[go: up one dir, main page]

WO2012017515A1 - Dispositif à micro-canal - Google Patents

Dispositif à micro-canal Download PDF

Info

Publication number
WO2012017515A1
WO2012017515A1 PCT/JP2010/063053 JP2010063053W WO2012017515A1 WO 2012017515 A1 WO2012017515 A1 WO 2012017515A1 JP 2010063053 W JP2010063053 W JP 2010063053W WO 2012017515 A1 WO2012017515 A1 WO 2012017515A1
Authority
WO
WIPO (PCT)
Prior art keywords
main body
glass tube
microchannel device
body substrate
base material
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2010/063053
Other languages
English (en)
Japanese (ja)
Inventor
忠雄 岩城
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Miraial Co Ltd
Original Assignee
Miraial Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Miraial Co Ltd filed Critical Miraial Co Ltd
Priority to PCT/JP2010/063053 priority Critical patent/WO2012017515A1/fr
Publication of WO2012017515A1 publication Critical patent/WO2012017515A1/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/56—Labware specially adapted for transferring fluids
    • B01L3/569—Glassware

Definitions

  • the present invention relates to a micro-channel device in which a fine channel for allowing fluid to pass is formed.
  • the microchannel device is used, for example, for connecting a minute channel between a plurality of devices, or for performing various measurements and chemical reactions in the minute channel.
  • the flow channel device is generally formed of a plastic material such as a fluororesin, a polyether ether ketone (PEEK) resin, or a liquid crystal polymer resin (for example, Patent Document 1).
  • micro-channel chips (or ⁇ -TAS chips) that perform various biochemical reactions and biological treatments in minute channels have good biocompatibility, high chemical stability, and high heat resistance. It is made of an excellent glass material.
  • various micro-channels are processed on the glass body base material using machining or photolithography processing technology, and finally a flat glass body base material is bonded to the opening surface by heat fusion or the like.
  • the microchannel device made of such a glass main body is difficult and extremely expensive, it may be made of a plastic material such as PDMS (Poly-Di-Methyl-Siloxane). (For example, patent document 2).
  • PDMS Poly-Di-Methyl-Siloxane
  • microchannel device in which a capillary is fitted into a part of a groove formed on a plastic base material, the surface of the groove is closed with a cover, and a channel is formed by the groove and the capillary (for example, Patent Documents) 3).
  • microchannel device in which the channel is made of plastic is inevitably inferior in chemical resistance compared to glass, no matter what plastic material is used. Therefore, it is desirable that the microchannel device in which chemical resistance or the like is regarded as important is made of glass.
  • glass has excellent chemical resistance, it is difficult to process and is expensive, and has the disadvantages of being easily damaged during handling.
  • the processing difficulty and the ease of breakage are more likely. It becomes prominent.
  • the object of the present invention is to provide a micro-flow path that can be formed in a durable plastic body substrate with easy processing (and therefore at low cost) by means of a glass material with excellent chemical resistance. It is to provide a road device.
  • the microchannel device of the present invention is a microchannel device in which a channel through which a fluid passes is provided in a plastic main body substrate, and has a bent portion in the middle.
  • a glass tube that is continuous over the entire length is embedded in a plastic base material, and both end faces of the glass tube are arranged so as to be flush with the surface of the main body base material.
  • the one end of the glass tube is formed as a fluid inlet and the other end as a discharge port, and the discharge port is disposed at a position other than the back of the position where the injection port is disposed in the main body base material. It is.
  • the glass tube may be embedded in the main body base material in a state where the main body base material is in contact with the entire circumference of the outer peripheral surface of the glass tube, and in that case, over the entire circumference of the outer peripheral surface over the entire length of the glass tube.
  • the glass tube may be embedded in the main body substrate so that the main body substrate contacts.
  • the glass tube may be embedded in the main body base material in a state where portions other than both end faces thereof are not exposed, and both ends of the glass tube may be arranged on the same surface of the main body base material.
  • a plurality of glass tubes may be embedded in the main body base material.
  • connection terminal for connecting an external device, and at least one end of the glass tube may be disposed in a region within the connection terminal,
  • the connection terminal may be formed integrally with the main body base material.
  • the connection terminal may be formed by cutting the main body base material.
  • the main body base material may be formed in a rotationally symmetric shape, and a plurality of glass tubes may be arranged radially in the main body base material, and annular grooves are formed horizontally in the main body base material, and are arranged radially. Further, the inlets of the plurality of glass tubes may be opened in the annular groove.
  • a protrusion and a recess that are positioned when connected to an external device may be formed on the main body base material, or the glass tube may be formed in a shape bent at least 90 ° in the middle. Good.
  • the main body base material may be formed of a thermosetting epoxy resin using an acid anhydride as a curing agent.
  • a glass tube that has a bent portion in the middle and is continuous over the entire length is embedded in a plastic main body base material so that both end faces of the glass tube are flush with the surface of the main body base material.
  • the flow path is formed by the internal space of the glass tube, and one end of the glass tube is a fluid inlet and the other end is a discharge port.
  • the channel can be formed in a durable plastic body substrate with easy processing (and therefore at low cost).
  • FIG. 1 is an external perspective view of a microchannel device according to a first embodiment of the present invention. It is sectional drawing which shows various modifications of the cross-sectional shape of the glass tube which concerns on the 1st Example of this invention. It is a partial expanded side sectional view of the vicinity of the injection port of the microchannel device according to the first embodiment of the present invention. It is a top view of the microchannel device concerning the 2nd example of the present invention. It is a top view of the microchannel device concerning the 3rd example of the present invention. It is side surface sectional drawing of the microchannel device which concerns on the 4th Example of this invention.
  • FIG. 1 and 2 are a side sectional view and an external perspective view of a microchannel device according to a first embodiment of the present invention.
  • a glass tube 2 is embedded in the main body substrate 1, and an internal space of the glass tube 2 is a flow path 3.
  • the glass tube 2 is continuous over the entire length, and is arranged so that both end surfaces thereof are the same surface as the surface of the main body base material 1.
  • One end of the glass tube 2 is a fluid inlet 4, and the other end is The discharge port 5 is provided.
  • the flow path 3 is formed only by the glass tube 2. Therefore, the fluid which passes the flow path 3 does not touch the plastic main body base 1, and excellent chemical resistance can be obtained.
  • the glass tube 2 is not straight and has a bent portion that is smoothly curved in the middle. Machining the glass is difficult and expensive, but the glass tube 2 can be bent and formed very easily and at low cost. Therefore, in the present invention, it is possible to easily form a channel having an appropriate shape according to the application.
  • the main body substrate 1 is in contact with the entire circumference of the outer peripheral surface over the entire length so that portions other than both end surfaces forming the injection port 4 and the discharge port 5 are not exposed to the outside of the main body substrate 1. It is embedded in the main body base material 1 in such a state. Therefore, even if the glass tube 2 has a bent shape, the main body base material 1 is not easily damaged when subjected to an impact or the like from the outside.
  • the glass tube 2 of this embodiment is formed and arranged so that both the injection port 4 and the discharge port 5 open on the upper surface 1a of the main body substrate 1 (that is, the upper surface in the direction of gravity in a normal use state). Yes. Therefore, it is easy to connect the inlet 4 and the outlet 5 to the external device.
  • the glass tube 2 is bent at a substantially right angle with a smooth curve at each position near the injection port 4 and the discharge port 5, which are both ends. It is formed straight in a direction parallel to 1a. Since the bent portion of the glass tube 2 is formed with a smooth curve in this way, not only is the bent portion difficult to break during manufacturing, but fluid that passes through the flow path 3 does not stay in the bent portion during use. The channel resistance does not increase.
  • the inner diameter of the glass tube 2 (that is, the diameter of the flow path 3) is at least 15 ⁇ m or more.
  • the inner diameter of the glass tube 2 is less than 15 ⁇ m, the manufacturing of the glass tube 2 becomes extremely difficult, for example, the flow path 3 is often blocked when the glass tube 2 is manufactured.
  • the outer diameter of the glass tube 2 takes a dimension corresponding to the diameter of the flow path 3 in consideration of durability and the like.
  • the outer diameter of the glass tube 2 having a flow path having a diameter of 15 ⁇ m is desirably 50 ⁇ m or more, preferably about 100 ⁇ m.
  • the outer diameter of the glass tube 2 having a channel having a diameter of about 100 ⁇ m is 300 ⁇ m or more, preferably about 500 ⁇ m.
  • the glass tube 2 of the present embodiment has a regular circular cross-sectional shape as shown in FIG. 3A, but is square, elliptical as shown in FIGS. 3B to 3D. It can be shaped, rectangular or other shapes.
  • the cross-sectional shape of the flow path 3 is similar to the outer shape of the glass tube 2 and has no uneven thickness. By doing so, not only the manufacture is easy, but also the possibility that the glass tube 2 is broken due to internal stress, internal strain or the like is reduced, and excellent durability can be obtained.
  • a low-cost glass material generally used such as soda glass, borosilicate glass or barium borosilicate glass can be used.
  • the characteristic corresponding to the intended purpose can also be acquired using special glass, such as quartz glass, low alkali glass, or non-alkali glass.
  • the main body base material 1 in which the glass tube 2 is embedded can be formed of a thermosetting plastic material or a thermoplastic plastic material.
  • thermosetting plastic material epoxy resin, silicone resin, urea resin, melamine resin, phenol resin, unsaturated polyester resin, alkyd resin, urethane resin, ebonite and the like can be used.
  • thermoplastic material fluorine resin, polyether ether ketone resin, liquid crystal polymer resin, polyethylene resin, polybutylene terephthalate resin, ABS resin, acrylic resin, polycarbonate resin, cyclic olefin resin, polystyrene resin, etc. should be used. Can do.
  • thermoplastic plastic material when used as the main body substrate 1, the glass tube 2 is broken unless the diameter of the glass tube 2 is at least about 2 mm. Therefore, it is preferable to use a thermosetting plastic material as the material of the glass tube 2 forming the flow path 3 of the micro flow path device.
  • thermosetting plastic materials an epoxy resin that has a small shrinkage at the time of curing at the time of manufacture and excellent in durability at the time of use is suitable as a material of the main body 1.
  • an epoxy resin in which an acid anhydride is used as a curing agent is optimal in that the shrinkage during curing is small.
  • Such a microchannel device according to the first embodiment of the present invention can be easily manufactured by, for example, a casting method.
  • the glass tube 2 is set in a mold shaped like the outer shape of the main body base material 1, an epoxy resin before curing is poured into the mold, heated or left at room temperature, and then from the mold.
  • the microchannel device of the present invention is obtained by removing the main body substrate 1 and the glass tube 2 integrated therewith.
  • the microchannel device may be manufactured by injection molding, casting, or other manufacturing methods.
  • FIG. 4 shows an example of a state in which such an injection nozzle 30 is connected to the injection port 4.
  • a fluid passage 32 through which a fluid passes is vertically formed in the nozzle body 31, and an O-ring 33 for sealing surrounds a fluid supply port 32 a that is an outlet opening of the fluid passage 32,
  • the nozzle body 31 is attached to the lower end surface.
  • the O-ring 33 is pressed against the upper surface 1 a of the main body substrate 1 with the fluid supply port 32 a facing the injection port 4. In that state, there is a gap between the nozzle main body 31 and the upper surface 1a of the main body base 1, and there is no possibility that the glass tube 2 is broken. However, the O-ring 33 may be crushed by the nozzle body 31 so that the fluid supply port 32 a is in close contact with the injection port 4.
  • connection part of the discharge outlet 5 and an external device can also be comprised similarly.
  • FIG. 5 and 6 are plan views of the microchannel device according to the second and third embodiments of the present invention.
  • three glass tubes 2 similar to those of the first embodiment are embedded in one main body base material 1 in parallel.
  • a plurality of independent flow paths 3 can be arranged on one main body base material 1.
  • the two glass tubes 2 are embedded so as to intersect each other, and the position of the injection port 4 and the position of the discharge port 5 are switched between the two glass tubes 2. Yes.
  • the freedom about piping of the flow path 3 increases.
  • FIG. 7 is a side cross-sectional view of a micro-channel device according to a fourth embodiment of the present invention, and the discharge port 5 is arranged on the upper surface 1a of the main body substrate 1 as in the first embodiment.
  • the inlet 4 is disposed on the side end face 1 b of the main body base 1.
  • the glass tube 2 formed in a straight line over the entire length and the discharge port 5 disposed at the position directly behind the injection port 4 in the main body base material 1 is poorly used as a microchannel device. Therefore, it is excluded from the object of the present invention.
  • FIG. 8 is a plan view of a micro-channel device according to a fifth embodiment of the present invention, in which a glass tube 2 formed in a meandering shape is embedded in the main body base material 1.
  • the length of the flow path 3 (that is, the distance from the injection port 4 to the discharge port 5) is formed long without increasing the size of the main body substrate 1, and the purpose is as a micro flow channel device. In some cases, the function corresponding to can be exhibited.
  • FIG. 9 is a partially enlarged side cross-sectional view of a microchannel device according to a sixth embodiment of the present invention.
  • a region surrounding the injection port 4 is formed so as to protrude from the periphery thereof, and the protruding portion serves as a connection terminal 6 for connecting the injection nozzle 30. 4 that are the same as those in FIG. 4 are assigned the same reference numerals as in FIG. 4, and detailed descriptions thereof are omitted.
  • connection terminal 6 is formed integrally with the main body base material 1 by the material itself forming the main body base material 1. Therefore, the production of the connection terminal 6 is not costly. However, the connection terminal 6 may be formed by cutting the end portion of the main body base material 1.
  • the inlet 4 is located at the center position of the upper end surface of the connection terminal 6.
  • An O-ring 61 for sealing the connection portion is mounted in an O-ring mounting groove 62 formed on the upper end surface of the connection terminal 6 so as to surround the injection port 4.
  • the surface on the nozzle body 31 side facing the connection terminal 6 is an umbrella-shaped guide hole 34 that covers the connection terminal 6 loosely. Therefore, when the nozzle body 31 is lowered so as to approach the connection terminal 6, the guide hole 34 moves along the outer edge of the connection terminal 6, and the fluid supply port 32 a of the fluid passage 32 is connected to the injection port 4. Automatically aligned to match position.
  • connection terminal 6 may be formed on the discharge port 5 side.
  • FIG. 10 is a partially enlarged side sectional view of a microchannel device according to a seventh embodiment of the present invention.
  • a region surrounding the injection port 4 is formed in a tapered tapered shape so as to be recessed from the surrounding region, and that portion serves as a connection terminal 6 '.
  • the tip of the nozzle body 31 is formed in a tapered shape that fits loosely into the connection terminal 6 ′, and an O-ring 33 is disposed on the tapered surface, similar to the sixth embodiment shown in FIG. 9.
  • the fluid supply port 32 a of the fluid passage 32 can be automatically aligned so as to match the position of the injection port 4.
  • FIG. 11 is a partial enlarged side cross-sectional view of a microchannel device according to an eighth embodiment of the present invention.
  • the connection terminal 6 suitable for connecting the tube 40 is integrally formed so as to protrude from the main body substrate 1.
  • connection terminal 41 is an annular retaining sleeve for pressing and fixing the end of the tube 40 connected to the connection terminal 6.
  • Protrusions 64 and 42 are formed on the circumference of the outer periphery of the connection terminal 6 and the inner periphery of the stop sleeve 41, and the tube 40 whose end is pressed by the stop sleeve 41 comes out of the connection terminal 6. It has a function to prevent it from falling out.
  • FIG. 12 is an external perspective view of a microchannel device according to a ninth embodiment of the present invention.
  • the connection terminal 106 on the injection port 4 side that protrudes from the upper surface 1a of the main body substrate 1 is formed in a shape that is smoothly bent by 90 ° in the protruding region. In this way, there are cases where the connection terminal 106 is bent and formed, so that it can be appropriately adapted to the usage environment of the microchannel device.
  • FIG. 13 is an external perspective view of a microchannel device according to a tenth embodiment of the present invention.
  • a pair of fixing portions (a first fixing portion 17A and a second fixing portion 17B) are provided on the side surface of the main body base 1, and each fixing portion 17A, 17B has a fixing hole (a first fixing hole). 18A and a second fixing hole 18B) are formed.
  • a positioning pin 19 is formed on the back side of the main body base 1.
  • Reference numeral 6 denotes the connection terminal described above.
  • the positioning pin 19 is inserted into the positioning hole of the fixing base (not shown), and the fixing screw (not shown) is inserted into the first fixing hole 18A and the second fixing hole 18B.
  • the microchannel device can be fixed at a predetermined position of the fixing base by tightening it in the screw hole of the fixing base.
  • FIG. 14 is a side cross-sectional view of a microchannel device according to an eleventh embodiment of the present invention.
  • the main body base material 1 is formed in a rotationally symmetric hat (hat) shape about the axis X, and a plurality of (for example, eight) glass tubes 2 are provided.
  • the discharge ports 5 are arranged radially so that the discharge ports 5 are positioned on the outer edge side of the back surface side of the main body base material 1 on the center side of the upper surface 1a.
  • Discharge port connection terminals 6B are individually formed on the discharge port 5 in a protruding manner. Further, all the inlets 4 are open at the bottom of an annular groove 65 formed horizontally on the upper end surface of one connection terminal 6, and all the flow paths 3 are connected to one annular groove 65 via the inlet 4. Communicated with.
  • 61 is an O-ring for sealing mounted near the outer periphery of the connection terminal 6 as described above.
  • a sealing O-ring 66 is also arranged on the inner peripheral side of the annular groove 65.
  • the fluid passage 32 of the injection nozzle 30 can be passed through the annular groove 65 simply by pressing the injection nozzle 30 against the connection terminal 6. And the flow paths 3 of all the glass tubes 2 can be connected. As a result, the fluid is supplied to all the flow paths 3 at the same pressure, and the fluid can be uniformly discharged from each discharge port 5.
  • FIG. 15 is an external perspective view of a microchannel device according to a twelfth embodiment of the present invention.
  • a part of the glass tube 2 is disposed so as to be exposed from the main body substrate 1.
  • Reference numeral 10 denotes a window hole formed in the main body substrate 1, and the glass tube 2 passes through the window hole 10.
  • the state of fluid flow can be directly observed, or laser light or the like can be applied to the exposed portion of the glass tube 2.
  • laser light or the like can be applied to the exposed portion of the glass tube 2.
  • the fluid can be heated and reacted locally.

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Micromachines (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention porte sur un tube de verre (2), qui a des sections incurvées au centre de celui-ci mais qui est continu le long de la totalité de la longueur de celui-ci, lequel tube est incorporé à l'intérieur d'un substrat de corps principal en matière plastique (1) ; les deux surfaces d'extrémité du tube de verre (2) sont agencées de façon à être dans la même position de surface que la surface du substrat de corps principal (1) ; un canal (3) est formé par l'espace à l'intérieur du tube de verre (2) ; et une extrémité du tube de verre (2) est une entrée de fluide (4), et l'autre extrémité est une sortie (5). Par conséquent, le canal incurvé (3) réalisé en un matériau en verre ayant une excellente résistance chimique peut être formé à l'intérieur d'un substrat de corps principal en matière plastique durable (1) à l'aide d'un processus facile (et, par conséquent, à un faible coût).
PCT/JP2010/063053 2010-08-03 2010-08-03 Dispositif à micro-canal Ceased WO2012017515A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/JP2010/063053 WO2012017515A1 (fr) 2010-08-03 2010-08-03 Dispositif à micro-canal

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2010/063053 WO2012017515A1 (fr) 2010-08-03 2010-08-03 Dispositif à micro-canal

Publications (1)

Publication Number Publication Date
WO2012017515A1 true WO2012017515A1 (fr) 2012-02-09

Family

ID=45559047

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2010/063053 Ceased WO2012017515A1 (fr) 2010-08-03 2010-08-03 Dispositif à micro-canal

Country Status (1)

Country Link
WO (1) WO2012017515A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015175781A (ja) * 2014-03-17 2015-10-05 島津エンジニアリング株式会社 自動シール装置
EP3278802A1 (fr) 2016-08-04 2018-02-07 Metabolys Nouveau traitement de la fibrose et stéatohépatite non alcoolique
WO2021061966A1 (fr) * 2019-09-25 2021-04-01 The Charles Stark Draper Laboratory Inc. Systèmes et procédés de fabrication de dispositifs microfluidiques fermés

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03163352A (ja) * 1989-08-28 1991-07-15 Univ Northeastern 高性能毛管電気泳動装置用統合温度制御／整合装置
JPH09251000A (ja) * 1996-03-14 1997-09-22 Bunshi Bio Photonics Kenkyusho:Kk キャピラリー電気泳動装置
JP2002207031A (ja) * 2001-01-11 2002-07-26 Shimadzu Corp マイクロチャンネル型チップ
WO2003058228A1 (fr) * 2001-12-28 2003-07-17 Cluster Technology Co., Ltd. Microplaquette pour electrophorese
JP2004058214A (ja) * 2002-07-29 2004-02-26 Kawamura Inst Of Chem Res 流路接続方法、流路接続用部材、マイクロ流体デバイス及びマイクロ流体デバイスの接続構造
JP2004085292A (ja) * 2002-08-26 2004-03-18 Hitachi Chem Co Ltd 電気泳動部材、その製造方法及びキャピラリ電気泳動装置
JP2005043188A (ja) * 2003-07-28 2005-02-17 Jasco Corp 微小径配管製造方法、微小径配管、及びそれを用いたマイクロチップ
WO2005084792A1 (fr) * 2004-02-18 2005-09-15 Hitachi Chemical Co., Ltd. Unité de support pour micro circuit de fluide
JP2007121130A (ja) * 2005-10-28 2007-05-17 Fujirebio Inc マイクロ流体デバイスおよびその製造方法
WO2008136465A1 (fr) * 2007-04-27 2008-11-13 National Institute Of Advanced Industrial Science And Technology Puce d'électrophorèse, dispositif d'électrophorèse et procédé d'analyse d'échantillon par un procédé d'électrophorèse capillaire
JP2009243965A (ja) * 2008-03-28 2009-10-22 Sumitomo Bakelite Co Ltd 流路デバイス、外装ケース付き流路デバイス、流路デバイスの使用方法
JP2010526291A (ja) * 2007-05-04 2010-07-29 クラロス ダイアグノスティクス， インコーポレイテッド 流体コネクタおよびマイクロ流体システム

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03163352A (ja) * 1989-08-28 1991-07-15 Univ Northeastern 高性能毛管電気泳動装置用統合温度制御／整合装置
JPH09251000A (ja) * 1996-03-14 1997-09-22 Bunshi Bio Photonics Kenkyusho:Kk キャピラリー電気泳動装置
JP2002207031A (ja) * 2001-01-11 2002-07-26 Shimadzu Corp マイクロチャンネル型チップ
WO2003058228A1 (fr) * 2001-12-28 2003-07-17 Cluster Technology Co., Ltd. Microplaquette pour electrophorese
JP2004058214A (ja) * 2002-07-29 2004-02-26 Kawamura Inst Of Chem Res 流路接続方法、流路接続用部材、マイクロ流体デバイス及びマイクロ流体デバイスの接続構造
JP2004085292A (ja) * 2002-08-26 2004-03-18 Hitachi Chem Co Ltd 電気泳動部材、その製造方法及びキャピラリ電気泳動装置
JP2005043188A (ja) * 2003-07-28 2005-02-17 Jasco Corp 微小径配管製造方法、微小径配管、及びそれを用いたマイクロチップ
WO2005084792A1 (fr) * 2004-02-18 2005-09-15 Hitachi Chemical Co., Ltd. Unité de support pour micro circuit de fluide
JP2007121130A (ja) * 2005-10-28 2007-05-17 Fujirebio Inc マイクロ流体デバイスおよびその製造方法
WO2008136465A1 (fr) * 2007-04-27 2008-11-13 National Institute Of Advanced Industrial Science And Technology Puce d'électrophorèse, dispositif d'électrophorèse et procédé d'analyse d'échantillon par un procédé d'électrophorèse capillaire
JP2010526291A (ja) * 2007-05-04 2010-07-29 クラロス ダイアグノスティクス， インコーポレイテッド 流体コネクタおよびマイクロ流体システム
JP2009243965A (ja) * 2008-03-28 2009-10-22 Sumitomo Bakelite Co Ltd 流路デバイス、外装ケース付き流路デバイス、流路デバイスの使用方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015175781A (ja) * 2014-03-17 2015-10-05 島津エンジニアリング株式会社 自動シール装置
EP3278802A1 (fr) 2016-08-04 2018-02-07 Metabolys Nouveau traitement de la fibrose et stéatohépatite non alcoolique
WO2018024805A1 (fr) 2016-08-04 2018-02-08 Metabolys Nouveau traitement pour la stéatohépatite non alcoolique et la fibrose
WO2021061966A1 (fr) * 2019-09-25 2021-04-01 The Charles Stark Draper Laboratory Inc. Systèmes et procédés de fabrication de dispositifs microfluidiques fermés
US11701652B2 (en) 2019-09-25 2023-07-18 The Charles Stark Draper Laboratory, Inc. Systems and methods for manufacturing closed microfluidic devices

Similar Documents

Publication Publication Date Title
CN103026239B (zh) 微流路芯片和微分析系统
US7513273B2 (en) Fluid flow control device
US20090114293A1 (en) Flow cell and process for producing the same
CN104602511A (zh) 滴灌用滴头及具备该滴灌用滴头的滴灌装置
JP5892491B2 (ja) 流路チップ
KR20110136629A (ko) 마이크로 밸브를 갖는 미세 유체 소자
WO2012017515A1 (fr) Dispositif à micro-canal
JPWO2019092989A1 (ja) マイクロ流体チップおよびマイクロ流体デバイス
JP2008224431A (ja) マイクロチップの製造方法、及びマイクロチップ
US20160008806A1 (en) Fluid handling device and method of using the same
JP2016107251A (ja) 流体取扱装置および流体取扱装置の製造方法
KR101531403B1 (ko) 미세유체 칩과 그의 제조방법, 미세유체 칩의 제조 방법에 의해 제조된 미세유체 칩, 그리고 미세유체 칩을 제조하기 위한 사출 성형 몰드
US20110014422A1 (en) Microchip and Method of Manufacturing Same
KR100988931B1 (ko) 미세 유체 칩 및 이를 제조하기 위한 사출 성형 몰드
US9162225B2 (en) Microchip
JP2012007920A (ja) マイクロ流路デバイスの製造方法
JP2014122831A (ja) マイクロ流路デバイス
JP2021109158A (ja) マイクロ流路チップ
JP6133298B2 (ja) 流体取扱装置および流体取扱方法
WO2009035126A1 (fr) Procédé de fabrication d'un dispositif microfluidique
JP5395480B2 (ja) マイクロチップ及びマイクロチップセット
JP4532457B2 (ja) マイクロ化学反応装置
JP2013224896A (ja) マイクロ流体チップ及びその製造方法並びに化学装置
JP2016017890A (ja) 流体デバイス及び流体デバイスの製造方法
KR20110102654A (ko) 마이크로 채널을 가진 구조물의 제조 방법 및 그 구조물

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 10855605

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 10855605

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: JP