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WO2017060295A1 - Procédé et système de traitement de petites pièces - Google Patents

Procédé et système de traitement de petites pièces Download PDF

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Publication number
WO2017060295A1
WO2017060295A1 PCT/EP2016/073784 EP2016073784W WO2017060295A1 WO 2017060295 A1 WO2017060295 A1 WO 2017060295A1 EP 2016073784 W EP2016073784 W EP 2016073784W WO 2017060295 A1 WO2017060295 A1 WO 2017060295A1
Authority
WO
WIPO (PCT)
Prior art keywords
pressure
treatment system
resistant container
treatment
container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2016/073784
Other languages
German (de)
English (en)
Inventor
Eric Netzhammer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of WO2017060295A1 publication Critical patent/WO2017060295A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/022—Filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
    • A61L2/04—Heat
    • A61L2/06—Hot gas
    • A61L2/07—Steam
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B67—OPENING, CLOSING OR CLEANING BOTTLES, JARS OR SIMILAR CONTAINERS; LIQUID HANDLING
    • B67C—CLEANING, FILLING WITH LIQUIDS OR SEMILIQUIDS, OR EMPTYING, OF BOTTLES, JARS, CANS, CASKS, BARRELS, OR SIMILAR CONTAINERS, NOT OTHERWISE PROVIDED FOR; FUNNELS
    • B67C7/00—Concurrent cleaning, filling, and closing of bottles; Processes or devices for at least two of these operations
    • B67C7/0073—Sterilising, aseptic filling and closing
    • A61L2103/05—
    • A61L2103/23—

Definitions

  • the invention relates to a treatment plant for the treatmen ⁇ development of small parts in a non-pressure-resistant containers.
  • treatment In the pharmaceutical industry, small parts of various shapes are needed for closing glass containers, for use as a component of syringes or similar applications. These small parts, for example, must be cleaned, sterilized and dried before they can be used. This process (cleaning, sterilization, drying, etc.) is referred to in the present description as "treatment.” The small parts are called “treated” when being subjected to the treatmen ⁇ development process. A system in which you can do either of the ⁇ -like treatment process is called "Be ⁇ treatment plant"
  • a "pressure-tight container” is understood to mean a container which is normally made of stainless steel and can withstand pressures which are required for a treatment process.
  • the pressure range starts at 0 bar absolute and reaches up to a few bar Overpressure (eg 3 bar overpressure).
  • Such containers can also withstand temperatures required by the present description, eg 0 ° C to 130 ° C. The loading of the container with the said pressures and temperatures corresponds to the intended operation of such a container.
  • non-pressure-resistant container in the sense of the present description is a container made of any material, for example stainless steel, aluminum, brass, plastic,
  • non-pressure-resistant containers that can withstand such pressure, but a treatment process would not be the intended operation of such containers.
  • plastic bottles for carbonated beverages can withstand very high pressures, but are not “pressure-proof” containers as used herein ".
  • Non-pressure-resistant containers can be dimensionally stable but also not dimensionally stable.
  • the invention has for its object to be able to treat small parts in non-pressure-resistant containers.
  • Fig. 1 the basic principle in which a non-pressure-resistant container is brought to a treatment plant in order to treat the contents within the treatment ⁇ system of this invention
  • Fig. 2 shows the connections and mechanical components which are at least necessary to be able to treat the non-pressure-resistant Benzol ⁇ ter within the treatment plant
  • Fig. 3 the shape of the treatment plant with its connec ⁇ sen
  • FIG. 4 shows various alternative embodiments
  • FIG. 5 shows a further possible embodiment
  • Fig. 6 the principle of treatment in non-pressure-resistant container.
  • Fig. 1 shows a pressure-resistant container 1, in which a non-pressure-resistant container 3 is included. If necessary, this non-pressure-resistant container is clamped in a holder 5, which stabilizes the shape of the non-pressure-resistant container for the duration of the treatment.
  • the holder 5 is rotatable (4) by means of a rotation axis 6 (visible in FIG. 2e). If the dimensional stability of the non-pressure-resistant container is large enough, the non-pressure-resistant container without form ⁇ stabilizing holder in the treatment plant can be placed and rotated ⁇ .
  • the media required for the treatment are supplied and removed via the connections 2 of the treatment plant. The number of these connections should be set up according to demand. The preparation of the media required for the treatment is not shown here. It corresponds to the state of the art.
  • the mög ⁇ union forms the flameproof container are illustrated only by way of example and not limited to just this.
  • Fig. 2a shows the non-pressure-resistant container 3 in the holder 5.
  • the flameproof container 1 is not shown.
  • a riser 13 is inserted into the non-pressure-resistant container.
  • a suitable distributor 14 is mounted, which evenly distributes incoming or outgoing media.
  • the riser ⁇ tube 13 is connected to the holder 5 so that it can maintain its position in the non-pressure-resistant container 3 throughout the treatment.
  • the riser is in the opening area of the non-pressure-resistant container with a sieve plate 12 provided whose holes are so large that media can easily flow through, but so small that the material to be treated does not fall from the non-pressure-resistant container when it is rotated.
  • a non-pressure-resistant container with two or more openings (20, 21) to use.
  • each opening must be placed and held.
  • the openings are provided with screen plates.
  • On a riser can be dispensed with in this case
  • FIG. 2 c there is a cylindrical connection 30 on the pressure-resistant container 1, which contains a lifting device 31.
  • the riser 13 can be pulled out of the non-pressure-resistant container into the cylinder 30 after treatment with the aid of a suitable hook 32.
  • the lifting device 31 is provided with a bellows 33 which hermetically seals the interior of the pressure- resistant container to the outside and to some mechanical parts of the lifting device.
  • connection 40 on the pressure-resistant container 1 in which the media connection 41 is accommodated.
  • the connection is movable, such that the connection to the riser 13 can be connected.
  • the media port 41 is also provided with a bellows 42 which hermetically seals the interior of the pressure-resistant container to the outside and to some mechanical parts of the media port.
  • the connection to the dip tube may be ⁇ metallic sealing with sufficient processing precision, otherwise a soft seal iskal- puts. Large differences in pressure from inside to outside mr ⁇ rule not. Small leaks are allowed.
  • FIG. 2e Another possibility shown in FIG. 2e is to connect the media connection 41 to move the supply through the axis of rotation 6.
  • the media connection 41 rotates together with the non-pressure-resistant container.
  • the bellows 43 provides the necessary mobility of the line, both as a lifting and as a rotational movement when placing the line.
  • the axis of rotation 6 is ⁇ out as a tube, the interior of this tube has no product contact. The interior of this tube may therefore include the drives for moving the media connection.
  • Fig. 2f the
  • FIG. 2g there is a cylindrical connection 50 on the pressure-resistant container 1, in which a closure unit 51 is accommodated.
  • the non-pressure-resistant container is tightly 29los ⁇ sen (53).
  • the closure is provided with a protective cap 54.
  • the type of closure is determined by the end user of the non-pressure-resistant container, the treatment plant can adapt to the circumstances. As closures come under other pharmaügoe Portsys ⁇ tems, welded-on films, flared lid,
  • Fig. 2h shows an example of a possible closure. It is first rotated in the opening 11 of the non-pressure-resistant Bejarl ⁇ ters A standard in the pharmaceutical industry beta port 60 (Baj onettver gleich). In order to seal the non-pressure-resistant container in the long term, a film 62 with a welding device 63 is welded onto the edge of the connection 11. In a third step, a protective cap is set to the closed opening 54, to ensure the mechanical ⁇ rule protection of the film. There are many more closures possible.
  • Fig. 3a shows some details of the riser 13 and the screen ⁇ plate 12. The opening of the non-pressure-resistant container 11 is held with the connection bracket 10 in position (see also Fig. 3b).
  • connection bracket 10 is attached to the rotating bracket 5 (not in the picture).
  • the connection holder 10 can be opened and closed by means of hinge 71 and closure 72.
  • the sheet 45 can not be seen because of the sectional view, it connects the media port 46 with the riser 13.
  • the screen plate 12 is folded in this view, in order to fill the non-pressure-resistant container with small parts can.
  • the screen plate 12 is with the
  • Hinges 74 opened and closed. The required closure to keep the screen plate 12 closed is not visible in the figure.
  • Fig. 3b shows some details of the riser 13 and the screen ⁇ sheet in the side view.
  • the groove 73 holds the opening 11 of the non-pressure-resistant container in the connection holder 10 in position (see also Fig. 3a).
  • the arc 45 which connects the media port 46 with the riser 13, see.
  • FIG. 3 c shows a holding plate 80 with a rectangular opening 81 in side view.
  • FIG. 3d shows two holding plates 80 with a rectangular opening 81 in plan view.
  • a matching hook 82 is pulled by a spring 84 through the openings 81 of the retaining plates 80.
  • the non-pressure-resistant container is rotated into position for removing the peg 13 (see FIG. 5). Then the Hebevor ⁇ direction 31 (not seen in the figure) is lowered.
  • the hook 32 at the lower end of the lifting device 31 (see FIG. 2 a) is designed such that it initially fits in a form-fitting manner on the hook 82 in the region of the axis of rotation 83.
  • the axis of rotation of the lifting device 31 is identical to the axis of rotation of the hook 82.
  • FIG. 4a shows some details of a possible film welding device.
  • a cylindrical connection 50 can be seen on the pressure-resistant container in which a welding insert can be seen.
  • direction 100 is mounted.
  • the design of the cylindrical At ⁇ statements is not relevant. It must be large enough to accommodate the welding device 100, so that the non-pressure-resistant container can rotate together with riser in the pressure-resistant container without poking at the welding device 100 when it is retracted.
  • the welding device 100 can be extended to us with a rod 102.
  • a bellows 101 serves to seal.
  • the eg round film has corresponding holes 105.
  • 103 grooves 104 are provided on the holders.
  • the welding device must be positioned in the pressure-resistant container so that accumulating condensate or cleaning liquids can not accumulate.
  • the opening of the non-pressure-resistant container 3 is rotated to the welding device.
  • the welding head 63 is heated until the correct temperature is reached.
  • Welding device 100 is extended.
  • the film slides out of the grooves 104 and is pressed onto the opening. Then the head 63 of the welding ⁇ reaches the opening and welded to the film.
  • Welding head is retracted again and the film slides from the holder 103. The process is complete.
  • no beta-port cover is shown, but he ⁇ te but could already be in the opening, as well as other types of closures. Control mechanisms, e.g. For example, temperature, position and success of welding are not shown.
  • FIG. 4b shows the non-pressure-resistant container 3 without the holder 5.
  • a cylindrical connection 50 .lamda.
  • the device 110 consists inter alia of a holder 111 which is provided with hooks 114 in order to hold the protective cap 54 in position on the groove 116 during the treatment process.
  • the hooks 114 are provided on the lower side with a flat surface 117 in order to push the protective cap 54 onto the connection of the non-pressure-resistant container 3.
  • An inclined plane 115 allows the hooks 114 to be easily removed from the assembled protective cap 54.
  • the protective cap 54 itself has hooks which engage in a groove 118.
  • hooks are designed so that they can be opened by hand if necessary.
  • the device With a rod 112, the device can be retracted and extended. During extension, the protective cap 54 would be placed on the connection of the non-pressure-resistant container 3. If the device remains turned again ⁇ driving, because of the levels 115/117, the protective cap 54 on the opening of the non-pressure-resistant container, the holder 111 but would be drawn back into the rest position again. The protective cap is then placed ready.
  • a bellows 113 has the task to protect the interior of réellefes ⁇ th container from contamination.
  • FIG. 4c shows the non-pressure-resistant container without the holder 5.
  • a device 120 which can turn a commercially available beta port into a connection 11 provided in a non-pressure-resistant container , This device also remains in the retracted state in the cylindrical connection while the non-pressure-resistant Be ⁇ container 3 rotates.
  • the device 120 has inter alia a rod 121 and a rotating device 123.
  • the lid can be inserted into the opening 11 of the non-pressure-resistant container and screwed by means of the rotating device 123.
  • the corresponding Baj onettver gleich is not shown.
  • a bellows 122 has the task to protect the interior of the pressure-resistant container from contamination. Fig.
  • FIG. 5 shows a possible treatment plant (not to scale).
  • the non-pressure-resistant container 3 is positioned by rotating about the axis 6 to the respective cylindrical terminals 30, 40, 50, 50 '50''and 136 so that there the necessary activity can be performed.
  • the required rotation of the non-pressure-resistant container to the respective terminals results in a circular pressure-resistant container 1.
  • This can be, for example, a horizontal cylinder or a ball.
  • FIG. 5a shows the position in which, for example, the foil can be welded on.
  • Fig. 5b shows the position in which e.g. insert a funnel to fill the non-pressure-resistant container.
  • Fig. 5c shows the position in which e.g. The riser pipe can be removed from the non-pressure-resistant container.
  • Fig. 5d shows the position in which e.g. insert a commercially available beta port into the non-pressure-resistant container.
  • Fig. 5e shows the position in which e.g. can put on a protective cap.
  • Fig. 5f shows the position in which you can empty eg water or condensate on the non-pressure-resistant container.
  • Fig. 6. Basically, the actual treatment is the same as the prior art: filling with the small parts, washing, sterilizing, drying, cooling. An important difference is that with the non-pressure-resistant containers used here, the small parts do not rest on a sieve, as is the case in the prior art. The washing effect is achieved here by the riser, which has a distributor at the bottom, and the movement of the container. In the prior art, the washed-out particles are discharged from the containers by overflow rinsing. A uniform flow of cleaning liquid is sent through the sieve on the floor until the container overflows.

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  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pressure Vessels And Lids Thereof (AREA)
  • Filling Or Discharging Of Gas Storage Vessels (AREA)

Abstract

L'installation de traitement de petites pièces accepte des contenants non résistants à la pression, dans lesquels se trouvent les pièces. Les petites pièces sont traitées à l'intérieur de ces contenants qui ne sont pas résistants à la pression, et les contenants non résistants à la pression ne sont pas fermés hermétiquement à l'intérieur de l'installation de traitement de manière à ce que, une fois prélevés de l'installation de traitement, tant les contenants non résistants à la pression que leur contenu soient stériles.
PCT/EP2016/073784 2015-10-06 2016-10-05 Procédé et système de traitement de petites pièces Ceased WO2017060295A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH01446/15 2015-10-06
CH01446/15A CH711612B1 (de) 2015-10-06 2015-10-06 Anlage zur Behandlung von kleinen Teilen.

Publications (1)

Publication Number Publication Date
WO2017060295A1 true WO2017060295A1 (fr) 2017-04-13

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PCT/EP2016/073784 Ceased WO2017060295A1 (fr) 2015-10-06 2016-10-05 Procédé et système de traitement de petites pièces

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CH (1) CH711612B1 (fr)
WO (1) WO2017060295A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT201700048057A1 (it) * 2017-05-04 2018-11-04 Last Tech S R L Dosatore e procedimento per utilizzarlo.
EP3613442A1 (fr) * 2016-08-09 2020-02-26 Atec Pharmatechnik Gmbh Récipient de transport et de transfert d'un produit stérile en vrac dans un isolateur

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155933A2 (fr) * 1984-03-23 1985-09-25 Vereinigte Edelstahlwerke Aktiengesellschaft (Vew) Appareil pour la stérilisation par la vapeur
WO2004028907A1 (fr) * 2002-09-26 2004-04-08 Getinge Disinfection Ab Dispositif pour desinfecter une poche renfermant un fluide anatomique
WO2008141936A2 (fr) * 2007-05-23 2008-11-27 Helvoet Pharma Belgium N.V. Pluralité d'objets à stériliser réunis dans un contenant de transport, contenant de transport et procédé de stérilisation de ces objets
WO2010040383A1 (fr) * 2008-10-07 2010-04-15 Eric Netzhammer Dispositif pour traiter de petites pièces
EP2502636A1 (fr) * 2011-03-24 2012-09-26 Atec Pharmatechnik Gmbh Récipient divisé et procédé de traitement de petits objets
WO2014056601A1 (fr) * 2012-10-11 2014-04-17 Fresenius Medical Care Deutschland Gmbh Procédé de stérilisation

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0155933A2 (fr) * 1984-03-23 1985-09-25 Vereinigte Edelstahlwerke Aktiengesellschaft (Vew) Appareil pour la stérilisation par la vapeur
WO2004028907A1 (fr) * 2002-09-26 2004-04-08 Getinge Disinfection Ab Dispositif pour desinfecter une poche renfermant un fluide anatomique
WO2008141936A2 (fr) * 2007-05-23 2008-11-27 Helvoet Pharma Belgium N.V. Pluralité d'objets à stériliser réunis dans un contenant de transport, contenant de transport et procédé de stérilisation de ces objets
WO2010040383A1 (fr) * 2008-10-07 2010-04-15 Eric Netzhammer Dispositif pour traiter de petites pièces
EP2502636A1 (fr) * 2011-03-24 2012-09-26 Atec Pharmatechnik Gmbh Récipient divisé et procédé de traitement de petits objets
WO2014056601A1 (fr) * 2012-10-11 2014-04-17 Fresenius Medical Care Deutschland Gmbh Procédé de stérilisation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3613442A1 (fr) * 2016-08-09 2020-02-26 Atec Pharmatechnik Gmbh Récipient de transport et de transfert d'un produit stérile en vrac dans un isolateur
IT201700048057A1 (it) * 2017-05-04 2018-11-04 Last Tech S R L Dosatore e procedimento per utilizzarlo.

Also Published As

Publication number Publication date
CH711612A1 (en) 2017-04-13
CH711612B1 (de) 2019-12-30

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