[go: up one dir, main page]

WO2009111852A3 - Procédé d'obtention d'une composition pharmaceutique à base de rétinoïdes, produit dérivé de rétinoïdes et utilisation correspondante - Google Patents

Procédé d'obtention d'une composition pharmaceutique à base de rétinoïdes, produit dérivé de rétinoïdes et utilisation correspondante Download PDF

Info

Publication number
WO2009111852A3
WO2009111852A3 PCT/BR2009/000072 BR2009000072W WO2009111852A3 WO 2009111852 A3 WO2009111852 A3 WO 2009111852A3 BR 2009000072 W BR2009000072 W BR 2009000072W WO 2009111852 A3 WO2009111852 A3 WO 2009111852A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid lipid
lipid nanoparticles
retinoic acid
nanoparticles containing
containing retinoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR2009/000072
Other languages
English (en)
Portuguese (pt)
Other versions
WO2009111852A2 (fr
Inventor
Lucas Antônio MIRANDA FERREIRA
Gisele Assis Castro Goulart
Rodrigo LAMBERT ORÉFICE
Vicente Tadeu Lopes Buono
Cleida Aprecida De Oliveira
Germán Arturo BOHÓRQUEZ MAHECHA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade Federal de Minas Gerais
Original Assignee
Universidade Federal de Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal de Minas Gerais filed Critical Universidade Federal de Minas Gerais
Publication of WO2009111852A2 publication Critical patent/WO2009111852A2/fr
Publication of WO2009111852A3 publication Critical patent/WO2009111852A3/fr
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

La présente invention concerne la préparation d'une composition de nanoparticules lipidiques solides contenant des rétinoïdes et des amines lipophiles, à application cosmétique. L'invention concerne également un procédé d'obtention d'une composition à forts taux d'encapsulation d'acide rétinoïque dans les nanoparticules lipidiques solides, par formation d'une paire ionique entre l'acide rétinoïque et les amines lipophiles, ainsi que son utilisation.
PCT/BR2009/000072 2008-03-13 2009-03-13 Procédé d'obtention d'une composition pharmaceutique à base de rétinoïdes, produit dérivé de rétinoïdes et utilisation correspondante Ceased WO2009111852A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0801417A BRPI0801417B8 (pt) 2008-03-13 2008-03-13 processo para obtenção de composição farmacêutica de retinóides, produto derivado de retinóides e uso
BRPI0801417-5 2008-03-13

Publications (2)

Publication Number Publication Date
WO2009111852A2 WO2009111852A2 (fr) 2009-09-17
WO2009111852A3 true WO2009111852A3 (fr) 2009-11-12

Family

ID=41065588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2009/000072 Ceased WO2009111852A2 (fr) 2008-03-13 2009-03-13 Procédé d'obtention d'une composition pharmaceutique à base de rétinoïdes, produit dérivé de rétinoïdes et utilisation correspondante

Country Status (2)

Country Link
BR (1) BRPI0801417B8 (fr)
WO (1) WO2009111852A2 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3892257A4 (fr) * 2018-12-04 2022-12-14 LG Household & Health Care Ltd. Capsule de rétinoïde à teneur élevée et à libération prolongée et composition servant à réduire les rides, contenant celle-ci

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214501A2 (fr) * 1985-09-11 1987-03-18 American Cyanamid Company Emulsions pour l'administration de médicaments peu solubles dans l'eau, ionisables basiques et hydrophobes
WO2000059475A1 (fr) * 1999-04-06 2000-10-12 Lipocine, Inc. Compositions et procedes d'administration amelioree d'agents therapeutiques hydrophobes ionisables

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214501A2 (fr) * 1985-09-11 1987-03-18 American Cyanamid Company Emulsions pour l'administration de médicaments peu solubles dans l'eau, ionisables basiques et hydrophobes
WO2000059475A1 (fr) * 1999-04-06 2000-10-12 Lipocine, Inc. Compositions et procedes d'administration amelioree d'agents therapeutiques hydrophobes ionisables

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CASTRO G. A. ET AL.: "Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne", J. OF MICROENCAPSULATION, vol. 24, no. 5, August 2007 (2007-08-01), pages 395 - 407 *
TROTTA M. ET AL.: "lnfluence of ion pairing on topical delivery of retinoic acid from microemulsions", J. OF CONTROLLED RELEASE, vol. 86, 2003, pages 315 - 321 *

Also Published As

Publication number Publication date
BRPI0801417B8 (pt) 2021-05-25
WO2009111852A2 (fr) 2009-09-17
BRPI0801417A2 (pt) 2009-11-10
BRPI0801417B1 (pt) 2019-04-09

Similar Documents

Publication Publication Date Title
CA2819052A1 (fr) Nanoparticule unique comportant un nano ecart entre un materiau noyau et une preparation materiau enveloppe et methode de preparation associee
WO2011150212A3 (fr) Nanoparticules magnétiques
WO2012027360A3 (fr) Nanostructures ramifiées pour électrodes de batterie
WO2013112224A3 (fr) Colloïdes superparamagnétiques présentant une meilleure stabilité de charge pour des structures photoniques accordables magnétiquement et de haute qualité
AU2014359194A1 (en) Lipid microcapsules preferably comprising a retinoid, and composition containing same, method for the production thereof, and use thereof in dermatology
WO2011017690A3 (fr) Administration intracellulaire d'agents de contraste avec des nanoparticules fonctionnalisées
BR112015014831A2 (pt) partículas anidras de pó a líquido
WO2010129910A3 (fr) Electrode comprenant des nanostructures pour cellules rechargeables
ATE539455T1 (de) Positives aktives elektrodenmaterial, lithiumsekundärbatterie und herstellungsverfahren dafür
MX2013011011A (es) Composicion de liberacion constante de plata para la purificacion del agua.
WO2014099167A3 (fr) Compositions à deux constituants contenant des complexes d'halogénure d'acide aminé de zinc tétrabasique et de la cystéine
BR112013019152A2 (pt) conector hermético, perfurável sem agulha e automaticamente resselável, para dispositivos a serem usados para coletar e administrar soluções líquidas para uso farmacêutico e/ou nutricional
WO2005094221A3 (fr) Nanostructures avec nanoparticules deposees par electrodeposition
WO2010079466A3 (fr) Particules de distribution
WO2012001012A3 (fr) Combinaison micellaire comprenant une nanoparticule et une pluralité de ligands tensioactifs polymérisables (surfomères)
WO2010059865A3 (fr) Appareil et procédé de fabrication d'une électrode à nanostructure en 3d pour une batterie ou un condensateur électrochimique
UA112540C2 (uk) Плівкова лікарська форма, яка містить вільну основу силденафілу, і спосіб її отримання
WO2013117588A3 (fr) Couche mince pour conducteur pour applications cérébrales
WO2010094043A3 (fr) Nanoparticules lipidiques exprimant le gadolinium destinées à l'imagerie par résonance magnétique
WO2008136853A3 (fr) Procédés de séparation de nanoparticules magnétiques
PH12014502887B1 (en) Water dispersible granule, and method for producing same
WO2012102516A3 (fr) Nanocomposite ayant à la fois des propriétés magnétiques et des caractéristiques lumineuses et procédé de préparation associé
ZA201304246B (en) Gelatin encapsulated oral care composition containing hydrophilic active,hydrophobic structuring agent and oil carrier
WO2014174495A3 (fr) Composition cosmétique améliorée
WO2011126269A3 (fr) Procédé de préparation d'un colloïde à amas magnétiques et colloïde à amas magnétiques préparé ainsi

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09720087

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09720087

Country of ref document: EP

Kind code of ref document: A2