YU101103A - Industrijski postupak sinteze za dobijanje tropenola - Google Patents

Industrijski postupak sinteze za dobijanje tropenola

Info

Publication number: YU101103A
Authority: YU; Yugoslavia
Prior art keywords: synthesis method; technical synthesis; tropenol; producing; producing tropenol
Prior art date: 2001-06-28

Application number

YU101103A

Other languages

English (en)

Serbo-Croatian (sh)

Inventor

Armin Walter Rapp

Rainer Sobotta

Original Assignee

Boehringer Ingelheim Pharma Gmbh. & Co.Kg.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-28

Filing date

2002-06-08

Publication date

2006-05-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=YU101103(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-06-08 Application filed by Boehringer Ingelheim Pharma Gmbh. & Co.Kg. filed Critical Boehringer Ingelheim Pharma Gmbh. & Co.Kg.

2006-05-25 Publication of YU101103A publication Critical patent/YU101103A/sh

2009-12-31 Publication of RS50436B publication Critical patent/RS50436B/sr

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Lock And Its Accessories (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Catalysts (AREA)

YUP-1011/03A 2001-06-28 2002-06-08 Industrijski postupak sinteze za dobijanje tropenola RS50436B (sr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE10131200		2001-06-28

Publications (2)

Publication Number	Publication Date
YU101103A true YU101103A (xx)	2006-05-25
RS50436B RS50436B (sr)	2009-12-31

Family

ID=7689774

Country Status (40)

Country	Link
US (1)	US6610849B2 (xx)
EP (3)	EP1808435B1 (xx)
JP (2)	JP4485192B2 (xx)
KR (3)	KR100866272B1 (xx)
CN (2)	CN1288154C (xx)
AR (1)	AR039056A1 (xx)
AT (3)	ATE294801T1 (xx)
AU (2)	AU2002257820B2 (xx)
BG (2)	BG66398B1 (xx)
BR (1)	BR0210664B1 (xx)
CA (1)	CA2451573C (xx)
CO (1)	CO5650166A2 (xx)
CY (1)	CY1107681T1 (xx)
CZ (1)	CZ296187B6 (xx)
DE (2)	DE50203015D1 (xx)
DK (3)	DK1404673T3 (xx)
EA (2)	EA006393B1 (xx)
EC (1)	ECSP034927A (xx)
EE (1)	EE05403B1 (xx)
EG (1)	EG23203A (xx)
ES (3)	ES2285318T3 (xx)
HR (2)	HRP20090110A2 (xx)
HU (2)	HU230036B1 (xx)
IL (2)	IL159239A0 (xx)
ME (1)	MEP42608A (xx)
MX (1)	MXPA03011516A (xx)
MY (1)	MY122932A (xx)
NO (1)	NO328154B1 (xx)
NZ (2)	NZ541395A (xx)
PE (1)	PE20030123A1 (xx)
PL (1)	PL209520B1 (xx)
PT (2)	PT1475379E (xx)
RS (1)	RS50436B (xx)
SA (1)	SA02230194B1 (xx)
SI (2)	SI1404673T1 (xx)
SK (1)	SK288022B6 (xx)
TW (1)	TW574220B (xx)
UA (2)	UA76761C2 (xx)
WO (1)	WO2003002562A1 (xx)
ZA (1)	ZA200308895B (xx)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10141377A1 (de)	2001-08-23	2003-03-13	Boehringer Ingelheim Pharma	Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) *	2002-05-31	2004-06-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Industrial process for preparing tropenol
US20090162562A1 (en) *	2007-12-24	2009-06-25	Bangalore Aswatha Nagaraj	Methods for Applying Thermal Barrier Coating Systems
PT2240477E (pt) *	2008-01-10	2014-11-19	Generics Uk Ltd	Um novo processo para a preparação de ésteres de escopina
WO2011015884A1 (en)	2009-08-07	2011-02-10	Generics [Uk] Limited	Process to prepare scopine esters
NZ597920A (en)	2009-08-07	2014-05-30	Generics Uk Ltd	Anhydrate of tiotropium bromide
CN102351856B (zh) *	2011-08-24	2013-05-01	商丘市韶华药业有限公司	一种α-托品醇的纯化方法
ITRM20110508A1 (it)	2011-09-27	2013-03-28	Lusochimica Spa	Processo per la preparazione degli esteri della scopina.
PT2607351T (pt) *	2011-12-22	2017-05-26	Cerbios-Pharma S A	Processo contínuo para a alquilação de aminas terciárias cíclicas
CN113292574B (zh) *	2020-02-21	2022-05-03	四川大学	一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) *	2020-04-13	2021-09-21	石家庄四药有限公司	异丙托溴铵的合成方法
CN113264929B (zh) *	2021-05-02	2023-10-10	润生药业有限公司	一种噻托溴铵的制备方法
CN115925534B (zh) *	2023-01-03	2025-03-07	绍兴民生医药股份有限公司	高纯度托品酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3931041C2 (de) *	1989-09-16	2000-04-06	Boehringer Ingelheim Kg	Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
NZ284075A (en) *	1994-04-19	1998-01-26	Neurosearch As	Tropane-2-aldoxine derivatives; neurotransmitter re-uptake inhibiting medicaments
DE19515625C2 (de) *	1995-04-28	1998-02-19	Boehringer Ingelheim Kg	Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

2002
- 2002-06-03 US US10/160,702 patent/US6610849B2/en not_active Expired - Lifetime
- 2002-06-08 DK DK02727610T patent/DK1404673T3/da active
- 2002-06-08 PT PT04018550T patent/PT1475379E/pt unknown
- 2002-06-08 EP EP07101821A patent/EP1808435B1/de not_active Expired - Lifetime
- 2002-06-08 ME MEP-426/08A patent/MEP42608A/xx unknown
- 2002-06-08 HR HR20090110A patent/HRP20090110A2/xx not_active Application Discontinuation
- 2002-06-08 EA EA200301292A patent/EA006393B1/ru not_active IP Right Cessation
- 2002-06-08 MX MXPA03011516A patent/MXPA03011516A/es active IP Right Grant
- 2002-06-08 SI SI200230153T patent/SI1404673T1/xx unknown
- 2002-06-08 AT AT02727610T patent/ATE294801T1/de active
- 2002-06-08 EE EEP200400045A patent/EE05403B1/xx not_active IP Right Cessation
- 2002-06-08 NZ NZ541395A patent/NZ541395A/en not_active IP Right Cessation
- 2002-06-08 EP EP04018550A patent/EP1475379B1/de not_active Revoked
- 2002-06-08 IL IL15923902A patent/IL159239A0/xx unknown
- 2002-06-08 PL PL366942A patent/PL209520B1/pl unknown
- 2002-06-08 EP EP02727610A patent/EP1404673B1/de not_active Expired - Lifetime
- 2002-06-08 CN CNB028128672A patent/CN1288154C/zh not_active Expired - Lifetime
- 2002-06-08 PT PT02727610T patent/PT1404673E/pt unknown
- 2002-06-08 NZ NZ530770A patent/NZ530770A/en not_active IP Right Cessation
- 2002-06-08 DE DE50203015T patent/DE50203015D1/de not_active Expired - Lifetime
- 2002-06-08 ES ES04018550T patent/ES2285318T3/es not_active Expired - Lifetime
- 2002-06-08 DK DK04018550T patent/DK1475379T3/da active
- 2002-06-08 ES ES07101821T patent/ES2374981T3/es not_active Expired - Lifetime
- 2002-06-08 HU HU0400332A patent/HU230036B1/hu unknown
- 2002-06-08 JP JP2003508943A patent/JP4485192B2/ja not_active Expired - Lifetime
- 2002-06-08 DE DE50209948T patent/DE50209948D1/de not_active Expired - Lifetime
- 2002-06-08 HR HR20031085A patent/HRP20031085B1/xx not_active IP Right Cessation
- 2002-06-08 AU AU2002257820A patent/AU2002257820B2/en not_active Expired
- 2002-06-08 DK DK07101821.2T patent/DK1808435T3/da active
- 2002-06-08 SK SK66-2004A patent/SK288022B6/sk not_active IP Right Cessation
- 2002-06-08 AT AT04018550T patent/ATE359285T1/de active
- 2002-06-08 HU HU1400554A patent/HU230379B1/hu unknown
- 2002-06-08 SI SI200230540T patent/SI1475379T1/sl unknown
- 2002-06-08 WO PCT/EP2002/006290 patent/WO2003002562A1/de not_active Ceased
- 2002-06-08 CZ CZ20040149A patent/CZ296187B6/cs not_active IP Right Cessation
- 2002-06-08 KR KR1020037017010A patent/KR100866272B1/ko not_active Expired - Lifetime
- 2002-06-08 KR KR1020087014692A patent/KR100886342B1/ko not_active Expired - Lifetime
- 2002-06-08 AT AT07101821T patent/ATE527257T1/de active
- 2002-06-08 CN CN2006101604057A patent/CN1982309B/zh not_active Expired - Lifetime
- 2002-06-08 ES ES02727610T patent/ES2242022T3/es not_active Expired - Lifetime
- 2002-06-08 BR BRPI0210664-7B1A patent/BR0210664B1/pt active IP Right Grant
- 2002-06-08 EA EA200501081A patent/EA009808B1/ru not_active IP Right Cessation
- 2002-06-08 CA CA2451573A patent/CA2451573C/en not_active Expired - Fee Related
- 2002-06-08 RS YUP-1011/03A patent/RS50436B/sr unknown
- 2002-06-25 PE PE2002000553A patent/PE20030123A1/es not_active Application Discontinuation
- 2002-06-26 EG EG2002060738A patent/EG23203A/xx active
- 2002-06-26 TW TW91114026A patent/TW574220B/zh not_active IP Right Cessation
- 2002-06-26 MY MYPI20022420A patent/MY122932A/en unknown
- 2002-06-28 AR ARP020102453A patent/AR039056A1/es not_active Application Discontinuation
- 2002-07-10 SA SA2230194A patent/SA02230194B1/ar unknown
- 2002-08-06 UA UA2004010605A patent/UA76761C2/uk unknown
2003
- 2003-03-28 KR KR10-2003-0019708A patent/KR100530661B1/ko not_active Expired - Fee Related
- 2003-11-14 ZA ZA200308895A patent/ZA200308895B/en unknown
- 2003-12-08 IL IL159239A patent/IL159239A/en active IP Right Grant
- 2003-12-17 BG BG108462A patent/BG66398B1/bg unknown
- 2003-12-17 NO NO20035633A patent/NO328154B1/no not_active IP Right Cessation
- 2003-12-23 CO CO03112174A patent/CO5650166A2/es active IP Right Grant
- 2003-12-24 EC EC2003004927A patent/ECSP034927A/es unknown
2006
- 2006-03-09 UA UAA200602562A patent/UA86031C2/ru unknown
2007
- 2007-06-21 CY CY20071100822T patent/CY1107681T1/el unknown
2008
- 2008-04-08 AU AU2008201565A patent/AU2008201565B2/en not_active Expired
2009
- 2009-10-13 JP JP2009236400A patent/JP2010043116A/ja active Pending
2013
- 2013-05-07 BG BG10111461A patent/BG111461A/en unknown

Also Published As

Publication number	Publication date
CN1520413A (zh)	2004-08-11
BR0210664B1 (pt)	2013-12-03
KR100886342B1 (ko)	2009-03-03
EP1404673B1 (de)	2005-05-04
BR0210664A (pt)	2004-08-10
HRP20031085A2 (en)	2004-04-30
KR100866272B1 (ko)	2008-11-03
EP1808435A1 (de)	2007-07-18
EE200400045A (et)	2004-04-15
BG66398B1 (bg)	2013-12-31
HU230036B1 (hu)	2015-05-28
EA006393B1 (ru)	2005-12-29
SI1475379T1 (sl)	2007-08-31
CA2451573A1 (en)	2003-01-09
UA86031C2 (ru)	2009-03-25
EP1404673A1 (de)	2004-04-07
HK1068613A1 (en)	2005-04-29
CZ2004149A3 (cs)	2004-05-12
EP1475379B1 (de)	2007-04-11
CN1982309B (zh)	2010-06-09
KR20040023631A (ko)	2004-03-18
PT1475379E (pt)	2007-05-31
HUP0400332A2 (hu)	2004-08-30
SA02230194B1 (ar)	2008-03-08
US20030022917A1 (en)	2003-01-30
MXPA03011516A (es)	2004-03-18
EP1808435B1 (de)	2011-10-05
MY122932A (en)	2006-05-31
AU2008201565A1 (en)	2008-05-01
ATE359285T1 (de)	2007-05-15
US6610849B2 (en)	2003-08-26
WO2003002562A1 (de)	2003-01-09
EE05403B1 (et)	2011-04-15
TW574220B (en)	2004-02-01
MEP42608A (en)	2011-02-10
UA76761C2 (uk)	2006-09-15
DE50209948D1 (de)	2007-05-24
ATE294801T1 (de)	2005-05-15
PE20030123A1 (es)	2003-03-31
AU2002257820B2 (en)	2008-05-08
ATE527257T1 (de)	2011-10-15
ECSP034927A (es)	2004-02-26
SI1404673T1 (sl)	2005-10-31
CA2451573C (en)	2010-09-21
KR20030078793A (ko)	2003-10-08
HK1103404A1 (zh)	2007-12-21
EA200501081A1 (ru)	2006-06-30
AR039056A1 (es)	2005-02-09
DK1475379T3 (da)	2007-09-03
DK1404673T3 (da)	2005-06-13
CY1107681T1 (el)	2013-04-18
IL159239A0 (en)	2004-06-01
EG23203A (en)	2004-07-31
DK1808435T3 (da)	2012-01-16
EA009808B1 (ru)	2008-04-28
JP2010043116A (ja)	2010-02-25
CN1982309A (zh)	2007-06-20
ES2285318T3 (es)	2007-11-16
PT1404673E (pt)	2005-07-29
PL209520B1 (pl)	2011-09-30
CO5650166A2 (es)	2006-06-30
CN1288154C (zh)	2006-12-06
SK288022B6 (sk)	2012-12-03
AU2008201565B2 (en)	2012-03-01
EP1475379A1 (de)	2004-11-10
PL366942A1 (en)	2005-02-07
NO328154B1 (no)	2009-12-21
NO20035633D0 (no)	2003-12-17
SK662004A3 (en)	2004-06-08
BG111461A (en)	2013-08-30
HU230379B1 (hu)	2016-03-29
ZA200308895B (en)	2004-06-09
NZ530770A (en)	2005-11-25
HUP0400332A3 (en)	2007-06-28
BG108462A (bg)	2005-01-31
IL159239A (en)	2010-05-17
ES2242022T3 (es)	2005-11-01
EA200301292A1 (ru)	2004-06-24
RS50436B (sr)	2009-12-31
NZ541395A (en)	2007-03-30
DE50203015D1 (de)	2005-06-09
JP4485192B2 (ja)	2010-06-16
HRP20031085B1 (en)	2011-12-31
ES2374981T3 (es)	2012-02-23
JP2004536830A (ja)	2004-12-09
CZ296187B6 (cs)	2006-01-11
KR100530661B1 (ko)	2005-11-22
HRP20090110A2 (en)	2009-04-30
KR20080065313A (ko)	2008-07-11

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