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WO2009075324A1 - ロキソプロフェン含有水性貼付剤 - Google Patents

ロキソプロフェン含有水性貼付剤 Download PDF

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Publication number
WO2009075324A1
WO2009075324A1 PCT/JP2008/072508 JP2008072508W WO2009075324A1 WO 2009075324 A1 WO2009075324 A1 WO 2009075324A1 JP 2008072508 W JP2008072508 W JP 2008072508W WO 2009075324 A1 WO2009075324 A1 WO 2009075324A1
Authority
WO
WIPO (PCT)
Prior art keywords
weight
loxoprofen
plaster
aqueous plaster
containing aqueous
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/JP2008/072508
Other languages
English (en)
French (fr)
Inventor
Kazuha Tani
Mitsuji Akazawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teikoku Seiyaku Co Ltd
Original Assignee
Teikoku Seiyaku Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Seiyaku Co Ltd filed Critical Teikoku Seiyaku Co Ltd
Priority to JP2009545446A priority Critical patent/JP5307727B2/ja
Priority to CA2708234A priority patent/CA2708234C/en
Priority to ES08860605T priority patent/ES2378597T3/es
Priority to EP08860605A priority patent/EP2228063B1/en
Priority to AU2008336605A priority patent/AU2008336605B2/en
Priority to AT08860605T priority patent/ATE543493T1/de
Priority to US12/747,644 priority patent/US10098858B2/en
Priority to CN200880120293XA priority patent/CN101896175B/zh
Priority to HK11104784.9A priority patent/HK1150758B/xx
Publication of WO2009075324A1 publication Critical patent/WO2009075324A1/ja
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Rheumatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Abstract

　ロキソプロフェン含有水性貼付剤において、ロキソプロフェンの良好な安定性と、優れた経皮吸収性を備えた製剤を提供するものであり、ロキソプロフェンまたはその塩、及びトリアセチンを含有してなることを特徴とする水性貼付剤であり、詳細には、膏体重量に対してロキソプロフェンまたはその塩を０．１～５重量％、トリアセチン０．５～５重量％、水溶性高分子１～３０重量％、架橋剤０．０１～５重量％、精製水１０～９０重量％、及び無機粉末０～２０重量％含有することを特徴とする水性貼付剤である。
PCT/JP2008/072508 2007-12-12 2008-12-11 ロキソプロフェン含有水性貼付剤 Ceased WO2009075324A1 (ja)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2009545446A JP5307727B2 (ja) 2007-12-12 2008-12-11 ロキソプロフェン含有水性貼付剤
CA2708234A CA2708234C (en) 2007-12-12 2008-12-11 Aqueous loxoprofen-containing patches
ES08860605T ES2378597T3 (es) 2007-12-12 2008-12-11 Emplastos acuosos con contenido de loxoprofeno
EP08860605A EP2228063B1 (en) 2007-12-12 2008-12-11 Loxoprofen-containing aqueous plaster
AU2008336605A AU2008336605B2 (en) 2007-12-12 2008-12-11 Loxoprofen-containing aqueous plaster
AT08860605T ATE543493T1 (de) 2007-12-12 2008-12-11 Loxoprofenhaltiges wässriges pflaster
US12/747,644 US10098858B2 (en) 2007-12-12 2008-12-11 Aqueous loxoprofen-containing patches
CN200880120293XA CN101896175B (zh) 2007-12-12 2008-12-11 含有环氧洛芬的水性贴剂
HK11104784.9A HK1150758B (en) 2007-12-12 2008-12-11 Loxoprofen-containing aqueous plaster

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007-320530 2007-12-12
JP2007320530 2007-12-12

Publications (1)

Publication Number Publication Date
WO2009075324A1 true WO2009075324A1 (ja) 2009-06-18

Family

ID=40755563

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072508 Ceased WO2009075324A1 (ja) 2007-12-12 2008-12-11 ロキソプロフェン含有水性貼付剤

Country Status (10)

Country Link
US (1) US10098858B2 (ja)
EP (1) EP2228063B1 (ja)
JP (1) JP5307727B2 (ja)
KR (1) KR101539801B1 (ja)
CN (1) CN101896175B (ja)
AT (1) ATE543493T1 (ja)
AU (1) AU2008336605B2 (ja)
CA (1) CA2708234C (ja)
ES (1) ES2378597T3 (ja)
WO (1) WO2009075324A1 (ja)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012102242A1 (ja) * 2011-01-24 2012-08-02 ニプロパッチ株式会社 含水系貼付剤
JP2013018745A (ja) * 2011-07-12 2013-01-31 Teikoku Seiyaku Co Ltd 外用貼付剤
JP2015193540A (ja) * 2013-03-29 2015-11-05 興和株式会社 ロキソプロフェン含有外用固形剤
JPWO2018070406A1 (ja) * 2016-10-12 2019-07-25 帝國製薬株式会社 水性貼付剤

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102000435B1 (ko) * 2018-01-18 2019-07-16 대화제약 주식회사 하이드로겔 패치 형태의 경피투여용 약학 조성물
CN113069437A (zh) * 2020-12-29 2021-07-06 北京湃驰泰克医药科技有限公司 一种含有洛索洛芬及其药用盐的外用凝胶贴膏剂及其制备方法

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6399008A (ja) * 1986-08-01 1988-04-30 ワ−ナ−−ランバ−ト・コンパニ− 経皮投与用組成物
JPS63126832A (ja) * 1986-08-27 1988-05-30 ワ−ナ−−ランバ−ト・コンパニ− 浸透増強系
US4814173A (en) * 1987-09-08 1989-03-21 Warner-Lambert Company Silicone elastomer transdermal matrix system
JPH10120560A (ja) 1996-08-26 1998-05-12 Sankyo Co Ltd ロキソプロフェン含有外用製剤
JPH10507199A (ja) * 1995-04-26 1998-07-14 セラテック・インコーポレーテッド 塩基性薬物を経皮的に送達するための透過増強剤としてのトリアセチン
WO2001017526A1 (en) * 1999-09-03 2001-03-15 Murphy Donald M Treatment of skin disorders
JP2004083579A (ja) * 2002-07-04 2004-03-18 Sankyo Co Ltd 解熱剤組成物
WO2005110482A1 (ja) * 2004-05-13 2005-11-24 Hisamitsu Pharmaceutical Co., Inc. 非ステロイド系消炎鎮痛剤を含有する外用経皮製剤
WO2006048939A1 (ja) * 2004-11-05 2006-05-11 Lead Chemical Co., Ltd. 非ステロイド消炎鎮痛薬を含有する非水系経皮吸収製剤

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR970009886B1 (ko) * 1981-08-30 1997-06-19 히사미쯔세이야꾸 가부시기가이샤 소염진통 첩부제
WO1993009783A1 (en) * 1991-11-15 1993-05-27 Ss Pharmaceutical Co., Ltd. Anti-inflammatory and analgesic plaster
US7018647B1 (en) * 1999-12-27 2006-03-28 Teikoku Seiyaku Co., Ltd Patches for external use
ATE517614T1 (de) * 2000-04-18 2011-08-15 Hisamitsu Pharmaceutical Co Pflaster enthaltend einen anti-inflammatorischen wirkstoff
US20070189978A1 (en) * 2004-06-07 2007-08-16 Jie Zhang Compositions and methods for dermally treating musculoskeletal pain

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6399008A (ja) * 1986-08-01 1988-04-30 ワ−ナ−−ランバ−ト・コンパニ− 経皮投与用組成物
JPS63126832A (ja) * 1986-08-27 1988-05-30 ワ−ナ−−ランバ−ト・コンパニ− 浸透増強系
US4814173A (en) * 1987-09-08 1989-03-21 Warner-Lambert Company Silicone elastomer transdermal matrix system
JPH10507199A (ja) * 1995-04-26 1998-07-14 セラテック・インコーポレーテッド 塩基性薬物を経皮的に送達するための透過増強剤としてのトリアセチン
JPH10120560A (ja) 1996-08-26 1998-05-12 Sankyo Co Ltd ロキソプロフェン含有外用製剤
WO2001017526A1 (en) * 1999-09-03 2001-03-15 Murphy Donald M Treatment of skin disorders
JP2004083579A (ja) * 2002-07-04 2004-03-18 Sankyo Co Ltd 解熱剤組成物
WO2005110482A1 (ja) * 2004-05-13 2005-11-24 Hisamitsu Pharmaceutical Co., Inc. 非ステロイド系消炎鎮痛剤を含有する外用経皮製剤
WO2006048939A1 (ja) * 2004-11-05 2006-05-11 Lead Chemical Co., Ltd. 非ステロイド消炎鎮痛薬を含有する非水系経皮吸収製剤

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
See also references of EP2228063A4
SOICHIRO IWAKURA ET AL.: "Seikei Pappu-zai no Hosuiryo no Yakubutsu Hoshutsuno Oyobi Nenchakusei ni Oyobosu Eikyo", THERAPEUTIC RESEARCH, vol. 3, no. 6, 1985, pages 969 - 973 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012102242A1 (ja) * 2011-01-24 2012-08-02 ニプロパッチ株式会社 含水系貼付剤
JP2014156497A (ja) * 2011-01-24 2014-08-28 Nipro Patch Co Ltd 含水系貼付剤
JP2014156499A (ja) * 2011-01-24 2014-08-28 Nipro Patch Co Ltd 含水系貼付剤
JP5781097B2 (ja) * 2011-01-24 2015-09-16 ニプロパッチ株式会社 含水系貼付剤
JP2013018745A (ja) * 2011-07-12 2013-01-31 Teikoku Seiyaku Co Ltd 外用貼付剤
JP2015193540A (ja) * 2013-03-29 2015-11-05 興和株式会社 ロキソプロフェン含有外用固形剤
JP2018123172A (ja) * 2013-03-29 2018-08-09 興和株式会社 ロキソプロフェン含有外用固形剤
JPWO2018070406A1 (ja) * 2016-10-12 2019-07-25 帝國製薬株式会社 水性貼付剤
JP7049258B2 (ja) 2016-10-12 2022-04-06 帝國製薬株式会社 水性貼付剤

Also Published As

Publication number Publication date
US10098858B2 (en) 2018-10-16
EP2228063B1 (en) 2012-02-01
US20110003893A1 (en) 2011-01-06
KR101539801B1 (ko) 2015-07-27
CA2708234C (en) 2015-11-24
ES2378597T3 (es) 2012-04-16
EP2228063A1 (en) 2010-09-15
HK1150758A1 (en) 2012-01-13
JP5307727B2 (ja) 2013-10-02
CN101896175B (zh) 2013-03-13
CN101896175A (zh) 2010-11-24
AU2008336605A1 (en) 2009-06-18
KR20100098681A (ko) 2010-09-08
JPWO2009075324A1 (ja) 2011-04-28
EP2228063A4 (en) 2010-12-15
ATE543493T1 (de) 2012-02-15
AU2008336605B2 (en) 2013-06-27
CA2708234A1 (en) 2009-06-18

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