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WO2008110374A3 - Pellets enthaltend pharmazeutische substanz, verfahren zu deren herstellung und deren verwendung - Google Patents

Pellets enthaltend pharmazeutische substanz, verfahren zu deren herstellung und deren verwendung Download PDF

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Publication number
WO2008110374A3
WO2008110374A3 PCT/EP2008/002026 EP2008002026W WO2008110374A3 WO 2008110374 A3 WO2008110374 A3 WO 2008110374A3 EP 2008002026 W EP2008002026 W EP 2008002026W WO 2008110374 A3 WO2008110374 A3 WO 2008110374A3
Authority
WO
WIPO (PCT)
Prior art keywords
production
same
pharmaceutical substance
pellets containing
pellets
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/EP2008/002026
Other languages
English (en)
French (fr)
Other versions
WO2008110374A2 (de
Inventor
Burkhard Schluetermann
Frederic Gerber
Michael Jacob
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ADD Advanced Drug Delivery Technologies AG
Original Assignee
ADD Advanced Drug Delivery Technologies AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ADD Advanced Drug Delivery Technologies AG filed Critical ADD Advanced Drug Delivery Technologies AG
Priority to JP2009553078A priority Critical patent/JP2010520909A/ja
Priority to EP08716523A priority patent/EP2170288A2/de
Priority to US12/449,946 priority patent/US20100080849A1/en
Publication of WO2008110374A2 publication Critical patent/WO2008110374A2/de
Publication of WO2008110374A3 publication Critical patent/WO2008110374A3/de
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Die Erfindung betrifft Pellets enthaltend eine pharmazeutische Substanz mit einer Bruchfestigkeit von mehr als 0,001 Newton, Verfahren zu deren Herstellung sowie pharmazeutische Präparate auf Basis solcher Pellets.
PCT/EP2008/002026 2007-03-13 2008-03-13 Pellets enthaltend pharmazeutische substanz, verfahren zu deren herstellung und deren verwendung Ceased WO2008110374A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2009553078A JP2010520909A (ja) 2007-03-13 2008-03-13 医薬物質を含むペレット、その作製方法及びその使用
EP08716523A EP2170288A2 (de) 2007-03-13 2008-03-13 Pellets enthaltend pharmazeutische substanz, verfahren zu deren herstellung und deren verwendung
US12/449,946 US20100080849A1 (en) 2007-03-13 2008-03-13 Pellets containing a pharmaceutical substance, method for the production thereof and use of the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007012105.0 2007-03-13
DE102007012105A DE102007012105A1 (de) 2007-03-13 2007-03-13 Pellets enthaltend pharmazeutische Substanz, Verfahren zu deren Herstellung und deren Verwendung

Publications (2)

Publication Number Publication Date
WO2008110374A2 WO2008110374A2 (de) 2008-09-18
WO2008110374A3 true WO2008110374A3 (de) 2009-06-25

Family

ID=39496221

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2008/002026 Ceased WO2008110374A2 (de) 2007-03-13 2008-03-13 Pellets enthaltend pharmazeutische substanz, verfahren zu deren herstellung und deren verwendung

Country Status (5)

Country Link
US (1) US20100080849A1 (de)
EP (1) EP2170288A2 (de)
JP (1) JP2010520909A (de)
DE (1) DE102007012105A1 (de)
WO (1) WO2008110374A2 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103432066A (zh) * 2013-07-23 2013-12-11 蚌埠丰原涂山制药有限公司 一种复方甘露醇注射液及其制备方法
EP3288556A4 (de) 2015-04-29 2018-09-19 Dexcel Pharma Technologies Ltd. Oral zerfallende zusammensetzungen
US10076494B2 (en) 2016-06-16 2018-09-18 Dexcel Pharma Technologies Ltd. Stable orally disintegrating pharmaceutical compositions
EP3721870A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
EP3721871A1 (de) * 2019-04-11 2020-10-14 ADD Advanced Drug Delivery Technologies, Ltd. Verfahren zur kontinuierlichen herstellung eines wirkstoffgranulats
CA3266007A1 (en) 2022-10-20 2024-05-02 Hermes Pharma Gmbh TALC-FREE ACTIVE INGREDIENT COATING
DE102024107710A1 (de) * 2024-03-18 2025-09-18 Glatt Gesellschaft Mit Beschränkter Haftung Verfahren zur Herstellung von Tabletten
DE102024107712A1 (de) * 2024-03-18 2025-09-18 Glatt Gesellschaft Mit Beschränkter Haftung Vorrichtung zur Herstellung von Tabletten

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038752A1 (de) * 1998-12-23 2000-07-06 Aventis Behring Gmbh Fibrinklebergranulat und verfahren zu dessen herstellung
EP1593424A1 (de) * 2004-05-05 2005-11-09 Glatt Ingenieurtechnik GmbH Verfahren zur Verkapselung flüchtiger oxidationsempfindlicher Substanzen sowie von Duft- und Geschmacksstoffen in Granulatform
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
WO2007017254A2 (de) * 2005-08-09 2007-02-15 Glatt Gmbh Verfahren zur herstellung von teilchen aus pharmazeutischen substanzen, kollektiven von diesen teilchen sowie deren verwendung

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1275463A (fr) * 1960-09-28 1961-11-10 Potasse & Engrais Chimiques Perfectionnements à la granulation et au séchage de produits fluides
FR2571045B1 (fr) * 1984-10-03 1987-12-11 Roquette Freres Mannitol granulaire directement compressible et son procede de fabrication
DE19730112A1 (de) 1997-07-14 1999-01-21 Ericsson Telefon Ab L M Empfangs- und Speichervorrichtung für Übertragungseinheiten
US7572769B2 (en) * 1998-12-23 2009-08-11 Csl Behring Gmbh Fibrin adhesive granulate and method for its preparation
US6498153B1 (en) * 1998-12-31 2002-12-24 Akzo Nobel N.V. Extended release growth promoting two component composition
US6716453B1 (en) * 1999-05-20 2004-04-06 Verion, Inc. Method for increasing the active loading of compressible composition forms
DE10322062A1 (de) 2003-05-15 2004-12-02 Glatt Ingenieurtechnik Gmbh Verfahren und Vorrichtung zum Aufbringen von Flüssigkeiten in eine Feststoffströmung eines Strahlschichtapparates

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038752A1 (de) * 1998-12-23 2000-07-06 Aventis Behring Gmbh Fibrinklebergranulat und verfahren zu dessen herstellung
EP1593424A1 (de) * 2004-05-05 2005-11-09 Glatt Ingenieurtechnik GmbH Verfahren zur Verkapselung flüchtiger oxidationsempfindlicher Substanzen sowie von Duft- und Geschmacksstoffen in Granulatform
DE102005005446A1 (de) * 2005-02-04 2006-08-10 Grünenthal GmbH Bruchfeste Darreichungsformen mit retardierter Freisetzung
WO2007017254A2 (de) * 2005-08-09 2007-02-15 Glatt Gmbh Verfahren zur herstellung von teilchen aus pharmazeutischen substanzen, kollektiven von diesen teilchen sowie deren verwendung

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
K.H. BAUER, K-H FRÖMMING, C. FÜHRER: "Pharmazeutische Technologie", 1986, GEORG THIEME VERLAG, STUTTGART, XP002526816 *

Also Published As

Publication number Publication date
DE102007012105A1 (de) 2008-09-18
US20100080849A1 (en) 2010-04-01
JP2010520909A (ja) 2010-06-17
EP2170288A2 (de) 2010-04-07
WO2008110374A2 (de) 2008-09-18

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