[go: up one dir, main page]

WO2009111852A3 - Solid lipid nanoparticles containing retinoids - Google Patents

Solid lipid nanoparticles containing retinoids Download PDF

Info

Publication number
WO2009111852A3
WO2009111852A3 PCT/BR2009/000072 BR2009000072W WO2009111852A3 WO 2009111852 A3 WO2009111852 A3 WO 2009111852A3 BR 2009000072 W BR2009000072 W BR 2009000072W WO 2009111852 A3 WO2009111852 A3 WO 2009111852A3
Authority
WO
WIPO (PCT)
Prior art keywords
solid lipid
lipid nanoparticles
retinoic acid
nanoparticles containing
containing retinoids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/BR2009/000072
Other languages
French (fr)
Portuguese (pt)
Other versions
WO2009111852A2 (en
Inventor
Lucas Antônio MIRANDA FERREIRA
Gisele Assis Castro Goulart
Rodrigo LAMBERT ORÉFICE
Vicente Tadeu Lopes Buono
Cleida Aprecida De Oliveira
Germán Arturo BOHÓRQUEZ MAHECHA
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universidade Federal de Minas Gerais
Original Assignee
Universidade Federal de Minas Gerais
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universidade Federal de Minas Gerais filed Critical Universidade Federal de Minas Gerais
Publication of WO2009111852A2 publication Critical patent/WO2009111852A2/en
Publication of WO2009111852A3 publication Critical patent/WO2009111852A3/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/11—Encapsulated compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/41—Amines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Nanotechnology (AREA)
  • Optics & Photonics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

The present invention describes the development of a solid lipid nanoparticle compound containing retinoids and lipophilic amines for cosmetic use. This invention also reports how the compound is processed with high encapsulation rates of retinoic acid in solid lipid nanoparticles through the formation of a ionic pair between retinoic acid in solid lipophilic nanoparticles through ion pairing between retinoic acid and lipophilic amines and their use.
PCT/BR2009/000072 2008-03-13 2009-03-13 Process to obtain a pharmaceutical composition of retinoids, derivative product of retinoids and its use Ceased WO2009111852A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI0801417A BRPI0801417B8 (en) 2008-03-13 2008-03-13 process for obtaining pharmaceutical composition of retinoids, retinoid-derived product and use
BRPI0801417-5 2008-03-13

Publications (2)

Publication Number Publication Date
WO2009111852A2 WO2009111852A2 (en) 2009-09-17
WO2009111852A3 true WO2009111852A3 (en) 2009-11-12

Family

ID=41065588

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BR2009/000072 Ceased WO2009111852A2 (en) 2008-03-13 2009-03-13 Process to obtain a pharmaceutical composition of retinoids, derivative product of retinoids and its use

Country Status (2)

Country Link
BR (1) BRPI0801417B8 (en)
WO (1) WO2009111852A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3892257A4 (en) * 2018-12-04 2022-12-14 LG Household & Health Care Ltd. High-content and sustained-release retinoid capsule, and composition for reducing wrinkles, containing same

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214501A2 (en) * 1985-09-11 1987-03-18 American Cyanamid Company Emulsion compositions for administration of sparingly water soluble ionizable basic hydrophobic drugs
WO2000059475A1 (en) * 1999-04-06 2000-10-12 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0214501A2 (en) * 1985-09-11 1987-03-18 American Cyanamid Company Emulsion compositions for administration of sparingly water soluble ionizable basic hydrophobic drugs
WO2000059475A1 (en) * 1999-04-06 2000-10-12 Lipocine, Inc. Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
CASTRO G. A. ET AL.: "Development of a new solid lipid nanoparticle formulation containing retinoic acid for topical treatment of acne", J. OF MICROENCAPSULATION, vol. 24, no. 5, August 2007 (2007-08-01), pages 395 - 407 *
TROTTA M. ET AL.: "lnfluence of ion pairing on topical delivery of retinoic acid from microemulsions", J. OF CONTROLLED RELEASE, vol. 86, 2003, pages 315 - 321 *

Also Published As

Publication number Publication date
BRPI0801417B8 (en) 2021-05-25
WO2009111852A2 (en) 2009-09-17
BRPI0801417A2 (en) 2009-11-10
BRPI0801417B1 (en) 2019-04-09

Similar Documents

Publication Publication Date Title
CA2819052A1 (en) Single nanoparticle having a nanogap between a core material and a shell material, and preparation method thereof
WO2011150212A3 (en) Magnetic nanoparticles
WO2012027360A3 (en) Branched nanostructures for battery electrodes
WO2013112224A3 (en) Superparamagnetic colloids with enhanced charge stability for high quality magnetically tunable photonic structures
AU2014359194A1 (en) Lipid microcapsules preferably comprising a retinoid, and composition containing same, method for the production thereof, and use thereof in dermatology
WO2011017690A3 (en) Intracellular delivery of contrast agents with functionalized nanoparticles
BR112015014831A2 (en) anhydrous particles of powder to liquid
WO2010129910A3 (en) Electrode including nanostructures for rechargeable cells
ATE539455T1 (en) POSITIVE ACTIVE ELECTRODE MATERIAL, LITHIUM SECONDARY BATTERY AND PRODUCTION METHOD THEREOF
MX2013011011A (en) Sustained silver release composition for water purification.
WO2014099167A3 (en) Two component compositions containing tetrabasic zinc-amino acid halide complexes and cysteine
BR112013019152A2 (en) hermetic, needle-pierceable, automatically resealable connector for devices to be used to collect and administer liquid solutions for pharmaceutical and / or nutritional use
WO2005094221A3 (en) Nanostructures with electrodeposited nanoparticles
WO2010079466A3 (en) Delivery particles
WO2012001012A3 (en) A micellular combination comprising a nanoparticle and a plurality of surfmer ligands
WO2010059865A3 (en) Apparatus and method for forming 3d nanostructure electrode for electrochemical battery or capacitor
UA112540C2 (en) A FILM MEDICINAL FORM CONTAINING THE FREE SILDENAFIL BASE AND THE METHOD OF OBTAINING THIS
WO2013117588A3 (en) A thin film for a lead for brain applications
WO2010094043A3 (en) Gadolinium expressed lipid nanoparticles for magnetic resonance imaging
WO2008136853A3 (en) Methods for separating magnetic nanoparticles
PH12014502887B1 (en) Water dispersible granule, and method for producing same
WO2012102516A3 (en) Nanocomposite having both magnetic properties and luminous characteristics and preparation method thereof
ZA201304246B (en) Gelatin encapsulated oral care composition containing hydrophilic active,hydrophobic structuring agent and oil carrier
WO2014174495A3 (en) An improved cosmetic composition
WO2011126269A3 (en) Preparation method of magnetic cluster colloid, and magnetic cluster colloid prepared thereby

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 09720087

Country of ref document: EP

Kind code of ref document: A2

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 09720087

Country of ref document: EP

Kind code of ref document: A2