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WO2010097217A2 - Dragéifiant pour la dragéification de médicaments et d'aliments - Google Patents

Dragéifiant pour la dragéification de médicaments et d'aliments Download PDF

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Publication number
WO2010097217A2
WO2010097217A2 PCT/EP2010/001167 EP2010001167W WO2010097217A2 WO 2010097217 A2 WO2010097217 A2 WO 2010097217A2 EP 2010001167 W EP2010001167 W EP 2010001167W WO 2010097217 A2 WO2010097217 A2 WO 2010097217A2
Authority
WO
WIPO (PCT)
Prior art keywords
coating
sugar
coating agent
per
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2010/001167
Other languages
German (de)
English (en)
Other versions
WO2010097217A3 (fr
Inventor
Christina Dahlhof
Roland Beck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sensient Food Colors Germany GmbH and Co KG
Original Assignee
Sensient Food Colors Germany GmbH and Co KG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sensient Food Colors Germany GmbH and Co KG filed Critical Sensient Food Colors Germany GmbH and Co KG
Priority to DE112010005235.2T priority Critical patent/DE112010005235B4/de
Publication of WO2010097217A2 publication Critical patent/WO2010097217A2/fr
Anticipated expiration legal-status Critical
Publication of WO2010097217A3 publication Critical patent/WO2010097217A3/fr
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/343—Products for covering, coating, finishing, decorating
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/50—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by shape, structure or physical form, e.g. products with supported structure
    • A23G3/54—Composite products, e.g. layered, coated, filled
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
    • A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
    • A23L29/212—Starch; Modified starch; Starch derivatives, e.g. esters or ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof

Definitions

  • the invention relates to a coating agent for coating medicaments and foods, in particular chocolate. It further relates to a method for coating tablets and foods with the coating agent, as well as uses of the coating agent.
  • a chocolate is a lentil-shaped candy whose core consists of whole milk, bitter or even white chocolate and which has a mostly colored sugar coating, which firmly adheres to the core.
  • the chocolate core must be provided with the wrapper.
  • the production of the wrapper is also called coating.
  • Quality means all aspects that reflect consumer satisfaction with the product.
  • the consumer is increasingly demanding higher quality features, such. B. taste, texture and appearance. Therefore, the manufacturers strive to produce the products in all aspects in a satisfactory and uniform quality.
  • a particular difficulty is posed by the growing consumer reservations about food ingredients, some of which, irrationally, believe that they are unnatural and therefore pose health risks.
  • Such a reservation concerns, for example, the use of titanium dioxide in coatings of dragees, which is used as a white pigment in the wrapping of sugar confectionery and coated pills. Since titanium dioxide is also used in tobacco products for the production of white ash and in sunscreens as a light filter substance and for tinting packaging material, it is considered by the consumer when used as a food color as a health risk.
  • the object of the invention is to eliminate the disadvantages of the prior art.
  • it is intended to specify a coating agent which has improved whiteness properties so that after coating a coating is obtained which satisfies the standards of use such as strength, durability and appearance, but does not contain "non-natural substances"
  • a coating agent for coating medicaments and foods in particular for the production of chocolate lentils, provided, wherein the coating agent a sugar solution and / or a polyol as a sugar-free base for a coating solution, at least one starch product, preferably two starch products, and Lecithin includes.
  • starch product in the present invention one or more unmodified starches, one or more modified starches, one or more hydrolyzed starches, one or more resistant starches, maize oxtrins or mixtures thereof.
  • the coating agent comprises a sugar solution or coating solution, tapioca starch, rice starch and lecithin.
  • the advantage of using a coating solution is that the coating solution also contains sugar-free coatings.
  • the coating agent comprises gum arabic.
  • the gum arabic ensures that during storage in the drageous surface no surfaces form, through which the core could shine through. Such surfaces are excluded by the gum arabic, which indicates better drying or binding of the residual water in the dragee is due.
  • the coating agent preferably comprises 10 g of gum arabic per kg of coating solution or per kg of sugar solution.
  • the coating agent is applied to the drug or food to obtain a dragee to give a solid edible white coating which firmly adheres to the core of the dragee thus obtained.
  • the core of the dragee is the medicine or the food.
  • the coating agent does not comprise any metal oxides, in particular no titanium dioxide.
  • tablet describes the form of the drug and should not be understood to mean that the drug already has a coating, although this is possible.
  • the coating agent according to the invention gives a coating with high color brilliance, high opacity and good distribution.
  • the coating agent comprises 1 to 20, preferably 5 to 15, particularly preferably 5 to 10 g of lecithin per kg of sugar solution or per kg of coating solution.
  • the coating agent according to the invention comprises 100 to 300, more preferably 150 to 250, more preferably 200 g of rice starch and tapioca starch per kg of sugar solution or per kg of coating solution.
  • a practicable variant of the invention provides that the coating agent comprises 50 g to 300 g of rice starch and tapioca starch per kg of sugar solution or per kg of coating solution. This dosage is already sufficient to achieve a white coloration of the surface of the dragee.
  • the weight ratio of rice starch to tapioca starch is preferably in the range from 1 to 5 to 1 to 20, more preferably from 1 to 7 to 1 to 15, and most preferably from 1 to 9.
  • a weight ratio of rice starch to tapioca starch has also been favorable 1 to 20 and 30 to 1 proved.
  • a preferred coating agent according to the invention has the following composition:
  • sugar solution is meant here a 50 to 85%, preferably 60 to 78%, particularly preferred 74% solution of sucrose in water.
  • a preferred sugar syrup is a 74/75 brix sugar syrup.
  • a suitable rice starch is Rice Starch Remy B7.
  • a suitable tapioca starch is C * Actistar 11700 tapioca starch.
  • a preferred lecithin is sunflower lecithin.
  • the components are mixed homogeneously with each other, for example in a mixer such as a high shear mixer, taking into account a processing temperature up to max. 60 ° C.
  • a process for the preparation of dragees which consist of a core of a tablet or of a foodstuff and a solid coating, the coating enveloping and firmly adhering to the core, the cores being coated with a coating agent according to the invention Coating device to be coated.
  • the coating agent is coated with a given number of layers of the coating agent applied to the core, wherein after the application of a layer, the layer is dried before another layer is applied. Likewise, the outer layer is dried.
  • the amount of coated coating agent varies per layer, with a smaller amount of coating agent being used to form the first, inner layer than for forming at least a portion of the following layers.
  • 10 to 80, more preferably 20 to 40, most preferably 29 or 30 layers of the coating agent are applied. Also advantageous has been the application of 5 to 40 layers of the coating agent. It has been shown that this number of layers is already sufficient to achieve a white coloration of the surface of the dragee, especially in light dragees and at an increased dosage in the coating solution.
  • the method is preferably carried out in a conventional coating device, for example a rotating kettle.
  • a conventional coating device for example a rotating kettle.
  • the cores are given and mixed with a predetermined, usually small subset of the coating.
  • the layer is dried, whereby a layer of the coating is obtained.
  • another subset of the coating agent is added to the kettle again.
  • this layer is again dried, whereby a further layer of the coating is obtained.
  • This process of loading the kettle with a portion of the coating agent, layering and drying is repeated until the predetermined number of layers of coating has been reached.
  • the coating is preferably carried out at a temperature of 30 ° to 60 0 C, more preferably 40 ° to 60 ° C, more preferably 50 ° to 60 ° C, while the 60 ° C should not be exceeded.
  • coated tablets which consist of a core of a tablet or of a foodstuff and of a solid coating, the coating enveloping the core and firmly adhering to it.
  • the coating is opaque, preferably multi-layered and white.
  • the dragee is a chocolate.
  • the coating agent is preferably used for the preparation of a coating of a tablet or food, preferably for the preparation of a chocolate-core chocolate, or for the preparation of a haze or white dye coating.
  • Fig. 1 is a photographic representation of shock lenses with
  • FIG. 2 shows a graphic representation of the amounts of coating material according to the invention applied per coat of the coating agent in the course of the coating
  • Fig. 3 is a photographic representation of chocolate with coatings according to the invention, wherein the number of layers per coating varies. Best Mode for Carrying Out the Invention Examples
  • Comparative Example 1 describes the coating of chocolate with a coating agent consisting solely of sugar solution or coating solution.
  • Comparative Example 2 describes the coating of chocolate with a coating agent consisting of sugar solution or coating solution and tapioca starch (200 g / kg sugar solution). As Tapioka starch C * Actistar 11700 was used. Apart from that, the preparation of the coating agent and the coating of the chocolate were carried out as described in Example 1.
  • Comparative Example 3 describes the coating of chocolate with a coating agent consisting of sugar solution or coating solution and rice starch (200 g / kg sugar solution).
  • the rice starch used was Rice Starch Remi B7. Apart from that, the preparation of the coating agent and the coating of the chocolate were carried out as described in Example 2.
  • the coatings have a good opacity, but a very uneven distribution.
  • Comparative Example 4 describes the coating of chocolate with a coating agent consisting of sugar solution or coating solution, tapioca starch and rice starch.
  • the coating agent contained a total of 200 g of tapioca starch and rice starch per kg of sugar solution or per kg of coating solution, the weight ratio of tapioca starch to rice starch being ke was 1 to 9.
  • Tapioka starch C * Actistar 11700 was used.
  • the rice starch used was Rice Starch Remi B7. Apart from that, the preparation of the coating agent and the coating of the chocolate were carried out as described in Example 2.
  • the coatings have a good hiding power and a better distribution than Example 3, but still an uneven surface than the reference with titanium dioxide. After drying, stains were visible on which the brown inlays show through.
  • Comparative Example 5 describes the coating of chocolate with a coating agent according to an embodiment of the invention.
  • the coating agent had the following composition given in Table 1:
  • a high shear mixer (Ultra Turrax T450 basic) the coating agent was prepared by stirring for 2 minutes at level 1. The resulting coating was then swept through a household sieve to ensure that the coating had no lumps. It had a pH of 5.86. Subsequently, in a rotating coating pan (ERWEKA AR 401, speed 250 min -1 ) with 1 kg of deposits consisting of chocolate lenses coated with a few layers of sugar, small amounts (here 7 to 16 g) of the coating (total 300 g ) at a temperature of 60 ° C. The amount of coating agent per layer is shown in Fig. 2.
  • the coatings have a good hiding power and a good distribution.
  • the deposits were also covered in white after drying.
  • the opacity and distribution of the coatings achieved similar blanket properties to coatings containing titanium dioxide (referred to as reference in Figure 1).
  • the illustration of chocolate bars with coatings according to the invention shown in FIG. 3, obtained according to example 1, shows that the covering power and the distribution of the coatings depend on the number of layers applied and the total application amount of the coating agent. In this case, the higher the number of layers and the higher the order quantity, the higher the opacity and the distribution of a coating.
  • the invention comprises the described and claimed coating agent, its preparation and use for the production of the embodiments of a food, in particular of chocolate.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Confectionery (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne un dragéifiant pour la dragéification de comprimés et d'aliments, en particulier pour la production de bonbons au chocolat. Selon l'invention, le dragéifiant comprend une solution de sucre et/ou un polyol en tant que base sans sucre pour une solution de dragéification, au moins un mais de préférence deux produits à base d'amidon et de la lécithine.
PCT/EP2010/001167 2009-02-25 2010-02-25 Dragéifiant pour la dragéification de médicaments et d'aliments Ceased WO2010097217A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DE112010005235.2T DE112010005235B4 (de) 2009-02-25 2010-02-25 Dragiermittel zum Dragieren von Arzneimitteln und Lebensmitteln

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE202009002583 2009-02-25
DE202009002583.7 2009-02-25
DE202009007393U DE202009007393U1 (de) 2009-02-25 2009-05-23 Dragiermittel zum Dragieren von Arzneimitteln und Lebensmitteln
DE202009007393.9 2009-05-23

Publications (2)

Publication Number Publication Date
WO2010097217A2 true WO2010097217A2 (fr) 2010-09-02
WO2010097217A3 WO2010097217A3 (fr) 2011-09-29

Family

ID=42356971

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2010/001167 Ceased WO2010097217A2 (fr) 2009-02-25 2010-02-25 Dragéifiant pour la dragéification de médicaments et d'aliments

Country Status (2)

Country Link
DE (2) DE202009007393U1 (fr)
WO (1) WO2010097217A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012068203A1 (fr) * 2010-11-16 2012-05-24 Kellogg Company Enrobage à teneur réduite en sucre contenant de l'amidon résistant et son procédé de fabrication

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013139488A2 (fr) * 2012-03-23 2013-09-26 Tiense Suikerraffinaderij N.V. Produit céréale glacé avec moins de sucre
US20150320075A1 (en) * 2012-12-20 2015-11-12 Tate & Lyle Ingredients Americas Llc Coating compositions for consumable articles
GB201408397D0 (en) * 2014-03-03 2014-06-25 Tate & Lyle Ingredients Coaring compositions for consumable articles

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1061163A (fr) 1974-11-22 1979-08-28 Ryuzo Nakatsuka Elements de moulage et produits moules
CZ297271B6 (cs) * 1994-07-12 2006-10-11 Bpsi Holdings, Inc. Suchá povlaková hmota pro výrobu filmu zabranujícímu prístupu vlhkosti, zpusob a tvorba povlaku
BR9806840C1 (pt) 1997-01-06 2000-05-30 Berwind Pharma Service Revestimentos de pelìcula e composições de revestimento de pelìcula com base em dextrina
AT500063A1 (de) 1999-11-23 2005-10-15 Sandoz Ag Beschichtete tablettenkerne
GB0323668D0 (en) 2003-10-09 2003-11-12 Nestec Sa Fat-based confectionery product coated with a film forming agent making it resistant to heat and shape stable to heat
EP2025245A1 (fr) 2007-08-10 2009-02-18 Südzucker Aktiengesellschaft Mannheim/Ochsenfurt Amidon de riz dans des nappages sans sucre

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
"Ullmanns Enzyklopädie der technischen Chemie 3.", vol. 4-19, pages: 10 - 260

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012068203A1 (fr) * 2010-11-16 2012-05-24 Kellogg Company Enrobage à teneur réduite en sucre contenant de l'amidon résistant et son procédé de fabrication
US8828466B2 (en) 2010-11-16 2014-09-09 Kellogg Company Ready-to-eat cereal with reduced sugar coating

Also Published As

Publication number Publication date
DE112010005235B4 (de) 2022-12-08
DE112010005235A5 (de) 2012-11-15
DE202009007393U1 (de) 2010-07-22
WO2010097217A3 (fr) 2011-09-29

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