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YU28897A - Biciklicno kondenzovani piridini - Google Patents

Biciklicno kondenzovani piridini

Info

Publication number
YU28897A
YU28897A YU28897A YU28897A YU28897A YU 28897 A YU28897 A YU 28897A YU 28897 A YU28897 A YU 28897A YU 28897 A YU28897 A YU 28897A YU 28897 A YU28897 A YU 28897A
Authority
YU
Yugoslavia
Prior art keywords
bicyclic
fused pyridines
pyridines
drugs
bicyclic fused
Prior art date
Application number
YU28897A
Other languages
English (en)
Inventor
Arndt Brandes
Michael Lögers
Gunter Schmidt
Rolf Angerbauer
Carsten Schmeck
Klaus-Dieter Bremm
Hilmar Bischoff
Delf Schmidt
Joachim Schuhmacher
Original Assignee
Bayer Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Aktiengesellschaft filed Critical Bayer Aktiengesellschaft
Publication of YU28897A publication Critical patent/YU28897A/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Biciklično kondenzovani piridini pripremaju se tako što se reakcijom odgovarajućih aldehida, pomoću Vitigovih ili Grinjarovih reagenasa, uvodi odgovarajući bočni niz. Biciklično kondenzovani piridini pogodni su kao delotvorne supstance u lekovima, naročito u lekovima za lečenje hiperlipoproteinemije i arterioskleroze.
YU28897A 1996-07-08 1997-07-08 Biciklicno kondenzovani piridini YU28897A (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19627430A DE19627430A1 (de) 1996-07-08 1996-07-08 Bicyclisch kondensierte Pyridine

Publications (1)

Publication Number Publication Date
YU28897A true YU28897A (sh) 2000-03-21

Family

ID=7799218

Family Applications (1)

Application Number Title Priority Date Filing Date
YU28897A YU28897A (sh) 1996-07-08 1997-07-08 Biciklicno kondenzovani piridini

Country Status (30)

Country Link
US (1) US6063788A (sh)
EP (1) EP0825185A1 (sh)
JP (1) JPH1067751A (sh)
KR (1) KR980009247A (sh)
CN (1) CN1172803A (sh)
AR (1) AR007716A1 (sh)
AU (1) AU722365B2 (sh)
BG (1) BG61972B1 (sh)
BR (1) BR9703886A (sh)
CA (1) CA2209609A1 (sh)
CO (1) CO4870759A1 (sh)
CZ (1) CZ214797A3 (sh)
DE (1) DE19627430A1 (sh)
EE (1) EE9700151A (sh)
HN (1) HN1997000082A (sh)
HR (1) HRP970331A2 (sh)
HU (1) HUP9701158A1 (sh)
ID (1) ID17659A (sh)
IL (1) IL121235A0 (sh)
MA (1) MA24261A1 (sh)
NO (1) NO308738B1 (sh)
NZ (1) NZ328260A (sh)
PE (1) PE87798A1 (sh)
PL (1) PL320954A1 (sh)
SG (1) SG46782A1 (sh)
SK (1) SK92697A3 (sh)
TN (1) TNSN97116A1 (sh)
TR (1) TR199700583A2 (sh)
YU (1) YU28897A (sh)
ZA (1) ZA976021B (sh)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262277B1 (en) 1994-09-13 2001-07-17 G.D. Searle And Company Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake
US6642268B2 (en) 1994-09-13 2003-11-04 G.D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors
US6268392B1 (en) 1994-09-13 2001-07-31 G. D. Searle & Co. Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors
WO2000038722A1 (en) 1998-12-23 2000-07-06 G.D. Searle & Co. COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS
WO2000038721A1 (en) 1998-12-23 2000-07-06 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications
AU776664B2 (en) 1998-12-23 2004-09-16 G.D. Searle Llc Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications
DE69908644T2 (de) 1998-12-23 2004-05-13 G.D. Searle Llc, Chicago Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen
PT1140188E (pt) 1998-12-23 2003-10-31 Searle Llc Combinacoes de inibidores do transporte de acidos biliares do ileo e de inibidores da proteina de transferencia de esteres de colesterilo para doencas cardiovasculares.
MXPA01006472A (es) 1998-12-23 2004-03-10 Searle Llc Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares.
US6562860B1 (en) 1998-12-23 2003-05-13 G. D. Searle & Co. Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications
US20010018446A1 (en) 1999-09-23 2001-08-30 G.D. Searle & Co. Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6924313B1 (en) 1999-09-23 2005-08-02 Pfizer Inc. Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity
US6683113B2 (en) 1999-09-23 2004-01-27 Pharmacia Corporation (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity
HK1052183A1 (zh) 2000-03-10 2003-09-05 Pharmacia Corporation 制造tetrahydrobenzothiepines的方法
US20040219619A1 (en) * 2000-07-21 2004-11-04 Ester Fernandez-Salas Methods of identifying compounds that alter toxin persistence and/or protease activity
US20050239782A1 (en) * 2001-04-18 2005-10-27 Heintzelman Geoffrey R Arylindenopyridines and related therapeutic and prophylactic methods
US6903109B2 (en) * 2001-04-18 2005-06-07 Ortho-Muniel Pharmaceutical, Inc. Arylindenopyridines and related therapeutic and prophylactic methods
US6958328B2 (en) * 2001-04-18 2005-10-25 Ortho-Mcneil Pharmaceutical, Inc Arylindenopyridines and related therapeutic and prophylactic methods
ATE486586T1 (de) 2001-06-22 2010-11-15 Pfizer Prod Inc Pharmazeutische zusammensetzungen, enthaltend adsorbate eines arzneimittels in amorpher form
PT1404300E (pt) 2001-06-22 2009-11-09 Bend Res Inc Composições farmacêuticas de dispersões de fármacos e polímeros neutros
US6740663B2 (en) 2001-11-02 2004-05-25 G.D. Searle, Llc Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake
WO2003061604A2 (en) 2002-01-17 2003-07-31 Pharmacia Corporation Novel alkyl/aryl hydroxy or keto thiepines.
DE60320940D1 (de) * 2002-02-01 2008-06-26 Pfizer Prod Inc Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien
US20040127510A1 (en) 2002-04-16 2004-07-01 Heintzelman Geoffrey R. Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods
CL2004001884A1 (es) 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
WO2005011635A2 (en) 2003-08-04 2005-02-10 Pfizer Products Inc. Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials
WO2005030185A2 (en) * 2003-09-26 2005-04-07 Japan Tobacco Inc. Method of inhibiting remnant lipoprotein production
MXPA06003927A (es) 2003-10-08 2008-02-07 Lilly Co Eli Compuestos y metodos para tratar dislipidemia.
ES2326326T3 (es) 2004-03-26 2009-10-07 Eli Lilly And Company Compuestos y procedimientos para tratar la dislipidemia.
MX2007007188A (es) * 2004-12-18 2007-08-14 Bayer Healthcare Ag Derivados de tetrahidroquinolina sustituidos en 4 con cicloalquilo y su uso como medicamentos.
EP2548894A1 (en) 2005-02-03 2013-01-23 Bend Research, Inc. Pharmaceutical compositions with enhanced performance
RU2008119687A (ru) 2005-10-21 2009-11-27 Новартис АГ (CH) Комбинации органических соединений
DE102006012548A1 (de) * 2006-03-18 2007-09-20 Bayer Healthcare Ag Substituierte Chromanol-Derivate und ihre Verwendung
PA8801401A1 (es) * 2007-10-25 2009-05-15 Janssen Pharmaceutica Nv Arilindenopirimidinas y su uso como adenosina a2a
US20130156720A1 (en) 2010-08-27 2013-06-20 Ironwood Pharmaceuticals, Inc. Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5169857A (en) * 1988-01-20 1992-12-08 Bayer Aktiengesellschaft 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis
GB8626344D0 (en) * 1986-11-04 1986-12-03 Zyma Sa Bicyclic compounds
NO177005C (no) * 1988-01-20 1995-07-05 Bayer Ag Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen
IE892088L (en) * 1988-07-12 1990-01-12 William Henry Deryk Morris Quinoline derivatives, their production and use
ZA911046B (en) * 1990-02-26 1992-10-28 Squibb & Sons Inc Quinoline and pyridine anchors for hmg-coa reductase inhibitors
JPH059179A (ja) * 1990-09-27 1993-01-19 Takeda Chem Ind Ltd 複素環化合物、その製造法及びａｃａｔ阻害剤

Also Published As

Publication number Publication date
BR9703886A (pt) 1998-11-03
AU722365B2 (en) 2000-08-03
PL320954A1 (en) 1998-01-19
SG46782A1 (en) 1998-02-20
CO4870759A1 (es) 1999-12-27
NZ328260A (en) 1998-09-24
ID17659A (id) 1998-01-15
HRP970331A2 (en) 1998-08-31
PE87798A1 (es) 1999-02-13
IL121235A0 (en) 1998-01-04
KR980009247A (ko) 1998-04-30
HU9701158D0 (en) 1997-09-29
TNSN97116A1 (fr) 2005-03-15
AR007716A1 (es) 1999-11-10
AU2844897A (en) 1998-01-15
ZA976021B (en) 1998-02-02
EP0825185A1 (de) 1998-02-25
HUP9701158A1 (hu) 1999-09-28
JPH1067751A (ja) 1998-03-10
BG61972B1 (bg) 1998-11-30
CZ214797A3 (cs) 1998-01-14
NO308738B1 (no) 2000-10-23
DE19627430A1 (de) 1998-01-15
TR199700583A2 (xx) 1998-01-21
SK92697A3 (en) 1998-02-04
CA2209609A1 (en) 1998-01-08
NO973144D0 (no) 1997-07-07
EE9700151A (et) 1998-02-16
HN1997000082A (es) 1997-12-26
US6063788A (en) 2000-05-16
MA24261A1 (fr) 1998-04-01
NO973144L (no) 1998-01-09
BG101746A (en) 1998-03-31
CN1172803A (zh) 1998-02-11

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