1/zh unknown
- 2001-02-01 CA CA002398840A patent/CA2398840A1/en not_active Abandoned
- 2001-02-01 AU AU30229/01A patent/AU3022901A/en not_active Abandoned
- 2001-02-01 BR BR0108283-3A patent/BR0108283A/pt not_active IP Right Cessation
- 2001-02-01 NZ NZ521061A patent/NZ521061A/en unknown
- 2001-02-01 JP JP2001557565A patent/JP2003524645A/ja not_active Withdrawn
- 2001-02-01 KR KR1020027010359A patent/KR20020089345A/ko not_active Withdrawn
- 2001-02-01 WO PCT/EP2001/001088 patent/WO2001058455A1/en not_active Ceased
- 2001-02-01 EA EA200200848A patent/EA200200848A1/ru unknown
- 2001-02-01 CN CN01804826A patent/CN1398185A/zh active Pending
- 2001-02-01 EE EEP200200440A patent/EE200200440A/xx unknown
- 2001-02-01 MX MXPA02007677A patent/MXPA02007677A/es unknown
- 2001-02-01 EP EP01902382A patent/EP1267889A1/en not_active Withdrawn
- 2001-02-01 US US10/182,728 patent/US20030153539A1/en not_active Abandoned
2002
- 2002-08-26 ZA ZA200206806A patent/ZA200206806B/en unknown

Also Published As

Publication number	Publication date
EE200200440A (et)	2003-12-15
CN1398185A (zh)	2003-02-19
EA200200848A1 (ru)	2002-12-26
US20030153539A1 (en)	2003-08-14
AU3022901A (en)	2001-08-20
NZ521061A (en)	2005-01-28
MXPA02007677A (es)	2002-12-13
KR20020089345A (ko)	2002-11-29
GB0003201D0 (en)	2000-04-05
WO2001058455A1 (en)	2001-08-16
BR0108283A (pt)	2002-10-29
HK1049967A1 (zh)	2003-06-06
CA2398840A1 (en)	2001-08-16
JP2003524645A (ja)	2003-08-19
EP1267889A1 (en)	2003-01-02

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