AR007716A1 - Piridinas fusionadas biciclicas, procedimiento para su preparacion, medicamentos que los contienen y el uso de dichos compuestos - Google Patents
Piridinas fusionadas biciclicas, procedimiento para su preparacion, medicamentos que los contienen y el uso de dichos compuestosInfo
- Publication number
- AR007716A1 AR007716A1 ARP970102972A ARP970102972A AR007716A1 AR 007716 A1 AR007716 A1 AR 007716A1 AR P970102972 A ARP970102972 A AR P970102972A AR P970102972 A ARP970102972 A AR P970102972A AR 007716 A1 AR007716 A1 AR 007716A1
- Authority
- AR
- Argentina
- Prior art keywords
- pyridines
- compounds
- fusioned
- bicycles
- procedure
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- RQMWVVBHJMUJNZ-UHFFFAOYSA-N 4-chloropyridin-2-amine Chemical compound NC1=CC(Cl)=CC=N1 RQMWVVBHJMUJNZ-UHFFFAOYSA-N 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 150000003222 pyridines Chemical class 0.000 abstract 2
- 102000012336 Cholesterol Ester Transfer Proteins Human genes 0.000 abstract 1
- 108010061846 Cholesterol Ester Transfer Proteins Proteins 0.000 abstract 1
- 150000001299 aldehydes Chemical class 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000001131 transforming effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
Las piridinas fusionadas bicíclicas de la fórmula general (I), donde A, D, E, R1 y R2 son como se ha definido en la memoria descriptiva. Se obtienenpiridinas fusionadas bicíclicas, introduciendo la correspondiente cadena lateral mediantetran sformación de los correspondientes aldehidos con auxiliode reactivos de Wittig o de Grignard. Los compuestos conforme a la fórmula general (I) poseen valiosísimas propiedades farmacológicas, superiores encomparación con el estado de latécnica, siendo especialmente inhibidores altamente activos de la proteína de transferencia colesterol-éster (PTCE) yestimulan el transporte inverso de colesterol.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19627430A DE19627430A1 (de) | 1996-07-08 | 1996-07-08 | Bicyclisch kondensierte Pyridine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR007716A1 true AR007716A1 (es) | 1999-11-10 |
Family
ID=7799218
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP970102972A AR007716A1 (es) | 1996-07-08 | 1997-07-02 | Piridinas fusionadas biciclicas, procedimiento para su preparacion, medicamentos que los contienen y el uso de dichos compuestos |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6063788A (es) |
| EP (1) | EP0825185A1 (es) |
| JP (1) | JPH1067751A (es) |
| KR (1) | KR980009247A (es) |
| CN (1) | CN1172803A (es) |
| AR (1) | AR007716A1 (es) |
| AU (1) | AU722365B2 (es) |
| BG (1) | BG61972B1 (es) |
| BR (1) | BR9703886A (es) |
| CA (1) | CA2209609A1 (es) |
| CO (1) | CO4870759A1 (es) |
| CZ (1) | CZ214797A3 (es) |
| DE (1) | DE19627430A1 (es) |
| EE (1) | EE9700151A (es) |
| HN (1) | HN1997000082A (es) |
| HR (1) | HRP970331A2 (es) |
| HU (1) | HUP9701158A1 (es) |
| ID (1) | ID17659A (es) |
| IL (1) | IL121235A0 (es) |
| MA (1) | MA24261A1 (es) |
| NO (1) | NO308738B1 (es) |
| NZ (1) | NZ328260A (es) |
| PE (1) | PE87798A1 (es) |
| PL (1) | PL320954A1 (es) |
| SG (1) | SG46782A1 (es) |
| SK (1) | SK92697A3 (es) |
| TN (1) | TNSN97116A1 (es) |
| TR (1) | TR199700583A2 (es) |
| YU (1) | YU28897A (es) |
| ZA (1) | ZA976021B (es) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262277B1 (en) | 1994-09-13 | 2001-07-17 | G.D. Searle And Company | Intermediates and processes for the preparation of benzothiepines having activity as inhibitors of ileal bile acid transport and taurocholate uptake |
| US6642268B2 (en) | 1994-09-13 | 2003-11-04 | G.D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothipines and HMG Co-A reductase inhibitors |
| US6268392B1 (en) | 1994-09-13 | 2001-07-31 | G. D. Searle & Co. | Combination therapy employing ileal bile acid transport inhibiting benzothiepines and HMG Co-A reductase inhibitors |
| WO2000038722A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle & Co. | COMBINATIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG CoA REDUCTASE INHIBITORS FOR CARDIOVASCULAR INDICATIONS |
| WO2000038721A1 (en) | 1998-12-23 | 2000-07-06 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and nicotinic acid derivatives for cardiovascular indications |
| AU776664B2 (en) | 1998-12-23 | 2004-09-16 | G.D. Searle Llc | Combinations of cholesteryl ester transfer protein inhibitors and fibric acid derivatives for cardiovascular indications |
| DE69908644T2 (de) | 1998-12-23 | 2004-05-13 | G.D. Searle Llc, Chicago | Kombnationen von cholesteryl ester transfer protein inhibitoren und gallensäure sequestriermitteln für kardiovaskuläre indikationen |
| PT1140188E (pt) | 1998-12-23 | 2003-10-31 | Searle Llc | Combinacoes de inibidores do transporte de acidos biliares do ileo e de inibidores da proteina de transferencia de esteres de colesterilo para doencas cardiovasculares. |
| MXPA01006472A (es) | 1998-12-23 | 2004-03-10 | Searle Llc | Combinaciones de inhibidores de transporte de acido biliar ileal y derivados de acido fibrico para indicaciones cardiovasculares. |
| US6562860B1 (en) | 1998-12-23 | 2003-05-13 | G. D. Searle & Co. | Combinations of ileal bile acid transport inhibitors and bile acid sequestering agents for cardiovascular indications |
| US20010018446A1 (en) | 1999-09-23 | 2001-08-30 | G.D. Searle & Co. | Substituted N-Aliphatic-N-Aromatictertiary-Heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US6924313B1 (en) | 1999-09-23 | 2005-08-02 | Pfizer Inc. | Substituted tertiary-heteroalkylamines useful for inhibiting cholesteryl ester transfer protein activity |
| US6683113B2 (en) | 1999-09-23 | 2004-01-27 | Pharmacia Corporation | (R)-chiral halogenated substituted N,N-Bis-benzyl aminioalcohol compounds useful for inhibiting cholesteryl ester transfer protein activity |
| HK1052183A1 (zh) | 2000-03-10 | 2003-09-05 | Pharmacia Corporation | 制造tetrahydrobenzothiepines的方法 |
| US20040219619A1 (en) * | 2000-07-21 | 2004-11-04 | Ester Fernandez-Salas | Methods of identifying compounds that alter toxin persistence and/or protease activity |
| US20050239782A1 (en) * | 2001-04-18 | 2005-10-27 | Heintzelman Geoffrey R | Arylindenopyridines and related therapeutic and prophylactic methods |
| US6903109B2 (en) * | 2001-04-18 | 2005-06-07 | Ortho-Muniel Pharmaceutical, Inc. | Arylindenopyridines and related therapeutic and prophylactic methods |
| US6958328B2 (en) * | 2001-04-18 | 2005-10-25 | Ortho-Mcneil Pharmaceutical, Inc | Arylindenopyridines and related therapeutic and prophylactic methods |
| ATE486586T1 (de) | 2001-06-22 | 2010-11-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen, enthaltend adsorbate eines arzneimittels in amorpher form |
| PT1404300E (pt) | 2001-06-22 | 2009-11-09 | Bend Res Inc | Composições farmacêuticas de dispersões de fármacos e polímeros neutros |
| US6740663B2 (en) | 2001-11-02 | 2004-05-25 | G.D. Searle, Llc | Mono- and di-fluorinated benzothiepine compounds as inhibitors of apical sodium co-dependent bile acid transport (ASBT) and taurocholate uptake |
| WO2003061604A2 (en) | 2002-01-17 | 2003-07-31 | Pharmacia Corporation | Novel alkyl/aryl hydroxy or keto thiepines. |
| DE60320940D1 (de) * | 2002-02-01 | 2008-06-26 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen amorpher dispersionen von wirkstoffen und lipophiler mikrophasenbildender materialien |
| US20040127510A1 (en) | 2002-04-16 | 2004-07-01 | Heintzelman Geoffrey R. | Arylindenopyridines and arylindenopyrimidines and related therapeutic and prophylactic methods |
| CL2004001884A1 (es) | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
| WO2005011635A2 (en) | 2003-08-04 | 2005-02-10 | Pfizer Products Inc. | Pharmaceutical compositions of adsorbates of amorphous drugs and lipophilic microphase-forming materials |
| WO2005030185A2 (en) * | 2003-09-26 | 2005-04-07 | Japan Tobacco Inc. | Method of inhibiting remnant lipoprotein production |
| MXPA06003927A (es) | 2003-10-08 | 2008-02-07 | Lilly Co Eli | Compuestos y metodos para tratar dislipidemia. |
| ES2326326T3 (es) | 2004-03-26 | 2009-10-07 | Eli Lilly And Company | Compuestos y procedimientos para tratar la dislipidemia. |
| MX2007007188A (es) * | 2004-12-18 | 2007-08-14 | Bayer Healthcare Ag | Derivados de tetrahidroquinolina sustituidos en 4 con cicloalquilo y su uso como medicamentos. |
| EP2548894A1 (en) | 2005-02-03 | 2013-01-23 | Bend Research, Inc. | Pharmaceutical compositions with enhanced performance |
| RU2008119687A (ru) | 2005-10-21 | 2009-11-27 | Новартис АГ (CH) | Комбинации органических соединений |
| DE102006012548A1 (de) * | 2006-03-18 | 2007-09-20 | Bayer Healthcare Ag | Substituierte Chromanol-Derivate und ihre Verwendung |
| PA8801401A1 (es) * | 2007-10-25 | 2009-05-15 | Janssen Pharmaceutica Nv | Arilindenopirimidinas y su uso como adenosina a2a |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5169857A (en) * | 1988-01-20 | 1992-12-08 | Bayer Aktiengesellschaft | 7-(polysubstituted pyridyl)-hept-6-endates useful for treating hyperproteinaemia, lipoproteinaemia or arteriosclerosis |
| GB8626344D0 (en) * | 1986-11-04 | 1986-12-03 | Zyma Sa | Bicyclic compounds |
| NO177005C (no) * | 1988-01-20 | 1995-07-05 | Bayer Ag | Analogifremgangsmåte for fremstilling av substituerte pyridiner, samt mellomprodukter til bruk ved fremstillingen |
| IE892088L (en) * | 1988-07-12 | 1990-01-12 | William Henry Deryk Morris | Quinoline derivatives, their production and use |
| ZA911046B (en) * | 1990-02-26 | 1992-10-28 | Squibb & Sons Inc | Quinoline and pyridine anchors for hmg-coa reductase inhibitors |
| JPH059179A (ja) * | 1990-09-27 | 1993-01-19 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及びａｃａｔ阻害剤 |
-
1996
- 1996-07-08 DE DE19627430A patent/DE19627430A1/de not_active Withdrawn
-
1997
- 1997-06-16 HN HN1997000082A patent/HN1997000082A/es unknown
- 1997-06-17 HR HR19627430.3A patent/HRP970331A2/hr not_active Application Discontinuation
- 1997-06-18 SG SG1997002082A patent/SG46782A1/en unknown
- 1997-06-25 EP EP97110360A patent/EP0825185A1/de not_active Withdrawn
- 1997-06-27 US US08/883,067 patent/US6063788A/en not_active Expired - Fee Related
- 1997-07-02 AR ARP970102972A patent/AR007716A1/es not_active Application Discontinuation
- 1997-07-03 AU AU28448/97A patent/AU722365B2/en not_active Ceased
- 1997-07-04 TR TR97/00583A patent/TR199700583A2/xx unknown
- 1997-07-04 IL IL12123597A patent/IL121235A0/xx unknown
- 1997-07-04 BG BG101746A patent/BG61972B1/bg unknown
- 1997-07-04 NZ NZ328260A patent/NZ328260A/en unknown
- 1997-07-04 ID IDP972332A patent/ID17659A/id unknown
- 1997-07-04 CA CA002209609A patent/CA2209609A1/en not_active Abandoned
- 1997-07-04 PL PL97320954A patent/PL320954A1/xx unknown
- 1997-07-07 KR KR1019970031342A patent/KR980009247A/ko not_active Withdrawn
- 1997-07-07 CO CO97037764A patent/CO4870759A1/es unknown
- 1997-07-07 TN TNTNSN97116A patent/TNSN97116A1/fr unknown
- 1997-07-07 HU HU9701158A patent/HUP9701158A1/hu unknown
- 1997-07-07 CZ CZ972147A patent/CZ214797A3/cs unknown
- 1997-07-07 JP JP9195235A patent/JPH1067751A/ja active Pending
- 1997-07-07 MA MA24705A patent/MA24261A1/fr unknown
- 1997-07-07 NO NO973144A patent/NO308738B1/no not_active IP Right Cessation
- 1997-07-07 SK SK926-97A patent/SK92697A3/sk unknown
- 1997-07-07 PE PE1997000581A patent/PE87798A1/es not_active Application Discontinuation
- 1997-07-07 ZA ZA9706021A patent/ZA976021B/xx unknown
- 1997-07-08 EE EE9700151A patent/EE9700151A/xx unknown
- 1997-07-08 CN CN97114558A patent/CN1172803A/zh active Pending
- 1997-07-08 BR BR9703886A patent/BR9703886A/pt active Search and Examination
- 1997-07-08 YU YU28897A patent/YU28897A/sh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9703886A (pt) | 1998-11-03 |
| AU722365B2 (en) | 2000-08-03 |
| PL320954A1 (en) | 1998-01-19 |
| SG46782A1 (en) | 1998-02-20 |
| CO4870759A1 (es) | 1999-12-27 |
| NZ328260A (en) | 1998-09-24 |
| ID17659A (id) | 1998-01-15 |
| HRP970331A2 (en) | 1998-08-31 |
| PE87798A1 (es) | 1999-02-13 |
| IL121235A0 (en) | 1998-01-04 |
| KR980009247A (ko) | 1998-04-30 |
| HU9701158D0 (en) | 1997-09-29 |
| TNSN97116A1 (fr) | 2005-03-15 |
| AU2844897A (en) | 1998-01-15 |
| ZA976021B (en) | 1998-02-02 |
| EP0825185A1 (de) | 1998-02-25 |
| HUP9701158A1 (hu) | 1999-09-28 |
| JPH1067751A (ja) | 1998-03-10 |
| BG61972B1 (bg) | 1998-11-30 |
| CZ214797A3 (cs) | 1998-01-14 |
| NO308738B1 (no) | 2000-10-23 |
| DE19627430A1 (de) | 1998-01-15 |
| TR199700583A2 (xx) | 1998-01-21 |
| YU28897A (sh) | 2000-03-21 |
| SK92697A3 (en) | 1998-02-04 |
| CA2209609A1 (en) | 1998-01-08 |
| NO973144D0 (no) | 1997-07-07 |
| EE9700151A (et) | 1998-02-16 |
| HN1997000082A (es) | 1997-12-26 |
| US6063788A (en) | 2000-05-16 |
| MA24261A1 (fr) | 1998-04-01 |
| NO973144L (no) | 1998-01-09 |
| BG101746A (en) | 1998-03-31 |
| CN1172803A (zh) | 1998-02-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |