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ZA200007060B - Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use. - Google Patents

Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use.

Info

Publication number
ZA200007060B
ZA200007060B ZA200007060A ZA200007060A ZA200007060B ZA 200007060 B ZA200007060 B ZA 200007060B ZA 200007060 A ZA200007060 A ZA 200007060A ZA 200007060 A ZA200007060 A ZA 200007060A ZA 200007060 B ZA200007060 B ZA 200007060B
Authority
ZA
South Africa
Prior art keywords
benzothiepine
compounds
producing
medicaments containing
dioxide derivatives
Prior art date
Application number
ZA200007060A
Other languages
English (en)
Inventor
Wendelin Frick
Alfons Enhsen
Heiner Glombik
Hubert Heuer
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Publication of ZA200007060B publication Critical patent/ZA200007060B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
    • C07D337/02—Seven-membered rings
    • C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
    • C07D337/08—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/04—Drugs for disorders of the urinary system for urolithiasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA200007060A 1998-06-10 2000-11-30 Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use. ZA200007060B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19825804A DE19825804C2 (de) 1998-06-10 1998-06-10 1,4-Benzothiepin-1,1-dioxidderivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel

Publications (1)

Publication Number Publication Date
ZA200007060B true ZA200007060B (en) 2001-07-18

Family

ID=7870440

Family Applications (2)

Application Number Title Priority Date Filing Date
ZA200007061A ZA200007061B (en) 1998-06-10 2000-11-30 Benzo(b)thiepine-1,1-dioxide derivatives, a method for the production thereof, medicaments containing these compounds, and their use.
ZA200007060A ZA200007060B (en) 1998-06-10 2000-11-30 Benzothiepine-1,1-dioxide derivatives, method for producing them, medicaments containing these compounds and their use.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ZA200007061A ZA200007061B (en) 1998-06-10 2000-11-30 Benzo(b)thiepine-1,1-dioxide derivatives, a method for the production thereof, medicaments containing these compounds, and their use.

Country Status (25)

Country Link
US (1) US6387944B1 (zh)
EP (2) EP1086092B1 (zh)
JP (2) JP4374426B2 (zh)
KR (2) KR100681721B1 (zh)
CN (2) CN1127497C (zh)
AR (2) AR018634A1 (zh)
AT (2) ATE227715T1 (zh)
AU (2) AU753275B2 (zh)
BR (2) BR9912188B1 (zh)
CA (2) CA2334775C (zh)
CZ (2) CZ297989B6 (zh)
DE (3) DE19825804C2 (zh)
DK (2) DK1086092T3 (zh)
ES (2) ES2182535T3 (zh)
HU (2) HU229761B1 (zh)
ID (2) ID28695A (zh)
IL (1) IL140078A (zh)
NO (1) NO327075B1 (zh)
NZ (1) NZ508681A (zh)
PL (2) PL196074B1 (zh)
PT (2) PT1086092E (zh)
RU (2) RU2215001C2 (zh)
TR (2) TR200003634T2 (zh)
WO (2) WO1999064410A1 (zh)
ZA (2) ZA200007061B (zh)

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DE69908643T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombinationen von cholesteryl ester transfer protein inhibitoren und nicotinsäure derivaten für kardiovaskuläre indikationen
SE0000772D0 (sv) 2000-03-08 2000-03-08 Astrazeneca Ab Chemical compounds
DE10064402A1 (de) * 2000-12-21 2002-06-27 Aventis Pharma Gmbh Diphenylazetidinonderivate, Verfahren zu deren Herstellung, diese Verbindungen enthaltende Arzneimittel und deren Verwendung
EG26979A (en) 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
DE50111751D1 (de) * 2000-12-21 2007-02-08 Sanofi Aventis Deutschland Neue diphenzylazetidinone, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung zur behandlung von lipidstoffwechselstörungen
WO2003018024A1 (de) * 2001-08-22 2003-03-06 Aventis Pharma Deutschland Gmbh Kombinationspräparate von 1,4- benzothiepin-1,1-dioxidderivaten mit weiteren wirkstoffen und deren verwendung
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TW202313579A (zh) 2021-06-03 2023-04-01 瑞典商艾爾比瑞歐公司 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途
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US5994391A (en) * 1994-09-13 1999-11-30 G.D. Searle And Company Benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
CN1084741C (zh) * 1994-09-13 2002-05-15 孟山都公司 具有回肠胆汁酸转运和牛磺胆酸盐摄入抑制剂作用的新的苯并硫杂䓬
CN1515567A (zh) * 1996-03-11 2004-07-28 G.D.ɪ����˾ 具有作为回肠胆汁酸转运和牛磺胆酸盐吸收抑制剂活性的新的苯并噻庚因
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US6096780A (en) * 1998-08-20 2000-08-01 Takeda Chemical Industries, Ltd. Quaternary ammonium salts and their use

Also Published As

Publication number Publication date
CA2334775A1 (en) 1999-12-16
HUP0102554A3 (en) 2002-12-28
ES2182535T3 (es) 2003-03-01
WO1999064409A3 (de) 2000-03-02
US6387944B1 (en) 2002-05-14
PL196074B1 (pl) 2007-12-31
CA2334773C (en) 2009-05-26
HK1039490A1 (zh) 2002-04-26
ATE259372T1 (de) 2004-02-15
JP2002517491A (ja) 2002-06-18
CZ20004591A3 (cs) 2001-04-11
IL140078A0 (en) 2002-02-10
KR100562184B1 (ko) 2006-03-20
PL345901A1 (en) 2002-01-14
AU4503199A (en) 1999-12-30
PT1086113E (pt) 2004-06-30
JP2002517490A (ja) 2002-06-18
HK1036799A1 (zh) 2002-01-18
CN1305487A (zh) 2001-07-25
EP1086092B1 (de) 2002-11-13
EP1086113A2 (de) 2001-03-28
CZ297925B6 (cs) 2007-05-02
PL344827A1 (en) 2001-11-19
JP4374426B2 (ja) 2009-12-02
BR9911123A (pt) 2006-01-03
CZ20004592A3 (cs) 2001-04-11
DE19825804C2 (de) 2000-08-24
WO1999064410A1 (de) 1999-12-16
KR100681721B1 (ko) 2007-02-15
IL140078A (en) 2004-08-31
ATE227715T1 (de) 2002-11-15
RU2220141C2 (ru) 2003-12-27
DE59908522D1 (de) 2004-03-18
DE19825804A1 (de) 1999-12-16
JP3374129B2 (ja) 2003-02-04
ZA200007061B (en) 2001-07-18
ID26876A (id) 2001-02-15
ES2215387T3 (es) 2004-10-01
HUP0102256A3 (en) 2002-04-29
AR018633A1 (es) 2001-11-28
AU4501999A (en) 1999-12-30
CN1305469A (zh) 2001-07-25
TR200003634T2 (tr) 2001-06-21
NO327075B1 (no) 2009-04-20
CZ297989B6 (cs) 2007-05-16
AU753275B2 (en) 2002-10-10
DK1086113T3 (da) 2004-05-24
EP1086092A1 (de) 2001-03-28
NO20006251D0 (no) 2000-12-08
DK1086092T3 (da) 2003-03-10
CA2334775C (en) 2009-10-13
HUP0102554A1 (hu) 2001-10-28
KR20010052701A (ko) 2001-06-25
HU229761B1 (hu) 2014-06-30
RU2215001C2 (ru) 2003-10-27
EP1086113B1 (de) 2004-02-11
CA2334773A1 (en) 1999-12-16
DE59903411D1 (de) 2002-12-19
ID28695A (id) 2001-06-28
HU228570B1 (en) 2013-04-29
PL196057B1 (pl) 2007-11-30
PT1086092E (pt) 2003-03-31
BR9911123B1 (pt) 2010-12-14
BR9912188B1 (pt) 2010-12-14
CN1152039C (zh) 2004-06-02
AU752633B2 (en) 2002-09-26
HUP0102256A1 (hu) 2001-12-28
NO20006251L (no) 2001-02-07
NZ508681A (en) 2002-06-28
TR200003632T2 (tr) 2001-04-20
AR018634A1 (es) 2001-11-28
BR9912188A (pt) 2001-04-10
CN1127497C (zh) 2003-11-12
KR20010052682A (ko) 2001-06-25
WO1999064409A2 (de) 1999-12-16

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