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BR0210664A - Processo de sìntese técnico para produção de tropenol - Google Patents

Processo de sìntese técnico para produção de tropenol

Info

Publication number
BR0210664A
BR0210664A BR0210664-7A BR0210664A BR0210664A BR 0210664 A BR0210664 A BR 0210664A BR 0210664 A BR0210664 A BR 0210664A BR 0210664 A BR0210664 A BR 0210664A
Authority
BR
Brazil
Prior art keywords
production
synthesis process
trophenol
technical synthesis
tropenol
Prior art date
Application number
BR0210664-7A
Other languages
English (en)
Other versions
BR0210664B1 (pt
Inventor
Armin Walter Rapp
Rainer Sobotta
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0210664(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of BR0210664A publication Critical patent/BR0210664A/pt
Publication of BR0210664B1 publication Critical patent/BR0210664B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Lock And Its Accessories (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Catalysts (AREA)

Abstract

"PROCESSO DE SìNTESE TéCNICO PARA PRODUçãO DE TROPENOL". A invenção refere-se a um novo processo de produção tecnicamente aplicável, para a preparação de tropenol, opcionalmente na forma de seus sais de adição ácidos.
BRPI0210664-7B1A 2001-06-28 2002-06-08 Processo para a produção de tropenol BR0210664B1 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10131200 2001-06-28
PCT/EP2002/006290 WO2003002562A1 (de) 2001-06-28 2002-06-08 Technische syntheseverfahren zur herstellung von tropenol

Publications (2)

Publication Number Publication Date
BR0210664A true BR0210664A (pt) 2004-08-10
BR0210664B1 BR0210664B1 (pt) 2013-12-03

Family

ID=7689774

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0210664-7B1A BR0210664B1 (pt) 2001-06-28 2002-06-08 Processo para a produção de tropenol

Country Status (40)

Country Link
US (1) US6610849B2 (pt)
EP (3) EP1808435B1 (pt)
JP (2) JP4485192B2 (pt)
KR (3) KR100866272B1 (pt)
CN (2) CN1288154C (pt)
AR (1) AR039056A1 (pt)
AT (3) ATE294801T1 (pt)
AU (2) AU2002257820B2 (pt)
BG (2) BG66398B1 (pt)
BR (1) BR0210664B1 (pt)
CA (1) CA2451573C (pt)
CO (1) CO5650166A2 (pt)
CY (1) CY1107681T1 (pt)
CZ (1) CZ296187B6 (pt)
DE (2) DE50203015D1 (pt)
DK (3) DK1404673T3 (pt)
EA (2) EA006393B1 (pt)
EC (1) ECSP034927A (pt)
EE (1) EE05403B1 (pt)
EG (1) EG23203A (pt)
ES (3) ES2285318T3 (pt)
HR (2) HRP20090110A2 (pt)
HU (2) HU230036B1 (pt)
IL (2) IL159239A0 (pt)
ME (1) MEP42608A (pt)
MX (1) MXPA03011516A (pt)
MY (1) MY122932A (pt)
NO (1) NO328154B1 (pt)
NZ (2) NZ541395A (pt)
PE (1) PE20030123A1 (pt)
PL (1) PL209520B1 (pt)
PT (2) PT1475379E (pt)
RS (1) RS50436B (pt)
SA (1) SA02230194B1 (pt)
SI (2) SI1404673T1 (pt)
SK (1) SK288022B6 (pt)
TW (1) TW574220B (pt)
UA (2) UA76761C2 (pt)
WO (1) WO2003002562A1 (pt)
ZA (1) ZA200308895B (pt)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) * 2002-05-31 2004-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Industrial process for preparing tropenol
US20090162562A1 (en) * 2007-12-24 2009-06-25 Bangalore Aswatha Nagaraj Methods for Applying Thermal Barrier Coating Systems
PT2240477E (pt) * 2008-01-10 2014-11-19 Generics Uk Ltd Um novo processo para a preparação de ésteres de escopina
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
NZ597920A (en) 2009-08-07 2014-05-30 Generics Uk Ltd Anhydrate of tiotropium bromide
CN102351856B (zh) * 2011-08-24 2013-05-01 商丘市韶华药业有限公司 一种α-托品醇的纯化方法
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
PT2607351T (pt) * 2011-12-22 2017-05-26 Cerbios-Pharma S A Processo contínuo para a alquilação de aminas terciárias cíclicas
CN113292574B (zh) * 2020-02-21 2022-05-03 四川大学 一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) * 2020-04-13 2021-09-21 石家庄四药有限公司 异丙托溴铵的合成方法
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法
CN115925534B (zh) * 2023-01-03 2025-03-07 绍兴民生医药股份有限公司 高纯度托品酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
NZ284075A (en) * 1994-04-19 1998-01-26 Neurosearch As Tropane-2-aldoxine derivatives; neurotransmitter re-uptake inhibiting medicaments
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

Also Published As

Publication number Publication date
CN1520413A (zh) 2004-08-11
BR0210664B1 (pt) 2013-12-03
KR100886342B1 (ko) 2009-03-03
EP1404673B1 (de) 2005-05-04
HRP20031085A2 (en) 2004-04-30
KR100866272B1 (ko) 2008-11-03
EP1808435A1 (de) 2007-07-18
EE200400045A (et) 2004-04-15
BG66398B1 (bg) 2013-12-31
HU230036B1 (hu) 2015-05-28
EA006393B1 (ru) 2005-12-29
SI1475379T1 (sl) 2007-08-31
CA2451573A1 (en) 2003-01-09
UA86031C2 (ru) 2009-03-25
EP1404673A1 (de) 2004-04-07
HK1068613A1 (en) 2005-04-29
CZ2004149A3 (cs) 2004-05-12
EP1475379B1 (de) 2007-04-11
CN1982309B (zh) 2010-06-09
KR20040023631A (ko) 2004-03-18
PT1475379E (pt) 2007-05-31
HUP0400332A2 (hu) 2004-08-30
SA02230194B1 (ar) 2008-03-08
US20030022917A1 (en) 2003-01-30
MXPA03011516A (es) 2004-03-18
EP1808435B1 (de) 2011-10-05
MY122932A (en) 2006-05-31
AU2008201565A1 (en) 2008-05-01
ATE359285T1 (de) 2007-05-15
US6610849B2 (en) 2003-08-26
WO2003002562A1 (de) 2003-01-09
EE05403B1 (et) 2011-04-15
TW574220B (en) 2004-02-01
MEP42608A (en) 2011-02-10
UA76761C2 (uk) 2006-09-15
DE50209948D1 (de) 2007-05-24
ATE294801T1 (de) 2005-05-15
PE20030123A1 (es) 2003-03-31
AU2002257820B2 (en) 2008-05-08
ATE527257T1 (de) 2011-10-15
ECSP034927A (es) 2004-02-26
SI1404673T1 (sl) 2005-10-31
CA2451573C (en) 2010-09-21
KR20030078793A (ko) 2003-10-08
HK1103404A1 (zh) 2007-12-21
EA200501081A1 (ru) 2006-06-30
AR039056A1 (es) 2005-02-09
DK1475379T3 (da) 2007-09-03
DK1404673T3 (da) 2005-06-13
CY1107681T1 (el) 2013-04-18
IL159239A0 (en) 2004-06-01
EG23203A (en) 2004-07-31
DK1808435T3 (da) 2012-01-16
EA009808B1 (ru) 2008-04-28
JP2010043116A (ja) 2010-02-25
CN1982309A (zh) 2007-06-20
ES2285318T3 (es) 2007-11-16
PT1404673E (pt) 2005-07-29
PL209520B1 (pl) 2011-09-30
CO5650166A2 (es) 2006-06-30
CN1288154C (zh) 2006-12-06
SK288022B6 (sk) 2012-12-03
AU2008201565B2 (en) 2012-03-01
EP1475379A1 (de) 2004-11-10
PL366942A1 (en) 2005-02-07
NO328154B1 (no) 2009-12-21
NO20035633D0 (no) 2003-12-17
SK662004A3 (en) 2004-06-08
BG111461A (en) 2013-08-30
HU230379B1 (hu) 2016-03-29
YU101103A (en) 2006-05-25
ZA200308895B (en) 2004-06-09
NZ530770A (en) 2005-11-25
HUP0400332A3 (en) 2007-06-28
BG108462A (bg) 2005-01-31
IL159239A (en) 2010-05-17
ES2242022T3 (es) 2005-11-01
EA200301292A1 (ru) 2004-06-24
RS50436B (sr) 2009-12-31
NZ541395A (en) 2007-03-30
DE50203015D1 (de) 2005-06-09
JP4485192B2 (ja) 2010-06-16
HRP20031085B1 (en) 2011-12-31
ES2374981T3 (es) 2012-02-23
JP2004536830A (ja) 2004-12-09
CZ296187B6 (cs) 2006-01-11
KR100530661B1 (ko) 2005-11-22
HRP20090110A2 (en) 2009-04-30
KR20080065313A (ko) 2008-07-11

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B15K Others concerning applications: alteration of classification

Free format text: ALTERADA DA INT. CL. C07D 451/10, C07D 451/02, C07D 471/08.

Ipc: C07D 451/10 (2006.01), C07D 451/02 (2006.01), C07D

B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07G Grant request does not fulfill article 229-c lpi (prior consent of anvisa) [chapter 7.7 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 03/12/2013, OBSERVADAS AS CONDICOES LEGAIS.