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WO2009033561A8 - Substituierte 6-phenylnikotinsäuren und ihre verwendung - Google Patents

Substituierte 6-phenylnikotinsäuren und ihre verwendung Download PDF

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Publication number
WO2009033561A8
WO2009033561A8 PCT/EP2008/006969 EP2008006969W WO2009033561A8 WO 2009033561 A8 WO2009033561 A8 WO 2009033561A8 EP 2008006969 W EP2008006969 W EP 2008006969W WO 2009033561 A8 WO2009033561 A8 WO 2009033561A8
Authority
WO
WIPO (PCT)
Prior art keywords
phenylnicotinic
substituted
acids
prophylaxis
treatment
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/006969
Other languages
English (en)
French (fr)
Other versions
WO2009033561A1 (de
Inventor
Lars BÄRFACKER
Barbara ALBRECHT-KÜPPER
Peter Kolkhof
Yolanda Cancho Grande
Adam Nitsche
Heinrich Meier
Carsten Schmeck
Jens Schamberger
Klemens Lustig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elanco Animal Health GmbH
Original Assignee
Bayer Animal Health GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US12/676,568 priority Critical patent/US8143411B2/en
Priority to CA2698471A priority patent/CA2698471A1/en
Priority to NZ583697A priority patent/NZ583697A/en
Priority to BRPI0816372-3A2A priority patent/BRPI0816372A2/pt
Priority to JP2010523302A priority patent/JP2010538025A/ja
Priority to AU2008298021A priority patent/AU2008298021A1/en
Application filed by Bayer Animal Health GmbH filed Critical Bayer Animal Health GmbH
Priority to EP08801700A priority patent/EP2197846A1/de
Priority to MX2010002565A priority patent/MX2010002565A/es
Publication of WO2009033561A1 publication Critical patent/WO2009033561A1/de
Anticipated expiration legal-status Critical
Publication of WO2009033561A8 publication Critical patent/WO2009033561A8/de
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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Abstract

Die vorliegende Anmeldung betrifft neue substituierte 6-Phenylnikotinsäure-Derivate, Verfahren zu ihrer Herstellung, ihre Verwendung zur Behandlung und/oder Prophylaxe von Krankheiten sowie ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von Krankheiten, vorzugsweise zur Behandlung und/oder Prophylaxe kardiovaskulärer Erkrankungen, insbesondere von Dyslipidämien, Arteriosklerose und Herzinsuffizienz.
PCT/EP2008/006969 2007-09-07 2008-08-26 Substituierte 6-phenylnikotinsäuren und ihre verwendung Ceased WO2009033561A1 (de)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA2698471A CA2698471A1 (en) 2007-09-07 2008-08-26 Substituted 6-phenylnicotinic acids and the use thereof
NZ583697A NZ583697A (en) 2007-09-07 2008-08-26 Substituted 6-phenylnicotinic acids and the use thereof
BRPI0816372-3A2A BRPI0816372A2 (pt) 2007-09-07 2008-08-26 Ácidos 6-fenilnicotínicos substituídos e seu uso
JP2010523302A JP2010538025A (ja) 2007-09-07 2008-08-26 置換６−フェニルニコチン酸およびそれらの使用
AU2008298021A AU2008298021A1 (en) 2007-09-07 2008-08-26 Substituted 6-phenylnicotinic acids and the use thereof
US12/676,568 US8143411B2 (en) 2007-09-07 2008-08-26 Substituted 6-phenylnicotinic acids and their use
EP08801700A EP2197846A1 (de) 2007-09-07 2008-08-26 Substituierte 6-phenylnikotinsäuren und ihre verwendung
MX2010002565A MX2010002565A (es) 2007-09-07 2008-08-26 Acidos 6-fenilnicotinicos substituidos y su uso.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007042754A DE102007042754A1 (de) 2007-09-07 2007-09-07 Substituierte 6-Phenylnikotinsäuren und ihre Verwendung
DE102007042754.0 2007-09-07

Publications (2)

Publication Number Publication Date
WO2009033561A1 WO2009033561A1 (de) 2009-03-19
WO2009033561A8 true WO2009033561A8 (de) 2010-06-10

Family

ID=40032794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/006969 Ceased WO2009033561A1 (de) 2007-09-07 2008-08-26 Substituierte 6-phenylnikotinsäuren und ihre verwendung

Country Status (16)

Country Link
US (1) US8143411B2 (de)
EP (1) EP2197846A1 (de)
JP (1) JP2010538025A (de)
KR (1) KR20100066545A (de)
AU (1) AU2008298021A1 (de)
BR (1) BRPI0816372A2 (de)
CA (1) CA2698471A1 (de)
CL (1) CL2008002537A1 (de)
DE (1) DE102007042754A1 (de)
MX (1) MX2010002565A (de)
NZ (1) NZ583697A (de)
PA (1) PA8794401A1 (de)
PE (1) PE20090954A1 (de)
TW (1) TW200914002A (de)
UY (1) UY31310A1 (de)
WO (1) WO2009033561A1 (de)

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CN102863432B (zh) 2007-05-09 2016-09-07 沃泰克斯药物股份有限公司 Cftr调节剂
KR20160040745A (ko) 2007-12-07 2016-04-14 버텍스 파마슈티칼스 인코포레이티드 3-(6-(1-(2,2-디플루오로벤조[ｄ][1,3]디옥솔-5-일)사이클로프로판카복스아미도)-3-메틸피리딘-2-일)벤조산의 고체 형태
NZ599684A (en) 2007-12-07 2013-08-30 Vertex Pharma Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
NZ602030A (en) 2008-02-28 2014-02-28 Vertex Pharma Heteroaryl derivatives as cftr modulators
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
RS62767B1 (sr) 2010-04-07 2022-01-31 Vertex Pharma Farmaceutski sastavi 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il) ciklopropankarboksamido)-3-metilpiriodin-2-il)benzojeve kiseline i njihova primena
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (de) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridin-4-carbonsäureamidderivate als kinaseinhibitoren
UA114619C2 (uk) 2012-01-25 2017-07-10 Вертекс Фармасьютікалз Інкорпорейтед СКЛАД 3-(6-(1-(2,2-ДИФТОРОБЕНЗО[d][1,3]ДІОКСОЛ-5-ІЛ)ЦИКЛОПРОПАНКАРБОКСАМІДО)-3-МЕТИЛПІРИДИН-2-ІЛ)БЕНЗОЙНОЇ КИСЛОТИ
US9113629B2 (en) * 2013-03-15 2015-08-25 Dow Agrosciences Llc 4-amino-6-(4-substituted-phenyl)-picolinates and 6-amino-2-(4-substituted-phenyl)-pyrimidine-4-carboxylates and their use as herbicides
HRP20210516T2 (hr) 2013-11-12 2021-10-01 Vertex Pharmaceuticals Incorporated Postupak proizvodnje farmaceutskih pripravaka za liječenje bolesti koje su posredovane putem cftr
RS62259B1 (sr) 2014-11-18 2021-09-30 Vertex Pharma Proces izvođenja ispitivanja visoke propusnosti tečne hromatografije visokih performansi

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US20100234432A1 (en) 2010-09-16
AU2008298021A1 (en) 2009-03-19
CA2698471A1 (en) 2009-03-19
CL2008002537A1 (es) 2009-03-20
JP2010538025A (ja) 2010-12-09
DE102007042754A1 (de) 2009-03-12
PE20090954A1 (es) 2009-07-24
MX2010002565A (es) 2010-04-30
KR20100066545A (ko) 2010-06-17
EP2197846A1 (de) 2010-06-23
NZ583697A (en) 2012-04-27
US8143411B2 (en) 2012-03-27
BRPI0816372A2 (pt) 2015-02-24
TW200914002A (en) 2009-04-01
PA8794401A1 (es) 2009-07-23
UY31310A1 (es) 2009-04-30

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