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WO2010038991A3 - 산삼 또는 인삼을 포함한 인삼류의 형성층 유래 식물줄기세포주를 유효성분으로 함유하는 후천성 면역결핍증의 예방 또는 치료용 조성물 - Google Patents

산삼 또는 인삼을 포함한 인삼류의 형성층 유래 식물줄기세포주를 유효성분으로 함유하는 후천성 면역결핍증의 예방 또는 치료용 조성물 Download PDF

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Publication number
WO2010038991A3
WO2010038991A3 PCT/KR2009/005618 KR2009005618W WO2010038991A3 WO 2010038991 A3 WO2010038991 A3 WO 2010038991A3 KR 2009005618 W KR2009005618 W KR 2009005618W WO 2010038991 A3 WO2010038991 A3 WO 2010038991A3
Authority
WO
WIPO (PCT)
Prior art keywords
ginseng
cell line
preventing
cambium
treating aids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/KR2009/005618
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English (en)
French (fr)
Other versions
WO2010038991A2 (ko
Inventor
장미옥
홍선미
이은경
진영우
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
UNHWA BIOTECH CORP
Original Assignee
UNHWA BIOTECH CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2009300536A priority Critical patent/AU2009300536A1/en
Priority to CA2738825A priority patent/CA2738825A1/en
Priority to JP2011528955A priority patent/JP2012504121A/ja
Priority to CN2009801386891A priority patent/CN102170891B/zh
Priority to BRPI0919298A priority patent/BRPI0919298A2/pt
Priority to EP09818001A priority patent/EP2363137A4/en
Application filed by UNHWA BIOTECH CORP filed Critical UNHWA BIOTECH CORP
Priority to US13/121,930 priority patent/US20110217273A1/en
Publication of WO2010038991A2 publication Critical patent/WO2010038991A2/ko
Publication of WO2010038991A3 publication Critical patent/WO2010038991A3/ko
Anticipated expiration legal-status Critical
Priority to US13/803,963 priority patent/US9415081B2/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H4/00—Plant reproduction by tissue culture techniques ; Tissue culture techniques therefor
    • A01H4/005—Methods for micropropagation; Vegetative plant propagation using cell or tissue culture techniques
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Nutrition Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Epidemiology (AREA)
  • Medical Informatics (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)

Abstract

본 발명은 산삼 또는 인삼을 포함하는 인삼류(Panax ginseng)의 형성층 유래 동질적인 세포주, 그 파쇄물, 그 추출물 및 그 배양물 중 어느 하나 이상을 유효성분으로 함유하는 후천성 면역결핍증(Acquired immunodeficiency syndrom, AIDS)의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 동질적인 세포주, 그 파쇄물, 그 추출물 및 그 배양물은 천연물 유래 조성물로서 기존 약물 치료제의 부작용을 최소화하여 인체에 안전하면서도, 효과적으로 CD4+ T 세포 등 T 세포의 수를 증가시키고 HIV(human immunodeficiency virus)의 수를 감소시켜 면역불능에 따른 기회적 감염, 신경기능장애, 신생물 성장, 궁극적으로 사망에 이르는 위험을 방지하므로, 후천성 면역결핍증의 예방, 치료 및 증상완화에 유용하다.
PCT/KR2009/005618 2008-09-30 2009-09-30 산삼 또는 인삼을 포함한 인삼류의 형성층 유래 식물줄기세포주를 유효성분으로 함유하는 후천성 면역결핍증의 예방 또는 치료용 조성물 Ceased WO2010038991A2 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2738825A CA2738825A1 (en) 2008-09-30 2009-09-30 Composition for preventing or treating aids comprising plant stem cell line derived from cambium of panax ginseng including wild ginseng or ginseng as active ingredient
JP2011528955A JP2012504121A (ja) 2008-09-30 2009-09-30 山参又は人参を含む人参類の形成層由来の植物幹細胞株を有効成分として含む後天性免疫不全症の予防又は治療用組成物
CN2009801386891A CN102170891B (zh) 2008-09-30 2009-09-30 有效成分包含来自野山参或人参等人参类形成层的植物干细胞系的组合物在预防或治疗进行获得性免疫缺陷综合症中的用途
BRPI0919298A BRPI0919298A2 (pt) 2008-09-30 2009-09-30 composição para a prevenção ou o tratamento da aids que compreende a linhagem de células do tronco da planta derivada do câmbio da panax ginseng incluindo ginseng selvagem ou ginseng como ingrediente ativo.
EP09818001A EP2363137A4 (en) 2008-09-30 2009-09-30 COMPOSITION FOR THE PREVENTION OR TREATMENT OF AIDS WITH PLANT GINSENG VEGETABLE GAMBLING LINE FROM THE BAMBIUM OF PANAX GINSENG OR GINSENG AS AN ACTIVE SUBSTANCE
AU2009300536A AU2009300536A1 (en) 2008-09-30 2009-09-30 Composition for preventing or treating aids containing plant stem cell line derived from cambium of Panax ginseng including wild ginseng or ginseng as active ingredient
US13/121,930 US20110217273A1 (en) 2008-09-30 2009-09-30 Composition for Preventing or Treating AIDS Containing Plant Stem Cell Line Derived from Cambium of Panax Ginseng Including Wild Ginseng or Ginseng as Active Ingredient
US13/803,963 US9415081B2 (en) 2008-09-30 2013-03-14 Composition for preventing or treating AIDS containing plant stem cell line derived from cambium of Panax ginseng including wild ginseng or ginseng as active ingredient

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2008-0095877 2008-09-30
KR20080095877 2008-09-30

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/121,930 A-371-Of-International US20110217273A1 (en) 2008-09-30 2009-09-30 Composition for Preventing or Treating AIDS Containing Plant Stem Cell Line Derived from Cambium of Panax Ginseng Including Wild Ginseng or Ginseng as Active Ingredient
US13/803,963 Continuation US9415081B2 (en) 2008-09-30 2013-03-14 Composition for preventing or treating AIDS containing plant stem cell line derived from cambium of Panax ginseng including wild ginseng or ginseng as active ingredient

Publications (2)

Publication Number Publication Date
WO2010038991A2 WO2010038991A2 (ko) 2010-04-08
WO2010038991A3 true WO2010038991A3 (ko) 2010-06-24

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/005618 Ceased WO2010038991A2 (ko) 2008-09-30 2009-09-30 산삼 또는 인삼을 포함한 인삼류의 형성층 유래 식물줄기세포주를 유효성분으로 함유하는 후천성 면역결핍증의 예방 또는 치료용 조성물

Country Status (10)

Country Link
US (2) US20110217273A1 (ko)
EP (1) EP2363137A4 (ko)
JP (1) JP2012504121A (ko)
KR (1) KR101147861B1 (ko)
CN (1) CN102170891B (ko)
AU (1) AU2009300536A1 (ko)
BR (1) BRPI0919298A2 (ko)
CA (1) CA2738825A1 (ko)
RU (1) RU2011117262A (ko)
WO (1) WO2010038991A2 (ko)

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Publication number Priority date Publication date Assignee Title
AU2006309568B8 (en) 2005-10-31 2012-04-05 Wellkey Holdings Limited Stability of secondary metabolite mass production through synchronized plant cell cultures
US8053238B2 (en) 2005-10-31 2011-11-08 Unhwa Corporation Isolated population of plant single cells and method of preparing the same
KR101064518B1 (ko) 2007-09-21 2011-09-19 주식회사 운화 저장근을 가지는 초본식물의 형성층 유래 식물줄기세포주 및 이의 분리방법
RU2011117262A (ru) 2008-09-30 2012-11-10 Унхва Корпорейшн (Kr) Композиция для профилактики или лечения спида, содержащая в качестве активного ингредиента линию стволовых клеток растений, полученную из камбия panax ginseng, в том числе из дикорастущего женьшеня или женьшеня
WO2016028129A1 (ko) * 2014-08-22 2016-02-25 주식회사 운화 희귀 진세노사이드를 고함유하는, 산삼 또는 인삼을 포함하는 인삼류 추출물, 인삼류 형성층 유래 식물줄기세포 또는 이의 추출물 제조방법
WO2020117309A1 (en) * 2018-12-06 2020-06-11 Rahimi Maryam Plant stem cell product treatments
CN112956415B (zh) * 2021-01-18 2021-09-24 山东安然纳米实业发展有限公司 一种人参不定根培养的液体培养基及培养方法
WO2024221401A1 (zh) * 2023-04-28 2024-10-31 上海珈凯生物股份有限公司 一种人参分生组织细胞快速培养方法及其低温保藏方法

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Title
See also references of EP2363137A4 *
SUNG, H ET AL.: "Korean Red Ginseng Slows Depletion of CD4 T Cells in Human Immunodeficiency Virus Type 1-Infected Patients", CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, vol. 12, no. 4, 2005, pages 497 - 501, XP008145827 *

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KR101147861B1 (ko) 2012-06-05
US9415081B2 (en) 2016-08-16
WO2010038991A2 (ko) 2010-04-08
CN102170891A (zh) 2011-08-31
JP2012504121A (ja) 2012-02-16
US20140099285A1 (en) 2014-04-10
EP2363137A4 (en) 2012-08-01
AU2009300536A1 (en) 2010-04-08
US20110217273A1 (en) 2011-09-08
RU2011117262A (ru) 2012-11-10
BRPI0919298A2 (pt) 2019-09-24
EP2363137A2 (en) 2011-09-07
KR20100037009A (ko) 2010-04-08
CA2738825A1 (en) 2010-04-08
CN102170891B (zh) 2013-08-14

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