ZA200104815B - Formulation with an improved therapeutic range, containing nucleotide synthesis inhibitors. - Google Patents

Formulation with an improved therapeutic range, containing nucleotide synthesis inhibitors. Download PDF

Info

Publication number: ZA200104815B
Authority: ZA; South Africa
Prior art keywords: compound; formula; preparation; nucleotide synthesis; cancer
Prior art date: 1998-12-10

Application number

ZA200104815A

Other languages

English (en)

Inventor

Juergen Lindner

Burkhard Haase

Original Assignee

Aventis Pharma Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-10

Filing date

2001-06-13

Publication date

2002-06-13

2001-06-13 Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh

2002-06-13 Publication of ZA200104815B publication Critical patent/ZA200104815B/en

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KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 1
239000006072 paste Substances 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
230000003285 pharmacodynamic effect Effects 0.000 description 1
239000000049 pigment Substances 0.000 description 1
239000004014 plasticizer Substances 0.000 description 1
229920002647 polyamide Polymers 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229920000642 polymer Polymers 0.000 description 1
229920001296 polysiloxane Polymers 0.000 description 1
229920005990 polystyrene resin Polymers 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
238000003825 pressing Methods 0.000 description 1
230000035755 proliferation Effects 0.000 description 1
230000006825 purine synthesis Effects 0.000 description 1
230000006824 pyrimidine synthesis Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000002904 solvent Substances 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000010254 subcutaneous injection Methods 0.000 description 1
239000007929 subcutaneous injection Substances 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
FAGUFWYHJQFNRV-UHFFFAOYSA-N tetraethylenepentamine Chemical compound NCCNCCNCCNCCN FAGUFWYHJQFNRV-UHFFFAOYSA-N 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
235000019871 vegetable fat Nutrition 0.000 description 1
239000001993 wax Substances 0.000 description 1
229940100445 wheat starch Drugs 0.000 description 1
239000011787 zinc oxide Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Dermatology (AREA)
Epidemiology (AREA)
Rheumatology (AREA)
Oncology (AREA)
Surgery (AREA)
Transplantation (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Otolaryngology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)

ZA200104815A 1998-12-10 2001-06-13 Formulation with an improved therapeutic range, containing nucleotide synthesis inhibitors. ZA200104815B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19857009A DE19857009A1 (de)	1998-12-10	1998-12-10	Zubereitung mit verbesserter therapeutischer Breite, enthaltend Nukleotidsyntheseinhibitoren

Publications (1)

Publication Number	Publication Date
ZA200104815B true ZA200104815B (en)	2002-06-13

Family

ID=7890633

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA200104815A ZA200104815B (en)	1998-12-10	2001-06-13	Formulation with an improved therapeutic range, containing nucleotide synthesis inhibitors.

Country Status (30)

Country	Link
EP (1)	EP1137438B1 (es)
JP (1)	JP2002531525A (es)
KR (1)	KR20010080729A (es)
CN (1)	CN1189214C (es)
AR (1)	AR021577A1 (es)
AT (1)	ATE218370T1 (es)
AU (1)	AU766810B2 (es)
BG (1)	BG105548A (es)
BR (1)	BR9916006A (es)
CA (1)	CA2354266A1 (es)
CZ (1)	CZ20012029A3 (es)
DE (2)	DE19857009A1 (es)
DK (1)	DK1137438T3 (es)
EA (1)	EA005136B1 (es)
EE (1)	EE200100305A (es)
ES (1)	ES2178496T3 (es)
HK (1)	HK1041598B (es)
HR (1)	HRP20010429A2 (es)
HU (1)	HUP0104624A3 (es)
IL (1)	IL143586A0 (es)
MX (1)	MXPA01005861A (es)
NO (1)	NO20012719L (es)
NZ (1)	NZ511882A (es)
PL (1)	PL349336A1 (es)
PT (1)	PT1137438E (es)
SI (1)	SI1137438T1 (es)
SK (1)	SK284842B6 (es)
WO (1)	WO2000033876A1 (es)
YU (1)	YU39901A (es)
ZA (1)	ZA200104815B (es)

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Publication number	Priority date	Publication date	Assignee	Title
DE10112924A1 (de) *	2001-03-13	2002-10-02	Erich Eigenbrodt	1-Butansäurederivate, pharmazeutische Zusammensetzungen enthaltend solche Derivate und Verwendungen solcher Derivate
US20040152772A1 (en) *	2001-03-13	2004-08-05	Erich Eigenbrodt	1-butyric acid derivatives and the use thereof
GB0123571D0 (en)	2001-04-05	2001-11-21	Aventis Pharm Prod Inc	Use of (Z)-2-cyano-3-hydroxy-but-2-enoic acid-(4'-trifluoromethylphenyl)-amide for treating multiple sclerosis
AU2003261354A1 (en) *	2002-08-02	2004-02-23	The Regents Of The University Of California	New uses for inhibitors of inosine monophosphate dehydrogenase
EP1534666A1 (de)	2002-09-06	2005-06-01	Schebo Biotech AG	Verbindungen zur modulation des glykolyse-enzym-und/oder transaminase-komplexes
JPWO2005060980A1 (ja) *	2003-12-24	2007-12-13	正彬少名子	疾患治療用医薬及び糖尿病治療用医薬
DE102005017592A1 (de) *	2005-04-16	2006-10-19	Lindner, Jürgen, Dr. med.	Darreichungsformen und Kombinationspräparate von Pyrimidinbiosyntheseinhibitoren zur Erzielung zusätzlicher Wirkungen auf das Immunsystem
BRPI0810202A2 (pt)	2007-05-03	2014-10-21	Pfizer Ltd	Derivados de piridina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4127737A1 (de) *	1991-08-22	1993-02-25	Hoechst Ag	Arzneimittel zur behandlung von abstossungsreaktionen bei organverpflanzungen
DK0538783T3 (da) *	1991-10-23	1996-02-05	Hoechst Ag	N-Phenyl-2-cyano-3-hydroxycrotonsyreamidderivater og deres anvendelse i lægemidler med immunmodulato riske egenskaber
IT1254519B (it) *	1992-03-16	1995-09-25	Chiesi Farma Spa	Associazioni di composti ad attivita' antivirale
DE19539638A1 (de) *	1995-10-25	1997-04-30	Hoechst Ag	Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
AU4596097A (en) *	1996-09-26	1998-04-17	Williams, James W.	Improved therapeutic uses of 4-quinoline-carboxylic acid derivatives

1998
- 1998-12-10 DE DE19857009A patent/DE19857009A1/de not_active Withdrawn
1999
- 1999-12-01 PT PT99961041T patent/PT1137438E/pt unknown
- 1999-12-01 IL IL14358699A patent/IL143586A0/xx unknown
- 1999-12-01 CA CA002354266A patent/CA2354266A1/en not_active Abandoned
- 1999-12-01 AT AT99961041T patent/ATE218370T1/de not_active IP Right Cessation
- 1999-12-01 ES ES99961041T patent/ES2178496T3/es not_active Expired - Lifetime
- 1999-12-01 SI SI9930063T patent/SI1137438T1/xx unknown
- 1999-12-01 KR KR1020017007176A patent/KR20010080729A/ko not_active Ceased
- 1999-12-01 AU AU17793/00A patent/AU766810B2/en not_active Ceased
- 1999-12-01 WO PCT/EP1999/009380 patent/WO2000033876A1/de not_active Ceased
- 1999-12-01 HU HU0104624A patent/HUP0104624A3/hu unknown
- 1999-12-01 EE EEP200100305A patent/EE200100305A/xx unknown
- 1999-12-01 CZ CZ20012029A patent/CZ20012029A3/cs unknown
- 1999-12-01 CN CNB998142433A patent/CN1189214C/zh not_active Expired - Fee Related
- 1999-12-01 MX MXPA01005861A patent/MXPA01005861A/es active IP Right Grant
- 1999-12-01 PL PL99349336A patent/PL349336A1/xx not_active Application Discontinuation
- 1999-12-01 EA EA200100647A patent/EA005136B1/ru not_active IP Right Cessation
- 1999-12-01 DE DE59901681T patent/DE59901681D1/de not_active Expired - Fee Related
- 1999-12-01 NZ NZ511882A patent/NZ511882A/en unknown
- 1999-12-01 DK DK99961041T patent/DK1137438T3/da active
- 1999-12-01 EP EP99961041A patent/EP1137438B1/de not_active Expired - Lifetime
- 1999-12-01 BR BR9916006-4A patent/BR9916006A/pt not_active IP Right Cessation
- 1999-12-01 JP JP2000586366A patent/JP2002531525A/ja not_active Withdrawn
- 1999-12-01 HK HK02103282.9A patent/HK1041598B/zh not_active IP Right Cessation
- 1999-12-01 YU YU39901A patent/YU39901A/sh unknown
- 1999-12-01 SK SK788-2001A patent/SK284842B6/sk unknown
- 1999-12-01 HR HR20010429A patent/HRP20010429A2/hr not_active Application Discontinuation
- 1999-12-07 AR ARP990106239A patent/AR021577A1/es not_active Application Discontinuation
2001
- 2001-05-30 BG BG105548A patent/BG105548A/xx unknown
- 2001-06-01 NO NO20012719A patent/NO20012719L/no not_active Application Discontinuation
- 2001-06-13 ZA ZA200104815A patent/ZA200104815B/en unknown

Also Published As

Publication number	Publication date
EA200100647A1 (ru)	2001-12-24
HK1041598A1 (en)	2002-07-12
YU39901A (sh)	2005-06-10
HUP0104624A3 (en)	2002-12-28
EE200100305A (et)	2002-08-15
SK7882001A3 (en)	2001-12-03
EA005136B1 (ru)	2004-12-30
IL143586A0 (en)	2002-04-21
WO2000033876A1 (de)	2000-06-15
SK284842B6 (sk)	2005-12-01
CA2354266A1 (en)	2000-06-15
PL349336A1 (en)	2002-07-15
JP2002531525A (ja)	2002-09-24
HUP0104624A2 (hu)	2002-04-29
NZ511882A (en)	2003-11-28
CN1329506A (zh)	2002-01-02
DE59901681D1 (de)	2002-07-11
AU766810B2 (en)	2003-10-23
DK1137438T3 (da)	2002-10-14
ATE218370T1 (de)	2002-06-15
AU1779300A (en)	2000-06-26
CZ20012029A3 (cs)	2002-02-13
NO20012719D0 (no)	2001-06-01
AR021577A1 (es)	2002-07-24
ES2178496T3 (es)	2002-12-16
BG105548A (en)	2001-12-29
KR20010080729A (ko)	2001-08-22
NO20012719L (no)	2001-06-01
MXPA01005861A (es)	2002-03-27
EP1137438A1 (de)	2001-10-04
BR9916006A (pt)	2001-09-04
PT1137438E (pt)	2002-11-29
DE19857009A1 (de)	2000-06-15
SI1137438T1 (en)	2002-08-31
EP1137438B1 (de)	2002-06-05
HRP20010429A2 (en)	2002-06-30
HK1041598B (zh)	2005-07-15
CN1189214C (zh)	2005-02-16

Publication	Publication Date	Title
JP2001519391A (ja)	2001-10-23	新規な組み合わせ物
JP4206131B2 (ja)	2009-01-07	５―メチルイソオキサゾール―４―カルボン酸―（４―トリフルオロメチル）―アニリドおよびｎ―（４―トリフルオロメチルフェニル）―２―シアノ―３―ヒドロキシクロトン酸アミドからなる配合製剤
JPH11349482A (ja)	1999-12-21	医薬
IE61232B1 (en)	1994-10-19	Medicaments to combat chronic graft-versus-host diseases and to combat autoimmune diseases, in particular systemic lupus erythematosus
ZA200104815B (en)	2002-06-13	Formulation with an improved therapeutic range, containing nucleotide synthesis inhibitors.
CA1069441A (en)	1980-01-08	Pharmaceutical composition containing 2,1,3-benzothiazole
EP0787491B1 (en)	2000-07-26	Preventive and remedy for type i allergic diseases
US20050255071A1 (en)	2005-11-17	Preparation having improved therapeutic breadth comprising nucleotide synthesis inhibitors
JPH0140009B2 (es)	1989-08-24
US4315934A (en)	1982-02-16	Organic compounds
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US4734405A (en)	1988-03-29	Combination product
JP2004051639A (ja)	2004-02-19	動脈硬化症治療のための医薬組成物
US4152435A (en)	1979-05-01	Compositions and methods to treat hypertension comprising a pyridazine and N-amidino-2-(2,6-dichlorophenyl) acetamide
KR20040032969A (ko)	2004-04-17	안지오텐신 ｉｉ 수용체 길항제를 함유하는 의약 조성물
EP1073332A1 (en)	2001-02-07	R-rabeprazole compositions and methods
US6025364A (en)	2000-02-15	Method of treating asthma
JPS6323969B2 (es)	1988-05-18
HK1018742B (en)	2004-08-20	Preparation containing a combination of 5-methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and n-(4-trifluoromethylphenyl)2-cyano-3-hydroxycrotonic acid amide
MXPA98007564A (es)	1999-02-24	Preparacion en combinacion que contiene 5-metil-4'-trifluometil-4'-isoxazolcarboxanilida y n-(4-trifluorometilfenil)-2-ciano-3-hidroxicrotonamida