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PE20030123A1 - Procedimiento de sintesis tecnico para la preparacion de tropenol - Google Patents

Procedimiento de sintesis tecnico para la preparacion de tropenol

Info

Publication number
PE20030123A1
PE20030123A1 PE2002000553A PE2002000553A PE20030123A1 PE 20030123 A1 PE20030123 A1 PE 20030123A1 PE 2002000553 A PE2002000553 A PE 2002000553A PE 2002000553 A PE2002000553 A PE 2002000553A PE 20030123 A1 PE20030123 A1 PE 20030123A1
Authority
PE
Peru
Prior art keywords
tropenol
preparation
synthesis procedure
cubr2
formula
Prior art date
Application number
PE2002000553A
Other languages
English (en)
Inventor
Rainer Sobotta
Armin Rapp
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7689774&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20030123(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of PE20030123A1 publication Critical patent/PE20030123A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Lock And Its Accessories (AREA)
  • Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION DE TROPENOL DE FORMULA I EVENTUALMENTE EN FORMA DE SUS SALES POR ADICION DE ACIDOS CARACTERIZADO PORQUE ESTERES ESCOPINICOS DE FORMULA II, DONDE R ES ALQUILO C1-C4, ALQUILEN C1-C4-FENILO OPCIONALMENTE SUSTITUIDOS CON HIDROXI, ALCOXI C1-C4 SE REDUCEN EN UN DISOLVENTE EN PRESENCIA DE ZINC, SALES METALICAS ACTIVANTES (FeCl3, CuCl2, CuI2, CuBr2, COMPLEJO CuBr2-SULFURO DE DIMETILO, SE SAPONIFICA UTILIZANDO BASES ADECUADAS. EL COMPUESTO PUEDE SER UTIL PARA LA PRERARACION DE BROMURO DE TIOTROPIO, BROMURO DE IPRATROPIO
PE2002000553A 2001-06-28 2002-06-25 Procedimiento de sintesis tecnico para la preparacion de tropenol PE20030123A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10131200 2001-06-28

Publications (1)

Publication Number Publication Date
PE20030123A1 true PE20030123A1 (es) 2003-03-31

Family

ID=7689774

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000553A PE20030123A1 (es) 2001-06-28 2002-06-25 Procedimiento de sintesis tecnico para la preparacion de tropenol

Country Status (40)

Country Link
US (1) US6610849B2 (es)
EP (3) EP1475379B1 (es)
JP (2) JP4485192B2 (es)
KR (3) KR100886342B1 (es)
CN (2) CN1288154C (es)
AR (1) AR039056A1 (es)
AT (3) ATE527257T1 (es)
AU (2) AU2002257820B2 (es)
BG (2) BG66398B1 (es)
BR (1) BR0210664B1 (es)
CA (1) CA2451573C (es)
CO (1) CO5650166A2 (es)
CY (1) CY1107681T1 (es)
CZ (1) CZ296187B6 (es)
DE (2) DE50203015D1 (es)
DK (3) DK1475379T3 (es)
EA (2) EA006393B1 (es)
EC (1) ECSP034927A (es)
EE (1) EE05403B1 (es)
EG (1) EG23203A (es)
ES (3) ES2242022T3 (es)
HR (2) HRP20031085B1 (es)
HU (2) HU230036B1 (es)
IL (2) IL159239A0 (es)
ME (1) MEP42608A (es)
MX (1) MXPA03011516A (es)
MY (1) MY122932A (es)
NO (1) NO328154B1 (es)
NZ (2) NZ541395A (es)
PE (1) PE20030123A1 (es)
PL (1) PL209520B1 (es)
PT (2) PT1404673E (es)
RS (1) RS50436B (es)
SA (1) SA02230194B1 (es)
SI (2) SI1475379T1 (es)
SK (1) SK288022B6 (es)
TW (1) TW574220B (es)
UA (2) UA76761C2 (es)
WO (1) WO2003002562A1 (es)
ZA (1) ZA200308895B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
US6747153B2 (en) * 2002-05-31 2004-06-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg Industrial process for preparing tropenol
US20090162562A1 (en) * 2007-12-24 2009-06-25 Bangalore Aswatha Nagaraj Methods for Applying Thermal Barrier Coating Systems
SI2240477T1 (sl) * 2008-01-10 2015-02-27 Generics (Uk) Limited Nov postopek za pripravo estrov skopina
WO2011015884A1 (en) 2009-08-07 2011-02-10 Generics [Uk] Limited Process to prepare scopine esters
US8697719B2 (en) 2009-08-07 2014-04-15 Generics [Uk] Limited Anhydrate of tiotropium bromide
CN102351856B (zh) * 2011-08-24 2013-05-01 商丘市韶华药业有限公司 一种α-托品醇的纯化方法
ITRM20110508A1 (it) 2011-09-27 2013-03-28 Lusochimica Spa Processo per la preparazione degli esteri della scopina.
LT2607351T (lt) * 2011-12-22 2017-06-12 Cerbios-Pharma S.A. Ciklinių tretinių aminų nepertraukiamo alkilinimo būdas
CN113292574B (zh) * 2020-02-21 2022-05-03 四川大学 一类手性多环的托品烷化合物及其制备方法和用途
CN111269226B (zh) * 2020-04-13 2021-09-21 石家庄四药有限公司 异丙托溴铵的合成方法
CN113264929B (zh) * 2021-05-02 2023-10-10 润生药业有限公司 一种噻托溴铵的制备方法
CN115925534B (zh) * 2023-01-03 2025-03-07 绍兴民生医药股份有限公司 高纯度托品酸的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3931041C2 (de) * 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
UA49801C2 (uk) * 1994-04-19 2002-10-15 Нейросерч А/С Похідні тропан-2-альдоксиму, спосіб їх отримання, фармацевтична композиція, спосіб лікування
DE19515625C2 (de) * 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern

Also Published As

Publication number Publication date
EP1475379A1 (de) 2004-11-10
SI1475379T1 (sl) 2007-08-31
CZ2004149A3 (cs) 2004-05-12
NO328154B1 (no) 2009-12-21
EP1404673B1 (de) 2005-05-04
SI1404673T1 (sl) 2005-10-31
NZ530770A (en) 2005-11-25
CN1288154C (zh) 2006-12-06
PL209520B1 (pl) 2011-09-30
DE50203015D1 (de) 2005-06-09
CN1982309B (zh) 2010-06-09
AR039056A1 (es) 2005-02-09
KR20030078793A (ko) 2003-10-08
JP2010043116A (ja) 2010-02-25
PL366942A1 (en) 2005-02-07
UA76761C2 (uk) 2006-09-15
EA200501081A1 (ru) 2006-06-30
HK1068613A1 (en) 2005-04-29
DK1475379T3 (da) 2007-09-03
CN1982309A (zh) 2007-06-20
EP1808435B1 (de) 2011-10-05
TW574220B (en) 2004-02-01
MEP42608A (en) 2011-02-10
SA02230194B1 (ar) 2008-03-08
US20030022917A1 (en) 2003-01-30
CA2451573A1 (en) 2003-01-09
BR0210664B1 (pt) 2013-12-03
JP4485192B2 (ja) 2010-06-16
EA006393B1 (ru) 2005-12-29
EA200301292A1 (ru) 2004-06-24
ZA200308895B (en) 2004-06-09
SK662004A3 (en) 2004-06-08
EE05403B1 (et) 2011-04-15
EA009808B1 (ru) 2008-04-28
CO5650166A2 (es) 2006-06-30
KR100886342B1 (ko) 2009-03-03
IL159239A (en) 2010-05-17
KR20080065313A (ko) 2008-07-11
PT1475379E (pt) 2007-05-31
HRP20031085B1 (en) 2011-12-31
ES2285318T3 (es) 2007-11-16
ES2374981T3 (es) 2012-02-23
EG23203A (en) 2004-07-31
EE200400045A (et) 2004-04-15
DK1808435T3 (da) 2012-01-16
ATE527257T1 (de) 2011-10-15
ECSP034927A (es) 2004-02-26
EP1404673A1 (de) 2004-04-07
CA2451573C (en) 2010-09-21
PT1404673E (pt) 2005-07-29
JP2004536830A (ja) 2004-12-09
SK288022B6 (sk) 2012-12-03
US6610849B2 (en) 2003-08-26
IL159239A0 (en) 2004-06-01
YU101103A (en) 2006-05-25
BG66398B1 (bg) 2013-12-31
HRP20031085A2 (en) 2004-04-30
HRP20090110A2 (en) 2009-04-30
BG111461A (en) 2013-08-30
HUP0400332A2 (hu) 2004-08-30
AU2008201565B2 (en) 2012-03-01
MY122932A (en) 2006-05-31
NZ541395A (en) 2007-03-30
RS50436B (sr) 2009-12-31
CZ296187B6 (cs) 2006-01-11
HU230379B1 (hu) 2016-03-29
AU2002257820B2 (en) 2008-05-08
DE50209948D1 (de) 2007-05-24
HUP0400332A3 (en) 2007-06-28
ATE359285T1 (de) 2007-05-15
BG108462A (bg) 2005-01-31
WO2003002562A1 (de) 2003-01-09
BR0210664A (pt) 2004-08-10
ES2242022T3 (es) 2005-11-01
AU2008201565A1 (en) 2008-05-01
HK1103404A1 (zh) 2007-12-21
KR100866272B1 (ko) 2008-11-03
HU230036B1 (hu) 2015-05-28
KR20040023631A (ko) 2004-03-18
DK1404673T3 (da) 2005-06-13
CY1107681T1 (el) 2013-04-18
KR100530661B1 (ko) 2005-11-22
MXPA03011516A (es) 2004-03-18
UA86031C2 (ru) 2009-03-25
EP1808435A1 (de) 2007-07-18
CN1520413A (zh) 2004-08-11
EP1475379B1 (de) 2007-04-11
NO20035633D0 (no) 2003-12-17
ATE294801T1 (de) 2005-05-15

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