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WO2017020279A1 - 包含头花蓼和黄连的组合物在制备抗幽门螺旋杆菌的药物中的用途 - Google Patents

包含头花蓼和黄连的组合物在制备抗幽门螺旋杆菌的药物中的用途 Download PDF

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Publication number
WO2017020279A1
WO2017020279A1 PCT/CN2015/086156 CN2015086156W WO2017020279A1 WO 2017020279 A1 WO2017020279 A1 WO 2017020279A1 CN 2015086156 W CN2015086156 W CN 2015086156W WO 2017020279 A1 WO2017020279 A1 WO 2017020279A1
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WIPO (PCT)
Prior art keywords
medicine
drug
phlegm
berberine
flower bud
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/CN2015/086156
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English (en)
French (fr)
Inventor
王子厚
周益成
张姝
丁莉梅
胡伏莲
罗昭逊
莫非
张丽艳
张淑华
金鑫
李正亮
周宏艳
何云
马领弟
郑伟霞
朱晓龙
赵书琴
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhejiang Zhongkang Pharmaceutical Co Ltd
Original Assignee
Zhejiang Zhongkang Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhejiang Zhongkang Pharmaceutical Co Ltd filed Critical Zhejiang Zhongkang Pharmaceutical Co Ltd
Priority to PCT/CN2015/086156 priority Critical patent/WO2017020279A1/zh
Priority to PCT/CN2016/093626 priority patent/WO2017020861A1/zh
Publication of WO2017020279A1 publication Critical patent/WO2017020279A1/zh
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704Polygonum, e.g. knotweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/718Coptis (goldthread)
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Definitions

  • the invention belongs to the field of traditional Chinese medicine, and particularly relates to a pharmaceutical composition comprising a flower bud and a berberine, and the use thereof for preparing an antibacterial, in particular, a medicament against Helicobacter pylori.
  • the head flower bud is the dry whole grass or aboveground part of the Polygonum capitatum Buch.-Ham.ex D.Don. It is a commonly used medicine in China's private and especially ethnic minority areas.
  • the head flower is sweet, spicy and cool; it has the functions of clearing away heat and dampness, detoxification and relieving pain, and blood stasis, diuretic and drenching.
  • pharmacological studies have shown that the head flower bud has a wide range of pharmacological activities, including analgesic, cooling, diuretic, anti-inflammatory, antibacterial and the like.
  • H.pylori H.p or HP in this context
  • HP infection is an important cause of a variety of chronic stomach diseases such as peptic ulcer, gastritis, and gastric cancer.
  • PPI proton pump inhibitor
  • expectorant the eradication rate is 90%.
  • these drug eradication programs have problems of toxic side effects, easy secondary resistance, double infection, and patient dependence.
  • H.pylori is a damp-heat and detoxification, which belongs to the category of "evil gas". It is difficult for a single Chinese medicine to cope with the complex and changeable condition of the disease. The role of the symptoms.
  • the invention is based on the single-flavored medicine of the head flower, and the other Chinese medicine is used to form the head flower bud composition, which improves the anti-Hp activity and has a good antibacterial effect on the gram-resistant bacteria, especially the methicillin-resistant epidermis.
  • Staphylococcus methicillin-sensitive Staphylococcus aureus, methicillin-resistant Staphylococcus aureus.
  • the addition of heat-clearing and detoxifying, tonic, diuresis, qi, blood circulation, dehumidification, phlegm, blood circulation, warming, dispelling cold, digestion can reduce the adverse reactions of single-flavor drugs.
  • the use of the pharmaceutical composition of the present invention in the preparation of a medicament for anti-Helicobacter pylori has not been reported.
  • It is an object of the present invention to provide a pharmaceutical composition comprising a flower bud, a berberine, and a composition for the preparation of a medicament for the effective antibacterial, in particular inhibition of Helicobacter pylori.
  • a first aspect of the present invention provides a pharmaceutical composition, characterized in that the composition comprises a head flower bud and a berberine.
  • Preferred compositions include 20-60 parts by weight of the head flower and 2-6 parts by weight of the berberine.
  • the composition consists of the head bud, berberine, and a composition selected from any one or more of the following: (1) a heat-clearing drug; (2) a tonic drug; (3) Lishui osmotic medicine; (4) qi medicine; (5) phlegm; (6) blood circulation phlegm; (7) cooling blood hemostasis; (8) phlegm and blood stasis; (9) Wenyang Dispel cold medicine; (10) digestion medicine; (11) solution medicine.
  • the present invention also provides a process for the preparation of the above pharmaceutical composition extract.
  • the present invention also discloses formulations containing a pharmaceutical composition which is formulated with a pharmaceutically acceptable excipient into a pharmaceutically acceptable oral formulation.
  • the oral preparation is selected from various available regular release preparations and sustained release preparations.
  • the sustained-release preparation is selected from the group consisting of a skeleton type, a membrane-controlled type, an osmotic pump type, and a gastric retention type sustained-release preparation.
  • the gastric retention type sustained release preparation is preferably a gastric floating agent.
  • the invention also discloses the use of any one of the pharmaceutical compositions of the invention in the preparation of an antibacterial drug.
  • the pathogen is selected from the group consisting of Gram-positive methicillin-resistant Staphylococcus aureus S. aureus (Methicllin-resistant, MRSA), methicillin-sensitive Staphylococcus aureus S. aureus (Methicin-suseptable), methoxy Stalinococcus epidermidis (MRSE), methicillin-sensitive Staphylococcus epidermidis (MSSE), also selected from Gram-negative Escherichia coli, Eco + , large intestine H. (non-ESBLS) Escherichia Coli, Eco - , Klebsiella Klebsiella (ESBLs) K. penumonia, KPN + , Klebsiella pneumoniae (non-ESBLs) K. penumonia, Pseudomonas aeruginosa (PAE).
  • MRSA methicillin-resistant Staphylococcus aureus
  • MRSA methicillin-sensitive Staphylococcus au
  • the invention also discloses the use of any one of the pharmaceutical compositions of the invention in the preparation of a medicament for preventing/treating Helicobacter pylori.
  • the present invention provides a novel pharmaceutical composition
  • a novel pharmaceutical composition comprising a head flower bud and a berberine.
  • Preferred compositions include 20-60 parts by weight of the head flower and 2-6 parts by weight of the berberine.
  • the composition consists of a flower bud, a berberine, and a composition selected from any one or more of the following: (1) a heat-clearing drug; (2) a tonic drug; 3) Lishui osmotic medicine; (4) qi medicine; (5) phlegm; (6) blood circulation phlegm; (7) cooling blood hemostasis; (8) phlegm and blood stasis; (9) temperature Yang disperse cold medicine; (10) digestion medicine; (11) solution medicine.
  • the heat-clearing medicine according to the present invention includes, but is not limited to, dandelion, andrographis, scutellaria, phellodendron, radix isatidis, sorghum, honeysuckle, Qinpi, nasturtium, yarrow, purple diced, peony bark, eucalyptus honey, water Tuanhua, medlar, Hedyotis diffusa, Scutellaria barbata, Radix Rehmanniae, Brucea javanica, Dalbergia; but does not include head flower buds, berberine.
  • the tonic drugs according to the present invention include, but are not limited to, licorice, Codonopsis, Atractylodes, Radix Paeoniae Alba, jujube, ginseng, tea, astragalus, and huangjing.
  • the water-wetting agent according to the present invention includes, but is not limited to, cockroaches, knotweed, and earthworms.
  • the qi medicines of the present invention include, but are not limited to, dried tangerine peel, woody fragrant, citrus aurantium, fragrant sage, perilla stalk, August stalk, and earthworm mustard.
  • the sputum medicine according to the present invention includes, but is not limited to, schisandra, medlar, pomegranate peel, ebony, and jellyfish.
  • the blood-activating and stasis-removing medicines of the present invention include, but are not limited to, Yanhusuo, Sanqi, Danshen, Shijiantong, Yujin, and Rhubarb.
  • the cooling blood hemostasis of the present invention includes, but is not limited to, white and mantle.
  • the phlegm-relieving peony of the present invention includes, but is not limited to, Pinellia ternata, Magnolia officinalis, Sinensis, and Ginkgo.
  • the Wenyang cold medicine according to the present invention includes, but is not limited to, Wujing, Galang, Pepper, Dried Ginger, and Wild Ai.
  • the anti-drug medicine of the present invention includes, but is not limited to, garlic, hawthorn, and betel nut.
  • the solution according to the present invention includes, but is not limited to, cassia twig, ginger, perilla leaf, and Bupleurum.
  • Preferred heat-clearing agents are selected from the group consisting of dandelion, cork, and xanthine
  • Preferred tonics are selected from the group consisting of Astragalus, Atractylodes, Angelica, and Polygonatum.
  • the preferred water-wetting type is selected from the group consisting of knotweed and earthworm.
  • Preferred gas types are selected from the group consisting of woody, citrus, and fragrant.
  • the preferred collection is selected from the group consisting of sea bream and medlar.
  • the preferred blood circulation is selected from the group consisting of Corydalis, Salvia, and Panax notoginseng.
  • the preferred cooling blood hemostasis is selected from white and white.
  • the preferred phlegm-resolving hydrazine is selected from the group consisting of Pinellia ternata and Magnolia officinalis
  • the preferred warming and dispelling cold is selected from Wujing and Galangal.
  • a preferred digestion drug is selected from the group consisting of hawthorn.
  • a preferred solution is selected from the group consisting of cassia twig, Bupleurum, and ginger.
  • compositions of the invention are as follows:
  • composition consists of any of the above-mentioned eleven types of medicinal properties.
  • composition is selected from any of the following groups:
  • composition of 1.1 includes a head flower bud, a berberine, and a heat-clearing drug.
  • the composition of 1.2 includes a head flower bud, a berberine, and a tonic drug.
  • the composition of 1.3 includes a head flower bud, a berberine, and a water-wetting agent.
  • composition described in 1.4 includes a head flower bud, a berberine, and a qi medicine.
  • the composition of 1.5 includes a head flower bud, a berberine, and a sputum.
  • composition described in 1.6 includes a head flower bud, a berberine, a blood stasis medicine.
  • composition described in 1.7 includes a head flower bud, a berberine, and a cooling blood hemostatic drug.
  • composition of 1.8 includes a head flower bud, a berberine, and a phlegm-relieving peony.
  • composition described in 1.9 includes the head flower bud, the berberine, and the warming and dispelling cold medicine.
  • the composition of 1.10 includes a head flower bud, a berberine, and a digestive.
  • the composition according to 1.11 includes a head flower bud, a berberine, and a solution.
  • composition is composed of a medicinal composition of any one of the above-mentioned eleven types of medicinal properties:
  • compositions include cep, berberine, and heat-clearing drugs.
  • the composition includes a head flower bud, a berberine, and a heat-clearing drug other than the head flower bud and the berberine.
  • the composition comprises a head flower bud, a berberine and a flower selected from the group consisting of dandelion, andrographis paniculata, scutellaria, phellodendron, radix isatidis, barley, honeysuckle, genus, nasturtium, yarrow, sage, peony, eucalyptus a composition of water, flower, scorpion, Hedyotis diffusa, Scutellaria barbata, Radix Rehmanniae, Brucea javanica, Dalbergia, and various heat-clearing drugs,
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, and tonic.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, and leachhinol.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, and qi.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, and sputum.
  • compositions are selected from any of the following groups:
  • composition consists of any of the first class of drugs, such as the head flower bud, the berberine, and the eleventh class of drugs.
  • composition described in 2.1 includes a head flower bud, a berberine, a heat-clearing drug, and a tonic drug.
  • composition described in 2.2 includes a head flower bud, a berberine, a heat-clearing drug, and a water-wetting agent.
  • composition described in 2.3 includes a head flower bud, a coptis, a heat-clearing drug, and a qi medicine.
  • the composition described in 2.4 includes a head flower bud, a berberine, a heat-clearing drug, and a sputum drug.
  • the composition of 2.5 includes a head flower bud, a berberine, a heat-clearing drug, a blood stasis drug.
  • composition described in 2.6 includes a head flower bud, a berberine, a heat-clearing drug, and a cooling blood hemostatic drug.
  • composition described in 2.7 includes a head flower bud, a berberine, a heat-clearing drug, and a phlegm-dampening phlegm.
  • the composition described in 2.8 includes a flower bud, a berberine, a heat-clearing drug, and a warming and dispelling cold medicine.
  • the composition described in 2.9 includes a head flower bud, a berberine, a heat-clearing drug, and a digestive drug.
  • composition described in 2.10 includes a flower bud, a coptis, a heat-clearing drug, and a drug.
  • the composition according to 2.11 includes a head flower bud, a berberine, a tonic drug, and a water-wetting agent.
  • composition described in 2.12 includes a head flower bud, a berberine, a tonic drug, and a qi medicine.
  • the composition according to 2.13 includes a flower bud, a berberine, a tonic, and a sputum.
  • composition according to 2.14 includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine.
  • composition according to 2.15 includes a head flower bud, a berberine, a tonic medicine, and a cooling blood hemostasis.
  • composition according to 2.16 includes a head flower bud, a berberine, a tonic drug, and a phlegm and blood stasis drug.
  • composition described in 2.17 includes the head flower bud, the berberine, the tonic medicine, and the warming and dispelling medicine.
  • composition according to 2.18 includes a flower bud, a berberine, a tonic, and a digestive.
  • the composition according to 2.19 includes a head flower bud, a berberine, a tonic drug, and a solution.
  • the composition according to 2.20 includes a head flower bud, a berberine, a water permeable medicine, and a qi medicine.
  • the composition according to 2.21 includes a flower bud, a berberine, a leachate, and a sputum.
  • composition according to 2.22 includes a flower bud, a berberine, a leachhin, a blood stasis drug.
  • composition according to 2.23 includes a head flower bud, a berberine, a water-wetting agent, and a blood-suppressing hemostatic agent.
  • composition according to 2.24 includes a flower bud, a berberine, a leachhin, and a phlegm.
  • composition according to 2.25 includes a head flower bud, a berberine, a water permeable medicine, and a warming and dispelling medicine.
  • composition according to 2.26 includes a head flower bud, a berberine, a leachhin, and a digestive.
  • the composition according to 2.27 includes a head flower bud, a berberine, a water-wetting agent, and a solution.
  • composition according to 2.28 includes a head flower bud, a berberine, a qi medicine, and a sputum medicine.
  • composition according to 2.29 includes the head flower bud, the berberine, the qi medicine, the blood circulation phlegm medicine.
  • the composition according to 2.30 includes a head flower bud, a berberine, a qi medicine, and a cooling blood hemostatic medicine.
  • composition according to 2.31 includes a head flower bud, a berberine, a qi medicine, and a phlegm phlegm.
  • the composition according to 2.32 includes a head flower bud, a berberine, a qi medicine, and a warming and dispelling medicine.
  • the composition according to 2.33 includes a head flower bud, a berberine, a qi medicine, and a digestive medicine.
  • composition according to 2.34 includes a head flower bud, a berberine, a qi medicine, and a prescription drug.
  • the composition according to 2.35 includes a head flower bud, a berberine, a sputum medicine, a blood circulation phlegm medicine.
  • composition according to 2.36 includes the head flower bud, the berberine, the phlegm, and the cooling blood hemostasis.
  • composition according to 2.37 includes a flower bud, a berberine, a phlegm, and a phlegm.
  • the composition according to 2.38 includes a head flower bud, a berberine, a sputum medicine, and a warming and dispelling medicine.
  • the composition according to 2.39 includes a flower bud, a berberine, a sputum, and a digestive.
  • composition according to 2.40 includes a flower bud, a berberine, a sputum, and a remedy.
  • composition described in 2.41 includes a head flower bud, a berberine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • composition according to 2.42 includes a flower bud, a berberine, a blood stasis phlegm, and a phlegm phlegm.
  • the composition according to 2.43 includes a flower bud, a berberine, a blood stasis medicine, and a warming and dispelling medicine.
  • the composition according to 2.44 includes a head flower bud, a berberine, a blood stasis medicine, and a digestive medicine.
  • the composition according to 2.45 includes a flower bud, a berberine, a blood stasis drug, and a remedy drug.
  • composition according to 2.46 includes the head flower bud, the berberine, the cooling blood hemostasis, the phlegm and blood stasis medicine.
  • composition according to 2.47 includes a flower bud, a berberine, a blood-suppressing hemostatic agent, and a warming and dispelling cold medicine.
  • the composition according to 2.48 includes a head flower bud, a berberine, a cooling blood hemostatic drug, and a digestive drug.
  • the composition according to 2.49 includes a head flower bud, a berberine, a cooling blood hemostatic drug, and a solution.
  • the composition according to 2.50 includes a flower bud, a berberine, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition according to 2.51 includes a head flower bud, a berberine, a phlegm and blood stasis medicine, and a digestive medicine.
  • composition described in 2.52 includes a head flower bud, a berberine, a phlegm-dampening peony, and a remedy.
  • the composition described in 2.53 includes a head flower bud, a berberine, a warming and dispelling cold medicine, and a digestive medicine.
  • composition described in 2.54 includes the head flower bud, the berberine, the warming and dispelling cold medicine, and the solution medicine.
  • the composition of 2.55 includes a head flower bud, a coptis, an anti-drug, and a solution.
  • composition is composed of a medicinal composition of the first class of drugs, such as the first flower bud, the berberine, and the eleventh medicinal properties:
  • compositions include the head flower bud, berberine, tonic, and water-wetting.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, tonic, and qi.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, tonic, and expectorant.
  • compositions are selected from any of the following groups:
  • composition comprising the group of flower head, berberine, tonic, and warming cold medicine is selected from any one of the following groups:
  • composition comprising the group of flower head, berberine, tonic, and drug solution is selected from any one of the following groups:
  • compositions include scutellaria, berberine, lysine, and qi.
  • compositions are selected from any of the following groups:
  • compositions include scutellaria, berberine, lysine, and sputum.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, qi, and sputum.
  • compositions are selected from any of the following groups:
  • composition consists of the head flower bud, the berberine, and any of the above-mentioned eleven types of drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a water-wetting agent.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a qi medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a cooling blood hemostatic drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, and a solution.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a water-wetting drug, and a gas-making drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, and a phlegm-receiving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, and a blood-activating and stasis drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, and a solution.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a qi medicine, and a digestion drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a qi medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a phlegm-removing drug, and a blood-activating phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a phlegm-receiving drug, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a sputum medicinal agent, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum medicinal agent, and a digestive medicinal agent.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a blood-activating phlegm, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a blood stasis drug, and a digestion drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a blood stasis drug, and a drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a cooling blood hemostatic drug, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a cooling blood hemostasis, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a cooling blood hemostatic drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a cooling blood hemostatic drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, and a digestive medicinal.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a warming and dispelling cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a digestive drug, and a solution.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a qi medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a phlegm.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-sparing osmotic drug, a blood-activating phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, and a phlegm-dampening drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, and a solution.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, and a prescription drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a phlegm, and a phlegm.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic, a sputum, and a digestive.
  • the composition includes a head flower bud, a berberine, a tonic drug, a sputum drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a cooling blood hemostasis, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a cooling blood hemostatic drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm-dampening phlegm, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a phlegm and blood stasis drug, and a digestive drug.
  • the composition includes a flower bud, a berberine, a tonic, a phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a warming and dispelling medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a warming and dispelling medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a digestive drug, and a solution.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a blood stasis drug.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, and a blood-suppressing hemostatic agent.
  • the composition includes a flower bud, a berberine, a leachhin, a phlegm, and a phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-receiving medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a leachate, a phlegm, and a digestive.
  • the composition includes a flower bud, a berberine, a leachate, a phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a leachhin, a blood stasis drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood-stopping drug, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a cooling blood hemostatic drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood hemostatic drug, and a solution.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening medicinal herb, and a digestive medicinal agent.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, an anti-drug, and a solution.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a phlegm phlegm medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostatic medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm-dampening phlegm, and a warm-yang dispelling medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm and blood stasis medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a digestion medicine, and a prescription medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, and a phlegm.
  • the composition includes a head flower bud, a berberine, a phlegm, a blood circulation phlegm, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostatic medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostatic medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, and a phlegm medicine.
  • the composition includes a head flower bud, a berberine, a phlegm, a phlegm, and a digestive.
  • the composition includes a head flower bud, a berberine, a phlegm, a phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a phlegm, a warming and dispelling medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a sputum, a digestive, and a remedy.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a cooling blood hemostasis, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a phlegm dampness phlegm medicine, and a yang yang medicine.
  • the composition includes a flower bud, a berberine, a blood stasis phlegm, a phlegm phlegm, and a digestive.
  • the composition includes a flower bud, a berberine, a blood stasis phlegm, a phlegm phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a blood stasis drug, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a blood stasis, a digestive, and a remedy.
  • the composition includes a head flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a digestive medicinal.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostasis, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostasis, a warming and dispelling cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostatic drug, a digestive drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a phlegm and blood stasis medicine, a warming and dispelling medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a phlegm-dampening phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a phlegm-dampening peony, a digestive medicinal agent, and a remedy drug.
  • the composition includes a flower bud, a berberine, a yangyang cold medicine, a digestive medicine, and a remedy.
  • composition is composed of a medicinal composition of the head bud, berberine, and any of the above eleven types of medicinal properties:
  • compositions include head flower buds, berberine, tonic medicine, water osmotic drug, and qi medicine.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, tonic, diuretic, and phlegm.
  • compositions are selected from any of the following groups:
  • compositions include cep, berberine, tonic, qi, and phlegm.
  • compositions are selected from any of the following groups:
  • a preferred composition comprising a group of head flower buds, berberine, tonic medicine, Wenyang cold medicine, and a solution medicine is selected from any one of the following groups:
  • compositions include scutellaria, berberine, lysine, qi, and sputum.
  • compositions are selected from the group consisting of:
  • composition consists of the head flower bud, berberine, and any of the above four drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, and a qi medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a phlegm-receiving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a blood-activating and stasis drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a digestive drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, and a solution.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a qi medicine, and a sputum medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a qi medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a qi medicine, and a digestion drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a qi medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a sputum medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a sputum medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a phlegm-receiving drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a sputum drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a sputum drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a blood-activating phlegm, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a blood-activating phlegm, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a blood stasis drug, and a drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a blood-suppressing hemostatic drug, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a cooling blood hemostasis, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a phlegm-dampening phlegm medicine, and a digestive medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a coptis, a heat-clearing drug, a tonic drug, a digestion drug, and a drug solution.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a qi medicine, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a gas-making drug, and a digestion drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, a blood-activating phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a phlegm-receiving drug, and a digestive drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a water-wetting drug, a phlegm-receiving drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a water-wetting drug, a blood-activating phlegm medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a blood-activating phlegm, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a blood-activating phlegm drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a blood-activating phlegm drug, and a food-eliminating drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a water-wetting drug, a blood-activating phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a cooling blood-stopping drug, and a warm-yang dispersing drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a water-wetting drug, a cooling blood-stopping drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a cooling blood-stopping drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a phlegm-dampening phlegm, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-dampening phlegm, and a food-eliminating drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a warm-yang dispersing drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a warm-yang dispersing drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting agent, a digestion-eliminating drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a sputum medicine, and a Wenyang cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine, and a phlegm-dampening phlegm medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a cooling blood hemostasis, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a cooling blood hemostasis, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm-dampening phlegm medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a qi medicine, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a qi medicine, a digestion drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicinal medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicinal medicine, a blood circulation phlegm medicine, and a phlegm-dampening phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum medicinal herb, a blood-activating phlegm drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a cooling blood hemostatic medicine, and a phlegm-dampening phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a cooling blood hemostasis medicine, and a warm-yang cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-receiving medicinal herb, a phlegm-dampening phlegm drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum medicinal herb, a phlegm-dampening phlegm drug, and a digestive medicinal drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a sputum medicinal herb, a phlegm-dampening phlegm drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a sputum medicinal agent, a warming and dispelling cold medicine, and a digestive medicinal agent.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a sputum medicine, a Wenyang cold medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a sputum medicinal drug, a digestive medicinal drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a phlegm-dampening phlegm medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a blood-activating phlegm, a cooling blood-stopping drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a blood stasis drug, a phlegm-dampening phlegm drug, and a digestion drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a blood stasis drug, a phlegm-dampening phlegm drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a blood-activating phlegm medicine, a warm-yang dispersing medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a blood stasis drug, a digestion drug, and a drug solution.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a cooling blood stopping medicine, a phlegm-dampening phlegm medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a cooling blood hemostasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a cooling blood-stopping drug, a warm-yang dispersing drug, and a solution-solving drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a cooling blood hemostatic drug, a digestive drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, a warming and dispelling cold medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a warming and dispelling cold medicine, a digestive medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, and a blood-suppressing medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a sputum medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a phlegm-receiving medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a leachhin, a phlegm, and a phlegm.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a sputum medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a phlegm drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a sputum drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a blood-activating phlegm medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a blood-activating phlegm, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a blood-activating phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-sparing osmotic drug, a blood-activating phlegm drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a blood-activating phlegm, and a solution.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a cooling blood hemostatic drug, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a phlegm-dampening phlegm, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a phlegm-dampening phlegm, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a digestive drug, and a solution.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a phlegm medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, and a warming medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a cooling blood hemostasis, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a cooling blood hemostasis, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a phlegm and blood stasis medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a qi medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a qi medicine, a digestion drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a phlegm phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a warm and yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a cooling blood hemostatic medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a cooling blood hemostatic medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm medicine, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a flower bud, a berberine, a tonic, a phlegm, a phlegm, and a digestive.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm, a phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic drug, a sputum medicinal agent, a warming and dispelling medicinal agent, and a digestive medicinal agent.
  • the composition includes a head flower bud, a berberine, a tonic drug, a sputum medicinal agent, a warming and dispelling cold medicine, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic drug, a sputum drug, a digestive drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a phlegm dampness phlegm medicine, and a yang yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine, a phlegm and blood stasis medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood stasis medicine, a phlegm phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a yangyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a blood circulation phlegm medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a flower bud, a berberine, a tonic, a blood stasis, a digestive, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a cooling blood hemostasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a cooling blood hemostasis, a warming and dispelling cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a cooling blood hemostasis, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm-dampening phlegm, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a phlegm-dampening phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic drug, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic drug, a warming and dispelling medicine, a digestion drug, and a solution.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a qi medicine, a sputum medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, a phlegm medicine, and a phlegm phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, and a phlegm phlegm medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a cooling blood hemostasis, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a phlegm phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a qi medicine, a digestion medicine, and a solution medicine.
  • the composition includes a flower bud, a berberine, a leachhin, a phlegm, a blood stasis, a blood stasis and a hemostatic.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a blood stasis, a phlegm and blood stasis.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-removing medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a leachate, a phlegm, a blood stasis, and a digestive.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a blood stasis, and a remedy.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a blood stasis, a phlegm and blood stasis.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-receiving medicine, a cooling blood-stopping medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-receiving medicine, a cooling blood-stopping medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a leachhin, a phlegm, a phlegm, a phlegm and a phlegm.
  • the composition includes a flower bud, a berberine, a leachhin, a phlegm, a phlegm, and a digestive.
  • the composition includes a head flower bud, a berberine, a leachhin, a phlegm, a phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a leachhin, a sputum, a stagnation, a stagnation, and a digestive.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-receiving agent, a warm-yang dispersing medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a water permeable medicine, a sputum medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a digestion-eliminating medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a solution-solving medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a phlegm-relieving phlegm, and a digestive.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, a warm-yang dispersing medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a blood-activating phlegm, an anti-drug, and a solution.
  • the composition includes a flower bud, a berberine, a water-wetting drug, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood-stopping agent, a phlegm-dampening phlegm, and a digestive medicinal.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a cooling blood-stopping drug, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood-stopping medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a cooling blood-stopping medicine, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting drug, a cooling blood-stopping drug, a digestion-eliminating drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a water-wetting agent, a warm-yang dispersing medicine, a digestive medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a phlegm phlegm medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a warm yang medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a cooling blood hemostasis, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, a phlegm phlegm medicine, and a food consuming medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm medicine, a phlegm phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a Wenyang cold medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a sputum medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm and blood stasis medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a warm and cold medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes the head flower bud, the berberine, the qi medicine, the blood circulation phlegm medicine, the phlegm and blood stasis medicine, and the warm yang medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a phlegm phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a phlegm phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a warm yang medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a blood circulation phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a phlegm and blood stasis medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostasis, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a cooling blood hemostatic medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm-dampening phlegm, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm and blood stasis medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a qi medicine, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a qi medicine, a Wenyang cold medicine, a digestion medicine, and a prescription medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a blood stasis, a phlegm and blood stasis.
  • the composition includes a head flower bud, a berberine, a sputum medicinal herb, a blood circulation phlegm medicine, a cooling blood hemostatic drug, and a warming and dissipating cold medicine.
  • the composition includes a flower bud, a berberine, a sputum medicinal herb, a blood circulation phlegm medicine, a cooling blood hemostatic drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a sputum medicinal herb, a blood circulation phlegm medicine, a cooling blood hemostatic drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a phlegm, and a phlegm medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a phlegm, and a diarrhea.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a blood stasis, a digestive, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a warming and dispelling cold medicine.
  • the composition includes a head flower bud, a berberine, a phlegm, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a digestive.
  • the composition includes a flower bud, a berberine, a phlegm, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a sputum medicinal medicine, a cooling blood stopping medicine, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a sputum medicine, a cooling blood hemostasis, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a blood-suppressing hemostatic, a digestive, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, a phlegm, a phlegm, a phlegm, and a digestive.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, a phlegm, a phlegm, and a remedy.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, a phlegm, a drug, and a drug.
  • the composition includes a head flower bud, a berberine, a sputum medicinal medicine, a warming and dispelling medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a blood circulation phlegm, a blood circulation hemostasis, a phlegm and blood stasis medicine, and a warming and dispelling medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a blood circulation hemostasis, a phlegm and blood stasis medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm and blood stasis medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a cooling blood hemostasis, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion medicine.
  • the composition includes a flower bud, a berberine, a blood stasis phlegm, a phlegm phlegm, a phlegm medicine, and a remedy.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm, a phlegm phlegm, a digestion drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a blood circulation phlegm medicine, a yangyang cold medicine, a digestion medicine, and a solution medicine.
  • the composition includes a flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, a warming and dispelling cold medicine, and a digestive medicine.
  • the composition includes a flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, a warming and dispelling medicine, and a remedy.
  • the composition includes a flower bud, a berberine, a blood-suppressing hemostatic agent, a phlegm-dampening phlegm, an anti-drug, and a remedy.
  • the composition includes a head flower bud, a berberine, a cooling blood hemostasis, a warming and dispelling medicine, a digestion medicine, and a solution medicine.
  • the composition includes a flower bud, a berberine, a phlegm, a phlegm, a phlegm, a phlegm, a phlegm, a remedy.
  • composition is composed of a head bud, a berberine, and any four of the above eleven drugs in a pharmaceutical composition:
  • compositions include the head flower bud, berberine, heat-clearing medicine, tonic medicine, qi medicine, and blood-activating phlegm medicine selected from the group consisting of:
  • compositions include the head flower bud, berberine, heat-clearing medicine, tonic medicine, phlegm-dampening phlegm medicine, and Wenyang chilling medicine selected from the group consisting of:
  • compositions include cep, berberine, tonic, diuretic, qi, and phlegm.
  • compositions are selected from the group consisting of:
  • composition consists of the head flower bud, berberine, and any of the above nine drugs.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, and a sputum medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, and a phlegm-dampening medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a gas-making drug, and a digestion drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a phlegm-receiving medicine, a blood-activating phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-receiving drug, and a cool blood-stopping Blood medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a phlegm-receiving medicine, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-receiving drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-receiving drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-receiving drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a blood-activating phlegm drug, and a cooling blood-stopping drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a blood-activating phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a blood-activating phlegm medicine, and a warm-yang medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-sparing osmotic drug, a blood-activating phlegm drug, and a digestion-eliminating drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a blood-activating phlegm drug, and a remedy drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a phlegm-dampening phlegm.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a warm-yang dispersing drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a digestive drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a cooling blood-stopping drug, and a solution-solving drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a phlegm-dampening phlegm, and a warm-yang dispelling medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-dampening phlegm, and a food-eliminating drug.
  • the composition includes a flower bud, a coptis, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a digestion drug, and a drug solution.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, and a blood-suppressing medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a cooling blood hemostasis, and a phlegm-dampening phlegm.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood hemostasis, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood hemostatic medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm medicine, and a digestion-eliminating medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm, and a remedy.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, a digestion medicine, and a solution medicine.
  • composition is composed of a flower bud, a berberine, and any five of the above eleven drugs in a pharmaceutical composition:
  • compositions include the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, blood circulation phlegm medicine, phlegm and blood stasis medicine.
  • compositions are selected from the group consisting of:
  • compositions include head flower buds, berberine, heat-clearing drugs, tonics, water-wetting drugs, qi medicines, blood-activating phlegm drugs, and remedies.
  • compositions are selected from the group consisting of:
  • composition consists of the head bud, berberine, and any of the above-mentioned eleven classes of drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm medicine, and a blood-suppressing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, and a cooling blood-stopping medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a blood-activating phlegm medicine, and a phlegm-dampening medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi-drug, a blood-activating phlegm, and a food-eliminating drug.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood-stopping medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a cooling blood-stopping medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a cooling blood hemostatic medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, and a phlegm Peony and solution.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a qi medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a warm-yang dispersing medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a digestion drug, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a phlegm-dampness phlegm medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a coptis, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood hemostasis medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting agent, a qi medicine, a sputum medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, a warm-yang dispersing medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, a digestion medicine, and a remedy medicine.
  • composition is composed of a medicinal composition of the first six classes of drugs, such as scutellaria, berberine, and the above eleven types of medicinal properties:
  • compositions include the head flower bud, the berberine, the tonic medicine, the water-wetting drug, the qi medicine, the phlegm medicine, the warm-yang powder medicine, and the solution medicine.
  • compositions are selected from the group consisting of:
  • composition consists of the head flower bud, berberine, and any of the above seven drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a cooling blood hemostatic medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a phlegm-dampness phlegm medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a coptis, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a warm-yang powder medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting agent, a gas medicine, a sputum medicine, a digestion medicine, and a medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a Wenyang cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a warm-yang medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a warm-yang powder medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting agent, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a digestion medicine, and a remedy medicine.
  • composition is composed of a medicinal composition of the genus, berberine, and any of the eleven types of drugs mentioned above:
  • compositions include head flower bud, berberine, tonic medicine, water-wetting drug, qi medicine, phlegm medicine, blood-activating phlegm medicine, phlegm-dampening phlegm medicine, and warm-yang dispersing medicine.
  • compositions are selected from the group consisting of:
  • the composition consists of the first eight types of drugs, such as the head bud, the berberine, and the above eleventh medicinal properties.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, and a phlegm-dampening medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-sparing osmotic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostasis medicine, and a Wenyang cold medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, Promote blood circulation to remove phlegm, cool blood to stop bleeding drugs, digestion drugs.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a warm-yang dispersing medicine, and a digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a warm-yang medicine, and a medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes the head flower bud, the berberine, the tonic medicine, the diarrhea medicine, the qi medicine, the phlegm medicine, the blood circulation phlegm medicine, the cooling blood hemostasis medicine, the phlegm and blood stasis medicine, the Wenyang cold medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a Wenyang cold medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a Wenyang cold medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a digestion medicine, and a solution medicine.
  • composition is composed of a medicinal composition of the genus, berberine, and any of the above-mentioned eleven types of medicinal properties:
  • compositions include head flower buds, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm, blood circulation hemostasis, phlegm and blood stasis medicine, and warming medicine.
  • compositions are selected from the group consisting of:
  • composition consists of the head bud, berberine, and any of the nine drugs listed above.
  • the composition includes a head flower bud, a berberine, a leachhin, a qi medicine, a sputum medicinal medicine, a blood circulation phlegm medicine, a blood circulation hemostasis medicine, a phlegm and blood stasis medicine, a yangyang cold medicine, a digestion medicine, Solution medicine.
  • the composition includes the head flower bud, berberine, tonic medicine, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution table medicine.
  • the composition includes a head flower bud, a berberine, a tonic drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping medicinal agent, a phlegm-dampening phlegm drug, a yang-yang medicinal drug, a digestion drug, and a solution.
  • Table medicine a head flower bud, a berberine, a tonic drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping medicinal agent, a phlegm-dampening phlegm drug, a yang-yang medicinal drug, a digestion drug, and a solution.
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea dialysis medicine, qi medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution Table medicine.
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, cooling blood to stop bleeding medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution table medicine.
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution table medicine.
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, Wenyang cold medicine, digestion medicine, solution medicine .
  • the composition includes the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, digestion medicine, solution medicine .
  • the composition includes a head flower bud, a beryl, a tonifying agent, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a yang yang medicine, Solution medicine.
  • the composition includes a head flower bud, a beryl, a tonifying agent, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a yang yang medicine, Digestive medicine.
  • the composition includes the head flower bud, berberine, heat-clearing medicine, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping medicinal agent, a phlegm-dampening phlegm drug, a warm-yang dispelling medicinal agent, a digestive medicinal drug, Solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, Solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing blood-suppressing medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution.
  • Table medicine The composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicine, a blood-suppressing blood-suppressing medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution. Table medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution.
  • Table medicine The composition includes a flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution. Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine. , to solve the drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine. , digestion drugs.
  • the composition includes a flower bud, a peony root, a heat-clearing drug, a tonic drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping medicinal agent, a phlegm-dampening phlegm drug, a yang-yang medicinal drug, a food-disinfecting drug, and a solution table. medicine.
  • the composition includes the head flower bud, berberine, heat-clearing medicine, tonic medicine, qi medicine, blood circulation phlegm medicine, cooling blood hemostasis medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine, solution table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a cooling blood hemostasis medicine, a phlegm-dampening phlegm medicine, a Wenyang cold medicine, a digestion medicine, and a remedy medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a remedy medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a Wenyang cold medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a yang-yang medicine, a solution Table medicine.
  • the composition includes the head flower bud, berberine, heat-clearing medicine, tonic medicine, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution.
  • Table medicine a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution. Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-receiving medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a phlegm-dampening phlegm drug, a warm-yang dispersing drug, a digestion drug, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a phlegm-removing drug, a blood-activating phlegm drug, a cooling blood-stopping drug, a warm-yang dispersing drug, a digestive drug, and a remedy drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, Solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, Digestive medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution table. medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi-drug, a blood-activating phlegm, a phlegm-dampening phlegm, a yang-yang medicinal agent, a digestion-preventing drug, and a solution. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang dispersing medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine. .
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a blood circulation Peony, cooling blood to stop bleeding, phlegm and blood stasis, Wenyang cold medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, Digestive medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-receiving medicinal agent, a phlegm-dampening phlegm drug, a yang-yang medicinal drug, a digestive medicinal drug, and a remedy drug. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, a Wenyang cold medicine, a digestion medicine, and a solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, and a solution.
  • Table medicine a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, and a solution. Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a warm-yang powder medicine, a digestion medicine, and a medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a phlegm-dampening phlegm medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, and a solution.
  • Table medicine a head flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, and a solution. Table medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a digestion medicine, and a remedy medicine.
  • the composition includes a flower bud, a berberine, a heat-clearing drug, a tonic drug, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang dispersing medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang medicine, and a food-eliminating medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a solution table. medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine. .
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a yang-yang Dispel cold medicine.
  • composition is composed of a head bud, a berberine, and any of the above nine drugs in a pharmaceutical composition:
  • compositions include head flower bud, berberine, heat-clearing medicine, tonic medicine, water-wetting drug, qi medicine, phlegm medicine, blood-activating phlegm medicine, cooling blood-stopping medicine, phlegm-dampening phlegm medicine, Wenyang powder Cold medicine, solution medicine.
  • compositions are selected from the group consisting of:
  • composition consists of the head flower bud, berberine, and any of the eleven types of drugs mentioned above.
  • the composition includes a head flower bud, a beryl, a tonifying agent, a water-wetting drug, a qi medicine, a sputum medicine, a blood circulation phlegm medicine, a cooling blood hemostatic medicine, a phlegm-dampening phlegm medicine, a yang yang medicine, Digestive medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing drug, a water-wetting drug, a qi medicine, a sputum medicinal medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a warm-yang dispersing medicine. , digestion drugs, solution drugs.
  • the composition includes the head flower bud, berberine, heat-clearing medicine, tonic medicine, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion Medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a phlegm-removing medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, Digestive medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispelling medicine, Digestive medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion. Medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a phlegm-dampening phlegm medicine, a warm-yang dispersing medicine, and a digestion Medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a warm-yang medicine, and a food-eliminating medicine. , to solve the drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, a digestion medicine. , to solve the drug.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a yang-yang Dispel cold medicine, solution medicine.
  • the composition includes a head flower bud, a berberine, a heat-clearing medicine, a tonic medicine, a water-wetting drug, a qi medicine, a sputum medicine, a blood-activating phlegm medicine, a cooling blood-stopping medicine, a phlegm-dampening phlegm medicine, and a yang-yang Dispel cold medicine, digestion medicine.
  • composition consists of a medicinal composition of the genus, berberine, and any of the eleven classes of drugs mentioned above:
  • compositions include head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion
  • the group of medicines is selected from any of the following groups:
  • compositions include the head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, Wenyang cold medicine, digestion medicine, solution medicine Groups are selected from any of the following groups:
  • composition consists of any of eleven drugs of the above ten medicinal properties.
  • composition is composed of a medicinal composition of the eleventh medicinal herb, a berberine, and any eleven drugs of the above-mentioned eleven types of medicinal properties:
  • compositions include head flower bud, berberine, tonic medicine, diarrhea phlegm, qi medicine, phlegm medicine, blood circulation phlegm medicine, cooling blood hemostatic medicine, phlegm and blood stasis medicine, Wenyang cold medicine, digestion Medicine, solution medicine.
  • compositions are selected from the group consisting of:
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting the head flower buds and other medicinal materials with an inorganic or organic solvent alone or in a mixed solvent.
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting and mixing the head flower buds and other medicinal materials with two or more mixed solvents of water and ethanol, acetone, and ethyl acetate.
  • a pharmaceutical composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting 5-30 times of water from the head flower and other herbs.
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting 5-30 times of a 30-100% organic solution of the head flower buds and other medicinal materials.
  • the pharmaceutical composition according to the first aspect of the present invention characterized in that the composition is extracted from 5-30 times of 30-99% of lower alcohol (C1-C5), acetone, acetic acid solution by head flower buds and other medicinal materials. And get.
  • lower alcohol C1-C5
  • acetone acetic acid solution by head flower buds and other medicinal materials. And get.
  • composition obtained by extracting 5-30 times of a 30-99% aqueous solution of ethanol as an extraction solvent.
  • the aqueous ethanol solution is preferably a 70% ethanol solution, and the solution is selected to be 6-8 times.
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting and mixing 5-15 times of a mixed solution of an alcohol and an ester of 5-95% of an anthraquinone and other medicinal materials.
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting and extracting 5-15 times of a mixed solution of 5-95% ethanol and ethyl acetate as an extraction solvent. .
  • composition according to the first aspect of the present invention characterized in that the composition is obtained by extracting 5 to 20 times of ethyl acetate, petroleum ether and diethyl ether from the head flower and other herbs.
  • composition prepared according to the method comprising the steps of: 5 to 30 times (e.g., 5 to 15 times, for example, 6 to 12) of the medicinal material constituting the composition.
  • water water
  • ethanol ethanol aqueous solution decoction and / or reflux extraction 1 to 5 times (for example, 2 to 3 times)
  • each 0.5 to 5 hours for example, 0.5 to 3 hours, for example, 1 to 3 hours
  • the filtrate was concentrated and dried.
  • composition prepared according to the method comprising the steps of: taking a medicinal material constituting the composition, adding 5 to 30 times (for example, 5 to 15 times, for example, 6 to 12 times) water is decoctioned at 50-100 ° C for 1 to 5 times (for example, 2 to 3 times), 0.5 to 5 hours each time (for example, 0.5 to 3 hours, for example, 1 to 3 hours), filtered and combined
  • the extract is concentrated to a thick paste having a relative density of 1.1 to 1.5 (for example, 1.2 to 1.4), and dried under reduced pressure.
  • composition prepared according to the method comprising the steps of: taking a medicinal material constituting the composition, adding 5 to 30 times (for example, 5 to 15 times, for example, 6 to 12 times) 30-99% ethanol aqueous solution is refluxed for 1 to 5 times (for example, 2 to 3 times) for 0.5 to 5 hours each time (for example, 0.5 to 3 hours, for example, 1 to 3 hours), and the extracts are filtered and combined. It is concentrated to a thick paste having a relative density of 1.1 to 1.5 (for example, 1.2 to 1.4) at 60 to 90 ° C (for example, 65 to 75 ° C), and dried under reduced pressure.
  • the above pharmaceutical composition further comprises one or more other drugs selected from the group consisting of: an antimicrobial agent, a proton pump inhibitor, a gastric mucosal protective agent, an antacid, and an H 2 receptor antagonist.
  • Preferred antimicrobial agents include, but are not limited to, penicillins such as amoxicillin, macrolides such as clarithromycin, and nitrazoles such as metronidazole.
  • Preferred proton pump inhibitors include, but are not limited to, omeprazole, lansoprazole, pantoprazole
  • Preferred gastric mucosal protective agents include, but are not limited to, sucralfate, smecta
  • Preferred antacids such as aluminum hydroxide magnesium
  • H 2 receptor antagonists such as cimetidine, ranitidine, famotidine.
  • the invention also discloses a method for preparing a pharmaceutical composition extract, characterized in that the step of the method is selected from any one or more of the following:
  • (1-7) is obtained by extracting and obtaining 5 to 15 times of a mixed solvent of 5 to 95% of an alcohol and an ester;
  • the invention includes all of the pharmaceutical composition extracts prepared by the above methods.
  • a second aspect of the invention provides a pharmaceutical formulation composition.
  • compositions of the present invention further comprise one or more non-toxic physiologically acceptable carriers.
  • the acceptable carriers include any excipients known in the art and excipients that function as controlled release. Commonly used excipients include diluents, binders, wetting agents, disintegrants, lubricants, glidants, porogens, plasticizers, fillers, solubilizers, and emulsifiers.
  • the diluent may be, but not limited to, starch, dextrin, sucrose, glucose, lactose, mannitol, sorbitol, xylitol, microcrystalline cellulose, calcium sulfate, calcium hydrogen phosphate, calcium carbonate, etc.;
  • the humectant may be but not Limited to water, ethanol, isopropanol, etc.
  • the binder may be starch slurry, dextrin, syrup, honey, glucose solution, microcrystalline cellulose, gum arabic, gelatin pulp, sodium carboxymethyl cellulose, methyl fiber , hydroxypropyl methylcellulose, ethyl cellulose, acrylic resin, carbomer, polyvinylpyrrolidone, polyethylene glycol, etc.
  • disintegrants can be, but are not limited to, dry starch, microcrystalline cellulose, low substitution Hydroxypropyl cellulose, cross-linked polyvinylpyrrolidone, croscarmellose sodium, sodium carboxymethyl star
  • the excipient that acts to slow release is selected from one or more of a hydrophilic gel material, a waxy material, and an insoluble material.
  • the hydrophilic gel material may be selected from the group consisting of hydroxypropylmethylcellulose, carbopol, sodium carboxymethylcellulose and alginate
  • the waxy lipid material may be selected from the group consisting of cetyl alcohol and ten.
  • the insoluble material may be selected from the group consisting of ethyl cellulose, acrylic resin, polyoxyethylene and polyethylene.
  • coloring agents may also be added to the pharmaceutical preparations as needed.
  • the invention also relates to formulations comprising a pharmaceutical composition and a pharmaceutically acceptable carrier.
  • a pharmaceutical composition Any dosage form suitable for human or animal use can be prepared by combining the composition with one or more pharmaceutically acceptable solid or liquid excipients and/or adjuvants.
  • the formulation can be prepared according to methods well known in the art.
  • the composition of the present invention is usually contained in a pharmaceutical preparation in an amount of 6 to 12 g.
  • the pharmaceutical preparation of the present invention is preferably an oral preparation for the purpose of administration and enhancing the therapeutic effect.
  • Oral preparation prepared by the pharmaceutical composition of the present invention includes granules, tablets, pills, capsules, oral liquid preparations And related sustained-release preparations and sustained-release preparations, the sustained-release preparations include skeletal type, membrane-controlled type, osmotic pump type, gastric retention type sustained release controlled release preparation, microcapsules, nanoparticles, lipids
  • the drug is a new carrier sustained-release controlled release preparation
  • the gastric retention-type sustained-release preparation is preferably a gastric floating agent.
  • the preparation process of the preparation is as follows:
  • the raw material was 31% of the composition, 31% of the IV acrylic resin, 31% of stearyl alcohol, 7% of MCC101, and an appropriate amount of magnesium stearate was added, and the film was directly compressed by a dry method to obtain a floating tablet of the first calyx composition.
  • a third aspect of the invention provides the use of a pharmaceutical composition for the preparation of an antibacterial agent.
  • the use according to the second aspect of the present invention is characterized in that the pathogen is selected from the group consisting of Gram-positive methicillin-resistant Staphylococcus aureus S. aureus (Methicllin-resistant, MRSA), methicillin-sensitive golden yellow Staphylococcus epidermidis (MRSE), methicillin-sensitive Staphylococcus epidermidis (MSSE), also selected from Gram-negative bacteria large intestine ESBLS Escherichia Coli, Eco + , Escherichia coli (non-ESBLS) Escherichia Coli, Eco - , Klebsiella Klebsiella (ESBLs) K. penumonia, KPN + , Klebsiella pneumonia (non-ESBLs) K. penumonia , Pseudomonas aeruginosa (PAE), Helicobacter pylori.
  • MRSA methicillin-resistant Staphylococcus aureus
  • MRSE me
  • extraction may be impregnation at normal temperature, or extraction at elevated temperatures (e.g., boiling and/or reflux), or a combination of these modes of operation. It may further comprise further processing the extract, such as further purification, such as solvent removal, precipitation removal impurities, solvent extraction, resin adsorption separation, and the like.
  • extract will include extracts of any purity that can be used to achieve any of the objectives of the invention, and the extraction purity of the extract can vary over a wide range.
  • the invention has the beneficial effects that the composition improves the single anti-Helicobacter pylori activity of the head flower bud, and the minimum antibacterial requirement of the water extract composition A for Hp ATCC700392 is 9.84 mg/ml, and the crude drug content of berberine is 0.98mg/ml, lower than the requirement of unilateral calyx unilateral (36.68mg/ml) and berberine unilateral (1.37mg/ml), enhancing the antibacterial synergistic effect between the head flower bud and the berberine; alcohol extracting composition A, composition B.
  • the minimum antibacterial requirement of the composition C to Hp ATCC700392 is 3.63, 19.48, 17.16 (mg/ml), which is lower than the requirement of the first flower (40.44 mg/ml);
  • the minimum antibacterial requirement of the composition A, the composition B and the composition C for Hp SS1 was 3.63, 2.44, 2.15 (mg/ml), respectively, which was lower than that of the head flower (5.06 mg/ml).
  • the required content; the minimum antibacterial requirement of the alcohol extracting composition B for the metronidazole-resistant strain is 4.87 mg/ml, which is lower than that required for the single flower (10.11 mg/ml).
  • the composition has good antibacterial activity.
  • the minimum antibacterial crude drug content of the water extracting composition A against Gram-positive bacteria was ⁇ 0.082 mg/ml, and the crude drug content of Rhizoma Coptidis and the head flower buds were 0.204 and 0.621 mg/ml, respectively; the lowest against Gram-negative bacteria
  • the crude drug content of the bacteria was ⁇ 0.0824 mg/ml, and the crude drug content of the berberine unilateral and the head flower buds were 0.204 and 5.175 mg/ml, respectively.
  • Figure 1 shows the results of clinical drug-resistant strain verification.
  • Figure 2 shows the results of in vitro inhibition of the composition against H. pylori.
  • Example 2 Referring to the same method as in Example 1, except that 750 g of medicinal herbs, 75 g of fried berberine, 250 g of Codonopsis pilosula, 250 g of medlar, and 150 g of dried tangerine peel were weighed, and the extract powder of the present example was obtained, 154 g.
  • Example 2 The same procedure as in Example 1 was carried out, except that 900 g of the medicinal material calyx was weighed and extracted, and 89 g of the extract powder of this example was obtained.
  • Example 2 The same procedure as in Example 1 was carried out, except that 660 g of the medicinal material of Rhizoma Coptidis was weighed, and 133 g of the extract powder of this example was obtained.
  • the method was the same as in the same manner as in Example 5 except that 300 g of medicinal materials, 30 g of fried berberine, 100 g of Codonopsis pilosula, 100 g of medlar, and 60 g of dried tangerine peel were weighed, and the extract powder of this example was obtained, 95 g.
  • Example 5 Referring to the same method as in Example 5, except that 300 g of the medicinal flower head flower, 30 g of fried berberine, 100 g of Codonopsis pilosula, 100 g of medlar, and 100 g of Schisandra were weighed, and the extract powder of this example was obtained, 102 g.
  • Example 5 The same procedure as in Example 5 was carried out, except that 1000 g of the medicinal material calyx was weighed and extracted, and the extract powder of this example was obtained, 109 g.
  • Example 5 The same procedure as in Example 5 was carried out except that 520 g of the Rhizoma Coptidis medicinal material was weighed, and the extract powder of this example was obtained, 95 g.
  • Example 2 Referring to the same method as in Example 1, the difference was that 80 kg of head flower buds, 8 kg of fried berberine, and 16 kg of raw licorice were weighed and extracted to obtain 8.1 kg of the extract powder of this example.
  • Example 2 Referring to the same method as in Example 1, the difference was that 54 kg of the flower head flower, 5.6 kg of fried berberine, 17.6 kg of Codonopsis pilosula, 17.6 kg of medlar, and 10.4 kg of dried tangerine peel were weighed, and the extract powder of this example was obtained, 17.0 kg.

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Abstract

一种包括头花蓼和黄连的药物组合物,及其制备方法和在制备抗菌,特别是抗幽门螺旋杆菌的药物中的应用。

Description

[根据细则37.2由ISA制定的发明名称] 包含头花蓼和黄连的组合物在制备抗幽门螺旋杆菌的药物中的用途 技术领域
本发明属于中药领域,具体涉及一种药物组合物,包含头花蓼和黄连,及其在制备抗菌,特别是针对幽门螺旋杆菌的药物的应用。
背景技术
头花蓼为蓼科植物头花蓼(Polygonum capitatum Buch.-Ham.ex D.Don)的干燥全草或地上部分,是我国民间特别是少数民族地区的常用药。头花蓼味甘、辛,性凉;具有清热利湿,解毒止痛,和血散瘀,利尿通淋等功效。近几年来药理研究表明,头花蓼具有广泛的药理活性,有镇痛、降温、利尿、抗炎、抗菌等作用。
幽门螺旋杆菌(Helicobacter pylori,在本文中可简称为H.pylori、Hp或HP)是普遍存在于人胃黏膜中的一种微需氧的革兰氏阴性菌。HP感染是引起多种慢性胃病如消化性溃疡、胃炎、胃癌的重要病因。目前国际上推荐的一线治疗方案主要以质子泵抑制剂(PPI)或铋剂为基础,合并两种抗生素组成的三联疗法,根除率达90%。但目前这些药物根除方案存在毒副作用大、易继发耐药、产生二重感染、患者依存性的问题。
中医药是根除幽门螺杆菌的一种新选择,随着中草药市场的不断发掘,越来越多的中药显示对Hp有较好的抑菌效果,研究以单味中药为主。CN 102824417A(中国专利申请号201210352856.6,公开日2012年12月19日)公开了头花蓼或其提取物用于治疗HP的新方法,据信该药或其提取物对HP的体外抑菌效果明显。
然而中医学认为人体是一个有机的整体,各个脏器循环运转相互影响,H.pylori为湿热郁毒,属“邪气”范畴,单味中药难以应付病情的复杂多变及发展,只能起到治标的作用。
本发明在头花蓼单味药的基础上,加以其他中药组成头花蓼组合物,提高了抗Hp的活性,对革兰氏菌具有较好的抗菌效果,特别是对耐甲氧西林表皮葡萄球菌、甲氧西林敏感金黄色葡萄球菌、耐甲氧西林金黄色葡萄球菌。且加入清热解毒、补益、利水渗湿、行气、活血化瘀、去湿化痰、活血化瘀、温阳散寒、消食的药材,能够减少单味药的不良反应。本发明中的药物组合物在制备抗幽门螺旋杆菌的药物中的应用尚未见报道。
发明内容
发明概述
本发明的目的在于提供一种药物组合物,包括头花蓼、黄连,还提供组合物用于制备有效抗菌,特别是抑制幽门螺旋杆菌的药物的应用。
为此,本发明第一方面提供了一种药物组合物,其特征在于,所述的组合物包括头花蓼、黄连。优选的组合物包括头花蓼20-60重量份、黄连2-6重量份。
在本发明的具体实施方案中,所述的组合物由头花蓼、黄连,和选自下述任一类或几类组合物组成:(1)清热类药物;(2)补益药物;(3)利水渗湿药;(4)行气药;(5)收涩药;(6)活血化瘀药;(7)凉血止血药;(8)祛湿化痰药;(9)温阳散寒药;(10)消食药;(11)解表药。
本发明还提供了上述药物组合物提取物的制备方法。
本发明还公开含有药物组合物的制剂,所述的组合物与药学上接受的辅料制成药剂学上接受的口服制剂。
所述的口服制剂选自各种可用的常释制剂和缓控释制剂。
所述的缓控释制剂选自骨架型、膜控型、渗透泵型、胃内滞留型缓控释制剂。
所述的胃内滞留型缓控释制剂优选为胃漂浮剂。
本发明还公开了本发明任意一组药物组合物在制备抗菌的药物中的应用。
所述的病菌选自革兰氏阳性菌甲氧西林耐药金黄色葡萄球菌S.aureus(Methicllin-resistant,MRSA)、甲氧西林敏感金黄色葡萄球菌S.aureus(Methicin-suseptable)、甲氧西林耐药表皮葡萄球菌(staphylococcus epidermidis,MRSE)、甲氧西林敏感表皮葡萄球菌(staphylococcus epidermidis,MSSE),还选自革兰氏阴性菌大肠埃希菌(ESBLS)Escherichia Coli,Eco+,大肠埃希菌(非ESBLS)Escherichia Coli,Eco-,肺炎克雷伯(ESBLs)K.penumonia,KPN+,肺炎克雷伯(非ESBLs)K.penumonia,铜绿假单胞菌(Pseudomonas aeruginosa,PAE)。
本发明还公开了本发明任意一组药物组合物在制备预防/治疗幽门螺旋杆菌的药物中的应用。
发明详述
本发明提供了一种新的药物组合物,所述的组合物包括头花蓼、黄连。优选的组合物包括头花蓼20-60重量份、黄连2-6重量份。
在本发明的一个具体实施方案中,所述的组合物由头花蓼、黄连,和选自下述任一类或几类组合物组成:(1)清热类药物;(2)补益药物;(3)利水渗湿药;(4)行气药;(5)收涩药;(6)活血化瘀药;(7)凉血止血药;(8)祛湿化痰药;(9)温阳散寒药;(10)消食药;(11)解表药。
(一)本发明所述的清热类药物包括但不限定于蒲公英、穿心莲、黄芩、黄柏、板蓝根、青黛、金银花、秦皮、金莲花、鱼腥草、紫花地丁、牡丹皮、桉树蜜、水团花、栀子、白花蛇舌草、半枝莲、生地黄、鸦胆子、大血藤;但是不包括头花蓼、黄连。
(二)本发明所述的补益药物包括但不限定于甘草、党参、白术、白芍、大枣、人参、茶叶、黄芪、黄精。
(三)本发明所述的利水渗湿药包括但不限定于茯苓、虎杖、土茯苓。
(四)本发明所述的行气药包括但不限定于陈皮、木香、枳实、香附、紫苏梗、八月札、土荆芥。
(五)本发明所述的收涩药包括但不限定于五味子、诃子、石榴皮、乌梅、海螵蛸。
(六)本发明所述的活血化瘀药包括但不限定于延胡索、三七、丹参、石见穿、郁金、大黄。
(七)本发明所述的凉血止血药包括但不限定于白及、地榆。
(八)本发明所述的祛湿化痰药包括但不限定于半夏、厚朴、旋复花、白果。
(九)本发明所述的温阳散寒药包括但不限定于吴茱萸、高良姜、胡椒、干姜、野艾。
(十)本发明所述的消食药包括但不限定于大蒜、山楂、槟榔。
(十一)本发明所述的解表药包括但不限定于桂枝、生姜、紫苏叶、柴胡。
优选的清热药选自蒲公英、黄柏、黄芩。
优选的补益类选自黄芪、白术、白芍、黄精。
优选的利水渗湿类选自虎杖、土茯苓。
优选的行气类选自木香、枳实、香附。
优选的收涩类选自海螵蛸、诃子。
优选的活血化瘀选自延胡索、丹参、三七。
优选的凉血止血选自白及。
优选的祛湿化痰选自半夏、厚朴。
优选的温阳散寒选自吴茱萸、高良姜。
优选的消食药选自山楂。
优选的解表药选自桂枝、柴胡、生姜。
本发明药物组合物中各种药材的优选的重量份比例如下:
Figure PCTCN2015086156-appb-000001
Figure PCTCN2015086156-appb-000002
所述的组合物由头花蓼、黄连,和上述十一类药性中的任意一类药物组成。例如所述的组合物选自如下任意一组:
1.1所述的组合物包括头花蓼、黄连、清热类药物。
1.2所述的组合物包括头花蓼、黄连、补益药物。
1.3所述的组合物包括头花蓼、黄连、利水渗湿药。
1.4所述的组合物包括头花蓼、黄连、行气药。
1.5所述的组合物包括头花蓼、黄连、收涩药。
1.6所述的组合物包括头花蓼、黄连、活血化瘀药。
1.7所述的组合物包括头花蓼、黄连、凉血止血药。
1.8所述的组合物包括头花蓼、黄连、祛湿化痰药。
1.9所述的组合物包括头花蓼、黄连、温阳散寒药。
1.10所述的组合物包括头花蓼、黄连、消食药。
1.11所述的组合物包括头花蓼、黄连、解表药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意一类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、清热类药物。
即所述的组合物包括头花蓼、黄连以及除头花蓼、黄连以外的清热类药物。
更优选的是所述的组合物包括头花蓼、黄连和选自蒲公英、穿心莲、黄芩、黄柏、板蓝根、青黛、金银花、秦皮、金莲花、鱼腥草、紫花地丁、牡丹皮、桉树蜜、水团花、栀子、白花蛇舌草、半枝莲、生地黄、鸦胆子、大血藤中的一种和多种清热类药物形成组合物,
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、蒲公英10-15重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、鱼腥草15-25重量份;
(3)头花蓼20-60重量份、黄连2-6重量份、黄柏3-12重量份、黄芩3-10重量份、栀子6-10重量份。
优选的组合物包括头花蓼、黄连、补益药物。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、黄精9-15重量份;
(2)优选头花蓼10-90重量份、黄连1-10重量份、甘草2-20重量份;
(3)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份;
(4)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、甘草4-9重量份。
其中
(1)优选头花蓼10-90重量份、黄连1-10重量份、甘草2-20重量份;
(2)更优选头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份;
(3)最优选头花蓼30重量份、黄连3重量份、甘草6重量份;
优选的组合物包括头花蓼、黄连、利水渗湿药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60、黄连2-6重量份、茯苓9-15重量份;
优选的组合物包括头花蓼、黄连、行气药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、陈皮5-10重量份;
优选的组合物包括头花蓼、黄连、收涩药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、五味子8-12重量份;
所述的组合物由头花蓼、黄连,和十一类药性中的任意二类药物组成。
2.1所述的组合物包括头花蓼、黄连、清热类药物、补益药。
2.2所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药。
2.3所述的组合物包括头花蓼、黄连、清热类药物、行气药。
2.4所述的组合物包括头花蓼、黄连、清热类药物、收涩药。
2.5所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药。
2.6所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药。
2.7所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药。
2.8所述的组合物包括头花蓼、黄连、清热类药物、温阳散寒药。
2.9所述的组合物包括头花蓼、黄连、清热类药物、消食药。
2.10所述的组合物包括头花蓼、黄连、清热类药物、解表药。
2.11所述的组合物包括头花蓼、黄连、补益药、利水渗湿药。
2.12所述的组合物包括头花蓼、黄连、补益药、行气药。
2.13所述的组合物包括头花蓼、黄连、补益药、收涩药。
2.14所述的组合物包括头花蓼、黄连、补益药、活血化瘀药。
2.15所述的组合物包括头花蓼、黄连、补益药、凉血止血药。
2.16所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药。
2.17所述的组合物包括头花蓼、黄连、补益药、温阳散寒药。
2.18所述的组合物包括头花蓼、黄连、补益药、消食药。
2.19所述的组合物包括头花蓼、黄连、补益药、解表药。
2.20所述的组合物包括头花蓼、黄连、利水渗湿药、行气药。
2.21所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药。
2.22所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药。
2.23所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药。
2.24所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药。
2.25所述的组合物包括头花蓼、黄连、利水渗湿药、温阳散寒药。
2.26所述的组合物包括头花蓼、黄连、利水渗湿药、消食药。
2.27所述的组合物包括头花蓼、黄连、利水渗湿药、解表药。
2.28所述的组合物包括头花蓼、黄连、行气药、收涩药。
2.29所述的组合物包括头花蓼、黄连、行气药、活血化瘀药。
2.30所述的组合物包括头花蓼、黄连、行气药、凉血止血药。
2.31所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药。
2.32所述的组合物包括头花蓼、黄连、行气药、温阳散寒药。
2.33所述的组合物包括头花蓼、黄连、行气药、消食药。
2.34所述的组合物包括头花蓼、黄连、行气药、解表药。
2.35所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药。
2.36所述的组合物包括头花蓼、黄连、收涩药、凉血止血药。
2.37所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药。
2.38所述的组合物包括头花蓼、黄连、收涩药、温阳散寒药。
2.39所述的组合物包括头花蓼、黄连、收涩药、消食药。
2.40所述的组合物包括头花蓼、黄连、收涩药、解表药。
2.41所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药。
2.42所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药。
2.43所述的组合物包括头花蓼、黄连、活血化瘀药、温阳散寒药。
2.44所述的组合物包括头花蓼、黄连、活血化瘀药、消食药。
2.45所述的组合物包括头花蓼、黄连、活血化瘀药、解表药。
2.46所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药。
2.47所述的组合物包括头花蓼、黄连、凉血止血药、温阳散寒药。
2.48所述的组合物包括头花蓼、黄连、凉血止血药、消食药。
2.49所述的组合物包括头花蓼、黄连、凉血止血药、解表药。
2.50所述的组合物包括头花蓼、黄连、祛湿化痰药、温阳散寒药。
2.51所述的组合物包括头花蓼、黄连、祛湿化痰药、消食药。
2.52所述的组合物包括头花蓼、黄连、祛湿化痰药、解表药。
2.53所述的组合物包括头花蓼、黄连、温阳散寒药、消食药。
2.54所述的组合物包括头花蓼、黄连、温阳散寒药、解表药。
2.55所述的组合物包括头花蓼、黄连、消食药、解表药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意二类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份;
(3)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、党参9-18重量份、茯苓9-15重量份;
(4)头花蓼20-60重量份、黄连2-6重量份、人参3-9重量份、白术6-12重量份、甘草2-6重量份、茯苓9-15重量份;
优选的组合物包括头花蓼、黄连、补益药、行气药。
进一步优选的组合物选自如下任意一组:
(1)优选头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、陈皮5-10重量份;
(2)优选头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、陈皮5-10重量份;
(3)进一步优选头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、甘草4-9重量份、陈皮5-10重量份。
优选的组合物包括头花蓼、黄连、补益药、收涩药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、五味子8-12重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、五味子8-12重量份;
(3)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、甘草4-9重量份、五味子8-12重量份;
所述的组合物包括头花蓼、黄连、补益药、温阳散寒药的组选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、白芍6-15重量份、吴茱萸2-5重量份
所述的组合物包括头花蓼、黄连、补益药、解表药的组选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、甘草2-6重量份、白芍6-15重量份、大枣6-15重量份、桂枝3-10重量份、生姜3-10重量份
优选的组合物包括头花蓼、黄连、利水渗湿药、行气药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、茯苓9-15重量份、陈皮5-10重量份;
优选的组合物包括头花蓼、黄连、利水渗湿药、收涩药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、茯苓9-15重量份、五味子8-12重量份;
优选的组合物包括头花蓼、黄连、行气药、收涩药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、陈皮5-10重量份、五味子8-12重量份;
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意三类药物组成。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、解表药。
述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、解表药。
所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药。
所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药。
所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、行气药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、行气药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、行气药、消食药。
所述的组合物包括头花蓼、黄连、补益药、行气药、解表药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、消食药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、消食药、解表药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、行气药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、行气药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、行气药、消食药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、消食药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、活血化瘀药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、消食药、解表药。
所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、凉血止血药、消食药、解表药。
所述的组合物包括头花蓼、黄连、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、温阳散寒药、消食药、解表药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意三类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼10-90重量份、黄连1-10重量份、党参3-50重量份、茯苓3-30重量份、陈皮2-20重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份;
(3)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份;
其中
(1)优选头花蓼10-90重量份、黄连1-10重量份、党参3-50重量份、茯苓3-30重量份、陈皮2-20重量份;
(2)更优选头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份;
(3)最优选头花蓼30-60重量份、黄连3重量份、党参10重量份、茯苓10重量份、陈皮6重量份;
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼10-90重量份、黄连1-10重量份、党参3-50重量份、茯苓3-30重量份、五味子2-20重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、五味子8-12重量份;
(3)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、党参9-18重量份、茯苓9-15重量份、五味子8-12重量份、
其中
(1)优选头花蓼10-90重量份、黄连1-10重量份、党参3-50重量份、茯苓3-30重量份、五味子2-20重量份;
(2)更优选头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、五味子重8-12量份;
(3)最优选头花蓼30-60重量份、黄连3重量份、党参10重量份、茯苓10重量份、 五味子10重量份。
优选的组合物包括头花蓼、黄连、补益药、行气药、收涩药。
进一步优选的组合物选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、陈皮5-10重量份、五味子8-12重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、陈皮5-10重量份、五味子8-12重量份;
(3)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、甘草4-9重量份、陈皮5-10重量份、五味子8-12重量份。
优选的组合物包括头花蓼、黄连、补益药、温阳散寒药、解表药的组选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、甘草2-6重量份、黄芪9-30重量份、党参9-18重量份、白芍6-15重量份、大枣6-15重量份、高良姜3-6重量份、干姜3-10重量份、桂枝3-10重量份。
优选的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份;
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意四类药物组成。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、收涩药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、补益药、行气药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、行气药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、行气药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、行气药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、行气药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、行气药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、收涩药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、凉血止血药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、消食药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、消食药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、消食药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、消食药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、利水渗湿药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、行气药、收涩药、消食药、解表药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、消食药、解表药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、行气药、凉血止血药、消食药、解表药。
所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、行气药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、消食药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、消食药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、收涩药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、消食药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、活血化瘀药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、凉血止血药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意四类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、清热药、补益药、行气药、活血化瘀药选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、蒲公英10-15重量份、黄芪9-30重量份、白芍6-15重量份、甘草2-6重量份、人参3-9重量份、紫苏梗5-10重量份、延胡索3-10重量份。
优选的组合物包括头花蓼、黄连、清热药、补益药、祛湿化痰药、温阳散寒药选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、黄芩3-10重量份、人参3-9重量份、甘草2-6重量份、大枣6-15重量份、半夏3-9重量份、干姜3-10重量份;
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份;
(3)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意五类药物组成。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、凉血止 血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、消食药、解表药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意五类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、祛湿化痰药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、延胡索3-10重量份、半夏3-9重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、丹参10-15重量份、厚朴3-10重量份。
优选的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、解表药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、延胡索3-10重量份、桂枝3-10重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、丹参10-15重量份、柴胡3-10重量份。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意六类药物组成。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、祛湿化 痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、消食药、解表药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意六类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、解表药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、吴茱萸2-5重量份、柴胡3-10重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、高良姜3-6重量份、桂枝3-10重量份;
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意七类药物组成。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、消食药、解表药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意七类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、半夏3-9重量份、吴茱萸2-5重量份、;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、厚朴3-10重量份、高良姜3-6重量份;
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意八类药物组成。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、 活血化瘀药、凉血止血药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、消食药、解表药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意八类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、半夏3-9重量份、吴茱萸2-5重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、厚朴3-10重量份、高良姜3-6重量份;
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意九类药物组成。
所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化 瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意九类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈 皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、半夏3-9重量份、吴茱萸2-5重量份、柴胡3-10重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、厚朴3-10重量份、高良姜3-6重量份、桂枝3-10重量份;
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意十类药物组成。
所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药。
所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意十类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药的组选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、半夏3-9重量份、吴茱萸2-5重量份、山楂9-12重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、厚朴3-10重 量份、高良姜3-6重量份、山楂9-12重量份。
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药的组选自如下任意一组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、吴茱萸2-5重量份、山楂9-12重量份、柴胡3-10重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、高良姜3-6重量份、山楂9-12重量份、桂枝3-10重量份。
所述的组合物由头花蓼、黄连、和上述十类药性中的任意十一类药物组成。
所述的组合物由头花蓼、黄连、和上述十一类药性中的任意十一类药物组成药物组合物中:
优选的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
进一步优选的组合物选自如下组:
(1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、半夏3-9重量份、吴茱萸2-5重量份、山楂9-12重量份、柴胡3-10重量份;
(2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、厚朴3-10重量份、高良姜3-6重量份、山楂9-12重量份、桂枝3-10重量份。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经无机、有机溶剂单独或混合溶剂提取并获得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经水与乙醇、丙酮、乙酸乙酯的两种、多种混合溶剂提取并获得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经5-30倍的水提取并获得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经5-30倍的30-100%的有机溶液提取并获得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经5-30倍的30-99%的低级醇(C1-C5)、丙酮、乙酸溶液提取并获得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经5-30倍的30-99%的乙醇水溶液为提取溶剂提取并获得。在一个实施例中,所述的乙醇水溶液优选为70%乙醇溶液,选取溶液倍数为6-8倍。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经5-15倍的5-95%的醇与酯混合溶液为提取溶剂提取并获得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经5-15倍的5-95%的乙醇与乙酸乙酯混合溶液为提取溶剂提取并获得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是头花蓼和其他药材经5-20倍的乙酸乙酯、石油醚、乙醚提取并获得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是按照包括如下步骤的方法制备:由组成组合物的药材用5~30倍(例如5~15倍,例如6~12倍)的水、乙醇、乙醇水溶液煎煮和/或回流提取1~5次(例如2~3次),每次0.5~5小时(例如0.5~3小时,例如1~3小时),过滤并浓缩滤液,干燥。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是按照包括如下步骤的方法制备:取组成组合物的药材,加5~30倍(例如5~15倍,例如6~12倍)的水,在50~100℃左右煎煮提取1~5次(例如2~3次),每次0.5~5小时(例如0.5~3小时,例如1~3小时),过滤并合并提取液,经浓缩至相对密度为1.1~1.5(例如1.2~1.4)的稠膏,减压干燥,即得。
根据本发明第一方面的药物组合物,其特征在于,所述组合物是按照包括如下步骤的方法制备:取组成组合物的药材,加5~30倍(例如5~15倍,例如6~12倍)的30~99%的乙醇水溶液回流提取1~5次(例如2~3次),每次0.5~5小时(例如0.5~3小时,例如1~3小时),过滤并合并提取液,60~90℃(例如65~75℃)浓缩至相对密度为1.1~1.5(例如1.2~1.4)的稠膏,减压干燥,即得。
上述药物组合物,其中还包含一种或多种其他的药物,该药物选自:抗微生物药、质子泵抑制剂、胃黏膜保护剂、制酸剂、H2受体拮抗剂。
优选的抗微生物药包括但不限定于青霉素类例如阿莫西林,大环内酯类例如克拉霉素,硝咪唑类例如甲硝唑
优选的质子泵抑制剂包括但不限定于奥美拉唑、兰索拉唑、泮托拉唑
优选的胃黏膜保护剂包括但不限定于硫糖铝、思密达
优选的制酸剂,如氢氧化铝镁合剂
优选的H2受体拮抗剂,如西咪替丁、雷尼替丁、法莫替丁。
本发明还公开药物组合物提取物的制备方法,其特征在于,所述的方法的步骤选自以下任意一项或多项:
(1-1)经无机、有机溶剂单独或混合溶剂提取并获得;
(1-2)经水与乙醇、丙酮、乙酸乙酯的二种、多种混合溶剂提取并获得;
(1-3)经5~30倍水做溶剂提取并获得;
(1-4)经5-30倍的30-99%的低级醇(C1-C5)、丙酮、乙酸溶液提取并获得;
(1-5)经5~30倍的30~99%的乙醇水溶液为提取溶剂并经提取并获得;
(1-6)经6~8倍的70%乙醇水溶液为溶剂提取并获得;
(1-7)经5~15倍的5~95%醇与酯的不同混合溶剂提取并获得;
(1-8)经5~20倍的乙酸乙酯、石油醚、乙醚作为提取溶剂并经提取并获得;
(2)按照包括如下步骤的方法制备:由组成组合物的药材用水、乙醇、乙醇水溶液煎煮和/或回流提取,过滤并浓缩滤液,干燥;
(3)按照包括如下步骤的方法制备:称取组成组合物的药材,加5~30倍的水煎煮,50~100℃提取1~5次,每次0.5~5小时,过滤并合并提取液,经浓缩至相对密度为1.1~1.5的稠膏,减压干燥,即得;
(4)按照包括如下步骤的方法制备:称取组成组合物的药材,加6~8倍的水煎煮,85~100℃提取2次,每次1~1.5小时,过滤并合并提取液,经浓缩至相对密度为1.2~1.3的稠膏,减压干燥,即得;
(5)按照包括如下步骤的方法制备:称取组成头花蓼组合物的药材,加5~30倍的乙醇、30~99%乙醇水溶液回流提取1~5次,每次0.5~5小时,过滤并合并提取液,经浓缩至相对密度为1.1~1.5的稠膏,减压干燥,即得;
(6)按照包括如下步骤的方法制备:称取组成头花蓼组合物的药材,加6~8倍的70%乙醇水溶液回流提取2次,每次1~1.5小时,过滤并合并提取液,经浓缩至相对密度为1.2~1.3的稠膏,减压干燥,即得。
本发明包括所有上述方法制备的药物组合物提取物。
本发明第二方面提供了一种药物制剂组合物。
为了使用的方便本发明中的组合物还包含一种或多种无毒生理学可接受的载体。所述的可接受的载体包括本领域公知的任何辅料及起控释作用的辅料。常用的辅料包括稀释剂、黏合剂、润湿剂、崩解剂、润滑剂、助流剂、致孔剂、增塑剂、填充剂、增溶剂和乳化剂。稀释剂可以是但不限于淀粉、糊精、蔗糖、葡萄糖、乳糖、甘露醇、山梨醇、木糖醇、微晶纤维素、硫酸钙、磷酸氢钙、碳酸钙等;湿润剂可以是但不限于水、乙醇、异丙醇等;粘合剂可以是淀粉浆、糊精、糖浆、蜂蜜、葡萄糖溶液、微晶纤维素、阿拉伯胶浆、明胶浆、羧甲基纤维素钠、甲基纤维素、羟丙基甲基纤维素、乙基纤维素、丙烯酸树脂、卡波姆、聚乙烯吡咯烷酮、聚乙二醇等;崩解剂可以是但不限于干淀粉、微晶纤维素、低取代羟丙基纤维素、交联聚乙烯吡咯烷酮、交联羧甲基纤维素钠、羧甲基淀粉钠、碳酸氢钠与枸橼酸、聚氧乙烯山梨糖醇脂肪酸酯、十二烷基磺酸钠等;润滑剂和助流剂可以是但不限于滑石粉、二氧化硅、硬脂酸盐、酒石酸、液体石蜡、聚乙二醇;增溶剂和乳化剂可以是但不限于乙醇、异丙醇、碳酸乙酯、乙酸乙酯、苄醇、苯甲酸苄酯、丙二醇、1,3-丁二醇、二甲基甲酰胺、油类(特别是棉籽油、花生油、玉米油、胚芽油、橄榄油、蓖麻油和芝麻油)、甘油、四氢呋喃醇、聚乙二醇和脱水山梨糖醇的脂肪酸酯及它们的混合物。起缓控释作用的辅料可以选自亲水性凝胶材料、蜡脂类材料和不溶性材料的一种或多种。所述的亲水性凝胶材料可以选自羟丙基甲基纤维素、卡波普、羧甲基纤维素钠和海藻酸盐,所述的蜡脂类材料可以选自十六醇、十八醇、蜂蜡、山嵛酸甘油酯、硬脂酸和巴西棕榈蜡,所述的不溶性材料可以选自乙基纤维素、丙烯酸树脂、聚氧乙烯和聚乙烯。
此外,如需要,也可以向药物制剂中添加着色剂、防腐剂、香料、矫味剂或其它添加剂。
为此本发明还涉及包含药物组合物和药学上可接受的载体制成的制剂。可通过将组合物与一种或多种药学上可接受的固体或液体赋形剂和/或辅剂结合,制成适于人或动物使用的任何剂型。该制剂可根据本领域公知的方法制备。本发明中的组合物在其药物制剂中的含量通常为6-12g。
为达到用药目的,增强治疗效果,本发明的药物制剂优选为口服制剂。
本发明中的药物组合物制备的口服制剂包括颗粒剂、片剂、丸剂、胶囊剂、口服液制剂 等有关的常释制剂与缓控释制剂,所述的缓控释制剂包括骨架型、膜控型、渗透泵型、胃内滞留型缓释缓控释制剂,微囊、纳米粒、脂质体等药物新载体缓释缓控释制剂,胃内滞留型缓控释制剂优选为胃漂浮剂。
以胃漂浮剂为例,该制剂的制备工艺如下:
原料为31%的组合物,31%Ⅳ丙烯酸树脂,31%十八醇,7%MCC101,加入适量硬脂酸镁,干法直接压片得到头花蓼组合物胃内漂浮片。
本发明第三方面提供了药物组合物在制备抗菌药物的应用。
根据本发明第二方面的应用,其特征在于,所述的病菌选自革兰氏阳性菌甲氧西林耐药金黄色葡萄球菌S.aureus(Methicllin-resistant,MRSA)、甲氧西林敏感金黄色葡萄球菌S.aureus(Methicin-suseptable)、甲氧西林耐药表皮葡萄球菌(staphylococcus epidermidis,MRSE)、甲氧西林敏感表皮葡萄球菌(staphylococcus epidermidis,MSSE),还选自革兰氏阴性菌大肠埃希菌(ESBLS)Escherichia Coli,Eco+,大肠埃希菌(非ESBLS)Escherichia Coli,Eco-,肺炎克雷伯(ESBLs)K.penumonia,KPN+,肺炎克雷伯(非ESBLs)K.penumonia,铜绿假单胞菌(Pseudomonas aeruginosa,PAE)、幽门螺旋杆菌。
在本发明中,术语“提取”可以是常温下的浸渍,或者在升高的温度下的提取(例如煎煮和/或回流),或者这些操作方式的结合。还可以进一步包括对提取物进行进一步处理,例如进一步纯化,例如除溶剂、沉淀除杂质、溶剂萃取、树脂吸附分离等。
如本文所述的,术语“提取物”将包括可用于实现本发明任何目的的任何纯度的提取物,提取物的提取纯度可以在较大的范围内变化。
本发明的有益效果在于:组合物提高了头花蓼单方抗幽门螺旋杆菌活性,水提组合物A对Hp ATCC700392的最低抑菌所需头花蓼生药含量为9.84mg/ml,黄连生药含量为0.98mg/ml,低于头花蓼单方(36.68mg/ml)和黄连单方(1.37mg/ml)所需含量,增强头花蓼与黄连间的抗菌协同作用;醇提组合物A、组合物B、组合物C对Hp ATCC700392的最低抑菌所需头花蓼生药含量分别为3.63、19.48、17.16(mg/ml),低于头花蓼单方(40.44mg/ml)所需含量;醇提组合物A、组合物B、组合物C对Hp SS1的最低抑菌所需头花蓼生药含量分别为3.63、2.44、2.15(mg/ml),低于头花蓼单方(5.06mg/ml)所需含量;醇提组合物B对耐甲硝唑菌株的最低抑菌所需头花蓼生药含量4.87mg/ml,低于头花蓼单方(10.11mg/ml)所需含量。
组合物具有良好的抗菌活性。水提组合物A对革兰氏阳性菌最低抑菌生药含量为<0.082mg/ml,黄连单方与头花蓼所需生药含量分别为0.204、0.621mg/ml;对革兰氏阴性菌最低抑菌生药含量为<0.0824mg/ml,黄连单方与头花蓼所需生药含量分别为0.204、5.175mg/ml。
附图说明
图1显示了临床耐药株验证结果。
图2显示了组合物对幽门螺旋杆菌体外抑制的结果。
具体实施方式
以下通过实施例形式的具体实施方式,对本发明的上述内容作进一步的详细说明。但不应将此理解为本发明上述主题的范围仅限于以下的实施例。凡基于本发明上述内容所实现的技术均属于本发明的范围。
实施例
实施例1:制备组合物A醇提浸膏粉()
称取头花蓼1350g、炒黄连135g、甘草270g,洗净,加入8倍量的70%乙醇进行水浴回流1.5小时,滤过;滤渣加入6倍量70%的乙醇,水浴回流提取1小时,滤过。合并两次滤液,浓缩得浸膏,减压干燥,得到本实施例浸膏粉,186g。
实施例2:制备组合物B醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼750g、炒黄连75g、党参250g、茯苓250g、陈皮150g进行提取,得本实施例浸膏粉,154g。
实施例3:制备组合物C醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼600g、炒黄连60g、党参200g、茯苓200g、五味子200g进行提取,得本实施例浸膏粉,140g。
实施例4:制备头花蓼单方醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼900g进行提取,得本实施例浸膏粉,89g。
实施例5:制备炒黄连醇提浸膏粉
参考实施例1相同方法,不同之处在于称取炒黄连药材660g,得本实施例浸膏粉,133g。
实施例6:制备组合物A水煎浸膏粉
称取头花蓼600g、炒黄连60g、生甘草120g,洗净,加入8倍量水煎煮1.5小时,滤过;滤渣加入6倍量水煎煮1.5小时,滤过,合并两次滤液,滤液浓缩为浸膏,减压干燥,得到本实施例浸膏粉,122g。
实施例7:制备组合物B水煎浸膏粉
方法参考实施例5相同方法,不同之处在于称取药材头花蓼300g、炒黄连30g、党参100g、茯苓100g、陈皮60g进行提取,得本实施例浸膏粉,95g。
实施例8:制备组合物C水煎浸膏粉
参考实施例5相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、党参100g、茯苓100g、五味子100g进行提取,得本实施例浸膏粉,102g。
实施例9:制备头花蓼单方水煎浸膏粉
参考实施例5相同的方法,不同之处在于称取药材头花蓼1000g进行提取,得本实施例浸膏粉,109g。
实施例10:制备炒黄连水煎浸膏粉
参考实施例5相同的方法,不同之处在于称取炒黄连药材520g,得本实施例浸膏粉,95g。
实施例11:制备组合物A水提浸膏粉
参考实施例1相同的方法,不同之处在于称取头花蓼80kg、炒黄连8kg、生甘草16kg,进行提取,得到本实施例浸膏粉,8.1kg。
实施例12:制备组合物B水提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼54kg、炒黄连5.6kg、党参17.6kg、茯苓17.6kg、陈皮10.4kg进行提取,得本实施例浸膏粉,17.0kg。
实施例13:制备组合物C水提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼48kg、炒黄连4.8kg、党参16kg、茯苓16kg、五味子16kg进行提取,得本实施例浸膏粉,20.0kg。
实施例14:制备炒黄连水提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材炒黄连76kg进行提取,得本实施例浸膏粉,3.1kg。
实施例15:制备组合物A醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取称取头花蓼500g、炒黄连50g、生甘草100g,进行提取,得到本实施例浸膏粉,64.2g。
实施例16:制备组合物B醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、党参100g、茯苓100g、陈皮60g进行提取,得本实施例浸膏粉,78g。
实施例17:制备组合物C醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、党参100g、茯苓100g、五味子100g进行提取,得本实施例浸膏粉,85.4g。
实施例18:制备头花蓼醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼600g进行提取,得本实施例浸膏粉,50.2g。
实施例19:制备组合物D醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、党参100g、茯苓100g进行提取,得本实施例浸膏粉,78.8g。
实施例20:制备组合物D水煎浸膏粉
参考实施例5相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、党参100g、茯苓100g进行提取,得本实施例浸膏粉,79g。
实施例21:制备组合物E醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、茯苓100g、陈皮60g进行提取,得本实施例浸膏粉,64g。
实施例22:制备组合物E水煎浸膏粉
参考实施例5相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、茯苓100g、陈皮60g进行提取,得本实施例浸膏粉,66g。
实施例23:制备组合物F醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、党参100g、五味子100g进行提取,得本实施例浸膏粉,80g。
实施例24:制备组合物F水煎浸膏粉
参考实施例5相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、党参100g、五味子100g进行提取,得本实施例浸膏粉,84g。
实施例25:制备组合物G醇提浸膏粉
参考实施例1相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、茯苓100g、五味子100g进行提取,得本实施例浸膏粉,86g。
实施例26:制备组合物G水煎浸膏粉
参考实施例5相同的方法,不同之处在于称取药材头花蓼300g、炒黄连30g、茯苓100g、五味子100g进行提取,得本实施例浸膏粉,88g。
药理实验
试验例1:组合物(实施例1)对幽门螺旋杆菌标准株及临床菌株抗菌活性检测。
1)实验菌株:
临床菌株:所用菌株为幽门螺旋杆菌ATCC700392、幽门螺旋杆菌SS1国际标准测序株,购自ATCC(美国菌种保藏中心)。
耐药菌株:收集于临床消化内科,经药敏实验验证。临床分离到三种菌株(命名)及其特性分别为:
HP R-1型:其对甲硝唑耐药,
HP R-2型:其对阿莫西林耐药,
HPR-3型:其对克拉霉素耐药。
2)试验使用的主要试剂
哥伦比亚血琼脂粉、脑心浸液琼脂干粉购自英国Oxoid公司,盐酸万古霉素、两性霉素、多粘菌素B、磺胺(TMP)、阿莫西林、克拉霉素、甲硝唑购自美国Sigma公司,触酶、氧化酶、尿素酶购自生物梅里埃公司,无菌脱纤维羊血购自南京便诊生物科技有限公司,无水乙醇(分析纯)购自重庆重庆川东化工有限公司化学试剂厂,二甲基亚砜(DMSO)分析纯购自北京萦莱宝科技有限公司。
3)试验样品
本发明一部分实施例所得组合物;实施例4、9所得头花蓼单方浸膏。
4)主要试剂和材料的制备:
4.1)含药平皿的配制:
根据体外药敏实验要求,实验时每个菌株的每个药物浓度需设置2个平行实验,实验需重复3次。每次于三角烧瓶中称取1.95g哥伦比亚血琼脂粉溶解于39.5mL去离子水中,高压灭菌后,待培养基冷却至50~55℃时加入5mL脱纤维无菌羊血(10%)、0.5mL混合抗生素(1%),再加入对应稀释度的药液5mL,混匀后倒入2个无菌平皿(d=90mm)中,凝固后4℃保存。头花蓼单方及组合物溶液的稀释度及对应平板的含药浓度见表1。
4.2)含溶媒血平板的配制(溶剂对照):方法同含样品血平板的配制,即加入相应体积相应浓度的二甲亚砜替代样品母液,以双蒸水作为溶剂则不需配制。
5)实验方法
5.1)幽门螺旋杆菌标准株及临床耐药株的复苏培养及菌株的鉴定
从-80℃冰箱中取出幽门螺旋杆菌ATCC700392和幽门螺旋杆菌SS1菌株及临床H.pylori耐阿莫西林株、H.pylori耐克拉霉素株、H.pylori耐甲硝唑株,置于37℃水浴箱中溶解,用接种环醮取菌液均匀涂布于含混合抗生素的哥伦比亚血平板上,置于37℃三气培养箱(85%N2,10%CO2,5%O2)中培养48h。对这两株标准菌株及三株临床株进行培养特性、革兰染色、尿素酶鉴定、过氧化氢酶鉴定、氧化酶鉴定。
5.2)菌液配制:将血平板上的菌落或菌苔刮至预冷含15mL脑心浸液肉汤管中,离心洗涤一次后,重悬于4℃脑心浸液肉汤中,将此菌液作10倍、100倍、1000倍稀释后,在紫外分光光度计上测菌液的OD600值,结果位于0.1~1.0之间的OD值与菌液浓度有较好的线性关系,菌液含量的计算公式如下:菌量/mL=2.2×108×OD600值×稀释倍数,将菌液稀释得到108CFU/mL。在15min内完成菌液配制和接种,接种过程中菌液需保持在4℃。
5.3)临床耐药株验证试验:将培养72h的幽门螺杆菌临床菌株用脑心浸液肉汤制备菌悬液,调配其浓度在1~9×108CFU/mL,分别用无菌棉签沾取菌悬液均匀涂布于浓度为甲硝唑256μg/mL,克拉霉素256μg/mL,阿莫西林256μg/mL的药物培养皿及空白培养皿上,每个药物浓度涂抹两个平皿,置于微需氧环境中37℃培养72h。以空白培养皿上H.pylori生长良好的情况下,以观察其生长情况,并对所生长细菌做革兰氏染色和生化鉴定试验。
5.4)头花蓼组合物的体外抗菌活性实验
5.4.1)菌液涂布:用一次性棉棒蘸取浓度为108CFU/mL菌液,在琼脂表面均匀涂布。按每种样品每个浓度均涂布2块平板。同时设阴性对照(即不加菌)、生长对照(即不加实验样品)、溶剂对照各两块平板。
5.4.2)培养:置于37℃三气培养箱中培养48h后观察结果。每个样品的每种菌株体外抗菌活性实验重复三次。
5.4.3)在阴性对照(即不加菌)无生长、生长对照(即不加药)生长良好、溶剂对照(即仅加溶剂)未见生长抑制现象的条件下,以完全无菌生长的样品最高稀释度为该菌株对相应样品的最低抑菌浓度(MIC)。
6)实验结果:
6.1)幽门螺杆菌的鉴定
两株幽门螺杆菌ATCC700392和SS1及临床分离株在普通哥伦比亚血平板上置于微需氧条 件下培养48h,菌落呈针尖状无色透明,光滑湿润,边缘整齐,凸起,呈小水滴样,菌苔灰白色,发油光。
生化试验:尿素酶试验阳性,氧化酶试验阳性,过氧化氢酶试验阳性;在显微镜油镜下观察,典型的海鸥状,S状,革兰染色阴性。
6.2)耐药株的验证
将临床已收集分离的H.pylori耐阿莫西林株、H.pylori耐克拉霉素株、H.pylori耐甲硝唑株共3种临床耐药株进行复苏,并对耐药情况核实。在药物浓度为甲硝唑256μg/mL,克拉霉素256μg/mL,阿莫西林256μg/mL是均生长状态良好,与空白组无区别。
6.3)头花蓼组合物的体外抗菌试验结果见表2。
头花蓼组合物对Hp ATCC700392和SS1的MIC为0.5mg/ml。
在本实验的平行试验中,同样验证了阿莫西林、甲硝唑、克拉霉素三者对上表中5种幽门螺旋杆菌的敏感性,结果显示三种药物对ATCC700392和SS1均敏感,而HP R-1对克拉霉素耐药,对另外两种药物敏感;HP R-2对阿莫西林耐药,对另外两种药物敏感;HP R-3对甲硝唑耐药,对另外两种药物敏感。头花蓼单方对Hp ATCC700392和SS1的MIC为4mg/ml,验证之前的实验结果。
试验例2:头花蓼组合物对幽门螺旋杆菌标准株及临床分离菌株抗菌活性检测。
基本上参考试验例1的方法,分别以实施例2-3、5-8、9所得头花蓼组合物为试药,测试其对ATCC700392、幽门螺旋杆菌SS1国际标准测序株、幽门螺旋杆菌耐甲硝唑株、幽门螺旋杆菌耐阿莫西林株、幽门螺旋杆菌耐克拉霉素株的抗菌活性。在阴性对照(即不加菌)无生长、生长对照(即不加药)生长良好、溶剂对照(即仅加溶剂)未见生长抑制现象,甲硝唑、阿莫西林、克拉霉素对照均对HP ATCC700392有抑制作用,头花蓼单方制剂对照对HP ATCC700392的最低抑菌浓度(MIC)为4mg/ml的情况下,实验做重复三次,本实验中所有组合物样品对五种幽门螺旋杆菌的MIC值在0.5~64mg/ml之间。黄连抑菌效果较好,其MIC值在<0.0625-0.25mg/ml之间。实验结果见表2。
表1实验样品溶液的稀释浓度
Figure PCTCN2015086156-appb-000003
表2本发明实施例的组合物对幽门螺旋杆菌体外抑菌结果(MIC)
Figure PCTCN2015086156-appb-000004
Figure PCTCN2015086156-appb-000005
试验例3:组合物对革兰氏菌抗菌活性检测实验
1)试验菌株
1.1)受试菌株
甲氧西林耐药金黄色葡萄球菌S.aureus(Methicllin-resistant,MRSA)6株、甲氧西林敏感金黄色葡萄球菌S.aureus(Methicin-suseptable,MSSA)6株、甲氧西林耐药表皮葡萄球菌(staphylococcus epidermidis,MRSE)5株、甲氧西林敏感表皮葡萄球菌(staphylococcus epidermidis,MSSE)5株、大肠埃希菌(ESBLS)Escherichia Coli,Eco+6株、大肠埃希菌(非ESBLS)Escherichia Coli,Eco-6株、肺炎克雷伯(ESBLs)K.penumonia,KPN+6株、肺炎克雷伯(非ESBLs)K.penumonia,KPN-6株、铜绿假单胞菌(Pseudomonas aeruginosa,PAE)5株、铜绿假单胞菌(Pseudomonas aeruginosa,PAE)5株。以上菌株均为2013年6月至2014年10月在四川地区、北京地区、上海等收集的临床分离致病菌。在收集单位经VITEK-60自动微生物鉴定仪鉴定。
1.2)质控菌株
金黄色葡萄球菌CMCC26003;大肠埃希菌ATCC25922;铜绿假单胞菌ATCC27853。购自中华人民共和国卫生部临床检测中心。
2)实验试剂与材料
头孢吡肟(标准品)源自中国食品药品检定研究院标准品;头花蓼水提单方由贵阳医学院提供,批号为14196,生药含量10.35g/g。
3)实验方法
以头花蓼单方、炒黄连单方、头孢吡肟为对照药材,用琼脂二倍稀释法进行样品体外抗菌的最低抑菌浓度。
3.1)头孢吡肟对照品
称取药品9.5mg,加入4.1ml的生理盐水,混匀,各吸取1ml于两个培养皿中,再加入15ml的培养基,使其终浓度为145ug/ml,再吸取2ml于西林瓶中,再在该西林瓶中加入2ml的生理盐水,混匀,各吸取1ml加入两个平皿中,再加入15ml的培养基,使其终浓度为72.4ug/ml,依照此法倍比稀释,使平皿内所含药物终浓度依次为128、64、32、16、8、4、2、1、0.5、0.25、0.125、0.06、0.03、0.015、0.008ug/ml。待冷却后用多点接种仪(MIT-P,SUKUMA)接种细菌,接种菌量约为104CFU/ml,每皿接种27株菌,2个皿接种54株菌,盖上皿盖。置于35-37℃培养箱内培养18-20h,观察记录结果。以平皿内未见细菌生长的药物最低浓度,判断为最低抑菌浓度(Minimal Inhibitory Concentration,MIC)。
3.2)头花蓼单方、黄连浸膏及试验样品配制方法
取灭菌烧杯,加入已称量好的中药样品7.68g,再定量加入约50℃的已融化的M-H琼脂培养基60ml,混匀后分别吸取15ml于两个平皿中,使其浓度为128mg/ml,再在剩余的30ml培养基中加入30ml培养基,混匀,分别再从中吸取15ml于2个培养皿中,使其浓度为64mg/ml,依照此法倍比稀释,使每皿内所含药物终浓度依次为128、64、32、16、8、4、2、1、0.5、0.25、0.125、0.06、0.03、0.015、0.008mg/ml。待冷却后用多点接种仪(MIT-P,SUKUMA)接种细菌,接种菌量约为104CFU/ml,每皿接种27株菌,2个皿接种54株菌,盖上皿盖。置于35-37℃培养箱内培养18-20h,观察记录结果。
4)实验结果
实验结果表明,头花蓼组合物对革兰氏阴性菌及革兰氏阳性菌有较好的抑制效果。实验结果见表3。
表3本发明实施例对革兰氏菌的抑菌MIC结果表
Figure PCTCN2015086156-appb-000006

Claims (39)

  1. 一种药物组合物,其特征在于,所述的组合物包括头花蓼、黄连。
  2. 一种药物组合物,其特征在于,所述的组合物包括头花蓼20-60重量份、黄连2-6重量份。
  3. 根据权利要求1的组合物,其特征在于,所述的组合物由头花蓼、黄连,和选自下述任一类或几类组合物组成:(1)清热类药物;(2)补益药物;(3)利水渗湿药;(4)行气药;(5)收涩药;(6)活血化瘀药;(7)凉血止血药;(8)祛湿化痰药;(9)温阳散寒药;(10)消食药;(11)解表药。
  4. 根据权利要求3的药物组合物,其特征在于,
    所述的清热类药物选自蒲公英、穿心莲、黄芩、黄柏、板蓝根、青黛、金银花、秦皮、金莲花、鱼腥草、紫花地丁、牡丹皮、桉树蜜、水团花、栀子、白花蛇舌草、半枝莲、生地黄、鸦胆子、大血藤;但是不包括头花蓼、黄连;
    所述的补益药物选自甘草、党参、白术、白芍、大枣、人参、茶叶、黄芪、黄精;
    所述的利水渗湿药选自茯苓、虎杖、土茯苓;
    所述的行气药选自陈皮、木香、枳实、香附、紫苏梗、八月札、土荆芥;
    所述的收涩药选自五味子、诃子、石榴皮、乌梅、海螵蛸;
    所述的活血化瘀药选自延胡索、三七、丹参、石见穿、郁金、大黄;
    所述的凉血止血药选自白及、地榆;
    所述的祛湿化痰药选自半夏、厚朴、旋复花、白果;
    所述的温阳散寒药选自吴茱萸、高良姜、胡椒、干姜、野艾;
    所述的消食药选自大蒜、山楂、槟榔;
    所述的解表药选自桂枝、生姜、紫苏叶、柴胡。
  5. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连,和下述十一类药性中的任意一类药物组成:(1)清热类药物;(2)补益药物;(3)利水渗湿药;(4)行气药;(5)收涩药;(6)活血化瘀药;(7)凉血止血药;(8)祛湿化痰药;(9)温阳散寒药;(10)消食药;(11)解表药。
  6. 根据权利要求4的组合物,其特征在于,所述的组合物选自如下任意一组:
    1.1所述的组合物包括头花蓼、黄连、清热类药物;
    1.2所述的组合物包括头花蓼、黄连、补益药物;
    1.3所述的组合物包括头花蓼、黄连、利水渗湿药;
    1.4所述的组合物包括头花蓼、黄连、行气药;
    1.5所述的组合物包括头花蓼、黄连、收涩药;
    1.6所述的组合物包括头花蓼、黄连、活血化瘀药;
    1.7所述的组合物包括头花蓼、黄连、凉血止血药;
    1.8所述的组合物包括头花蓼、黄连、祛湿化痰药;
    1.9所述的组合物包括头花蓼、黄连、温阳散寒药;
    1.10所述的组合物包括头花蓼、黄连、消食药;
    1.11所述的组合物包括头花蓼、黄连、解表药。
  7. 根据权利要求6的药物组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、清热类药物的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、蒲公英10-15重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、鱼腥草15-25重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、黄柏3-12重量份、黄芩3-10重量份、栀子6-10重量份;
    所述的组合物包括头花蓼、黄连、补益药物的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、黄精9-15重量份;
    (2)头花蓼10-90重量份、黄连1-10重量份、甘草2-20重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份;
    (4)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、甘草4-9重量份;
    所述的组合物包括头花蓼、黄连、利水渗湿药的组选自如下任意一组:
    (1)头花蓼20-60、黄连2-6重量份、茯苓9-15重量份;
    所述的组合物包括头花蓼、黄连、行气药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、陈皮5-10重量份;
    所述的组合物包括头花蓼、黄连、收涩药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、五味子8-12重量份。
  8. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连,和十一类药性中的任意二类药物组成;
    2.1所述的组合物包括头花蓼、黄连、清热类药物、补益药;
    2.2所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药;
    2.3所述的组合物包括头花蓼、黄连、清热类药物、行气药;
    2.4所述的组合物包括头花蓼、黄连、清热类药物、收涩药;
    2.5所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药;
    2.6所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药;
    2.7所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药;
    2.8所述的组合物包括头花蓼、黄连、清热类药物、温阳散寒药;
    2.9所述的组合物包括头花蓼、黄连、清热类药物、消食药;
    2.10所述的组合物包括头花蓼、黄连、清热类药物、解表药;
    2.11所述的组合物包括头花蓼、黄连、补益药、利水渗湿药;
    2.12所述的组合物包括头花蓼、黄连、补益药、行气药;
    2.13所述的组合物包括头花蓼、黄连、补益药、收涩药;
    2.14所述的组合物包括头花蓼、黄连、补益药、活血化瘀药;
    2.15所述的组合物包括头花蓼、黄连、补益药、凉血止血药;
    2.16所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药;
    2.17所述的组合物包括头花蓼、黄连、补益药、温阳散寒药;
    2.18所述的组合物包括头花蓼、黄连、补益药、消食药;
    2.19所述的组合物包括头花蓼、黄连、补益药、解表药;
    2.20所述的组合物包括头花蓼、黄连、利水渗湿药、行气药;
    2.21所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药;
    2.22所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药;
    2.23所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药;
    2.24所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药;
    2.25所述的组合物包括头花蓼、黄连、利水渗湿药、温阳散寒药;
    2.26所述的组合物包括头花蓼、黄连、利水渗湿药、消食药;
    2.27所述的组合物包括头花蓼、黄连、利水渗湿药、解表药;
    2.28所述的组合物包括头花蓼、黄连、行气药、收涩药;
    2.29所述的组合物包括头花蓼、黄连、行气药、活血化瘀药;
    2.30所述的组合物包括头花蓼、黄连、行气药、凉血止血药;
    2.31所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药;
    2.32所述的组合物包括头花蓼、黄连、行气药、温阳散寒药;
    2.33所述的组合物包括头花蓼、黄连、行气药、消食药;
    2.34所述的组合物包括头花蓼、黄连、行气药、解表药;
    2.35所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药;
    2.36所述的组合物包括头花蓼、黄连、收涩药、凉血止血药;
    2.37所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药;
    2.38所述的组合物包括头花蓼、黄连、收涩药、温阳散寒药;
    2.39所述的组合物包括头花蓼、黄连、收涩药、消食药;
    2.40所述的组合物包括头花蓼、黄连、收涩药、解表药;
    2.41所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药;
    2.42所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药;
    2.43所述的组合物包括头花蓼、黄连、活血化瘀药、温阳散寒药;
    2.44所述的组合物包括头花蓼、黄连、活血化瘀药、消食药;
    2.45所述的组合物包括头花蓼、黄连、活血化瘀药、解表药;
    2.46所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药;
    2.47所述的组合物包括头花蓼、黄连、凉血止血药、温阳散寒药;
    2.48所述的组合物包括头花蓼、黄连、凉血止血药、消食药;
    2.49所述的组合物包括头花蓼、黄连、凉血止血药、解表药;
    2.50所述的组合物包括头花蓼、黄连、祛湿化痰药、温阳散寒药;
    2.51所述的组合物包括头花蓼、黄连、祛湿化痰药、消食药;
    2.52所述的组合物包括头花蓼、黄连、祛湿化痰药、解表药;
    2.53所述的组合物包括头花蓼、黄连、温阳散寒药、消食药;
    2.54所述的组合物包括头花蓼、黄连、温阳散寒药、解表药;
    2.55所述的组合物包括头花蓼、黄连、消食药、解表药。
  9. 根据权利要求8的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、党参9-18重量份、茯苓9-15重量份;
    (4)头花蓼20-60重量份、黄连2-6重量份、人参3-9重量份、白术6-12重量份、甘草2-6重量份、茯苓9-15重量份;
    所述的组合物包括头花蓼、黄连、补益药、行气药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、陈皮5-10重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、陈皮5-10重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、甘草4-9重量份、陈皮5-10重量份;
    所述的组合物包括头花蓼、黄连、补益药、收涩药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、五味子8-12重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、五味子8-12重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、甘草4-9重量份、五味子8-12重量份;
    所述的组合物包括头花蓼、黄连、补益药、温阳散寒药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、白芍6-15重量份、吴茱萸2-5重量份;
    所述的组合物包括头花蓼、黄连、补益药、解表药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、甘草2-6重量份、白芍6-15重量份、大枣6-15重量份、桂枝3-10重量份、生姜3-10重量份;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、茯苓9-15重量份、陈皮5-10重量份;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、茯苓9-15重量份、五味子8-12重量份;
    所述的组合物包括头花蓼、黄连、行气药、收涩药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、陈皮5-10重量份、五味子8-12重量份。
  10. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十一类药性中的任意三类药物组成;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、解表药;
    述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、凉血止血药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、温阳散寒药、消食药、解表药。
  11. 根据权利要求10的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药的组选自如下任意一组:
    (1)头花蓼10-90重量份、黄连1-10重量份、党参3-50重量份、茯苓3-30重量份、陈皮2-20重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药的组选自如下任意一组:
    (1)头花蓼10-90重量份、黄连1-10重量份、党参3-50重量份、茯苓3-30重量份、五味子2-20重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、五味子8-12重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、党参9-18重量份、茯苓9-15重量份、五味子8-12重量份;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、陈皮5-10重量份、五味子8-12重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、陈皮5-10重量份、五味子8-12重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、甘草4-9重量份、陈皮5-10重量份、五味子8-12重量份;
    所述的组合物包括头花蓼、黄连、补益药、温阳散寒药、解表药的组选自如下组:
    (1)头花蓼20-60重量份、黄连2-6重量份、甘草2-6重量份、黄芪9-30重量份、党参9-18重量份、白芍6-15重量份、大枣6-15重量份、高良姜3-6重量份、干姜3-10重量份、桂枝3-10重量份;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药选自如下组:
    (1)头花蓼20-60重量份、黄连2-6重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份。
  12. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十一类药性中的任意四类药物组成;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、收涩药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、活血化瘀药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、凉血止血药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、收涩药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、活血化瘀药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、凉血止血药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、收涩药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、活血化瘀药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、凉血止血药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、利水渗湿药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、收涩药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、活血化瘀药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、凉血止血药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、行气药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、活血化瘀药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、凉血止血药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、收涩药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、凉血止血药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、活血化瘀药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、凉血止血药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、凉血止血药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、祛湿化痰药、温阳散寒药、消食药、解表药。
  13. 根据权利要求12的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、清热药、补益药、行气药、活血化瘀药选自如下组:
    (1)头花蓼20-60重量份、黄连2-6重量份、蒲公英10-15重量份、黄芪9-30重量份、白芍6-15重量份、甘草2-6重量份、人参3-9重量份、紫苏梗5-10重量份、延胡索3-10重 量份;
    所述的组合物包括头花蓼、黄连、清热药、补益药、祛湿化痰药、温阳散寒药选自如下组:
    (1)头花蓼20-60重量份、黄连2-6重量份、黄芩3-10重量份、人参3-9重量份、甘草2-6重量份、大枣6-15重量份、半夏3-9重量份、干姜3-10重量份;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份;
    (3)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份。
  14. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十一类药性中的任意五类药物组成;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药、祛湿化 痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、消食药、解表药。
  15. 根据权利要求14的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、祛湿化痰药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10 重量份、延胡索3-10重量份、半夏3-9重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、丹参10-15重量份、厚朴3-10重量份;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、解表药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、延胡索3-10重量份、桂枝3-10重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、丹参10-15重量份、柴胡3-10重量份。
  16. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十一类药性中的任意六类药物组成;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、解 表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、消食药、解表药。
  17. 根据权利要求16的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、解表药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、吴茱萸2-5重量份、柴胡3-10重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、高良姜3-6重量份、桂枝3-10重量份。
  18. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十一类药性中的任意七类药物组成;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、消食药、解表药。
  19. 根据权利要求18的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、半夏3-9重量份、吴茱萸2-5重量份、;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、厚朴3-10重量份、高良姜3-6重量份。
  20. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十一类 药性中的任意八类药物组成;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、消食药、解表药。
  21. 根据权利要求20的组合物,其特征在于,
    9.1所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、半夏3-9重量份、 吴茱萸2-5重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、厚朴3-10重量份、高良姜3-6重量份。
  22. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十一类药性中的任意九类药物组成;
    所述的组合物包括头花蓼、黄连、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化 瘀药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药。
  23. 根据权利要求22的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、半夏3-9重量份、吴茱萸2-5重量份、柴胡3-10重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、厚朴3-10重量份、高良姜3-6重量份、桂枝3-10重量份。
  24. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十一类药性中的任意十类药物组成;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、祛湿化痰药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、消食药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、解表药;
    所述的组合物包括头花蓼、黄连、清热类药物、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药。
  25. 根据权利要求24的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、半夏3-9重量份、吴茱萸2-5重量份、山楂9-12重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、厚朴3-10重量份、高良姜3-6重量份、山楂9-12重量份;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、温阳散寒药、消食药、解表药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、吴茱萸2-5重量份、山楂9-12重量份、柴胡3-10重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、高良姜3-6重量份、山楂9-12重量份、桂枝3-10重量份。
  26. 根据权利要求3的组合物,其特征在于,所述的组合物由头花蓼、黄连、和上述十类药性中的任意十一类药物组成;
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药。
  27. 根据权利要求26的组合物,其特征在于,
    所述的组合物包括头花蓼、黄连、补益药、利水渗湿药、行气药、收涩药、活血化瘀药、凉血止血药、祛湿化痰药、温阳散寒药、消食药、解表药的组选自如下任意一组:
    (1)头花蓼20-60重量份、黄连2-6重量份、党参9-18重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、延胡索3-10重量份、白及6-15重量份、半夏3-9重量份、吴茱萸2-5重量份、山楂9-12重量份、柴胡3-10重量份;
    (2)头花蓼20-60重量份、黄连2-6重量份、甘草4-9重量份、茯苓9-15重量份、陈皮5-10重量份、五味子8-12重量份、丹参10-15重量份、白及6-15重量份、厚朴3-10重量份、高良姜3-6重量份、山楂9-12重量份、桂枝3-10重量份。
  28. 根据权利要求1-27中任一项的药物组合物,其中还包含一种或多种其他的药物,该药物选自:抗微生物药、质子泵抑制剂、胃黏膜保护剂、制酸剂、H2受体拮抗剂。
  29. 根据权利要求28的组合物,其特征在于,
    所述的抗微生物药选自青霉素类例如阿莫西林,大环内酯类例如克拉霉素,硝咪唑类例如甲硝唑
    所述的质子泵抑制剂选自奥美拉唑、兰索拉唑、泮托拉唑
    所述的胃黏膜保护剂选自硫糖铝、思密达
    所述的制酸剂,如氢氧化铝镁合剂
    所述的H2受体拮抗剂,如西咪替丁、雷尼替丁、法莫替丁。
  30. 一种药物组合物提取物的制备方法,其特征在于,所述的方法的选自以下任意一项或多项:
    (1-1)权利要求1-27中任意一项的药物组合物经无机、有机溶剂单独或混合溶剂提取并获得;
    (1-2)权利要求1-27中任意一项的药物组合物经水与乙醇、丙酮、乙酸乙酯的二种、多种混合溶剂提取并获得;
    (1-3)权利要求1-27中任意一项的药物组合物经5~30倍水做溶剂提取并获得;
    (1-4)权利要求1-27中任意一项的药物组合物经5-30倍的30-99%的低级醇(C1-C5)、丙酮、乙酸溶液提取并获得;
    (1-5)权利要求1-27中任意一项的药物组合物经5~30倍的30~99%的乙醇水溶液为提取溶剂并经提取并获得;
    (1-6)权利要求1-27中任意一项的药物组合物经6~8倍的70%乙醇水溶液为溶剂提取并获得;
    (1-7)权利要求1-27中任意一项的药物组合物经5~15倍的5~95%醇与酯的不同混合溶剂提取并获得;
    (1-8)权利要求1-27中任意一项的药物组合物经5~20倍的乙酸乙酯、石油醚、乙醚作为提取溶剂并经提取并获得;
    (2)按照包括如下步骤的方法制备:权利要求1-27中任意一项的药物组合物,用水、乙醇、乙醇水溶液煎煮和/或回流提取,过滤并浓缩滤液,干燥;
    (3)按照包括如下步骤的方法制备:权利要求1-27中任意一项的药物组合物,加5~30倍的水煎煮,50~100℃提取1~5次,每次0.5~5小时,过滤并合并提取液,经浓缩至相对密度为1.1~1.5的稠膏,减压干燥,即得;
    (4)按照包括如下步骤的方法制备:权利要求1-27中任意一项的药物组合物,加6~8倍的水煎煮,85~100℃提取2次,每次1~1.5小时,过滤并合并提取液,经浓缩至相对密度为1.2~1.3的稠膏,减压干燥,即得;
    (5)按照包括如下步骤的方法制备:权利要求1-27中任意一项的药物组合物,加5~30倍的乙醇、30~99%乙醇水溶液回流提取1~5次,每次0.5~5小时,过滤并合并提取液,经浓缩至相对密度为1.1~1.5的稠膏,减压干燥,即得;
    (6)按照包括如下步骤的方法制备:权利要求1-27中任意一项的药物组合物,加6~8倍的70%乙醇水溶液回流提取2次,每次1~1.5小时,过滤并合并提取液,经浓缩至相对密度为1.2~1.3的稠膏,减压干燥,即得。
  31. 权利要求30制备的药物组合物提取物。
  32. 一种药物制剂组合物,其特征在于,含有作为活性成分的权利要求1-29中任意一项的药物组合物和\或权利要求31的药物组合物提取物与药学上接受的辅料。
  33. 根据权利要求32的药物制剂组合物,其特征在于,所述的药物制剂组合物是口服制剂。
  34. 根据权利要求33的药物组合物,其特征在于,所述的口服制剂选自各种可用的常释制剂和缓控释制剂。
  35. 根据权利要求34的药物组合物,其特征在于,所述的缓控释制剂选自骨架型、膜控型、渗透泵型、胃内滞留型缓控释制剂。
  36. 根据权利要求35的药物组合物,其特征在于,所述的胃内滞留型缓控释制剂选自为胃漂浮剂。
  37. 权利要求1-29中任意一项的药物组合物和\或权利要求31的药物组合物提取物在制备抗菌的药物中的应用。
  38. 根据权利要求37的应用,其特征在于,所述的病菌选自革兰氏阳性菌甲氧西林耐药金黄色葡萄球菌S.aureus(Methicllin-resistant,MRSA)、甲氧西林敏感金黄色葡萄球菌S.aureus(Methicin-suseptable)、甲氧西林耐药表皮葡萄球菌(staphylococcus epidermidis,MRSE)、甲氧西林敏感表皮葡萄球菌(staphylococcus epidermidis,MSSE),还选自革兰氏阴性菌大肠埃希菌(ESBLS)Escherichia Coli,Eco+,大肠埃希菌(非ESBLS)Escherichia Coli,Eco-,肺炎克雷伯(ESBLs)K.penumonia,KPN+,肺炎克雷伯(非ESBLs)K.penumonia,铜绿假单胞菌(Pseudomonas aeruginosa,PAE)。
  39. 权利要求1-29中任意一项的药物组合物和\或权利要求31的药物组合物提取物在制备预防/治疗幽门螺旋杆菌的药物中的应用。
PCT/CN2015/086156 2015-08-05 2015-08-05 包含头花蓼和黄连的组合物在制备抗幽门螺旋杆菌的药物中的用途 Ceased WO2017020279A1 (zh)

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